Best TWAS P=6.47e-49 · Best GWAS P=3.94e-46 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | DYM | 0.30 | 0.01 | enet | 15 | 0.01 | 1.2e-01 | 12.7 | 12.8 | 2.0e-37 | 0.81 | 0.02 | 0.85 | FALSE |
| 2 | GTEx | Esophagus Mucosa | DYM | 0.12 | 0.01 | enet | 12 | 0.04 | 1.0e-03 | 14.2 | 11.0 | 4.8e-28 | 0.73 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Muscle Skeletal | HDHD2 | 0.13 | 0.03 | enet | 14 | 0.08 | 1.3e-08 | -4.2 | 5.7 | 9.4e-09 | -0.11 | 0.07 | 0.92 | TRUE |
| 4 | METSIM | Adipose | CTIF | 0.06 | 0.00 | blup | 710 | 0.01 | 3.4e-03 | 1.7 | -8.2 | 3.5e-16 | -0.18 | 0.18 | 0.04 | TRUE |
| 5 | YFS | Blood | DYM | 0.05 | 0.05 | lasso | 4 | 0.04 | 1.5e-13 | -13.2 | 14.7 | 6.5e-49 | 0.76 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | C18orf32 | 0.05 | 0.05 | lasso | 5 | 0.04 | 3.5e-03 | -5.8 | 5.8 | 8.4e-09 | 0.41 | 0.05 | 0.04 | TRUE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C18orf32 | 0.03 | 0.03 | lasso | 5 | 0.03 | 3.3e-04 | -4.6 | 5.9 | 3.5e-09 | 0.39 | 0.39 | 0.03 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C18orf32 | 0.04 | 0.03 | blup | 48 | 0.04 | 6.5e-05 | 5.2 | 9.6 | 6.8e-22 | 0.57 | 0.66 | 0.05 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DYM | 0.07 | 0.03 | lasso | 4 | 0.03 | 3.2e-04 | -8.1 | 8.2 | 1.7e-16 | 0.39 | 0.92 | 0.02 | FALSE |