382 significantly associated models · 127 unique genes
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# | chr | p0 | p1 | # assoc genes | # joint genes | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 11181327 | 12600396 | 2 | 1 | 6.2e-13 | 1.2e-12 | 3.5e-04 | 75 | CLCN6 |
2 | 1 | 26428864 | 27820430 | 1 | 1 | 4.2e-08 | 9.2e-06 | 2.2e-01 | 92 | PIGV |
3 | 1 | 88621347 | 90053563 | 1 | 1 | 7.8e-09 | 2.2e-08 | 1.1e-01 | 92 | GTF2B |
4 | 1 | 112312154 | 114196883 | 6 | 4 | 7.3e-18 | 4.0e-15 | 3.9e-01 | 99 | CAPZA1 RHOC SLC16A1 WNT2B |
5 | 1 | 230142626 | 231548480 | 1 | 1 | 3.0e-14 | 1.4e-13 | 1.0e+00 | 100 | AGT |
6 | 2 | 24021231 | 25692112 | 1 | 1 | 4.9e-08 | 5.2e-07 | 2.7e-07 | -5 | NCOA1 |
7 | 2 | 26223547 | 27689899 | 3 | 2 | 5.5e-09 | 5.5e-26 | 4.7e-17 | 37 | KCNK3 SLC35F6 |
8 | 2 | 215101843 | 216697115 | 1 | 1 | 1.2e-07 | 2.2e-04 | 8.6e-03 | 50 | ABCA12 |
9 | 3 | 26720690 | 28211713 | 1 | 1 | 3.9e-08 | 2.7e-09 | 2.3e-02 | 85 | SLC4A7 |
10 | 3 | 137189600 | 138819532 | 2 | 1 | 5.7e-08 | 1.7e-07 | 1.0e+00 | 100 | DBR1 |
11 | 4 | 80488345 | 82578407 | 2 | 1 | 1.4e-09 | 2.7e-26 | 3.0e-18 | 33 | C4orf22 |
12 | 5 | 130830617 | 132425049 | 5 | 1 | 7.7e-08 | 8.2e-08 | 1.0e+00 | 100 | SLC22A5 |
13 | 6 | 33856903 | 35362848 | 1 | 1 | 1.0e-07 | 5.3e-05 | 2.9e-02 | 71 | C6orf106 |
14 | 6 | 42611872 | 44034691 | 2 | 1 | 5.4e-10 | 6.7e-10 | 1.0e+00 | 100 | ZNF318 |
15 | 6 | 125970401 | 127355237 | 1 | 1 | 7.2e-11 | 4.7e-20 | 6.1e-14 | 33 | CENPW |
16 | 7 | 6502367 | 7988091 | 1 | 1 | 9.4e-10 | 1.0e-07 | 6.3e-01 | 99 | C1GALT1 |
17 | 7 | 26969253 | 27533292 | 2 | 1 | 2.7e-14 | 1.8e-14 | 2.4e-02 | 91 | HOXA10 |
18 | 7 | 129917130 | 131315092 | 1 | 1 | 3.1e-11 | 3.8e-14 | 3.0e-06 | 62 | RP11-138A9.1 |
19 | 8 | 8092025 | 13120332 | 17 | 2 | 3.6e-10 | 2.8e-10 | 1.2e-03 | 74 | FAM167A NEIL2 |
20 | 10 | 18221643 | 19074958 | 1 | 1 | 4.9e-08 | 1.4e-10 | 4.2e-10 | 5 | CACNB2 |
21 | 10 | 103987875 | 105647095 | 2 | 1 | 2.1e-08 | 4.4e-09 | 7.9e-02 | 91 | NT5C2 |
22 | 10 | 115555541 | 116053000 | 1 | 1 | 5.7e-08 | 2.1e-11 | 1.6e-05 | 58 | ADRB1 |
23 | 11 | 1213806 | 2705175 | 5 | 8 | 1.2e-15 | 8.7e-17 | NaN | NaN | LOC100133545 LSP1 MRPL23-AS1 TNNT3 |
24 | 11 | 46570859 | 47977454 | 2 | 1 | 3.3e-09 | 4.8e-08 | 3.6e-01 | 97 | ACP2 |
25 | 11 | 65157820 | 65733393 | 2 | 2 | 2.1e-09 | 3.8e-09 | 1.9e-02 | 84 | RNASEH2C SIPA1 |
26 | 11 | 99859184 | 101559718 | 2 | 1 | 4.4e-19 | 3.7e-19 | 1.0e+00 | 100 | ARHGAP42 |
27 | 12 | 111154626 | 113517494 | 8 | 1 | 1.4e-11 | 9.8e-16 | 1.6e-06 | 64 | SH2B3 |
28 | 13 | 29386474 | 30865365 | 1 | 1 | 7.1e-08 | 9.8e-10 | 3.1e-04 | 65 | SLC7A1 |
29 | 15 | 74042497 | 76108550 | 11 | 1 | 9.1e-11 | 9.5e-11 | 6.6e-02 | 92 | MPI |
30 | 15 | 80743350 | 81292020 | 1 | 1 | 1.2e-07 | 1.5e-10 | 3.0e-04 | 68 | FAM108C1 |
31 | 15 | 90712555 | 92135418 | 2 | 1 | 2.5e-20 | 4.8e-17 | 5.4e-01 | 100 | FES |
32 | 16 | 3462595 | 5510848 | 5 | 2 | 5.0e-11 | 3.7e-10 | 1.3e-03 | 74 | MGRN1 TRAP1 |
33 | 16 | 81230341 | 81993974 | 1 | 1 | 1.5e-08 | 1.1e-10 | 1.0e-05 | 53 | CMIP |
34 | 16 | 89013848 | 90172696 | 12 | 1 | 3.5e-12 | 1.9e-12 | 6.7e-02 | 93 | CDK10 |
35 | 17 | 6644945 | 8484683 | 4 | 2 | 2.8e-08 | 5.7e-08 | 7.2e-01 | 100 | CYB5D1 FGF11 |
36 | 17 | 42607368 | 43913030 | 6 | 2 | 1.2e-08 | 3.1e-07 | 9.8e-01 | 100 | FMNL1 LRRC37A4P |
37 | 17 | 44788310 | 45510971 | 2 | 1 | 9.4e-08 | 1.2e-06 | 1.8e-01 | 92 | NSF |
38 | 17 | 60858059 | 62259376 | 1 | 1 | 1.1e-08 | 1.1e-08 | 1.0e+00 | 100 | ACE |
39 | 17 | 78665405 | 80023050 | 1 | 1 | 9.4e-08 | 8.9e-08 | 3.4e-01 | 97 | RP11-1055B8.4 |
40 | 19 | 16462417 | 18007950 | 2 | 1 | 4.2e-09 | 1.6e-08 | 9.7e-03 | 79 | MYO9B |
41 | 20 | 7419920 | 9648826 | 1 | 2 | 2.0e-09 | 6.4e-13 | 1.0e-03 | 79 | PLCB1 |
42 | 20 | 57525478 | 58079512 | 1 | 1 | 1.1e-15 | 2.4e-22 | 3.2e-09 | 63 | ZNF831 |
43 | 20 | 61667526 | 62912463 | 2 | 2 | 8.7e-09 | 2.1e-08 | 1.0e+00 | 100 | LIME1 ZBTB46 |
Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
---|
study | tissue | # hits | % hits/tests | avg chisq |
---|
study | tissue | # hits | % hits/tests | avg chisq |
---|---|---|---|---|
GTEx | Brain Frontal Cortex BA9 | 4 | 0.433 | 2.2 |
GTEx | Ovary | 3 | 0.330 | 2.2 |
GTEx | Artery Aorta | 14 | 0.470 | 2.1 |
GTEx | Breast Mammary Tissue | 6 | 0.304 | 2.1 |
GTEx | Breast Mammary Tissue (Male) | 5 | 0.419 | 2.1 |
GTEx | Heart Atrial Appendage | 3 | 0.190 | 2.1 |
GTEx | Pancreas | 4 | 0.245 | 2.1 |
GTEx | Prostate | 2 | 0.240 | 2.1 |
GTEx | Skin Not Sun Exposed Suprapubic | 12 | 0.488 | 2.1 |
GTEx | Small Intestine Terminal Ileum | 0 | 0.000 | 2.1 |
GTEx | Uterus | 1 | 0.176 | 2.1 |
GTEx | Adipose Subcutaneous | 10 | 0.286 | 2.0 |
GTEx | Adipose Visceral Omentum | 5 | 0.246 | 2.0 |
GTEx | Adrenal Gland | 1 | 0.069 | 2.0 |
GTEx | Artery Tibial | 11 | 0.292 | 2.0 |
GTEx | Brain Cortex | 1 | 0.097 | 2.0 |
GTEx | Brain Hypothalamus | 2 | 0.339 | 2.0 |
GTEx | Brain Nucleus accumbens basal ganglia | 0 | 0.000 | 2.0 |
GTEx | Breast Mammary Tissue (Female) | 6 | 0.365 | 2.0 |
GTEx | Cells EBV-transformed lymphocytes | 2 | 0.141 | 2.0 |
GTEx | Colon Sigmoid | 2 | 0.137 | 2.0 |
GTEx | Colon Transverse | 5 | 0.242 | 2.0 |
GTEx | Esophagus Gastroesophageal Junction | 0 | 0.000 | 2.0 |
GTEx | Esophagus Mucosa | 11 | 0.331 | 2.0 |
GTEx | Esophagus Muscularis | 8 | 0.248 | 2.0 |
GTEx | Heart Left Ventricle | 3 | 0.196 | 2.0 |
GTEx | Lung | 7 | 0.244 | 2.0 |
GTEx | Skin Sun Exposed Lower leg | 11 | 0.302 | 2.0 |
GTEx | Stomach | 2 | 0.138 | 2.0 |
GTEx | Testis | 6 | 0.190 | 2.0 |
ROSMAP | Brain Pre-frontal Cortex | 10 | 0.228 | 2.0 |
The Cancer Genome Atlas | Skin Cutaneous Melanoma | 1 | 0.187 | 2.0 |
GTEx | Artery Coronary | 0 | 0.000 | 1.9 |
GTEx | Brain Caudate basal ganglia | 3 | 0.326 | 1.9 |
GTEx | Brain Cerebellar Hemisphere | 2 | 0.134 | 1.9 |
GTEx | Brain Cerebellum | 6 | 0.303 | 1.9 |
GTEx | Brain Hippocampus | 1 | 0.191 | 1.9 |
GTEx | Cells Transformed fibroblasts | 11 | 0.262 | 1.9 |
GTEx | Muscle Skeletal | 7 | 0.242 | 1.9 |
GTEx | Nerve Tibial | 9 | 0.208 | 1.9 |
GTEx | Pituitary | 0 | 0.000 | 1.9 |
GTEx | Spleen | 2 | 0.142 | 1.9 |
GTEx | Thyroid | 13 | 0.325 | 1.9 |
GTEx | Vagina | 2 | 0.315 | 1.9 |
GTEx | Whole Blood | 6 | 0.301 | 1.9 |
CommonMind | Brain Pre-frontal Cortex | 14 | 0.260 | 1.9 |
The Cancer Genome Atlas | Colon Adenocarcinoma | 6 | 0.291 | 1.9 |
The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | 6 | 0.220 | 1.9 |
The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | 12 | 0.293 | 1.9 |
The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | 9 | 0.439 | 1.9 |
The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | 6 | 0.377 | 1.9 |
The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | 5 | 0.377 | 1.9 |
The Cancer Genome Atlas | Rectum Adenocarcinoma | 1 | 0.145 | 1.9 |
The Cancer Genome Atlas | Stomach Adenocarcinoma | 6 | 0.356 | 1.9 |
The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | 0 | 0.000 | 1.9 |
GTEx | Brain Putamen basal ganglia | 0 | 0.000 | 1.8 |
GTEx | Liver | 0 | 0.000 | 1.8 |
METSIM | Adipose | 11 | 0.239 | 1.8 |
NTR | Blood | 4 | 0.167 | 1.8 |
The Cancer Genome Atlas | Bladder Urothelial Carcinoma | 3 | 0.181 | 1.8 |
The Cancer Genome Atlas | Breast Invasive Carcinoma | 16 | 0.363 | 1.8 |
The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | 2 | 0.182 | 1.8 |
The Cancer Genome Atlas | Esophageal Carcinoma | 2 | 0.292 | 1.8 |
The Cancer Genome Atlas | Glioblastoma Multiforme | 2 | 0.196 | 1.8 |
The Cancer Genome Atlas | Brain Lower Grade Glioma | 8 | 0.186 | 1.8 |
The Cancer Genome Atlas | Lung Adenocarcinoma | 9 | 0.306 | 1.8 |
The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | 7 | 0.279 | 1.8 |
The Cancer Genome Atlas | Pancreatic Adenocarcinoma | 1 | 0.060 | 1.8 |
The Cancer Genome Atlas | Soft Tissue Sarcoma | 2 | 0.187 | 1.8 |
The Cancer Genome Atlas | Testicular Germ Cell Tumors | 2 | 0.156 | 1.8 |
YFS | Blood | 12 | 0.260 | 1.7 |
The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | 2 | 0.181 | 1.7 |
The Cancer Genome Atlas | Prostate Adenocarcinoma | 6 | 0.130 | 1.7 |
The Cancer Genome Atlas | Thyroid Carcinoma | 8 | 0.155 | 1.7 |