TWAS hub - R3HCC1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0650	0.0274	6.8e-03	0.067	NA	0.054	NA	0.052	1.7e-05	NA	1.1e-04	NA	0.00015
2	GTEx	Skin Sun Exposed Lower leg	0.1030	0.0340	8.5e-05	0.051	NA	0.053	NA	0.004	4.6e-05	NA	3.4e-05	NA	0.14000
3	ROSMAP	Brain Pre-frontal Cortex	0.0344	0.0152	6.0e-03	0.040	0.007	0.010	0.006	0.020	6.1e-06	0.038	1.8e-02	0.047	0.00110

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Illness, injury, bereavement, stress in last 2 years	11.6	14.2	18.9	4.3	4.4	2.2
Impedance of arm (left)	10.2	47.2	51.4	6.6	7.2	6.8
Impedance of whole body	10.1	51.4	59.9	7.1	7.7	6.6
Impedance of leg (right)	10.0	48.6	59.7	6.9	7.7	6.2
Impedance of arm (right)	9.6	44.6	50.9	7.1	6.8	6.0
Body mass index (BMI)	8.7	37.1	54.9	-7.4	-6.3	-4.1
Impedance of leg (left)	8.6	41.6	51.7	6.3	7.2	5.8
Handedness (chirality/laterality): Left-handed	8.1	9.8	14.1	-2.9	-3.8	-2.6
Pain type(s) experienced in last month: Hip pain	7.9	9.9	18.5	-4.3	-2.8	-1.9
Multivitamins +/- minerals	7.6	9.7	12.3	-3.5	-3.1	-2.6
BMI	7.3	42.2	69.4	-8.3	-6.6	-3.7
Medication: Amlodipine	5.9	8.3	10.5	-2.8	-3.2	-2.6
Hip circumference	5.0	21.4	29.3	-5.4	-4.9	-3.3
Vitamin and mineral supplements	4.7	6.3	9.2	3.0	2.4	2.0
Leg fat percentage (left)	4.7	17.0	30.8	-5.5	-4.1	-1.9
Heart disease (mother)	4.1	5.0	10.0	-3.2	-2.1	-0.7
Arm fat percentage (right)	4.0	15.8	26.9	-5.2	-4.0	-2.1
Standing height	4.0	39.3	66.6	8.2	6.2	3.6
High blood pressure (siblings)	4.0	5.8	9.8	-3.1	-2.1	-1.7
Qualifications: CSEs or equivalent	3.9	5.2	6.9	-2.6	-2.1	-2.1
Arm fat mass (right)	3.9	16.1	23.6	-4.9	-4.2	-2.7
Waist Hip Ratio (WHR)	3.7	16.6	20.6	4.2	4.5	3.4
Arm fat percentage (left)	3.7	14.6	27.5	-5.2	-3.7	-1.5
Nervous feelings	3.6	6.8	14.5	3.8	2.3	0.6
Arm fat mass (left)	3.6	14.7	22.8	-4.8	-4.0	-2.4
Eye problems/disorders: Glaucoma	3.6	4.3	4.4	2.1	2.1	2.1
Leg fat percentage (right)	3.5	12.6	24.2	-4.9	-3.4	-1.4
Eye problems/disorders: None of the above	3.5	4.1	5.5	-1.9	-1.7	-2.3
Age at last live birth	3.5	5.1	6.0	1.9	2.4	2.4
Leg fat mass (left)	3.5	13.6	22.7	-4.8	-3.6	-2.2
Medication: Blood pressure	3.4	6.4	9.8	-3.1	-2.6	-1.6
Serious illness, injury or assault to yourself	3.2	3.8	5.2	-2.3	-1.9	-1.6
Financial difficulties in last 2 years	3.2	4.2	5.1	-2.2	-2.3	-1.6
Ever taken oral contraceptive pill	3.2	3.6	5.0	-2.2	-1.7	-1.7
Other serious medical condition/disability diagnosed by doctor	3.1	4.0	8.5	-2.9	-1.9	0.0
Alcohol intake versus 10 years previously	3.0	4.5	6.5	-2.3	-2.5	-1.3
Lung cancer (father)	3.0	3.5	8.2	-1.0	-1.1	-2.9
Leg fat mass (right)	3.0	11.7	19.7	-4.4	-3.4	-2.0
Heart attack/myocardial infarction (self-reported)	3.0	3.8	4.9	-2.2	-2.0	-1.6
Waist circumference	2.9	10.5	17.6	-4.2	-3.2	-1.9
Time employed in main current job	2.9	3.3	7.0	0.5	1.6	2.6
Suffer from ‘nerves’	2.9	4.6	9.5	3.1	1.8	0.9
Age at First Birth	2.8	4.1	6.8	2.2	2.6	0.7
Mood swings	2.8	5.1	6.1	1.9	2.4	2.5
Reaction Time	2.7	5.1	7.1	1.6	2.7	2.4
Height	2.7	51.5	85.9	9.3	6.7	4.9
Past tobacco smoking	2.7	5.0	9.9	3.1	2.1	0.8
Schizophrenia vs Biploar Disorder	2.6	3.4	4.6	-2.0	-2.1	-1.2
Prostate Cancer	2.6	3.7	4.7	1.9	2.2	1.7
Smoking Status	2.6	6.3	12.9	-3.6	-2.4	-0.6
Comparative body size at age 10	2.6	7.2	10.2	-3.2	-3.0	-1.6
Medication: Aspirin	2.5	3.3	6.4	-2.5	-1.6	-0.9
Bipolar Disorder (2018)	2.3	3.7	6.4	2.5	1.8	1.2
LDL Cholesterol	2.3	3.6	5.5	-1.4	-2.3	-1.8
Heart attack	2.3	2.9	3.5	-1.9	-1.7	-1.6
Hair/balding pattern: Pattern 3	2.3	3.5	4.8	-2.2	-2.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.6	4.1	-1.9	-1.8	-2.0
Health satisfaction	2.3	3.0	8.1	-2.8	-0.8	0.4
Smoking status: Previous	2.3	3.5	7.5	-2.7	-1.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.9	7.4	2.7	2.5	1.0
Miserableness	2.3	3.9	6.5	1.8	2.6	1.5
Worry (Nagel 2018)	2.2	4.7	10.3	3.2	1.9	0.5
Coronary Artery Disease (CAD)	2.2	2.7	3.7	-1.6	-1.3	-1.9
Ever used hormone-replacement therapy (HRT)	2.2	2.8	3.5	-1.4	-1.8	-1.9
Illnesses of siblings	2.2	3.1	7.0	2.6	1.2	1.0
Medication: Aspirin	2.2	2.9	6.2	-2.5	-1.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	3.6	-1.7	-1.9	-0.8
Body fat percentage	2.1	8.3	17.3	-4.2	-2.7	-0.7
Age at first live birth	2.1	3.7	5.7	1.8	2.4	1.5
Pulse wave peak to peak time	2.1	2.4	3.2	1.1	1.8	1.6
Medication: Ibuprofen	2.1	2.5	5.4	-2.3	-1.5	-0.2
Comparative height size at age 10	2.1	11.8	14.4	3.6	3.8	2.9
Ever smoked	2.1	3.6	7.4	-2.7	-1.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.5	-1.8	-1.9	-0.5
Medication: Cholesterol lowering	2.0	3.2	5.7	-2.4	-1.8	-0.8
Headache pain in last month	2.0	3.4	3.7	1.9	1.7	1.9
Whole body fat mass	2.0	8.3	14.8	-3.9	-2.9	-1.4
Qualifications: nursing, teaching	2.0	3.2	3.3	-1.8	-1.8	-1.8
Weight	1.9	9.1	11.4	-3.4	-3.3	-2.3
Hypertension (Self-reported)	1.9	5.4	7.2	-2.7	-1.9	-2.4
Osteoarthritis (self-reported)	1.9	2.5	3.4	-1.1	-1.7	-1.8
Illnesses of father: High blood pressure	1.9	2.3	5.6	-0.8	-0.8	-2.4
HbA1C	1.8	2.0	4.0	-1.0	-0.9	-2.0
Rheumatoid Arthritis	1.8	2.4	3.7	-1.9	-1.8	-0.6
Ever had hysterectomy (womb removed)	1.8	2.0	3.2	-1.8	-1.6	0.4
Happiness	1.8	2.2	5.8	0.1	0.9	2.4
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	4.1	2.0	1.7	1.3
Mean time to correctly identify matches	1.8	3.4	6.9	1.0	1.5	2.6
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	3.8	-1.9	-1.5	-0.5
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.4	1.4	0.9	1.9
Neuroticism (Nagel 2018)	1.7	4.1	5.8	2.4	2.2	1.2
Primary Biliary Cirrhosis	1.7	2.4	4.0	2.0	1.4	1.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	3.1	-1.1	-1.1	-1.8
Fluid intelligence score	1.7	3.5	7.2	2.7	1.3	1.3
Exposure to tobacco smoke at home	1.7	1.9	2.8	-1.7	-1.5	-0.8
Peak expiratory flow (PEF)	1.7	3.9	10.0	-0.7	-1.1	-3.2
Leg pain on walking	1.7	2.1	4.4	-2.1	-1.3	-0.5
Arm fat-free mass (left)	1.7	8.7	12.2	-2.1	-3.0	-3.5
Mean Putamen Volume	1.6	1.9	2.8	-0.2	-1.7	-1.7
Age when periods started (menarche)	1.6	3.9	10.1	3.2	1.2	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.6	3.9	1.5	2.0	1.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.8	-2.2	0.3	1.2
Medication: Blood pressure	1.6	2.8	3.5	-1.9	-1.7	-1.4
Friendships satisfaction	1.6	2.0	3.1	0.4	1.6	1.8
Financial situation satisfaction	1.6	2.0	3.3	-1.8	-1.2	-1.1
Alcohol drinker status: Previous	1.6	1.9	3.3	-1.8	-1.1	-1.0
Intelligence (Savage-Jansen 2018)	1.5	4.7	5.8	2.4	2.1	2.0
Medication for hormone replacement therapy	1.5	1.6	2.8	1.7	1.3	0.6
Falls in the last year	1.5	2.0	3.6	-1.9	-1.0	1.2
Loud music exposure frequency	1.5	1.6	2.0	-1.4	-1.0	-1.4
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	5.2	1.2	1.5	2.3
Birth weight	1.5	3.2	5.2	-1.3	-1.7	-2.3
Qualifications: College or University degree	1.5	4.7	9.3	3.1	2.1	0.6
Leg predicted mass (right)	1.5	7.9	9.4	-2.3	-3.1	-3.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	2.3	-1.4	-1.5	-1.3
Verbal and Numeric Reasoning (VNR)	1.4	3.4	6.3	2.5	1.5	1.3
Neuroticism (2016)	1.4	2.0	4.1	2.0	1.4	0.1
Hypothyroidism (self reported)	1.4	3.1	4.0	1.6	1.7	2.0
Hearing difficulty/problems: Yes	1.4	2.2	4.2	-2.0	-1.4	-0.5
Medication: Metformin	1.4	2.0	2.7	-1.1	-1.4	-1.6
Pack years adult smoking proportion	1.4	2.1	5.5	-2.3	-0.7	0.4
Supplements: Glucosamine	1.4	1.8	3.4	-0.8	-1.1	-1.9
Trunk fat mass	1.4	5.9	11.0	-3.3	-2.4	-0.9
Neuroticism score	1.4	3.0	4.0	2.0	1.8	1.3
Illnesses of mother	1.4	1.8	3.2	1.8	1.0	1.1
Shortness of breath walking on level ground	1.4	1.6	3.5	-1.9	-1.2	-0.1
Migraine (self-reported)	1.4	1.7	3.0	1.1	1.0	1.7
Pulse rate, automated reading	1.4	4.4	6.0	2.0	1.8	2.5
Overall health rating	1.4	3.0	7.5	-2.7	-0.1	1.2
Family relationship satisfaction	1.4	1.7	4.5	-0.6	0.6	2.1
Leg fat-free mass (right)	1.4	7.7	9.1	-2.3	-3.0	-3.0
Medication: Gliclazide	1.4	1.6	2.4	-1.2	-0.9	-1.5
Fractured/broken bones in last 5 years	1.4	1.8	2.7	-1.6	-1.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.5	0.2	1.0	2.1
Pack years of smoking	1.4	2.1	5.5	-2.3	-0.7	0.6
Arm predicted mass (left)	1.4	7.4	10.0	-2.0	-2.8	-3.2
Leg fat-free mass (left)	1.3	6.7	7.8	-2.2	-2.8	-2.7
Trunk fat percentage	1.3	5.2	11.6	-3.4	-2.0	-0.2
High blood pressure	1.3	3.7	4.8	-2.1	-1.3	-2.2
Leg predicted mass (left)	1.3	6.8	8.0	-2.2	-2.8	-2.8
Forced vital capacity (FVC)	1.3	5.2	8.9	2.5	3.0	-0.3
Medication: Ramipril	1.3	1.7	2.1	-1.5	-1.1	-1.3
Pulse wave Arterial Stiffness index	1.3	1.5	2.1	-0.7	-1.4	-1.5
Arm fat-free mass (right)	1.3	6.4	8.7	-1.9	-2.6	-3.0
Arm predicted mass (right)	1.3	6.4	8.1	-2.0	-2.7	-2.8
Alcohol intake frequency.	1.3	3.0	4.4	-1.9	-2.1	-1.1
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.7	-1.6	-1.1	-0.7
Medication: Bendroflumethiazide	1.3	1.9	2.3	-1.4	-1.5	-1.3
Depressed Affect (Nagel 2018)	1.2	2.5	4.2	0.8	2.1	1.6
Ulcerative Colitis	1.2	1.8	2.5	1.6	1.0	1.3
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.8	0.3	0.8	1.9
Number of children fathered	1.2	1.4	1.9	1.2	0.9	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.4	1.2	1.2	1.2
Basal metabolic rate	1.2	6.6	7.7	-2.1	-2.8	-2.8
HDL Cholesterol	1.1	1.8	3.7	0.9	0.9	1.9
Triglycerides	1.1	1.8	3.7	-0.2	-1.3	-1.9
Cardiovascular Disease	1.1	3.6	5.2	-2.2	-0.8	-2.3
Number of treatments/medications taken	1.1	2.1	3.0	-1.7	-1.7	-0.7
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.6	0.4	1.0	1.9
Supplements: Zinc	1.1	1.2	2.3	0.8	1.5	0.7
Hayfever, allergic rhinitis or eczema	1.1	2.3	3.7	1.9	1.7	0.7
Had other major operations	1.1	1.4	2.7	-1.2	-1.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.7	-1.6	-1.1	0.2
Forced vital capacity (FVC), Best measure	1.1	4.2	8.3	2.1	2.9	-0.2
Worry too long after embarrassment	1.1	1.8	2.3	1.1	1.4	1.5
Medication for pain relief, constipation, heartburn	1.1	1.8	3.7	1.9	1.1	-0.7
Illnesses of father: Heart disease	1.1	1.5	2.7	-1.6	-1.4	-0.1
Ever had bowel cancer screening	1.1	1.2	2.0	-1.4	-1.2	-0.5
Whole body water mass	1.1	6.1	8.0	-1.7	-2.7	-2.8
Mother’s age at death	1.1	1.3	2.3	1.1	1.5	0.6
Age started oral contraceptive pill	1.1	1.4	3.9	-0.3	-2.0	0.4
Diastolic blood pressure, automated reading	1.1	3.5	4.5	2.1	2.1	1.3
Prospective memory result	1.0	1.2	2.3	1.0	1.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	6.4	1.7	2.5	-0.5
Blood clot in the leg (DVT)	1.0	1.3	3.5	-0.2	0.5	1.9
Medication: Seretide 50 evohaler	1.0	1.1	1.8	1.1	0.6	1.3
Whole body fat-free mass	1.0	5.9	8.0	-1.7	-2.6	-2.8
Mineral and other dietary supplements	1.0	1.4	2.5	0.5	1.2	1.6
Depression (Nagel 2018)	0.9	1.4	3.1	0.2	1.0	1.8
Major Depression (MDD)	0.9	1.1	1.7	1.2	-0.6	-1.3
Neuroticism	0.9	2.2	3.3	1.8	1.6	0.8
Current tobacco smoking	0.9	1.5	2.9	-1.7	-1.2	-0.3
Fed-up feelings	0.9	1.6	3.5	0.6	1.0	1.9
Mouth/teeth dental problems	0.9	1.3	2.7	1.6	-0.2	-1.1
Worrier / anxious feelings	0.9	1.7	4.2	2.0	0.5	0.8
Birth weight of first child	0.9	1.7	3.5	-1.9	-0.9	-0.8
Glaucoma (self-reported)	0.9	1.1	1.4	1.2	0.8	1.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.8	-1.3	-1.0	0.7
Neck or shoulder pain in last month	0.9	1.3	2.9	-1.7	-0.8	-0.7
Commuting to job workplace: Walk	0.9	1.0	1.4	0.6	1.1	1.2
Osteoporosis (self-reported)	0.9	1.1	2.0	1.4	0.9	0.7
Illnesses of father: None of the above (group 1)	0.9	1.1	1.4	1.1	1.2	0.7
Wears glasses or contact lenses	0.9	1.0	2.0	-0.5	-1.4	-0.9
Commuting to job workplace: Public transport	0.9	1.0	2.2	0.4	0.8	1.5
Bipolar Disorder or Schizophrenia	0.8	2.0	2.8	1.2	1.7	1.3
Alzheimer’s Disease (in father)	0.8	0.9	1.7	-0.1	-1.3	-1.0
Alzheimer’s Disease (including proxy)	0.8	1.2	2.4	-1.5	-0.7	-0.8
Lupus	0.8	1.3	3.4	1.8	0.6	0.2
Allergy or Eczema	0.8	2.1	3.3	1.8	1.5	0.8
Lung FEV1/FVC ratio	0.8	3.9	4.5	-1.6	-2.1	-2.1
Relative age voice broke	0.8	1.3	2.9	1.7	0.8	0.5
Taking other prescription medications	0.8	1.2	2.1	-0.7	-1.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.7	1.7	2.2	-0.9
Noisy workplace	0.8	1.0	1.7	-1.3	0.8	0.8
Medication: Omeprazole	0.8	1.0	2.2	-0.8	-0.4	1.5
Number of full sisters	0.8	1.0	2.6	-1.6	-0.6	0.2
Eye problems/disorders: Cataract	0.8	0.9	1.3	0.9	0.7	1.2
Smoking status: Current	0.8	1.3	2.2	-1.5	-1.3	-0.2
Commuting to job workplace: Cycle	0.8	1.0	1.5	1.1	0.5	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	2.9	1.6	0.9	1.7
Body Mass Index (BMI) (2010)	0.7	1.0	1.8	-1.3	-0.8	-0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	-1.3	-0.7	-0.4
Systolic blood pressure, automated reading	0.7	1.9	3.5	-1.9	-1.1	-1.0
Medication: Simvastatin	0.7	1.1	1.8	-1.2	-1.3	-0.0
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.7	1.6	1.2	0.8
Number of full brothers	0.7	0.8	1.8	-0.6	-0.6	-1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-1.3	-0.7	-0.3
Long-standing illness, disability or infirmity	0.7	1.0	3.1	-1.8	-0.2	0.2
Breast cancer (self-reported)	0.7	0.8	1.4	1.2	0.9	0.3
Alcohol drinker status: Never	0.7	0.9	1.6	0.0	-1.3	-1.0
Pain experienced in last month	0.7	1.1	3.1	1.8	0.5	-0.1
Bipolar Disorder (2011)	0.6	0.6	1.3	0.7	0.1	-1.1
Lung FVC	0.6	3.0	5.4	-2.3	-0.9	-1.7
Stomach or abdominal pain in last month	0.6	0.8	2.3	-0.1	0.3	1.5
High blood pressure (mother)	0.6	0.8	1.3	-1.0	0.0	-1.2
Alcohol usually taken with meals	0.6	1.0	1.7	0.5	1.3	1.1
Allergy	0.6	1.4	2.5	-1.6	-1.1	-0.8
Trunk fat-free mass	0.6	3.2	5.6	-0.7	-1.9	-2.4
Trunk predicted mass	0.6	3.4	5.8	-0.8	-1.9	-2.4
Breastfed as a baby	0.6	0.8	1.4	-0.9	-1.2	0.4
Diabetes diagnosed by doctor	0.6	1.0	1.9	-1.4	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.7	-1.1	-0.1	-1.6
Myopia	0.6	0.8	1.8	0.5	-0.7	-1.3
Systolic Blood Pressure	0.5	2.5	4.5	-1.3	-1.1	-2.1
Chronotype (morning person)	0.5	1.2	2.0	1.4	1.2	0.1
Tanning	0.5	5.9	10.1	-0.3	-2.8	-3.2
Hand grip strength (left)	0.5	1.4	2.5	1.6	0.6	-1.1
Relative age of first facial hair	0.5	1.1	2.3	0.8	1.5	0.6
Angina	0.5	0.6	0.8	-0.9	-0.8	-0.7
Medication: Co-codamol	0.5	0.6	1.7	-0.4	-1.3	0.2
Diabetes (mother)	0.5	0.6	1.1	-1.0	-0.4	-0.7
Hand grip strength (right)	0.5	1.3	2.4	1.2	1.5	0.4
Medication: Levothyroxine sodium	0.5	0.8	1.0	1.0	0.7	1.0
Diabetes (self-reported)	0.5	0.8	1.9	-1.4	-0.6	-0.4
Father’s age at death	0.5	0.6	1.5	1.2	0.5	-0.4
Illnesses of siblings: Diabetes	0.5	0.7	2.0	-1.4	0.1	0.1
Medication for cholesterol	0.5	0.7	1.1	1.1	0.7	0.7
Back pain experienced in last month	0.5	0.8	2.3	-1.5	-0.1	-0.3
Hearing aid user	0.5	0.5	0.9	1.0	0.8	0.2
Medication: Lisinopril	0.5	0.6	1.5	-1.2	-0.5	-0.3
Number of operations (self-reported)	0.5	0.7	1.8	-0.6	-1.3	-0.2
Ever depressed for a whole week	0.5	0.7	1.4	-1.2	-0.7	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	-0.8	-0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-0.4	-0.0	1.1
Pulse rate	0.4	0.7	1.1	0.9	0.4	-1.0
Medication: Lansoprazole	0.4	0.4	0.5	-0.6	-0.6	-0.7
Gout (self-reported)	0.4	0.5	0.9	0.2	0.9	0.8
Exposure to tobacco smoke outside home	0.4	0.6	0.8	-0.8	-0.5	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-0.7	-0.2	0.9
Knee pain experienced in last month	0.4	0.7	1.4	-1.2	-0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-0.3	-0.0	1.1
High cholesterol (Self-reported)	0.4	0.7	1.3	-1.2	-0.7	-0.5
Unable to work because of sickness or disability	0.4	0.5	1.1	-1.0	-0.6	0.3
Breast Cancer	0.3	0.6	0.9	-0.9	-0.3	-0.9
Ovarian Cancer	0.3	0.4	0.5	-0.5	-0.7	-0.7
Crohns Disease (2012)	0.3	0.5	0.7	0.8	-0.9	0.2
Fasting Glucose	0.3	0.3	0.9	0.2	-0.3	-0.9
Schizophrenia (2014)	0.3	0.6	0.9	-0.4	0.8	1.0
Severe depression (siblings)	0.3	0.3	0.7	-0.8	0.3	0.3
Townsend deprivation index at recruitment	0.3	0.4	0.9	-0.6	-0.0	0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	-0.8	-0.7	-0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.4	-0.5	-0.6	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.5	-0.9	0.3
Medication: Atenolol	0.3	0.4	0.7	0.8	-0.5	0.6
Sitting height	0.3	1.9	3.2	1.5	0.4	-1.8
Had menopause	0.3	0.4	0.4	0.6	-0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	-0.2	1.1	0.6
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-1.0	-0.8	0.4
Length of working week for main job	0.3	0.3	0.3	-0.6	0.4	0.6
Medication: Paracetamol	0.3	0.5	0.8	-0.9	-0.0	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.5	-0.9	0.4
Emphysema/chronic bronchitis	0.3	0.4	1.1	0.1	0.0	1.0
Chest pain or discomfort	0.3	0.5	1.0	-0.4	1.0	0.6
Supplements: Vitamin C	0.3	0.3	0.8	0.9	0.3	-0.3
Average weekly red wine intake	0.3	0.4	0.8	0.7	0.9	0.2
Loneliness, isolation	0.3	0.4	0.6	-0.5	0.7	0.7
Number of self-reported non-cancer illnesses	0.3	0.6	1.6	-1.3	-0.3	-0.1
Medication: Paracetamol	0.3	0.5	1.0	-0.7	0.1	1.0
Medication: Atorvastatin	0.3	0.3	1.0	0.2	1.0	0.0
Risk taking	0.3	0.5	1.5	-1.2	-0.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	0.1	-0.2	0.9
Schizophrenia (2018)	0.2	0.5	0.6	-0.5	0.8	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.8	0.2	0.1
Crohns Disease (2017)	0.2	0.3	0.8	0.9	-0.4	0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	1.0	-0.6	0.4
Ulcerative Colitis (UC)	0.2	0.4	1.3	0.1	-1.1	-0.0
Blood Eosinophil Count	0.2	1.9	3.3	1.2	1.8	0.9
Blood Platelet Count	0.2	2.3	3.8	2.0	1.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.9	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	-0.2	-0.8	-0.7
Number of incorrect matches in round	0.2	0.4	0.8	-0.9	0.0	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.4	0.2	0.8
Asthma	0.2	0.4	1.1	1.0	0.3	-0.2
Pulse wave reflection index	0.2	0.2	0.6	-0.3	-0.8	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.6	-0.2	0.7
Angina (self-reported)	0.2	0.3	0.3	-0.5	-0.5	-0.6
Medication: Allopurinol	0.2	0.3	0.8	-0.0	0.3	-0.9
Had major operations	0.2	0.3	0.8	-0.9	-0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.6	-0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.1	-0.5	0.5
Asthma (self-reported)	0.2	0.4	1.1	1.0	0.3	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.3	-0.5	0.3	0.5
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.8	-0.1	-0.6
Irritability	0.2	0.4	1.0	1.0	0.4	0.3
Supplements: Calcium	0.2	0.2	0.4	-0.1	-0.6	-0.3
Blood White Count	0.1	0.5	0.7	-0.8	-0.8	0.5
Respiratory disease	0.1	0.3	0.6	0.2	-0.8	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.6	0.1	-0.5
Hair Pigment	0.1	1.8	5.1	0.6	2.2	0.0
Sensitivity / hurt feelings	0.1	0.2	0.7	0.8	0.2	0.2
Diabetes (father)	0.1	0.1	0.3	0.2	0.3	0.5
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	0.2	0.0
Maternal smoking around birth	0.1	0.1	0.3	0.1	0.1	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.1	0.7	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.3	0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.2	-0.9	-0.4
Qualifications: None of the above	0.1	0.2	0.4	0.1	-0.5	0.7
Pain all over the body in last month	0.1	0.1	0.1	0.3	-0.3	0.3
Number of live births	0.1	0.1	0.1	0.3	0.2	0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.8	-0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.4	-0.5	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.0	0.8	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.3	-0.4	-0.3
Guilty feelings	0.1	0.1	0.2	-0.4	-0.3	-0.3
Heart disease (siblings)	0.1	0.1	0.3	-0.5	-0.2	-0.2
Blood Red Count	0.0	0.3	0.8	0.5	-0.0	-0.9
Heel T-Score	0.0	0.4	0.6	0.7	0.1	0.7
Average weekly spirits intake	0.0	0.0	0.1	-0.4	-0.1	-0.0
Depression (self-reported)	0.0	0.1	0.1	0.3	0.1	-0.2
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	-0.1	-0.0
Cholesterol lowering medication	0.0	0.1	0.1	0.2	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.2	-0.1	-0.1

Hub : Genes

R3HCC1L

Models

Trait associations