Best TWAS P=1.69e-09 · Best GWAS P=6.55e-09 conditioned to 0.125
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UGGT1 | 0.07 | 0.05 | lasso | 3 | 0.06 | 1.7e-05 | 5.8 | -5.8 | 6.7e-09 | -1.00 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | UGGT1 | 0.16 | 0.16 | lasso | 3 | 0.17 | 1.1e-09 | 5.8 | -5.6 | 2.8e-08 | -0.98 | 0.01 | 0.99 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | ERCC3 | 0.23 | 0.02 | enet | 27 | 0.05 | 2.4e-02 | 5.2 | -5.3 | 1.3e-07 | -0.04 | 0.02 | 0.75 | FALSE |
4 | GTEx | Breast Mammary Tissue | MAP3K2 | 0.23 | 0.07 | lasso | 5 | 0.07 | 1.8e-04 | 4.7 | 5.5 | 3.4e-08 | 0.01 | 0.02 | 0.95 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | UGGT1 | 0.13 | 0.13 | lasso | 3 | 0.12 | 2.3e-09 | 5.6 | -5.8 | 7.4e-09 | -0.98 | 0.01 | 0.99 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | ERCC3 | 0.17 | 0.08 | lasso | 3 | 0.10 | 1.8e-04 | 4.9 | -5.2 | 1.8e-07 | 0.05 | 0.03 | 0.94 | FALSE |
7 | GTEx | Esophagus Mucosa | ERCC3 | 0.18 | 0.13 | lasso | 7 | 0.13 | 9.7e-09 | 4.8 | -5.3 | 1.4e-07 | 0.06 | 0.02 | 0.97 | FALSE |
8 | GTEx | Esophagus Muscularis | UGGT1 | 0.12 | 0.13 | lasso | 7 | 0.13 | 2.7e-08 | 5.8 | -5.8 | 6.5e-09 | -1.00 | 0.01 | 0.99 | FALSE |
9 | GTEx | Esophagus Muscularis | ERCC3 | 0.18 | 0.11 | lasso | 7 | 0.15 | 3.2e-09 | 4.8 | -5.2 | 2.5e-07 | 0.05 | 0.02 | 0.97 | FALSE |
10 | GTEx | Nerve Tibial | UGGT1 | 0.18 | 0.15 | enet | 18 | 0.13 | 1.6e-09 | 5.8 | -6.0 | 1.7e-09 | -0.91 | 0.01 | 0.99 | TRUE |
11 | GTEx | Skin Sun Exposed Lower leg | UGGT1 | 0.07 | 0.07 | lasso | 5 | 0.05 | 6.3e-05 | 5.8 | -5.8 | 4.8e-09 | -1.00 | 0.01 | 0.98 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | MAP3K2 | 0.06 | 0.04 | enet | 11 | 0.04 | 5.0e-04 | 5.2 | 5.4 | 7.7e-08 | 0.02 | 0.01 | 0.98 | FALSE |
13 | GTEx | Spleen | ERCC3 | 0.44 | 0.42 | enet | 21 | 0.42 | 4.9e-12 | 4.8 | -5.3 | 1.4e-07 | 0.04 | 0.02 | 0.97 | FALSE |
14 | METSIM | Adipose | UGGT1 | 0.10 | 0.10 | enet | 17 | 0.10 | 2.5e-14 | 5.6 | -5.2 | 1.6e-07 | -0.93 | 0.01 | 0.99 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | MAP3K2 | 0.11 | 0.08 | enet | 19 | 0.08 | 3.2e-10 | 4.9 | 5.4 | 6.0e-08 | -0.05 | 0.02 | 0.98 | FALSE |
16 | YFS | Blood | ERCC3 | 0.07 | 0.03 | bslmm | 457 | 0.05 | 6.5e-16 | 5.0 | -5.6 | 2.1e-08 | 0.05 | 0.02 | 0.98 | TRUE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UGGT1 | 0.02 | 0.02 | blup | 65 | 0.02 | 2.5e-04 | 5.6 | -5.8 | 5.0e-09 | -0.89 | 0.01 | 0.89 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | UGGT1 | 0.04 | 0.00 | blup | 65 | 0.02 | 8.6e-03 | 5.7 | -5.4 | 7.7e-08 | -0.91 | 0.01 | 0.79 | FALSE |