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chr14:103,325,757-104,892,153

Best TWAS P=2.04e-11 · Best GWAS P=2.26e-11 conditioned to 0.0449

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Nerve Tibial	TRMT61A	0.10	0.00	lasso	5	0.01	1.0e-01	-5.9	6.7	2.0e-11	-0.83	0.14	0.68	TRUE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BAG5	0.03	0.03	lasso	1	0.02	9.5e-04	-6.7	6.7	2.8e-11	-1.00	0.00	0.97	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	XRCC3	0.06	0.03	blup	46	0.06	2.3e-07	3.4	6.6	4.3e-11	-0.71	0.02	0.97	FALSE
40	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZFYVE21	0.34	-0.01	lasso	7	0.07	8.0e-03	-6.1	-6.6	5.7e-11	0.74	0.00	0.48	FALSE
2	GTEx	Adipose Subcutaneous	RP11-73M18.6	0.08	0.05	lasso	4	0.05	3.7e-05	-6.1	6.4	1.5e-10	-0.96	0.02	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-73M18.8	0.16	0.07	lasso	5	0.10	1.1e-05	-6.0	6.4	1.6e-10	-0.88	0.06	0.92	FALSE
15	GTEx	Colon Transverse	RP11-73M18.8	0.26	0.04	enet	23	0.06	8.4e-04	-6.1	6.3	2.8e-10	-0.78	0.04	0.96	FALSE
29	YFS	Blood	ZFYVE21	0.01	0.00	blup	339	0.00	8.9e-03	-4.2	6.3	2.8e-10	-0.75	0.02	0.92	FALSE
24	GTEx	Thyroid	RP11-73M18.8	0.15	0.11	enet	12	0.10	2.8e-08	-5.7	6.3	3.6e-10	-0.71	0.39	0.61	FALSE
4	GTEx	Adrenal Gland	RP11-73M18.8	0.16	0.09	lasso	4	0.06	3.2e-03	-6.7	6.3	3.7e-10	-0.95	0.01	0.98	FALSE
13	GTEx	Cells Transformed fibroblasts	RP11-73M18.8	0.17	0.08	enet	15	0.10	3.1e-08	-5.5	6.2	4.2e-10	-0.87	0.07	0.93	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RP11-73M18.8	0.21	0.09	enet	12	0.16	1.3e-05	-5.0	6.2	4.4e-10	-0.82	0.04	0.94	FALSE
32	The Cancer Genome Atlas	Esophageal Carcinoma	PPP1R13B	0.26	0.03	enet	12	0.12	1.4e-04	-6.1	-6.2	4.4e-10	0.78	0.00	0.94	FALSE
21	GTEx	Spleen	RP11-73M18.8	0.33	0.37	lasso	3	0.36	5.2e-10	-6.2	6.2	7.3e-10	-0.88	0.06	0.93	FALSE
25	GTEx	Uterus	RP11-73M18.8	0.34	0.12	lasso	5	0.18	1.6e-04	-5.7	6.1	8.6e-10	-0.76	0.05	0.66	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	RP11-73M18.8	0.12	0.03	lasso	4	0.01	1.4e-01	-5.8	6.1	9.7e-10	-0.78	0.04	0.48	FALSE
22	GTEx	Testis	XRCC3	0.17	0.10	enet	4	0.08	2.1e-04	-5.9	6.0	1.5e-09	-0.81	0.25	0.50	FALSE
23	GTEx	Thyroid	XRCC3	0.12	0.07	lasso	6	0.05	1.3e-04	-5.7	6.0	2.1e-09	-0.75	0.19	0.64	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BAG5	0.06	0.02	blup	30	0.03	1.4e-04	-6.1	6.0	2.5e-09	-0.84	0.08	0.80	FALSE
19	GTEx	Skin Sun Exposed Lower leg	BAG5	0.06	0.05	lasso	1	0.06	1.8e-05	-5.9	5.9	3.2e-09	-0.91	0.06	0.92	FALSE
27	METSIM	Adipose	BAG5	0.06	0.07	lasso	3	0.07	4.5e-10	-5.8	5.8	5.5e-09	-0.91	0.38	0.62	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	BAG5	0.01	0.02	lasso	3	0.01	7.6e-04	-5.7	5.8	6.7e-09	-0.93	0.02	0.89	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	BAG5	0.04	0.05	lasso	2	0.04	9.1e-05	-5.8	5.8	6.7e-09	-0.91	0.08	0.90	FALSE
9	GTEx	Breast Mammary Tissue	RP11-73M18.8	0.19	0.14	enet	21	0.26	2.0e-13	3.6	5.8	7.0e-09	-0.69	0.30	0.70	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TRMT61A	0.06	0.03	lasso	3	0.04	6.6e-06	-6.1	5.8	8.4e-09	-0.83	0.04	0.96	FALSE
16	GTEx	Esophagus Mucosa	RP11-73M18.8	0.11	0.06	lasso	12	0.10	2.1e-07	3.4	5.8	8.9e-09	-0.73	0.15	0.84	FALSE
6	GTEx	Brain Cortex	RP11-73M18.8	0.35	0.13	enet	34	0.25	1.2e-07	3.7	5.7	9.6e-09	-0.61	0.35	0.60	FALSE
17	GTEx	Lung	RP11-73M18.8	0.11	0.08	lasso	2	0.05	1.0e-04	-5.7	5.7	1.0e-08	-0.73	0.29	0.62	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	XRCC3	0.13	0.05	blup	46	0.06	4.6e-04	3.3	5.7	1.1e-08	-0.68	0.01	0.87	FALSE
28	YFS	Blood	XRCC3	0.05	0.04	lasso	2	0.05	3.0e-17	-5.9	5.7	1.4e-08	-0.69	0.56	0.44	FALSE
14	GTEx	Cells Transformed fibroblasts	RP11-73M18.6	0.07	0.02	lasso	5	0.00	1.3e-01	-5.7	5.7	1.6e-08	-0.76	0.03	0.77	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61A	0.02	0.00	blup	34	0.01	6.2e-02	-5.8	5.6	2.1e-08	-0.82	0.01	0.73	FALSE
26	GTEx	Whole Blood	RP11-73M18.8	0.13	0.10	lasso	5	0.14	1.4e-12	3.3	5.6	2.9e-08	-0.75	0.13	0.87	FALSE
12	GTEx	Cells Transformed fibroblasts	XRCC3	0.24	0.04	enet	34	0.08	2.7e-06	3.4	5.5	3.4e-08	-0.51	0.88	0.09	FALSE
20	GTEx	Skin Sun Exposed Lower leg	RP11-73M18.8	0.11	0.11	lasso	4	0.12	5.1e-10	3.4	5.5	3.4e-08	-0.62	0.55	0.45	FALSE
10	GTEx	Breast Mammary Tissue (Female)	XRCC3	0.19	0.03	enet	27	0.09	1.5e-03	3.3	5.4	6.0e-08	-0.58	0.22	0.33	FALSE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	BAG5	0.17	-0.01	blup	32	0.02	1.3e-01	-6.1	5.3	1.1e-07	-0.84	0.01	0.33	FALSE
8	GTEx	Breast Mammary Tissue	XRCC3	0.15	0.01	enet	37	0.01	1.0e-01	3.4	5.3	1.4e-07	-0.51	0.49	0.44	FALSE
5	GTEx	Artery Aorta	RP11-73M18.8	0.08	0.05	lasso	3	0.07	8.0e-05	3.4	5.2	1.8e-07	-0.62	0.13	0.66	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	XRCC3	0.04	0.02	enet	8	0.04	5.4e-06	-5.7	5.2	2.3e-07	-0.56	0.05	0.85	FALSE