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chr10:130,566,749-132,263,732

Best TWAS P=8.91e-11 · Best GWAS P=1.46e-10 conditioned to 0.0981

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
24	GTEx	Stomach	MGMT	0.33	0.20	enet	9	0.25	2.3e-12	-6.2	6.5	8.9e-11	-0.86	0.02	0.98	TRUE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MGMT	0.26	0.32	lasso	10	0.37	2.9e-43	-5.9	6.5	9.7e-11	-0.86	0.06	0.94	FALSE
27	GTEx	Vagina	MGMT	0.33	0.23	lasso	4	0.24	3.3e-06	-6.0	6.3	2.3e-10	-0.91	0.02	0.94	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	MGMT	0.34	0.31	lasso	6	0.28	9.8e-11	-6.4	6.3	2.7e-10	-0.97	0.00	1.00	FALSE
21	GTEx	Prostate	MGMT	0.25	0.13	lasso	4	0.20	9.4e-06	-5.9	6.3	3.1e-10	-0.86	0.03	0.93	FALSE
23	GTEx	Small Intestine Terminal Ileum	MGMT	0.31	0.14	enet	11	0.21	1.6e-05	-6.4	6.3	3.6e-10	-0.90	0.02	0.94	FALSE
15	GTEx	Heart Atrial Appendage	MGMT	0.41	0.17	enet	33	0.22	4.6e-10	-5.1	6.2	4.1e-10	-0.82	0.04	0.96	FALSE
4	GTEx	Adrenal Gland	MGMT	0.39	0.25	lasso	6	0.30	1.5e-11	-5.9	6.2	6.6e-10	-0.86	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MGMT	0.25	0.05	blup	234	0.12	1.9e-06	-5.1	6.2	7.3e-10	-0.67	0.03	0.95	FALSE
26	GTEx	Thyroid	MGMT	0.44	0.35	lasso	11	0.43	1.9e-35	-5.9	6.1	8.3e-10	-0.84	0.12	0.88	FALSE
10	GTEx	Cells Transformed fibroblasts	MGMT	0.45	0.30	enet	31	0.42	4.8e-34	-6.0	6.1	1.4e-09	-0.83	0.06	0.94	FALSE
22	GTEx	Skin Sun Exposed Lower leg	MGMT	0.45	0.30	enet	42	0.46	1.6e-41	-6.4	6.0	2.1e-09	-0.85	0.00	1.00	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	MGMT	0.32	0.29	lasso	1	0.21	2.4e-06	-6.0	6.0	2.7e-09	-0.75	0.06	0.90	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MGMT	0.40	0.24	enet	29	0.37	1.9e-22	-5.9	6.0	2.7e-09	-0.80	0.08	0.92	FALSE
43	The Cancer Genome Atlas	Soft Tissue Sarcoma	MGMT	0.14	0.05	blup	235	0.11	5.4e-07	-6.3	5.9	3.1e-09	-0.85	0.01	0.99	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	MGMT	0.41	0.38	enet	46	0.48	3.6e-69	-5.1	5.9	3.4e-09	-0.81	0.21	0.79	FALSE
19	GTEx	Nerve Tibial	MGMT	0.50	0.23	enet	46	0.42	6.9e-32	-6.0	5.9	3.8e-09	-0.81	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	MGMT	0.39	0.31	enet	60	0.35	1.8e-37	-5.1	5.9	4.3e-09	-0.72	0.84	0.16	FALSE
5	GTEx	Artery Tibial	MGMT	0.42	0.30	enet	22	0.46	1.9e-40	-6.4	5.9	4.5e-09	-0.88	0.00	1.00	FALSE
8	GTEx	Breast Mammary Tissue	MGMT	0.60	0.21	enet	13	0.33	1.6e-17	-5.1	5.9	4.7e-09	-0.85	0.08	0.92	FALSE
18	GTEx	Lung	MGMT	0.39	0.24	enet	28	0.33	5.5e-26	-5.1	5.8	5.7e-09	-0.85	0.06	0.94	FALSE
17	GTEx	Liver	MGMT	0.46	0.39	lasso	4	0.42	8.2e-13	-5.1	5.8	6.2e-09	-0.77	0.12	0.88	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGMT	0.16	0.17	enet	22	0.21	2.4e-41	-5.1	5.8	6.3e-09	-0.84	0.80	0.20	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MGMT	0.29	0.27	lasso	14	0.31	6.0e-38	-5.9	5.8	6.7e-09	-0.87	0.03	0.97	FALSE
6	GTEx	Brain Cerebellar Hemisphere	MGMT	0.53	0.15	lasso	8	0.19	1.3e-05	-5.9	5.8	7.7e-09	-0.78	0.04	0.91	FALSE
20	GTEx	Pancreas	MGMT	0.32	0.03	lasso	7	0.17	8.0e-08	-5.1	5.8	7.9e-09	-0.65	0.06	0.91	FALSE
13	GTEx	Esophagus Mucosa	MGMT	0.41	0.33	enet	37	0.38	2.3e-26	-5.1	5.7	1.2e-08	-0.75	0.49	0.51	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MGMT	0.10	0.09	enet	23	0.10	1.9e-11	-6.0	5.7	1.5e-08	-0.78	0.04	0.96	FALSE
9	GTEx	Breast Mammary Tissue (Female)	MGMT	0.46	0.31	lasso	4	0.33	1.1e-10	-5.1	5.6	1.8e-08	-0.79	0.11	0.88	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MGMT	0.19	0.06	blup	239	0.09	1.1e-06	-5.1	5.6	1.8e-08	-0.68	0.36	0.63	FALSE
2	GTEx	Adipose Subcutaneous	MGMT	0.39	0.27	enet	30	0.48	1.2e-44	-6.0	5.6	1.9e-08	-0.79	0.06	0.94	FALSE
30	NTR	Blood	MGMT	0.08	0.07	lasso	8	0.08	3.7e-24	-5.1	5.6	2.2e-08	-0.83	0.71	0.29	FALSE
29	METSIM	Adipose	MGMT	0.18	0.11	lasso	9	0.18	1.5e-25	-4.3	5.5	3.5e-08	-0.86	0.12	0.88	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	MGMT	0.13	0.07	lasso	5	0.10	2.4e-11	-5.1	5.5	3.8e-08	-0.79	0.61	0.39	FALSE
11	GTEx	Colon Sigmoid	MGMT	0.55	0.21	enet	29	0.29	9.1e-11	-5.1	5.5	4.5e-08	-0.77	0.01	0.99	FALSE
16	GTEx	Heart Left Ventricle	MGMT	0.27	0.20	lasso	7	0.22	6.3e-12	-5.1	5.4	7.0e-08	-0.76	0.24	0.76	FALSE
3	GTEx	Adipose Visceral Omentum	MGMT	0.39	0.16	enet	11	0.24	9.1e-13	-5.1	5.4	7.1e-08	-0.80	0.23	0.77	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	MGMT	0.15	0.08	lasso	4	0.10	7.5e-08	-5.1	5.4	7.7e-08	-0.78	0.52	0.47	FALSE
32	YFS	Blood	MGMT	0.50	0.40	enet	94	0.55	1.6e-218	-5.1	5.4	7.8e-08	-0.74	0.85	0.15	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	MGMT	0.11	0.07	enet	16	0.14	2.8e-16	-5.1	5.4	8.2e-08	-0.84	0.24	0.76	FALSE
34	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MGMT	0.18	0.03	blup	239	0.12	2.3e-06	-5.1	5.4	8.5e-08	-0.76	0.12	0.86	FALSE
25	GTEx	Testis	MGMT	0.49	0.34	lasso	5	0.35	2.8e-16	-5.1	5.3	8.9e-08	-0.70	0.62	0.38	FALSE
28	GTEx	Whole Blood	MGMT	0.10	0.03	enet	10	0.04	2.5e-04	4.0	5.3	1.3e-07	-0.69	0.21	0.78	FALSE
14	GTEx	Esophagus Muscularis	MGMT	0.50	0.29	enet	40	0.34	3.4e-21	-5.1	5.2	1.8e-07	-0.75	0.12	0.88	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	MGMT	0.48	0.37	enet	52	0.48	2.0e-52	-5.1	5.2	2.6e-07	-0.74	0.67	0.33	FALSE