Best TWAS P=6.55e-11 · Best GWAS P=2.14e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | PLK1S1 | 0.07 | 0.08 | enet | 10 | 0.08 | 4.0e-07 | 7.0 | 6.5 | 6.6e-11 | 0.97 | 0.02 | 0.98 | TRUE |
2 | GTEx | Esophagus Mucosa | PLK1S1 | 0.11 | 0.11 | lasso | 5 | 0.09 | 7.8e-07 | 5.2 | 5.2 | 1.9e-07 | 0.83 | 0.15 | 0.85 | FALSE |
3 | GTEx | Skin Not Sun Exposed Suprapubic | PLK1S1 | 0.21 | 0.09 | lasso | 6 | 0.12 | 5.3e-07 | 6.6 | 5.9 | 3.5e-09 | 0.93 | 0.06 | 0.94 | FALSE |
4 | GTEx | Testis | PLK1S1 | 0.64 | 0.34 | enet | 33 | 0.39 | 1.0e-18 | 5.3 | 5.2 | 2.2e-07 | 0.79 | 0.56 | 0.44 | FALSE |
5 | GTEx | Whole Blood | PLK1S1 | 0.08 | 0.04 | enet | 9 | 0.02 | 4.0e-03 | 5.3 | 5.3 | 8.8e-08 | 0.89 | 0.05 | 0.94 | FALSE |
6 | YFS | Blood | XRN2 | 0.34 | 0.61 | lasso | 10 | 0.61 | 3.5e-258 | 5.1 | 5.2 | 2.3e-07 | 0.49 | 1.00 | 0.00 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLK1S1 | 0.05 | 0.07 | enet | 9 | 0.07 | 5.5e-15 | 5.0 | 5.7 | 9.4e-09 | 0.88 | 0.17 | 0.83 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLK1S1 | 0.04 | 0.03 | blup | 64 | 0.04 | 4.0e-05 | 5.3 | 5.9 | 4.1e-09 | 0.88 | 0.15 | 0.84 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PLK1S1 | 0.09 | 0.02 | blup | 64 | 0.05 | 3.1e-03 | 5.5 | 5.5 | 4.9e-08 | 0.78 | 0.03 | 0.51 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLK1S1 | 0.19 | 0.12 | enet | 14 | 0.13 | 4.3e-13 | 5.2 | 5.6 | 2.1e-08 | 0.80 | 0.97 | 0.03 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | PLK1S1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | 5.2 | 5.3 | 1.1e-07 | 0.85 | 0.18 | 0.52 | FALSE |