Hub : Genes

XRN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2090	0.0760	0.00360	0.010	NA	0.030	NA	0.027	9.8e-02	NA	1.1e-02	NA	1.5e-02
2	GTEx	Breast Mammary Tissue (Female)	0.2146	0.0911	0.02000	0.015	NA	0.002	NA	-0.009	1.1e-01	NA	2.9e-01	NA	8.3e-01
3	GTEx	Cells Transformed fibroblasts	0.1000	0.0430	0.00280	-0.002	NA	-0.002	NA	0.004	5.3e-01	NA	5.0e-01	NA	1.6e-01
4	GTEx	Esophagus Muscularis	0.0960	0.0480	0.00980	-0.004	NA	-0.005	NA	-0.004	8.2e-01	NA	9.0e-01	NA	7.6e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0611	0.0257	0.00046	0.029	0.017	0.007	0.020	0.019	1.2e-04	2.2e-03	3.5e-02	1.2e-03	1.5e-03
6	YFS	Blood	0.3403	0.0359	0.00000	0.608	0.573	0.606	0.606	0.607	5.5e-259	1.1e-235	1.9e-257	1.2e-257	3.5e-258

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.2	0.5	-0.7	-0.1	-0.7	-0.1	0.5	0.4
Bipolar Disorder or Schizophrenia	1.7	4.1	6.1	-2.4	-1.8	-1.8	-1.2	2.3	2.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	-1.3	0.3	1.0	-0.2	-0.1	0.6
Depression (Nagel 2018)	1.1	1.7	4.4	-0.5	-0.3	-1.6	-0.5	1.7	2.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.6	-1.6	-0.9	-0.2	-0.3	-0.5	-0.6
Neuroticism (Nagel 2018)	0.4	0.8	1.9	-1.0	0.1	1.4	-0.2	-1.4	-0.5
Schizophrenia (2018)	2.5	5.3	8.0	-2.6	-2.3	-1.7	-1.5	2.6	2.8
Schizophrenia vs Biploar Disorder	2.9	3.9	7.9	-1.8	-1.2	-1.1	-1.9	2.8	2.4
Worry (Nagel 2018)	0.4	0.8	2.8	-1.7	-0.9	-0.0	-0.7	-0.9	0.3
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	-0.3	-1.2	1.2	1.2	-1.5	-1.3
Alzheimer’s Disease (in father)	1.2	1.3	2.9	-1.3	-0.2	-1.7	-1.3	0.8	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.7	-0.9	-0.4	0.4	-0.5	0.0
Crohns Disease (2017)	1.1	2.4	6.3	-1.1	-1.0	-1.3	-2.5	1.4	1.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	1.4	0.8	-0.6	-1.2	0.4	0.0
Ulcerative Colitis (UC)	1.0	1.9	6.4	2.5	2.1	-0.1	0.0	-0.1	-0.7
Major Depression (MDD)	0.4	0.5	1.2	-0.4	-0.8	0.5	-1.1	-0.9	-0.2
Reaction Time	0.5	0.9	3.0	0.8	-1.7	-0.1	-0.5	-1.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	-0.8	-0.4	-0.3	-0.1	-0.5	-0.8
Breast Cancer	0.7	1.6	3.5	0.4	-0.7	1.5	0.6	-1.8	-1.9
Ovarian Cancer	0.3	0.4	1.4	0.4	-0.2	-0.1	0.6	-0.3	-1.2
Prostate Cancer	0.5	0.6	1.4	0.5	1.0	-1.2	-1.1	-0.0	0.2
Age at First Birth	1.1	1.6	3.9	1.2	0.5	1.3	1.4	-0.7	-2.0
Bipolar Disorder (2011)	0.4	0.3	1.2	-1.1	-0.5	-0.5	-0.4	-0.4	0.2
Body Mass Index (BMI) (2010)	0.7	0.9	2.0	1.1	0.4	-0.9	0.2	-1.4	-1.2
Coronary Artery Disease (CAD)	0.6	0.8	1.5	0.9	1.0	1.2	0.4	-0.6	-0.9
Crohns Disease (2012)	0.4	0.6	2.1	-0.4	-1.4	-0.3	-1.0	-0.1	0.3
Mean Putamen Volume	0.2	0.2	0.6	0.7	0.4	0.2	0.3	-0.7	0.3
Fasting Glucose	0.8	0.9	2.6	-1.5	-1.6	-0.6	-0.1	-0.3	0.2
HbA1C	0.6	0.6	2.5	0.3	-0.6	-0.4	0.4	-1.6	-0.7
HDL Cholesterol	0.4	0.7	1.5	-1.2	0.2	-0.2	-1.2	0.4	1.0
LDL Cholesterol	1.4	2.3	3.5	1.6	1.7	1.9	0.6	-1.0	-1.9
Lupus	0.4	0.6	2.9	1.7	0.3	-0.4	-0.3	-0.4	-0.6
Neuroticism (2016)	1.0	1.4	5.4	-1.4	-2.3	0.5	0.6	-0.3	0.6
Primary Biliary Cirrhosis	0.5	0.7	2.3	1.0	1.5	-0.4	-0.0	0.5	0.9
Rheumatoid Arthritis	1.0	1.4	4.0	-0.7	-1.6	-0.5	0.2	0.9	2.0
Schizophrenia (2014)	2.3	5.1	8.5	-2.3	-2.1	-1.9	-2.0	2.3	2.9
Triglycerides	1.5	2.4	3.6	1.8	-0.1	1.3	1.8	-1.6	-1.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	3.0	0.1	-1.7	-0.5	-0.3	-0.3	0.4
Ulcerative Colitis	1.7	2.4	5.8	2.4	0.8	0.2	-1.8	-1.7	-1.4
Blood Eosinophil Count	0.1	0.5	1.8	1.3	-0.3	0.7	0.3	-0.3	-0.4
Blood Platelet Count	0.1	1.1	2.6	1.2	0.5	0.9	0.3	-1.6	-1.2
Blood Red Count	0.4	3.5	12.7	-3.6	-2.7	-0.3	-0.7	-0.3	0.4
Blood White Count	0.2	1.5	3.8	-2.0	-1.4	-0.3	-0.5	0.2	1.6
Heel T-Score	0.1	0.8	2.4	0.9	1.2	-1.6	0.1	0.1	-0.2
BMI	0.1	0.6	3.1	1.8	0.1	-0.3	0.3	0.1	0.6
Height	1.2	23.6	50.7	-3.5	-3.8	-4.6	-5.1	4.0	7.1
Waist Hip Ratio (WHR)	0.4	1.9	5.8	0.2	0.4	0.8	0.4	-2.1	-2.4
Systolic Blood Pressure	0.8	3.8	9.2	-3.0	-1.1	-0.5	-0.5	2.5	2.5
Smoking Status	0.5	1.3	2.1	-1.0	-1.2	1.2	-0.8	-1.4	-0.9
Allergy or Eczema	0.7	1.7	3.0	1.1	-0.5	1.1	-1.7	-1.6	-1.5
Cardiovascular Disease	2.4	7.9	20.6	-2.3	-0.7	-1.6	-1.0	4.5	4.1
Hypothyroidism (self reported)	0.8	1.8	3.3	0.1	1.0	-1.7	-0.8	1.8	1.7
Respiratory disease	0.8	1.9	2.6	-1.0	-1.4	-1.6	-1.6	1.5	0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.6	0.7	1.6	-1.2	-0.3	1.6	1.4
Lung FEV1/FVC ratio	0.8	3.9	8.6	0.9	-0.3	2.5	0.9	-2.5	-2.9
Lung FVC	2.1	10.6	32.4	-1.4	-0.3	-2.6	-0.4	5.7	4.7
Neuroticism	0.7	1.8	4.0	-1.6	-1.4	0.7	-0.9	-2.0	-1.0
Chronotype (morning person)	2.7	6.4	11.7	2.4	1.5	2.6	-0.2	-3.4	-3.4
Hair Pigment	0.0	1.0	2.2	-1.5	-1.0	-0.0	-0.2	1.1	1.2
Tanning	0.4	4.6	7.4	2.3	2.7	1.9	2.6	-1.6	-1.4
Hand grip strength (left)	0.5	1.2	1.6	-0.8	-0.7	-1.3	-1.2	1.2	1.2
Number of treatments/medications taken	1.4	2.5	6.0	-1.2	-0.9	-2.4	-2.0	0.8	1.5
Average weekly spirits intake	0.6	0.7	1.0	-0.8	0.4	-0.6	1.0	1.0	0.9
Sensitivity / hurt feelings	0.4	0.6	1.4	1.0	-0.9	0.4	1.2	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.0	-0.2	-0.1	-1.2	-1.1	1.9	2.0
Hearing difficulty/problems: Yes	0.5	0.7	2.1	-0.2	-1.1	-0.9	-1.4	-0.6	-0.4
Relative age of first facial hair	0.6	1.2	5.1	-0.7	-0.7	-0.8	-2.3	0.5	-0.2
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.1	0.3	0.5	-1.2	-2.0	1.1	1.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.9	-1.3	-1.7	-1.6	-1.1	0.1	0.9
Ever had hysterectomy (womb removed)	0.4	0.4	1.7	0.2	0.5	-0.1	-1.3	-0.8	-0.2
Systolic blood pressure, automated reading	0.3	1.0	1.8	-1.0	-0.8	-0.9	0.2	1.2	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	0.7	0.2	-0.2	-0.3	1.1	0.7
Angina	0.5	0.7	2.3	0.7	-0.1	0.7	1.5	-0.9	-0.4
Medication for hormone replacement therapy	0.7	0.8	2.4	-0.3	-0.1	-1.6	-1.2	-0.9	-0.3
Vitamin and mineral supplements	0.5	0.6	2.3	-0.0	1.5	0.8	0.5	0.6	0.4
Supplements: Zinc	2.7	2.9	6.4	-2.2	-1.6	-2.5	-0.7	1.2	1.3
Medication: Co-codamol	0.7	0.8	2.9	0.6	0.8	1.7	0.3	-0.7	-0.3
Medication: Metformin	0.2	0.2	0.7	0.8	-0.5	-0.3	0.5	0.1	-0.3
Diabetes (father)	1.1	1.3	2.6	1.4	1.6	1.5	0.5	-0.4	-0.9
Diabetes (mother)	0.7	0.9	2.7	0.0	-1.1	-1.6	-1.1	-0.3	0.4
Severe depression (siblings)	2.4	2.6	5.0	2.2	2.1	0.1	-0.1	-2.0	-1.5
Pack years adult smoking proportion	1.8	2.8	6.9	-2.6	-1.6	-1.5	-1.6	0.0	1.6
Impedance of leg (right)	0.4	1.8	6.0	0.0	1.1	1.3	0.4	-1.3	-2.4
Leg fat-free mass (left)	1.2	6.1	18.7	-0.0	-1.3	-2.2	-0.8	3.3	4.3
Trunk fat percentage	0.3	1.1	3.1	1.6	0.3	0.6	1.8	0.6	-0.3
Hand grip strength (right)	1.6	4.2	6.9	-1.8	-1.6	-2.2	-1.6	2.3	2.6
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.2	0.5	-0.5	-1.2	0.6	1.1
Current tobacco smoking	0.3	0.5	1.4	-0.3	-0.9	-0.2	-1.2	-1.0	0.1
Average weekly fortified wine intake	0.4	0.4	1.2	0.1	0.7	0.2	0.8	0.6	1.1
Maternal smoking around birth	0.5	0.8	1.8	-0.1	0.2	0.3	1.0	1.3	1.3
Fed-up feelings	0.6	1.0	2.9	-0.6	1.2	0.2	-0.0	1.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	5.1	0.3	1.1	-1.3	-1.3	2.3	1.8
Relative age voice broke	1.3	1.9	9.0	-0.9	-0.9	-0.6	-3.0	-0.8	-0.2
Taking other prescription medications	2.7	4.1	10.1	-0.7	-0.7	-3.2	-2.0	2.0	2.4
Age when periods started (menarche)	1.7	4.2	9.2	-3.0	-1.4	-2.0	-1.0	1.7	2.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	-0.6	0.4	-0.8	-0.6	-0.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.3	1.0	0.3	-1.1	-0.4	-0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.5	-0.6	-0.7	-0.5	-0.2	-1.2	-0.7
Qualifications: CSEs or equivalent	1.0	1.3	2.5	-0.1	0.3	-1.0	-1.3	1.4	1.6
Serious illness, injury or assault to yourself	0.8	0.9	2.1	-0.7	-1.5	-0.3	-1.1	-1.2	-0.3
High blood pressure	1.4	3.9	8.0	-2.0	-1.1	-1.3	-1.0	2.8	2.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.4	1.8	0.1	1.4	-0.4	-1.0	-1.4
Multivitamins +/- minerals	0.4	0.5	1.9	0.4	-1.4	0.3	0.8	-0.5	-0.2
Stomach or abdominal pain in last month	5.8	7.2	13.9	-2.1	-1.9	-3.7	-3.7	0.6	2.7
Supplements: Glucosamine	0.9	1.2	5.0	-1.2	-2.2	0.2	0.5	-0.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.5	0.2	1.2	-0.4	-0.9	0.6	0.3
Medication: Atenolol	2.2	2.8	6.9	-1.3	-0.6	-1.5	0.5	2.3	2.6
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.4	0.6	0.6	0.3	0.6	0.3
Sitting height	1.2	8.2	23.9	-1.0	-2.3	-2.3	-1.6	3.4	4.9
Chronic bronchitis/emphysema (father)	2.1	2.4	5.1	-1.7	-1.6	-2.2	-1.3	0.9	1.3
High blood pressure (mother)	0.5	0.6	1.8	-1.3	-0.9	1.0	-0.5	0.2	0.4
Body mass index (BMI)	0.2	1.0	3.0	1.7	-0.3	0.2	1.2	0.7	0.9
Impedance of leg (left)	0.4	1.9	6.0	0.0	1.1	1.5	0.5	-1.2	-2.5
Leg predicted mass (left)	1.1	6.1	18.5	-0.1	-1.4	-2.1	-0.8	3.3	4.3
Trunk fat mass	0.3	1.1	2.4	1.3	-0.3	-0.4	0.9	1.5	1.3
Waist circumference	0.4	1.3	2.8	0.8	0.2	-1.3	-0.4	1.6	1.7
Number of incorrect matches in round	0.5	0.8	2.6	0.3	-0.6	1.2	1.6	-0.6	-0.5
Past tobacco smoking	0.4	0.7	2.0	1.4	0.0	0.2	0.9	-1.1	-0.0
Alcohol usually taken with meals	0.9	1.5	3.8	1.5	1.9	-0.6	0.4	-1.1	-1.1
Nervous feelings	0.1	0.1	0.3	-0.4	-0.6	-0.0	-0.2	0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.5	-0.5	0.3	-1.4	-2.1	0.1	0.5
Hearing difficulty/problems with background noise	1.2	1.9	6.6	-1.1	-2.6	0.4	-1.3	-1.0	-1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.9	-0.5	-0.3	0.0	0.6	1.0
Had menopause	0.9	1.2	1.9	0.3	0.8	1.4	1.4	-1.1	-1.1
Had other major operations	1.2	1.4	3.4	-0.0	1.3	-1.3	-1.8	1.2	0.5
Forced vital capacity (FVC)	1.9	7.2	18.8	-0.7	-0.3	-2.2	-0.8	4.3	4.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	0.5	0.4	-1.3	-0.5	0.6	1.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	4.2	1.2	-1.0	-0.2	-1.0	-2.0	-1.0
Qualifications: None of the above	0.6	1.2	3.6	-0.5	-1.2	-0.9	-0.2	1.1	1.9
Financial difficulties in last 2 years	0.9	1.3	4.5	-1.2	-2.1	-0.8	-0.4	-0.2	0.8
Mouth/teeth dental problems	0.7	1.1	2.7	-1.6	0.4	-0.2	-0.2	1.2	1.5
Heart attack	0.0	0.1	0.1	0.1	-0.3	-0.3	0.0	-0.1	0.3
Allergy	0.2	0.4	1.8	-1.3	0.3	0.4	0.8	0.1	0.3
Pain all over the body in last month	0.7	0.8	1.9	-0.2	-0.8	0.4	-1.3	-1.4	0.1
Diabetes (self-reported)	0.6	0.9	3.2	1.8	0.8	-0.4	0.6	1.0	0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.9	0.9	0.9	1.7	0.6	-0.3	-1.3
Medication: Ramipril	2.0	2.5	7.8	-2.8	-1.9	0.2	-1.5	1.0	0.5
Medication: Simvastatin	2.1	3.1	7.9	-1.8	-0.8	-1.5	-1.1	2.8	1.9
Fluid intelligence score	0.1	0.1	0.4	-0.3	0.0	-0.4	-0.1	-0.4	-0.6
Illnesses of siblings	0.7	1.0	2.8	1.2	0.4	1.7	0.6	-0.4	-1.0
Neuroticism score	0.4	0.9	2.0	-1.4	-1.3	0.2	-0.8	-1.0	-0.1
Weight	0.7	3.5	10.2	1.1	-1.0	-1.4	0.2	2.6	3.2
Impedance of arm (right)	0.6	2.9	8.9	0.3	2.5	1.1	0.4	-1.0	-3.0
Arm fat percentage (right)	0.3	1.2	4.2	2.1	0.6	0.7	1.4	0.2	-0.4
Trunk fat-free mass	1.7	10.0	30.6	-0.1	-1.6	-3.1	-1.8	3.7	5.5
Hip circumference	0.8	3.6	9.9	0.7	0.2	-1.5	-0.3	3.0	3.1
Time employed in main current job	1.1	1.3	2.4	-0.8	-0.2	-1.3	-1.2	1.2	1.6
Alcohol intake versus 10 years previously	0.7	1.1	3.5	0.0	0.2	-1.0	-1.9	1.2	0.8
Father’s age at death	1.1	1.5	2.2	1.3	0.8	-1.3	1.1	-1.0	-1.5
Worrier / anxious feelings	0.2	0.4	0.8	-0.2	-0.9	0.3	0.9	-0.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.0	-1.5	-0.1	-2.2	-2.1	1.8	2.1
Falls in the last year	1.1	1.4	4.6	0.2	1.0	-1.6	-2.2	-0.1	0.6
Hair/balding pattern: Pattern 3	0.6	0.8	1.9	0.3	-1.2	1.4	1.2	0.1	-0.3
Number of live births	0.7	1.0	2.6	-1.3	-0.0	-0.9	-0.6	1.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	7.9	-0.4	-0.1	-1.3	-0.4	2.8	2.8
Pulse rate	1.1	1.9	5.9	-0.4	-0.3	1.0	1.5	2.4	1.3
Happiness	1.4	1.7	3.5	0.7	0.9	-1.2	-0.6	1.9	1.9
Noisy workplace	0.2	0.3	0.8	-0.4	0.6	0.3	-0.2	-0.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.7	-1.2	-0.6	-1.1	-1.2	0.7	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.1	0.7	-1.0	-0.6	-0.0	0.1
Mouth/teeth dental problems: Dentures	1.1	1.9	3.9	-0.3	0.0	-2.0	-0.8	2.0	1.7
Asthma	1.4	2.7	6.2	-0.9	-0.9	-2.5	-1.1	2.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.5	0.7	-0.4	1.3	-0.0	-1.2	-1.9
Medication: Cholesterol lowering	0.6	0.9	2.3	-0.5	-1.2	-1.5	-0.2	0.2	1.1
Depression (self-reported)	0.5	0.6	2.0	1.4	-0.5	-0.2	-0.8	-1.0	-0.1
Medication: Lansoprazole	1.0	1.1	3.1	0.4	0.4	-1.5	-1.8	0.7	0.8
Prospective memory result	1.4	1.7	3.1	-1.7	-1.8	-0.3	-1.2	-1.6	-0.4
Lung cancer (father)	0.6	0.7	1.4	0.7	-0.3	1.2	1.1	-0.8	-0.2
Illnesses of mother	0.7	0.9	3.3	0.6	1.8	-0.8	-0.6	0.9	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.8	-0.8	-0.6	-1.7	-0.6	2.1	2.6
Pulse wave Arterial Stiffness index	2.6	3.0	5.3	-1.6	-1.4	-2.2	-2.3	0.9	1.5
Impedance of arm (left)	0.7	3.4	10.7	0.5	2.2	1.4	0.8	-1.4	-3.3
Arm fat mass (right)	0.3	1.0	2.5	1.6	-0.1	-0.3	0.6	1.3	1.3
Trunk predicted mass	1.7	9.7	30.1	-0.0	-1.5	-3.1	-1.7	3.6	5.5
Standing height	1.0	10.3	26.7	-0.9	-1.3	-3.3	-2.0	4.1	5.2
Length of working week for main job	0.2	0.2	0.3	0.2	0.5	0.4	0.5	0.5	0.2
Exposure to tobacco smoke at home	2.6	2.9	8.7	-1.0	-1.0	-1.5	-1.0	1.8	3.0
Breastfed as a baby	1.7	2.1	4.0	0.7	1.5	-1.7	2.0	1.5	0.8
Tense / ‘highly strung’	0.5	0.8	1.8	-0.9	-1.2	0.1	-1.3	-0.9	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.4	0.8	-0.3	-0.6	-0.7	-1.5	-0.2
Hair/balding pattern: Pattern 4	2.5	6.1	10.7	3.2	-0.1	2.5	3.3	-2.1	-2.3
Birth weight of first child	0.3	0.5	1.4	1.2	1.2	-0.1	0.3	0.1	0.3
Peak expiratory flow (PEF)	0.3	0.7	1.4	-1.0	-0.2	-1.0	-1.2	0.6	0.6
Pulse wave reflection index	2.4	3.0	5.9	-1.8	-2.4	-1.6	-2.3	-0.8	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.3	-0.3	0.4	-0.8	-0.7	-0.3
Loud music exposure frequency	3.3	3.6	7.7	-2.3	-0.9	-0.2	-0.5	2.7	2.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.8	-0.1	0.7	1.2	0.6	-0.8	-1.9
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.0	1.2	0.2	0.9	-0.9	-1.7	-2.2
Blood clot in the leg (DVT)	0.4	0.5	1.1	1.0	0.4	-1.1	-0.2	-0.5	-0.5
Medication: Paracetamol	1.9	3.1	6.6	0.4	-0.7	2.4	-0.0	-2.4	-2.6
Headache pain in last month	0.4	0.6	1.6	-0.3	0.9	0.7	-0.7	-0.4	-1.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	6.2	1.1	1.2	2.2	1.0	-1.4	-2.5
Glaucoma (self-reported)	0.5	0.6	1.3	0.8	1.1	-0.2	1.1	0.6	-0.4
Gout (self-reported)	1.3	1.7	4.9	-0.1	0.2	2.2	0.7	-1.6	-1.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.3	-0.2	0.7	-1.5	-0.9	1.3	1.2
Medication: Amlodipine	2.8	3.9	4.8	-1.8	-2.0	-1.9	-1.7	2.2	2.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.8	-0.4	-0.7	0.9	1.4	-0.1	-0.6
Birth weight	0.6	1.4	4.8	0.1	0.2	-2.2	-1.5	1.1	0.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.7	1.0	-0.3	-1.3	0.2	-0.6	-0.1
High blood pressure (siblings)	1.4	2.0	5.6	-2.4	-0.7	-1.2	-1.0	1.2	1.6
Forced vital capacity (FVC), Best measure	1.7	6.1	14.8	-1.1	-0.7	-2.6	-0.9	3.6	3.9
Body fat percentage	0.3	1.3	3.4	1.8	0.1	0.8	1.8	0.2	-0.6
Leg fat percentage (right)	0.3	1.2	3.6	1.9	-0.3	0.8	1.6	-0.4	-0.6
Arm fat-free mass (right)	1.5	7.8	23.8	-0.5	-2.2	-2.5	-1.1	3.2	4.9
Exposure to tobacco smoke outside home	1.7	2.2	6.1	-0.9	-0.9	0.8	1.0	2.5	2.0
Comparative body size at age 10	1.6	4.3	10.3	1.6	0.4	1.7	1.3	-2.9	-3.2
Number of full brothers	0.7	0.8	2.5	1.2	0.3	-0.6	-1.6	-0.8	-0.0
Worry too long after embarrassment	1.5	2.5	4.2	1.4	0.4	1.8	1.2	-2.1	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	5.2	-0.6	0.1	-1.5	-2.3	0.6	1.2
Wheeze or whistling in the chest in last year	0.5	0.8	2.2	-0.5	-1.0	-1.5	-1.0	0.4	0.5
Number of children fathered	0.8	1.0	2.0	0.4	1.0	-1.1	1.1	-0.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.5	1.2	0.0	0.6	0.6	0.6	0.1
Age at first live birth	1.0	1.8	4.1	0.4	-0.1	1.0	1.4	-1.9	-2.0
Pulse wave peak to peak time	2.2	2.5	4.7	1.6	1.3	2.0	2.2	-0.8	-1.3
Health satisfaction	1.2	1.6	3.6	0.1	-0.1	-1.9	-1.8	1.2	1.0
Shortness of breath walking on level ground	1.2	1.4	3.7	-0.7	-0.8	-0.9	-1.9	0.3	1.7
Qualifications: College or University degree	0.5	1.5	4.5	-1.2	-2.1	0.1	-1.4	-0.9	0.0
Eye problems/disorders: None of the above	0.3	0.3	0.9	1.0	0.7	0.2	0.1	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	2.1	2.5	5.5	1.3	0.7	1.6	0.1	-2.2	-2.3
Emphysema/chronic bronchitis	1.3	1.5	3.9	-1.0	-2.0	0.1	-1.9	-0.4	0.1
Medication for pain relief, constipation, heartburn	0.6	1.1	2.0	-1.2	0.4	-0.9	-1.0	1.4	1.0
Neck or shoulder pain in last month	1.8	2.6	6.9	-2.3	-1.6	-0.5	-2.6	-0.2	0.7
Medication: Blood pressure	1.2	2.1	4.9	-1.8	-0.8	-1.1	-0.7	1.4	2.2
Angina (self-reported)	0.5	0.7	2.6	0.5	-0.3	0.5	1.6	-0.8	-0.3
Migraine (self-reported)	0.5	0.6	1.0	0.3	0.9	-1.0	0.2	-1.0	-0.8
Medication: Ibuprofen	0.8	1.0	2.4	-0.0	-0.7	1.2	-0.3	-1.1	-1.5
Medication: Allopurinol	0.8	1.0	2.1	-0.1	0.1	0.9	1.1	-1.5	-1.4
Medication: Omeprazole	1.1	1.3	4.0	0.1	-0.2	-2.0	0.2	0.8	1.7
Medication: Seretide 50 evohaler	1.9	2.2	5.6	0.1	-0.3	-2.4	0.0	2.0	1.9
Mean time to correctly identify matches	0.4	0.7	2.0	0.7	-1.2	-0.1	0.1	-1.4	-0.6
Heart disease (mother)	0.3	0.4	1.3	0.5	-1.2	0.1	-0.7	0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.4	-1.3	-0.3	0.8	-1.5	-0.6	-0.6
Whole body fat mass	0.3	1.1	2.2	1.1	-0.4	-0.4	0.8	1.5	1.5
Leg fat mass (right)	0.2	0.9	1.6	1.2	-0.9	-0.1	0.8	1.1	1.3
Arm predicted mass (right)	1.4	7.4	23.0	-0.2	-2.0	-2.4	-1.1	3.2	4.8
Pulse rate, automated reading	1.3	4.3	9.4	-2.7	-1.9	-0.5	0.2	2.2	3.1
Alcohol intake frequency.	0.4	1.0	3.8	0.4	-0.3	-0.7	-2.0	-0.5	-1.0
Comparative height size at age 10	1.3	7.0	16.9	0.8	0.1	-3.2	-0.6	4.1	3.7
Number of full sisters	1.1	1.4	5.1	-1.6	-0.4	-0.5	-2.2	0.2	-0.2
Suffer from ‘nerves’	0.1	0.2	0.5	-0.3	-0.7	-0.1	-0.4	-0.2	0.7
Overall health rating	1.9	4.2	6.0	-2.0	-2.3	-2.1	-2.4	1.4	2.0
Chest pain or discomfort	0.1	0.1	0.2	0.2	0.4	-0.1	0.2	-0.1	-0.4
Had major operations	0.7	0.8	1.7	-0.7	-0.0	-1.3	-0.7	1.3	0.6
Age at last live birth	0.1	0.2	0.7	-0.8	0.5	-0.4	0.2	-0.1	-0.0
Family relationship satisfaction	0.3	0.4	0.9	-0.3	0.4	-0.9	-0.9	0.1	0.6
Leg pain on walking	1.2	1.5	4.2	-0.6	0.8	-1.4	-2.0	0.1	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	6.4	-1.4	-0.1	-1.8	-2.5	1.6	2.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.0	-0.2	1.0	0.2	0.9	0.7	1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.2	0.6	1.8	0.6	0.4	0.6	0.2
Medication: Aspirin	0.5	0.6	2.2	1.1	0.1	0.1	1.5	-0.4	0.5
Supplements: Vitamin C	1.1	1.3	3.2	-1.8	-1.1	-1.4	-0.1	1.0	0.6
Knee pain experienced in last month	1.8	2.8	6.2	0.5	0.3	-2.5	-1.1	1.8	2.4
Hypertension (Self-reported)	1.6	4.6	9.3	-2.2	-1.3	-1.4	-1.0	3.0	2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	5.7	0.5	-2.4	-0.8	-0.1	0.1	0.8
Illnesses of father: Heart disease	2.7	3.7	5.8	1.8	2.2	2.4	1.0	-1.8	-2.0
Illnesses of siblings: Diabetes	0.4	0.5	1.1	1.1	0.4	0.1	0.6	-0.7	-1.0
Smoking status: Previous	0.2	0.3	0.8	-0.9	0.2	0.0	-0.4	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.9	-1.7	-1.4	-0.7	-2.2	1.3	1.3
Whole body fat-free mass	1.5	8.6	26.7	-0.1	-1.5	-2.7	-1.3	3.6	5.2
Leg fat-free mass (right)	1.2	6.3	18.5	-0.0	-1.4	-2.2	-1.0	3.4	4.3
Arm fat percentage (left)	0.4	1.4	4.6	2.2	0.6	0.8	1.7	0.1	-0.5
Average weekly red wine intake	0.4	0.6	2.5	-0.1	-0.4	-0.0	-1.1	-1.6	-0.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	0.5	-0.5	0.5	-0.0	-1.4	-1.3
Mood swings	0.6	1.1	1.9	-1.3	-0.5	-0.5	-1.2	1.0	1.4
Loneliness, isolation	0.4	0.5	1.3	0.1	0.6	0.8	-0.1	-1.1	-0.7
Long-standing illness, disability or infirmity	1.5	2.3	5.2	-1.3	-1.6	-1.7	-2.3	-0.0	1.2
Ever had bowel cancer screening	2.1	2.5	9.9	-0.3	0.2	-2.1	-3.1	0.4	0.8
Diabetes diagnosed by doctor	0.9	1.4	2.5	1.3	1.3	-1.2	-0.3	1.6	1.0
Ever had stillbirth, spontaneous miscarriage or termination	5.5	5.8	12.9	-3.2	-1.3	-2.1	-3.6	1.3	2.0
Friendships satisfaction	2.3	2.8	5.5	-1.5	0.7	-2.4	-1.2	1.4	2.3
Qualifications: nursing, teaching	0.9	1.4	5.0	-1.3	-0.2	-0.2	-2.2	-1.0	-0.6
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.4	-1.0	-0.3	-0.8	-0.5	-0.7
Eye problems/disorders: Cataract	0.1	0.1	0.4	-0.0	-0.0	-0.5	0.1	0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.2	1.4	-0.2	0.7	1.1	-1.5	-0.8
Medication for cholesterol	1.9	2.8	5.6	1.4	0.1	2.4	1.8	-2.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	3.8	1.9	1.8	1.9	1.5	-0.8	-1.6
Back pain experienced in last month	0.5	0.8	1.5	-1.0	-1.2	-1.0	-0.7	-0.4	0.6
Mineral and other dietary supplements	0.6	0.8	2.0	1.0	1.4	1.3	0.0	0.3	-0.2
Breast cancer (self-reported)	1.2	1.4	4.3	-0.3	-0.3	-2.1	-1.8	0.4	0.7
Asthma (self-reported)	1.5	3.0	6.5	-0.8	-0.9	-2.5	-1.1	2.5	1.6
Osteoporosis (self-reported)	3.2	4.0	7.3	-1.9	-1.4	-2.7	-2.4	1.4	1.9
Osteoarthritis (self-reported)	0.5	0.6	2.0	-0.2	-0.9	0.6	-1.4	-0.7	-0.5
Medication: Aspirin	0.3	0.4	0.7	0.8	0.3	0.6	0.6	-0.8	0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.4	0.1	-0.4	0.4	0.5	-0.1
Illnesses of father: None of the above (group 1)	1.3	1.6	3.8	-0.9	-1.0	-1.5	-0.8	1.1	1.9
Smoking status: Current	0.2	0.4	1.1	-0.1	-0.6	0.2	-0.9	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.8	-2.4	-2.1	-1.2	-0.9	0.8	0.9
Whole body water mass	1.4	8.2	26.1	-0.0	-1.6	-2.7	-1.3	3.5	5.1
Leg predicted mass (right)	1.2	6.2	18.6	-0.0	-1.3	-2.1	-0.9	3.4	4.3
Arm fat mass (left)	0.3	1.0	2.3	1.5	-0.3	-0.2	0.8	1.3	1.3
Number of self-reported non-cancer illnesses	2.2	3.8	6.5	-1.4	-1.4	-2.1	-1.9	2.0	2.5
Average weekly champagne plus white wine intake	2.7	3.7	5.4	1.7	1.9	2.1	1.8	-1.6	-2.3
Miserableness	0.9	1.6	3.2	-1.5	0.4	-0.4	-1.0	1.6	1.8
Guilty feelings	3.9	5.9	13.5	0.3	-0.6	3.1	0.7	-3.7	-3.4
Wears glasses or contact lenses	0.5	0.6	1.0	-1.0	-0.6	0.7	0.9	0.9	0.4
Ever taken oral contraceptive pill	0.8	0.9	2.8	0.1	0.7	1.7	0.1	-0.6	-1.3
Hearing aid user	0.7	0.8	2.4	-0.1	0.2	-1.5	-1.5	-0.6	0.0
Mother’s age at death	0.3	0.3	0.8	0.3	0.4	0.6	0.9	-0.5	-0.6
Financial situation satisfaction	2.7	3.3	9.5	-0.8	0.1	-1.9	-0.8	3.1	2.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	5.1	0.6	2.3	-0.2	-1.1	1.0	0.1
Commuting to job workplace: Public transport	1.5	1.8	5.0	0.4	-0.7	1.2	0.5	-1.8	-2.2
Eye problems/disorders: Glaucoma	0.5	0.5	1.1	0.6	1.1	0.1	0.9	-0.4	-0.9
Medication: Blood pressure	1.7	3.3	5.2	-1.7	-0.8	-2.3	-1.8	1.9	2.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.5	0.3	-0.4	-0.3	-1.9	0.7	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.3	0.2	-0.2	0.4	0.6	-1.5	-1.0
High cholesterol (Self-reported)	0.1	0.3	0.6	0.2	0.2	-0.8	-0.4	0.3	0.8
Medication: Bendroflumethiazide	0.4	0.7	2.3	-0.5	-0.5	-0.9	-1.5	0.6	0.4
Medication: Paracetamol	1.5	2.3	5.1	-0.0	-0.2	2.0	-0.6	-2.0	-2.3
Medication: Lisinopril	2.1	2.7	8.8	0.1	0.4	-3.0	-0.6	1.1	2.4
Medication: Atorvastatin	1.2	1.5	2.7	-0.7	-1.5	-1.6	-1.2	0.3	1.4
Illnesses of father: High blood pressure	0.7	0.8	2.1	0.2	0.8	0.1	0.8	1.5	1.3
Alcohol drinker status: Never	1.1	1.4	3.0	-0.5	-1.2	-1.7	-1.7	0.1	0.8
Ever smoked	0.3	0.5	1.4	-0.9	0.2	-0.3	-1.2	0.5	0.3
Basal metabolic rate	1.3	7.4	23.1	0.2	-1.4	-2.4	-1.0	3.5	4.8
Leg fat percentage (left)	0.4	1.4	4.2	2.1	-0.3	0.9	1.7	-0.3	-0.6
Arm fat-free mass (left)	1.5	7.4	22.3	-0.2	-2.2	-2.4	-1.2	3.2	4.7
Number of operations (self-reported)	0.3	0.5	1.5	0.0	1.1	-0.2	-1.2	-0.1	-0.4
Average weekly beer plus cider intake	1.5	2.2	5.8	-1.4	-0.6	1.1	1.6	2.4	1.1
Irritability	0.6	0.9	3.7	-1.1	0.2	-0.6	-1.9	-0.4	0.3
Risk taking	0.4	0.6	1.7	0.0	-0.5	-0.2	-1.3	-1.2	0.2
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.7	1.5	2.2	-0.0	0.4	-0.9	-0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.2	0.4	0.9	-1.1	-1.1	0.4	-0.4
Age started oral contraceptive pill	0.8	1.0	2.2	0.3	-0.2	0.7	1.5	-1.2	-1.3
Diastolic blood pressure, automated reading	0.4	1.2	2.0	-1.0	-1.2	-1.0	-0.5	1.3	1.4
Ever depressed for a whole week	0.6	0.7	1.9	0.7	-0.9	-0.6	-1.4	-0.9	-0.4
Unable to work because of sickness or disability	0.3	0.4	2.2	0.1	-0.4	0.0	-1.5	-0.3	0.2
Commuting to job workplace: Cycle	1.4	1.7	4.9	2.1	2.2	0.8	-0.5	0.3	-0.6
Myopia	0.9	1.3	3.7	-0.7	0.2	-0.8	-0.7	1.9	1.6
Vascular/heart problems diagnosed by doctor	1.4	3.8	6.2	2.4	1.6	1.1	1.2	-2.5	-2.5
Cholesterol lowering medication	2.4	3.6	11.5	-1.4	0.3	-1.8	-0.9	3.4	2.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.0	0.2	-0.3	-1.7	1.2	0.9	1.7
Pain experienced in last month	2.0	3.4	10.2	1.8	1.6	1.6	3.2	0.1	-1.1
Supplements: Calcium	0.3	0.4	1.8	-0.1	-0.3	-1.3	-0.1	0.5	-0.2
Basal cell carcinoma (self-reported)	0.6	0.8	1.7	-0.9	0.2	-0.9	-0.6	0.9	1.3
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	0.3	-0.2	-0.2	0.3	-0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.6	1.2	0.8	-1.3	-0.0	-0.3	-0.4
Heart disease (siblings)	0.4	0.5	1.0	-1.0	-0.8	-0.7	-0.7	-0.0	0.7
Alcohol drinker status: Previous	0.7	0.8	2.1	-0.0	0.1	1.2	0.2	-1.2	-1.4
Pack years of smoking	1.7	2.5	5.8	-2.4	-1.5	-1.5	-1.5	-0.1	1.4
Impedance of whole body	0.5	2.6	9.3	0.0	1.7	1.3	0.5	-1.3	-3.1
Leg fat mass (left)	0.2	1.0	1.9	1.4	-0.7	0.0	0.8	1.1	1.2
Arm predicted mass (left)	1.5	7.6	22.8	-0.1	-2.1	-2.5	-1.2	3.2	4.8