Best TWAS P=1.29e-11 · Best GWAS P=1.51e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | MARK4 | 0.28 | 0.25 | lasso | 3 | 0.26 | 5.5e-25 | -5.0 | -5.5 | 4.8e-08 | -0.54 | 0.97 | 0.03 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CKM | 0.03 | 0.03 | lasso | 2 | 0.03 | 2.1e-06 | 6.7 | -6.8 | 1.3e-11 | -0.98 | 0.00 | 1.00 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CKM | 0.06 | 0.03 | blup | 39 | 0.06 | 5.2e-07 | 3.8 | -5.4 | 7.0e-08 | -0.78 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CKM | 0.05 | 0.04 | blup | 38 | 0.06 | 2.1e-07 | 4.3 | -5.2 | 1.9e-07 | -0.75 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | CKM | 0.06 | 0.02 | blup | 38 | 0.04 | 9.1e-06 | 6.7 | -5.9 | 4.8e-09 | -0.81 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CKM | 0.03 | 0.01 | blup | 38 | 0.02 | 3.3e-03 | 4.3 | -5.9 | 2.9e-09 | -0.78 | 0.01 | 0.90 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CKM | 0.08 | 0.07 | blup | 38 | 0.09 | 1.2e-08 | 3.8 | -5.6 | 1.9e-08 | -0.68 | 0.02 | 0.98 | FALSE |