Best TWAS P=3.02e-34 · Best GWAS P=5.1e-33 conditioned to 0.154
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EIF2AK3 | 0.08 | 0.05 | lasso | 7 | 0.07 | 3.7e-09 | 10.5 | 8.9 | 3.6e-19 | 0.83 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | AC062029.1 | 0.14 | 0.10 | enet | 11 | 0.12 | 1.3e-09 | 11.3 | 12.2 | 3.0e-34 | 0.94 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | RPIA | 0.10 | 0.02 | lasso | 4 | 0.04 | 7.3e-04 | -1.5 | 5.9 | 4.5e-09 | 0.51 | 0.12 | 0.57 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | AC062029.1 | 0.07 | 0.08 | lasso | 3 | 0.07 | 3.0e-06 | 12.0 | 11.5 | 1.1e-30 | 0.98 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Lung | RPIA | 0.16 | 0.00 | enet | 31 | 0.05 | 8.5e-05 | -1.5 | 5.9 | 4.5e-09 | 0.37 | 0.09 | 0.06 | FALSE |
| 6 | GTEx | Lung | AC062029.1 | 0.08 | 0.00 | lasso | 5 | 0.01 | 2.5e-02 | -5.3 | 7.7 | 1.8e-14 | 0.57 | 0.06 | 0.22 | FALSE |
| 7 | GTEx | Nerve Tibial | RPIA | 0.10 | 0.03 | lasso | 10 | 0.04 | 1.3e-03 | 11.3 | 10.4 | 1.9e-25 | 0.80 | 0.05 | 0.33 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | RPIA | 0.05 | 0.05 | blup | 194 | 0.04 | 4.3e-06 | 10.5 | 8.0 | 1.2e-15 | 0.69 | 0.01 | 0.99 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | EIF2AK3 | 0.11 | 0.09 | lasso | 5 | 0.09 | 2.0e-11 | 12.0 | 11.3 | 2.0e-29 | 0.97 | 0.00 | 1.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | ANKRD36BP2 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.8e-03 | -7.0 | 5.3 | 1.2e-07 | 0.47 | 0.17 | 0.05 | FALSE |
| 11 | YFS | Blood | RPIA | 0.05 | 0.04 | lasso | 12 | 0.05 | 1.1e-14 | -7.2 | -6.6 | 3.1e-11 | -0.42 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPIA | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.6e-04 | -3.6 | 7.0 | 3.3e-12 | 0.66 | 0.01 | 0.90 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EIF2AK3 | 0.13 | 0.01 | enet | 17 | 0.02 | 4.0e-03 | 12.0 | 6.6 | 5.5e-11 | 0.71 | 0.00 | 0.94 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPIA | 0.07 | 0.00 | blup | 34 | 0.01 | 1.8e-02 | 10.5 | 6.7 | 2.1e-11 | 0.51 | 0.00 | 0.85 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPIA | 0.05 | 0.01 | blup | 34 | 0.02 | 4.0e-03 | 10.5 | 6.8 | 1.0e-11 | 0.51 | 0.00 | 0.71 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | EIF2AK3 | 0.03 | 0.01 | blup | 54 | 0.02 | 1.1e-02 | -5.3 | 6.0 | 1.4e-09 | 0.54 | 0.03 | 0.19 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | RPIA | 0.20 | 0.03 | enet | 11 | 0.14 | 1.5e-13 | -1.5 | 8.1 | 8.2e-16 | 0.64 | 0.02 | 0.98 | FALSE |