TWAS
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About
Usage
Models
Genes
Traits
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Traits
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Medication: Blood pressure
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chr2:26,223,547-27,689,899
Best TWAS P=5.48e-09 · Best GWAS P=5.47e-26 conditioned to 4.73e-17
26.2M
26.4M
26.6M
26.8M
27M
27.2M
27.4M
27.6M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
METSIM
Adipose
SLC35F6
0.04
0.01
blup
362
0.02
1.1e-03
4.5
5.8
5.5e-09
0.48
0.10
0.46
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
KCNK3
0.24
0.15
lasso
3
0.15
6.5e-19
5.4
-5.3
1.3e-07
-0.34
1.00
0.00
TRUE
1
GTEx
Skin Sun Exposed Lower leg
SLC35F6
0.10
0.04
lasso
4
0.05
4.2e-05
-3.8
5.5
3.2e-08
0.37
0.45
0.08
FALSE
4
The Cancer Genome Atlas
Esophageal Carcinoma
C2orf18
0.20
0.02
blup
30
0.06
6.7e-03
5.5
5.2
1.6e-07
0.45
0.01
0.55
FALSE