Best TWAS P=3.38e-16 · Best GWAS P=6.39e-19 conditioned to 0.000275
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | R3HCC1L | 0.06 | 0.07 | enet | 8 | 0.05 | 1.1e-04 | 7.9 | 8.2 | 3.4e-16 | 0.87 | 0.02 | 0.97 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | R3HCC1L | 0.10 | 0.05 | enet | 14 | 0.05 | 3.4e-05 | -3.9 | 6.2 | 6.9e-10 | 0.68 | 0.18 | 0.81 | FALSE |
| 3 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOXL4 | 0.07 | 0.04 | blup | 51 | 0.03 | 7.4e-05 | -4.8 | -5.4 | 7.0e-08 | -0.47 | 0.44 | 0.21 | FALSE |
| 4 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOXL4 | 0.08 | 0.00 | blup | 51 | 0.02 | 9.4e-03 | 2.2 | 6.2 | 7.4e-10 | 0.62 | 0.01 | 0.46 | FALSE |