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chr6:134,905,567-136,516,257

Best TWAS P=5.64e-14 · Best GWAS P=3.26e-09 conditioned to 0.766

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AHI1	0.40	0.27	lasso	5	0.34	1.0e-28	4.1	-5.6	1.7e-08	-0.68	0.96	0.03	FALSE
2	GTEx	Adipose Visceral Omentum	AHI1	0.17	0.18	lasso	4	0.19	5.6e-10	4.1	-5.2	2.5e-07	-0.58	0.83	0.14	FALSE
3	GTEx	Artery Aorta	AHI1	0.28	0.01	enet	27	0.08	3.2e-05	4.1	-5.7	1.5e-08	-0.74	0.02	0.94	FALSE
4	GTEx	Artery Tibial	AHI1	0.11	0.03	enet	16	0.09	1.8e-07	4.7	-5.6	2.6e-08	-0.71	0.05	0.95	FALSE
5	GTEx	Brain Caudate basal ganglia	AHI1	0.25	0.06	enet	24	0.15	5.4e-05	3.7	-5.5	3.4e-08	-0.67	0.03	0.82	FALSE
6	GTEx	Brain Cerebellar Hemisphere	AHI1	0.35	0.05	lasso	10	0.15	9.8e-05	4.1	-5.8	6.6e-09	-0.65	0.04	0.92	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RP3-388E23.2	0.19	0.18	enet	17	0.26	2.4e-07	4.1	-5.4	7.3e-08	-0.67	0.04	0.84	FALSE
8	GTEx	Brain Cortex	AHI1	0.51	0.27	lasso	6	0.37	3.3e-11	5.3	-5.8	8.6e-09	-0.66	0.14	0.84	FALSE
9	GTEx	Brain Cortex	RP3-388E23.2	0.28	0.16	enet	13	0.19	5.8e-06	4.1	-5.9	2.8e-09	-0.72	0.12	0.78	FALSE
10	GTEx	Brain Frontal Cortex BA9	AHI1	0.19	0.00	enet	14	0.05	1.5e-02	2.9	-7.5	5.6e-14	-0.52	0.05	0.38	TRUE
11	GTEx	Brain Putamen basal ganglia	AHI1	0.30	0.11	enet	36	0.12	1.0e-03	4.1	-5.1	2.8e-07	-0.62	0.08	0.68	FALSE
12	GTEx	Breast Mammary Tissue	AHI1	0.34	0.29	lasso	4	0.35	1.1e-18	4.1	-5.7	1.4e-08	-0.66	0.95	0.04	FALSE
13	GTEx	Breast Mammary Tissue (Male)	AHI1	0.19	0.06	lasso	2	0.14	3.2e-04	4.1	-5.7	1.3e-08	-0.64	0.04	0.43	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	AHI1	0.38	0.24	enet	19	0.23	5.4e-08	5.3	-6.0	1.4e-09	-0.64	0.04	0.96	TRUE
15	GTEx	Cells EBV-transformed lymphocytes	RP3-388E23.2	0.26	0.05	lasso	6	0.02	7.1e-02	5.5	-5.7	1.5e-08	-0.66	0.03	0.86	FALSE
16	GTEx	Cells Transformed fibroblasts	AHI1	0.44	0.21	enet	22	0.32	4.4e-24	4.5	-5.4	6.9e-08	-0.69	0.38	0.62	FALSE
17	GTEx	Cells Transformed fibroblasts	RP3-388E23.2	0.13	0.13	lasso	5	0.15	3.5e-11	4.1	-5.5	3.3e-08	-0.62	0.86	0.13	FALSE
18	GTEx	Esophagus Mucosa	AHI1	0.30	0.24	lasso	8	0.32	4.6e-22	5.5	-6.1	7.8e-10	-0.69	0.03	0.97	FALSE
19	GTEx	Nerve Tibial	AHI1	0.41	0.36	lasso	5	0.41	5.8e-31	4.1	-5.4	8.6e-08	-0.61	0.96	0.03	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	AHI1	0.41	0.31	lasso	7	0.40	9.1e-24	5.5	-6.3	3.6e-10	-0.72	0.02	0.98	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RP3-388E23.2	0.14	0.03	enet	17	0.12	3.7e-07	5.2	-6.0	1.9e-09	-0.76	0.04	0.92	FALSE
22	GTEx	Skin Sun Exposed Lower leg	AHI1	0.33	0.22	enet	14	0.34	1.0e-28	4.1	-6.2	6.1e-10	-0.71	0.66	0.34	FALSE
23	GTEx	Skin Sun Exposed Lower leg	RP3-388E23.2	0.10	0.06	enet	6	0.04	3.1e-04	5.3	-5.8	5.3e-09	-0.72	0.05	0.92	FALSE
24	GTEx	Small Intestine Terminal Ileum	AHI1	0.51	0.01	enet	19	0.06	2.0e-02	5.5	-5.5	3.9e-08	-0.65	0.03	0.54	FALSE
25	GTEx	Spleen	AHI1	0.31	0.21	lasso	3	0.38	8.6e-11	5.2	-6.2	4.8e-10	-0.78	0.02	0.95	FALSE
26	GTEx	Testis	AHI1	0.37	0.32	enet	25	0.37	3.5e-17	5.5	-6.1	1.3e-09	-0.71	0.03	0.97	FALSE
27	GTEx	Testis	RP3-388E23.2	0.23	0.19	lasso	3	0.24	5.7e-11	4.1	-5.7	1.0e-08	-0.64	0.26	0.71	FALSE
28	METSIM	Adipose	AHI1	0.25	0.22	lasso	7	0.28	1.1e-42	5.3	-6.1	1.3e-09	-0.68	0.04	0.96	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	AHI1	0.40	0.24	lasso	6	0.26	1.1e-33	4.1	-5.4	5.4e-08	-0.72	0.96	0.04	FALSE
30	YFS	Blood	AHI1	0.24	0.30	bslmm	414	0.33	1.4e-110	5.5	-5.9	3.9e-09	-0.68	0.03	0.97	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHI1	0.06	0.02	lasso	7	0.02	1.3e-04	5.5	-5.8	7.7e-09	-0.78	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AHI1	0.06	0.08	blup	73	0.06	1.1e-03	5.5	-5.1	2.7e-07	-0.70	0.02	0.89	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AHI1	0.18	0.19	lasso	4	0.18	6.4e-20	5.5	-5.6	2.7e-08	-0.64	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AHI1	0.13	0.16	lasso	3	0.16	1.2e-17	5.5	-5.7	9.4e-09	-0.68	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AHI1	0.05	0.05	lasso	1	0.04	1.5e-03	5.3	-5.3	1.1e-07	-0.61	0.02	0.78	FALSE
36	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AHI1	0.36	0.30	lasso	3	0.29	1.0e-10	5.3	-5.9	3.9e-09	-0.72	0.03	0.97	FALSE