Best TWAS P=3.37e-10 · Best GWAS P=2.07e-08 conditioned to 0.371
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CKM | 0.03 | 0.03 | lasso | 2 | 0.03 | 2.1e-06 | -5.6 | 5.8 | 6.9e-09 | -0.98 | 0.00 | 1.00 | FALSE |
2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CKM | 0.06 | 0.03 | blup | 39 | 0.06 | 5.2e-07 | -4.6 | 5.9 | 3.3e-09 | -0.78 | 0.01 | 0.99 | FALSE |
3 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CKM | 0.07 | 0.04 | blup | 38 | 0.04 | 3.9e-03 | -4.5 | 5.2 | 2.0e-07 | -0.61 | 0.03 | 0.37 | FALSE |
4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CKM | 0.05 | 0.04 | blup | 38 | 0.06 | 2.1e-07 | -4.4 | 5.5 | 4.5e-08 | -0.75 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Lung Adenocarcinoma | CKM | 0.06 | 0.02 | blup | 38 | 0.04 | 9.1e-06 | -5.6 | 6.3 | 3.4e-10 | -0.81 | 0.00 | 1.00 | TRUE |
6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CKM | 0.10 | 0.02 | blup | 39 | 0.07 | 3.1e-05 | -4.5 | 5.5 | 3.8e-08 | -0.62 | 0.02 | 0.72 | FALSE |
7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CKM | 0.03 | 0.01 | blup | 38 | 0.02 | 3.3e-03 | -4.4 | 5.7 | 1.1e-08 | -0.78 | 0.01 | 0.86 | FALSE |
8 | The Cancer Genome Atlas | Thyroid Carcinoma | CKM | 0.08 | 0.07 | blup | 38 | 0.09 | 1.2e-08 | -4.2 | 5.6 | 2.7e-08 | -0.68 | 0.02 | 0.98 | FALSE |