Hub : Traits :

Qualifications: A levels/AS levels or equivalent

460 significantly associated models · 88 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	41130424	42542658	1	1	2.3e-07	3.0e-07	9.4e-04	58	FOXO6
2	1	43152610	45153116	10	4	3.1e-12	3.9e-13	8.2e-01	100	ARTN MED8 ST3GAL3
3	1	71163715	73435171	1	1	8.2e-08	1.8e-08	1.8e-06	28	NEGR1
4	2	43899918	45698128	1	1	3.0e-08	5.4e-10	5.0e-03	80	CAMKMT
5	2	100193898	101731705	2	1	6.0e-10	2.4e-10	1.0e+00	100	LONRF2
6	2	156594333	158165818	1	1	8.3e-09	5.1e-09	3.2e-03	74	GPD2
7	2	161297929	162790882	1	1	4.0e-08	5.3e-10	1.5e-03	74	TANK
8	3	48029118	51043528	29	7	3.9e-26	1.4e-23	1.0e+00	100	APEH IP6K2 MST1R RBM6 RNF123 UBA7
9	3	84767271	86367480	1	1	3.4e-09	2.7e-08	5.6e-03	75	CADM2
10	4	151637154	153275701	1	1	2.4e-07	8.6e-08	1.2e-04	48	FAM160A1
11	5	59353199	61156570	4	1	6.3e-09	5.9e-09	1.6e-01	94	ERCC8
12	7	1161158	2969983	1	1	6.1e-08	1.5e-08	1.0e-02	79	MAD1L1
13	7	23913624	25432157	1	1	9.6e-09	5.5e-09	1.0e+00	100	MPP6
14	7	74339397	75842792	3	1	2.2e-07	4.2e-07	2.1e-01	94	POM121C
15	8	142629143	144515639	2	2	1.7e-08	2.6e-09	4.7e-03	78	THEM6 TSNARE1
16	10	10349662	12076043	1	1	7.6e-08	1.1e-08	7.2e-03	78	CELF2
17	10	64195778	65606229	2	1	1.4e-08	8.9e-09	6.0e-02	89	NRBF2
18	10	103940629	104440050	1	1	1.4e-07	4.9e-09	9.9e-03	81	CUEDC2
19	11	94805896	96276010	4	1	2.9e-13	1.1e-12	3.8e-01	98	AP001877.1
20	12	122713991	124591385	11	1	1.4e-14	7.4e-15	7.7e-02	95	RP11-282O18.3
21	16	9598191	10524165	1	1	1.4e-08	1.3e-10	1.8e-03	76	GRIN2A
22	19	36003721	36487759	1	1	2.9e-07	3.3e-06	3.7e-01	96	LIN37
23	19	45569009	46073472	1	1	3.4e-10	2.1e-08	3.7e-01	98	CKM

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Qualifications: College or University degree	18.88	31	20	44.4	0.98	2.1e-24	AP001877.1 APEH ARTN CADM2 CAMKMT CELF2 CKM CUEDC2 ERCC8 FAM160A1 FOXO6 GPD2 GRIN2A IP6K2 LIN37 LONRF2 MAD1L1 MED8 MPP6 MST1R NEGR1 NRBF2 POM121C RBM6 RNF123 RP11-282O18.3 ST3GAL3 TANK THEM6 TSNARE1 UBA7
Qualifications: None of the above	14.53	24	18	40.0	-0.98	1.3e-17	AP001877.1 APEH ARTN CAMKMT CELF2 CKM ERCC8 FAM160A1 GRIN2A LONRF2 MED8 MPP6 MST1R NEGR1 NRBF2 POM121C RBM6 RNF123 RP11-282O18.3 ST3GAL3 TANK THEM6 TSNARE1 UBA7
Intelligence (Savage-Jansen 2018)	13.65	23	15	33.3	0.97	2.1e-16	AP001877.1 APEH ARTN CAMKMT CKM CUEDC2 ERCC8 FAM160A1 FOXO6 LIN37 LONRF2 MED8 MST1R NEGR1 NRBF2 POM121C RBM6 RNF123 RP11-282O18.3 ST3GAL3 TANK TSNARE1 UBA7
Fluid intelligence score	11.22	17	9	20.0	0.99	1.7e-14	APEH ARTN CAMKMT CELF2 CKM FAM160A1 FOXO6 LONRF2 MED8 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 ST3GAL3 TANK UBA7
Verbal and Numeric Reasoning (VNR)	11.11	15	11	24.4	0.97	5.9e-11	APEH ARTN CKM CUEDC2 FAM160A1 FOXO6 LONRF2 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 ST3GAL3 TANK UBA7
Qualifications: nursing, teaching	9.33	14	6	13.3	0.96	2.6e-08	AP001877.1 APEH CADM2 CELF2 ERCC8 FAM160A1 MAD1L1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 ST3GAL3 UBA7
Qualifications: O levels/GCSEs or equivalent	9.30	16	3	6.7	0.96	2.2e-09	AP001877.1 APEH ARTN CAMKMT CKM FAM160A1 GPD2 MPP6 MST1R NRBF2 POM121C RNF123 RP11-282O18.3 ST3GAL3 THEM6 TSNARE1
Age at first live birth	9.04	7	4	8.9	0.99	6.5e-07	AP001877.1 APEH MST1R NRBF2 RBM6 RNF123 UBA7
Age at First Birth	8.93	6	5	11.1	1.00	2.1e-06	APEH LONRF2 MST1R RBM6 RNF123 UBA7
Body mass index (BMI)	8.63	15	9	20.0	-0.89	4.2e-06	APEH CADM2 CAMKMT IP6K2 LIN37 LONRF2 MPP6 MST1R NEGR1 NRBF2 POM121C RBM6 RNF123 THEM6 UBA7
Age at last live birth	8.58	7	4	8.9	0.99	1.1e-06	AP001877.1 APEH LONRF2 MST1R RBM6 RNF123 UBA7
Leg fat mass (left)	8.56	12	9	20.0	-0.88	6.5e-05	APEH CADM2 IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Leg fat mass (right)	8.47	12	9	20.0	-0.88	6.3e-05	APEH CADM2 IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Leg fat percentage (left)	8.47	13	11	24.4	-0.90	1.5e-05	APEH CADM2 CAMKMT IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Leg fat percentage (right)	8.44	14	10	22.2	-0.89	6.8e-06	AP001877.1 APEH CADM2 CAMKMT IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
BMI	7.79	14	11	24.4	-0.86	4.0e-05	APEH CADM2 CAMKMT IP6K2 LIN37 LONRF2 MST1R NEGR1 NRBF2 POM121C RBM6 RNF123 THEM6 UBA7
Overall health rating	7.37	9	6	13.3	-0.99	7.2e-08	APEH CKM MST1R RBM6 RNF123 TANK THEM6 TSNARE1 UBA7
Arm fat mass (right)	7.20	11	8	17.8	-0.88	1.9e-04	APEH CADM2 IP6K2 LONRF2 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Arm fat mass (left)	7.12	11	8	17.8	-0.87	2.0e-04	APEH CADM2 IP6K2 LONRF2 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Whole body fat mass	6.91	12	9	20.0	-0.88	6.3e-05	APEH CADM2 IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Alcohol intake versus 10 years previously	6.71	6	4	8.9	-0.87	1.0e-02	APEH MST1R NEGR1 RBM6 RNF123 UBA7
Body fat percentage	6.43	13	10	22.2	-0.89	2.0e-05	APEH CADM2 CAMKMT IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Irritable Bowel Disease (IBD)	6.34	5	5	11.1	0.96	2.4e-03	APEH MST1R RBM6 RNF123 UBA7
Arm fat percentage (left)	6.25	13	8	17.8	-0.88	3.3e-05	APEH CADM2 CAMKMT IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Arm fat percentage (right)	6.19	13	8	17.8	-0.88	2.8e-05	APEH CADM2 CAMKMT IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Waist circumference	5.78	10	8	17.8	-0.85	9.8e-04	APEH CADM2 LONRF2 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Alcohol usually taken with meals	5.75	7	1	2.2	1.00	6.1e-07	CADM2 ERCC8 GRIN2A MED8 NEGR1 NRBF2 TSNARE1
Weight	5.69	11	8	17.8	-0.76	4.4e-03	APEH CADM2 LONRF2 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 THEM6 UBA7
Average weekly beer plus cider intake	5.67	6	1	2.2	-0.98	6.4e-05	CADM2 MST1R NRBF2 RBM6 RNF123 UBA7
Trunk fat mass	5.57	11	8	17.8	-0.88	1.6e-04	APEH CADM2 IP6K2 LONRF2 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Average weekly red wine intake	5.44	4	1	2.2	0.98	1.8e-02	AP001877.1 CAMKMT NRBF2 RP11-282O18.3
Number of treatments/medications taken	5.32	7	4	8.9	-0.87	5.3e-03	APEH MST1R NEGR1 RBM6 RNF123 TANK UBA7
Wheeze or whistling in the chest in last year	5.25	5	4	8.9	-0.99	1.1e-04	APEH MST1R RBM6 RNF123 UBA7
Fed-up feelings	5.24	7	4	8.9	-0.99	6.6e-06	APEH LONRF2 MST1R RBM6 RNF123 THEM6 UBA7
Crohns Disease (2012)	5.14	5	5	11.1	0.98	4.3e-04	APEH MST1R RBM6 RNF123 UBA7
Crohns Disease (2017)	5.13	5	5	11.1	0.96	2.4e-03	APEH MST1R RBM6 RNF123 UBA7
Trunk fat percentage	5.10	12	8	17.8	-0.89	3.9e-05	APEH CADM2 IP6K2 LONRF2 MPP6 MST1R NEGR1 POM121C RBM6 RNF123 THEM6 UBA7
Diastolic blood pressure, automated reading	5.10	12	8	17.8	-0.89	5.7e-05	APEH MED8 MPP6 MST1R NRBF2 POM121C RBM6 RNF123 RP11-282O18.3 THEM6 TSNARE1 UBA7
Taking other prescription medications	5.07	4	4	8.9	-1.00	1.4e-05	MST1R RBM6 RNF123 UBA7
Miserableness	5.00	7	4	8.9	-0.99	2.9e-06	APEH CELF2 MST1R RBM6 RNF123 TANK UBA7
Ulcerative Colitis (UC)	4.96	5	5	11.1	0.97	1.4e-03	APEH MST1R RBM6 RNF123 UBA7
Ulcerative Colitis	4.79	5	4	8.9	0.98	3.1e-03	APEH MST1R RBM6 RNF123 UBA7
Alcohol intake frequency.	4.73	8	4	8.9	-0.90	9.7e-04	APEH MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 TSNARE1 UBA7
Leg pain on walking	4.72	4	3	6.7	-1.00	4.8e-05	MST1R RBM6 RNF123 UBA7
Impedance of arm (right)	4.49	9	7	15.6	0.80	5.9e-03	APEH CADM2 ERCC8 MST1R NEGR1 NRBF2 RBM6 RNF123 UBA7
Mood swings	4.47	6	2	4.4	-0.99	4.7e-05	APEH CELF2 MST1R RBM6 RNF123 UBA7
Blood Platelet Count	4.44	6	4	8.9	0.12	8.2e-01	CKM FAM160A1 MPP6 NRBF2 RP11-282O18.3 ST3GAL3
Mouth/teeth dental problems: Dentures	4.43	4	0	0.0	-1.00	2.2e-04	MST1R RBM6 RNF123 UBA7
Impedance of arm (left)	4.43	10	7	15.6	0.82	2.0e-03	APEH CADM2 ERCC8 LIN37 MST1R NEGR1 NRBF2 RBM6 RNF123 UBA7
Qualifications: CSEs or equivalent	4.41	6	0	0.0	-0.98	7.3e-04	FOXO6 MST1R RBM6 RNF123 ST3GAL3 UBA7
Smoking Status	4.37	6	5	11.1	-0.98	5.4e-04	CADM2 CELF2 ERCC8 MED8 ST3GAL3 TANK
Qualifications: NVQ or HND or HNC or equivalent	4.30	3	0	0.0	-1.00	2.5e-03	MST1R RBM6 RNF123
Maternal smoking around birth	4.27	3	0	0.0	0.00	1.0e+00	CKM MED8 RNF123
Arm predicted mass (left)	4.18	10	7	15.6	-0.58	6.1e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Arm fat-free mass (left)	4.12	10	7	15.6	-0.58	6.3e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Depressed Affect (Nagel 2018)	4.11	8	4	8.9	-0.98	3.3e-06	APEH CELF2 MST1R RBM6 RNF123 TANK THEM6 UBA7
Hip circumference	4.11	11	8	17.8	-0.68	1.6e-02	APEH CADM2 LONRF2 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 THEM6 UBA7
Ever highly irritable/argumentative for 2 days	3.99	4	0	0.0	-1.00	2.2e-04	MST1R RBM6 RNF123 UBA7
Age when periods started (menarche)	3.90	7	3	6.7	-0.74	5.6e-02	APEH MED8 MST1R NEGR1 NRBF2 RBM6 ST3GAL3
Pain experienced in last month	3.89	5	0	0.0	1.00	2.2e-06	APEH MST1R RBM6 RNF123 UBA7
Arm predicted mass (right)	3.87	10	7	15.6	-0.56	7.0e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Diabetes (self-reported)	3.84	3	2	4.4	-1.00	3.9e-03	RBM6 RNF123 UBA7
Exposure to tobacco smoke at home	3.84	2	0	0.0	0.00	1.0e+00	RNF123 UBA7
Arm fat-free mass (right)	3.82	10	7	15.6	-0.55	7.9e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Financial situation satisfaction	3.81	3	0	0.0	0.00	1.0e+00	APEH RNF123 UBA7
Commuting to job workplace: Public transport	3.77	2	0	0.0	0.00	1.0e+00	LONRF2 NEGR1
Basal metabolic rate	3.59	10	8	17.8	-0.55	8.1e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Impedance of whole body	3.57	11	9	20.0	0.78	2.7e-03	APEH CADM2 ERCC8 LIN37 MST1R NEGR1 NRBF2 POM121C RBM6 RNF123 UBA7
Medication for cholesterol, blood pressure or diabetes	3.56	3	0	0.0	0.00	1.0e+00	RBM6 RNF123 UBA7
Medication: Co-codamol	3.52	4	0	0.0	-1.00	4.1e-06	MST1R RBM6 RNF123 UBA7
Body Mass Index (BMI) (2010)	3.50	1	1	2.2	0.00	1.0e+00	NEGR1
Blood White Count	3.43	11	8	17.8	-0.69	1.3e-02	APEH CKM FAM160A1 FOXO6 MED8 MPP6 MST1R NRBF2 RBM6 RNF123 UBA7
Noisy workplace	3.43	1	0	0.0	0.00	1.0e+00	LIN37
Father's age at death	3.39	3	0	0.0	0.00	1.0e+00	APEH RNF123 UBA7
Leg fat-free mass (left)	3.36	11	8	17.8	-0.53	7.4e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 UBA7
Exposure to tobacco smoke outside home	3.36	1	0	0.0	0.00	1.0e+00	UBA7
Leg predicted mass (left)	3.34	11	8	17.8	-0.53	7.6e-02	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 UBA7
Major Depression (MDD)	3.33	1	1	2.2	0.00	1.0e+00	NEGR1
Type 2 Diabetes (T2D) (2018)	3.31	4	2	4.4	-0.99	4.3e-04	MST1R RBM6 RNF123 UBA7
Diabetes diagnosed by doctor	3.30	3	1	2.2	-0.99	7.9e-03	RBM6 RNF123 UBA7
Prospective memory result	3.28	1	0	0.0	0.00	1.0e+00	RBM6
Smoking status: Current	3.26	1	1	2.2	0.00	1.0e+00	ST3GAL3
Chronic bronchitis/emphysema (mother)	3.25	2	0	0.0	0.00	1.0e+00	RBM6 UBA7
Current tobacco smoking	3.24	1	0	0.0	0.00	1.0e+00	ST3GAL3
Pulse rate, automated reading	3.18	8	5	11.1	-0.85	3.9e-03	APEH IP6K2 MST1R NEGR1 POM121C RBM6 RNF123 UBA7
Age started oral contraceptive pill	3.16	1	0	0.0	0.00	1.0e+00	RNF123
Risk taking	3.13	3	1	2.2	0.00	1.0e+00	CADM2 FAM160A1 GRIN2A
Whole body water mass	3.02	10	8	17.8	-0.47	1.4e-01	APEH CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Past tobacco smoking	3.01	3	1	2.2	0.00	1.0e+00	CADM2 CELF2 TANK
Health satisfaction	3.01	2	0	0.0	0.00	1.0e+00	TSNARE1 UBA7
Leg fat-free mass (right)	2.97	10	8	17.8	-0.49	1.3e-01	CADM2 ERCC8 FAM160A1 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 UBA7
Leg predicted mass (right)	2.96	10	7	15.6	-0.48	1.3e-01	CADM2 ERCC8 FAM160A1 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 UBA7
Breastfed as a baby	2.95	1	0	0.0	0.00	1.0e+00	RP11-282O18.3
Whole body fat-free mass	2.94	9	8	17.8	-0.46	1.8e-01	CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Coronary Artery Disease (CAD)	2.86	1	0	0.0	0.00	1.0e+00	RBM6
Average weekly spirits intake	2.86	1	0	0.0	0.00	1.0e+00	APEH
Schizophrenia (2018)	2.85	4	0	0.0	-0.42	5.8e-01	ERCC8 MED8 RP11-282O18.3 ST3GAL3
Medication: Seretide 50 evohaler	2.85	1	0	0.0	0.00	1.0e+00	UBA7
Number of live births	2.84	2	0	0.0	0.00	1.0e+00	RBM6 RNF123
Knee pain experienced in last month	2.83	1	0	0.0	0.00	1.0e+00	RBM6
Comparative body size at age 10	2.81	3	2	4.4	0.00	1.0e+00	CADM2 ERCC8 NEGR1
Number of operations (self-reported)	2.79	2	0	0.0	0.00	1.0e+00	NEGR1 TANK
Ever had bowel cancer screening	2.74	2	0	0.0	0.00	1.0e+00	RNF123 UBA7
Loneliness, isolation	2.71	1	0	0.0	0.00	1.0e+00	APEH
Commuting to job workplace: Car/motor vehicle	2.67	1	0	0.0	0.00	1.0e+00	NEGR1
Systolic blood pressure, automated reading	2.66	6	2	4.4	-0.75	8.6e-02	APEH MED8 MPP6 RNF123 TSNARE1 UBA7
Ever smoked	2.59	2	1	2.2	0.00	1.0e+00	CADM2 CELF2
Heel bone mineral density (BMD) T-score, automated (left)	2.58	4	2	4.4	-0.99	7.1e-04	MST1R RBM6 RNF123 UBA7
Medication for pain relief, constipation, heartburn	2.58	1	0	0.0	0.00	1.0e+00	RP11-282O18.3
Smoking status: Previous	2.56	1	1	2.2	0.00	1.0e+00	CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.51	1	1	2.2	0.00	1.0e+00	NEGR1
Medication: Blood pressure	2.51	1	0	0.0	0.00	1.0e+00	RNF123
Trunk fat-free mass	2.46	9	7	15.6	-0.40	2.5e-01	CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Illnesses of siblings	2.44	1	0	0.0	0.00	1.0e+00	ST3GAL3
Trunk predicted mass	2.43	9	6	13.3	-0.39	2.6e-01	CADM2 ERCC8 FAM160A1 MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Medication: Ventolin 100micrograms inhaler	2.41	2	0	0.0	0.00	1.0e+00	RBM6 UBA7
Schizophrenia (2014)	2.39	3	1	2.2	0.00	1.0e+00	ERCC8 RP11-282O18.3 ST3GAL3
Heel T-Score	2.38	7	6	13.3	-0.90	2.3e-03	APEH MST1R NEGR1 RBM6 RNF123 RP11-282O18.3 UBA7
Mean time to correctly identify matches	2.38	1	0	0.0	0.00	1.0e+00	RNF123
Impedance of leg (left)	2.37	10	5	11.1	0.38	2.6e-01	AP001877.1 ERCC8 FAM160A1 MST1R NEGR1 POM121C RBM6 RNF123 RP11-282O18.3 UBA7
Number of children fathered	2.36	1	0	0.0	0.00	1.0e+00	CADM2
Heel bone mineral density (BMD) T-score, automated (right)	2.34	4	1	2.2	-0.99	9.3e-04	MST1R RBM6 RNF123 UBA7
Impedance of leg (right)	2.29	9	5	11.1	0.47	1.7e-01	AP001877.1 ERCC8 FAM160A1 MST1R NEGR1 POM121C RBM6 RNF123 UBA7
Worrier / anxious feelings	2.29	2	1	2.2	0.00	1.0e+00	AP001877.1 CADM2
Neuroticism score	2.28	3	0	0.0	0.00	1.0e+00	CELF2 RNF123 UBA7
Prostate Cancer	2.24	1	0	0.0	0.00	1.0e+00	UBA7
Unable to work because of sickness or disability	2.24	1	0	0.0	0.00	1.0e+00	ERCC8
Neuroticism (2016)	2.23	1	0	0.0	0.00	1.0e+00	TANK
Vascular/heart problems diagnosed by doctor	2.21	4	0	0.0	0.40	6.0e-01	MED8 NEGR1 NRBF2 TSNARE1
Number of self-reported non-cancer illnesses	2.18	1	1	2.2	0.00	1.0e+00	NEGR1
Cardiovascular Disease	2.15	4	1	2.2	-0.27	7.3e-01	MED8 NEGR1 RNF123 THEM6
Bipolar Disorder or Schizophrenia	2.14	4	2	4.4	-0.20	8.0e-01	MED8 MPP6 RP11-282O18.3 ST3GAL3
Systolic Blood Pressure	2.13	7	3	6.7	-0.64	1.2e-01	APEH MED8 MPP6 POM121C RNF123 TSNARE1 UBA7
Friendships satisfaction	2.13	1	0	0.0	0.00	1.0e+00	AP001877.1
Neuroticism	2.12	3	0	0.0	0.00	1.0e+00	RNF123 TSNARE1 UBA7
Reaction Time	2.11	1	0	0.0	0.00	1.0e+00	RNF123
Neuroticism (Nagel 2018)	2.08	3	0	0.0	0.00	1.0e+00	CELF2 THEM6 TSNARE1
Relative age voice broke	2.07	2	0	0.0	0.00	1.0e+00	NRBF2 POM121C
Long-standing illness, disability or infirmity	2.07	1	0	0.0	0.00	1.0e+00	NEGR1
Forced expiratory volume in 1-second (FEV1), Best measure	2.00	4	0	0.0	1.00	3.3e-03	APEH MST1R RNF123 UBA7
HDL Cholesterol	1.98	2	0	0.0	0.00	1.0e+00	NRBF2 RBM6
Townsend deprivation index at recruitment	1.97	1	0	0.0	0.00	1.0e+00	CKM
High blood pressure	1.96	4	0	0.0	-0.11	8.9e-01	MED8 NEGR1 NRBF2 TSNARE1
Fractured/broken bones in last 5 years	1.96	1	0	0.0	0.00	1.0e+00	ERCC8
Supplements: Zinc	1.92	1	0	0.0	0.00	1.0e+00	NRBF2
Hypertension (Self-reported)	1.92	5	0	0.0	-0.64	2.5e-01	MPP6 NEGR1 NRBF2 THEM6 TSNARE1
Frequency of depressed mood in last 2 weeks	1.90	1	0	0.0	0.00	1.0e+00	CELF2
Worry (Nagel 2018)	1.89	3	0	0.0	0.00	1.0e+00	AP001877.1 CADM2 TSNARE1
Hand grip strength (right)	1.88	3	0	0.0	0.00	1.0e+00	CADM2 CUEDC2 FAM160A1
Respiratory disease	1.84	1	0	0.0	0.00	1.0e+00	RBM6
Forced vital capacity (FVC), Best measure	1.84	5	0	0.0	0.82	9.0e-02	APEH FOXO6 MST1R RNF123 UBA7
Breast Cancer	1.83	2	0	0.0	0.00	1.0e+00	APEH UBA7
Forced expiratory volume in 1-second (FEV1)	1.83	4	0	0.0	0.99	1.4e-02	APEH GPD2 MST1R UBA7
Hayfever, allergic rhinitis or eczema	1.82	3	0	0.0	0.00	1.0e+00	IP6K2 NEGR1 RP11-282O18.3
Chronotype (morning person)	1.77	1	0	0.0	0.00	1.0e+00	CAMKMT
Nervous feelings	1.77	3	1	2.2	0.00	1.0e+00	AP001877.1 CADM2 TSNARE1
Relative age of first facial hair	1.75	2	0	0.0	0.00	1.0e+00	MED8 NRBF2
Mouth/teeth dental problems: Mouth ulcers	1.74	1	0	0.0	0.00	1.0e+00	AP001877.1
Alcohol drinker status: Previous	1.74	1	0	0.0	0.00	1.0e+00	POM121C
Comparative height size at age 10	1.72	5	3	6.7	0.99	1.3e-03	CAMKMT FAM160A1 MED8 RP11-282O18.3 ST3GAL3
Allergy	1.69	2	1	2.2	0.00	1.0e+00	NEGR1 RP11-282O18.3
Lung FVC	1.67	8	2	4.4	0.48	2.3e-01	APEH FOXO6 GPD2 MST1R NRBF2 RBM6 RP11-282O18.3 UBA7
Worry too long after embarrassment	1.64	1	0	0.0	0.00	1.0e+00	THEM6
Hand grip strength (left)	1.63	3	0	0.0	0.00	1.0e+00	CADM2 CUEDC2 FAM160A1
Allergy or Eczema	1.60	2	0	0.0	0.00	1.0e+00	NEGR1 RP11-282O18.3
Forced vital capacity (FVC)	1.60	5	0	0.0	0.75	1.5e-01	APEH FAM160A1 FOXO6 MST1R UBA7
Triglycerides	1.54	1	1	2.2	0.00	1.0e+00	NRBF2
Illnesses of father: None of the above (group 1)	1.53	1	0	0.0	0.00	1.0e+00	CUEDC2
Osteoporosis (self-reported)	1.49	1	0	0.0	0.00	1.0e+00	IP6K2
Sitting height	1.47	4	2	4.4	0.93	6.9e-02	CAMKMT MED8 RP11-282O18.3 ST3GAL3
Blood Red Count	1.45	13	5	11.1	-0.48	1.0e-01	AP001877.1 CAMKMT CKM ERCC8 IP6K2 MED8 MST1R NRBF2 POM121C RBM6 RNF123 ST3GAL3 UBA7
Lung FEV1/FVC ratio	1.36	2	2	4.4	0.00	1.0e+00	NEGR1 NRBF2
Pulse rate	1.35	1	0	0.0	0.00	1.0e+00	IP6K2
Hypothyroidism (self reported)	1.34	1	1	2.2	0.00	1.0e+00	TANK
Waist Hip Ratio (WHR)	1.32	2	1	2.2	0.00	1.0e+00	ERCC8 RP11-282O18.3
Bipolar Disorder (2018)	1.21	1	0	0.0	0.00	1.0e+00	MPP6
Irritability	1.21	1	0	0.0	0.00	1.0e+00	CELF2
Height	1.20	12	6	13.3	0.84	6.4e-04	AP001877.1 CAMKMT ERCC8 FAM160A1 MED8 MPP6 MST1R NRBF2 POM121C RNF123 RP11-282O18.3 ST3GAL3
Standing height	1.20	6	3	6.7	0.97	1.6e-03	CAMKMT FAM160A1 MED8 MPP6 NRBF2 RP11-282O18.3
Hypothyroidism/myxoedema (self-reported)	1.15	1	0	0.0	0.00	1.0e+00	TANK
Blood Eosinophil Count	1.10	4	3	6.7	-0.85	6.8e-02	CKM RBM6 RP11-282O18.3 UBA7
High cholesterol (Self-reported)	1.05	1	0	0.0	0.00	1.0e+00	CADM2
Tanning	0.45	1	0	0.0	0.00	1.0e+00	CADM2
Hair Pigment	0.12	1	1	2.2	0.00	1.0e+00	RP11-282O18.3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellar Hemisphere	8	0.537	2.6
GTEx	Vagina	1	0.157	2.6
GTEx	Brain Frontal Cortex BA9	5	0.541	2.5
GTEx	Esophagus Gastroesophageal Junction	6	0.415	2.5
GTEx	Heart Atrial Appendage	3	0.190	2.5
GTEx	Pancreas	9	0.551	2.5
GTEx	Adipose Visceral Omentum	9	0.442	2.4
GTEx	Brain Caudate basal ganglia	3	0.326	2.4
GTEx	Brain Cerebellum	7	0.353	2.4
GTEx	Brain Hypothalamus	2	0.339	2.4
GTEx	Brain Putamen basal ganglia	2	0.321	2.4
GTEx	Breast Mammary Tissue	5	0.253	2.4
GTEx	Cells EBV-transformed lymphocytes	3	0.211	2.4
GTEx	Colon Sigmoid	6	0.410	2.4
GTEx	Colon Transverse	7	0.339	2.4
GTEx	Esophagus Mucosa	12	0.361	2.4
GTEx	Esophagus Muscularis	13	0.402	2.4
GTEx	Heart Left Ventricle	5	0.327	2.4
GTEx	Muscle Skeletal	10	0.346	2.4
GTEx	Ovary	1	0.110	2.4
GTEx	Skin Not Sun Exposed Suprapubic	10	0.407	2.4
GTEx	Small Intestine Terminal Ileum	3	0.651	2.4
GTEx	Spleen	3	0.213	2.4
GTEx	Stomach	4	0.275	2.4
GTEx	Uterus	0	0.000	2.4
GTEx	Adipose Subcutaneous	9	0.258	2.3
GTEx	Artery Aorta	10	0.336	2.3
GTEx	Artery Tibial	13	0.346	2.3
GTEx	Brain Cortex	3	0.290	2.3
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	2.3
GTEx	Breast Mammary Tissue (Female)	5	0.304	2.3
GTEx	Cells Transformed fibroblasts	19	0.452	2.3
GTEx	Liver	4	0.558	2.3
GTEx	Lung	10	0.348	2.3
GTEx	Nerve Tibial	19	0.440	2.3
GTEx	Prostate	1	0.120	2.3
GTEx	Skin Sun Exposed Lower leg	14	0.385	2.3
GTEx	Thyroid	14	0.350	2.3
ROSMAP	Brain Pre-frontal Cortex	11	0.251	2.3
The Cancer Genome Atlas	Glioblastoma Multiforme	4	0.391	2.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.271	2.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	2.3
GTEx	Artery Coronary	2	0.169	2.2
GTEx	Breast Mammary Tissue (Male)	1	0.084	2.2
GTEx	Pituitary	3	0.269	2.2
GTEx	Testis	8	0.254	2.2
GTEx	Whole Blood	4	0.201	2.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	4	0.242	2.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	3	0.273	2.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	9	0.439	2.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	6	0.239	2.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	8	0.482	2.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	5	0.377	2.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	3	0.235	2.2
GTEx	Adrenal Gland	1	0.069	2.1
METSIM	Adipose	11	0.239	2.1
NTR	Blood	9	0.375	2.1
CommonMind	Brain Pre-frontal Cortex	10	0.186	2.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	10	0.227	2.1
The Cancer Genome Atlas	Colon Adenocarcinoma	3	0.145	2.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	7	0.257	2.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	11	0.268	2.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	13	0.302	2.1
The Cancer Genome Atlas	Lung Adenocarcinoma	8	0.272	2.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	3	0.188	2.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	2.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	2.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	3	0.178	2.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	2.1
GTEx	Brain Hippocampus	1	0.191	2.0
YFS	Blood	9	0.195	2.0
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	2.0
The Cancer Genome Atlas	Prostate Adenocarcinoma	11	0.238	2.0
The Cancer Genome Atlas	Thyroid Carcinoma	16	0.310	2.0