Best TWAS P=4.61e-11 · Best GWAS P=2.97e-15 conditioned to 2.75e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Brain Frontal Cortex BA9 | METTL10 | 0.24 | 0.00 | lasso | 3 | 0.02 | 9.3e-02 | -3.8 | -6.6 | 4.6e-11 | -0.58 | 0.06 | 0.51 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | ZRANB1 | 0.09 | 0.07 | lasso | 4 | 0.06 | 1.3e-08 | 4.8 | -5.7 | 1.3e-08 | 0.02 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | METTL10 | 0.33 | 0.16 | lasso | 3 | 0.18 | 7.6e-06 | 6.4 | -6.3 | 2.3e-10 | -0.42 | 0.36 | 0.36 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | METTL10 | 0.11 | 0.00 | enet | 15 | 0.03 | 7.3e-04 | -3.2 | -5.6 | 2.1e-08 | -0.38 | 0.71 | 0.24 | FALSE |
| 5 | GTEx | Brain Hippocampus | LHPP | 0.35 | 0.01 | lasso | 7 | 0.08 | 5.2e-03 | -0.8 | 5.4 | 7.0e-08 | 0.39 | 0.03 | 0.69 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | METTL10 | 0.11 | 0.02 | lasso | 6 | 0.03 | 1.6e-02 | -4.9 | -5.2 | 1.7e-07 | -0.47 | 0.06 | 0.66 | FALSE |