Best TWAS P=2.46e-26 · Best GWAS P=1.79e-31 conditioned to 0.000723
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UFL1 | 0.06 | 0.01 | enet | 17 | 0.01 | 2.5e-02 | 10.5 | 6.9 | 5.7e-12 | 0.68 | 0.04 | 0.68 | FALSE |
2 | GTEx | Adipose Visceral Omentum | FHL5 | 0.11 | 0.00 | lasso | 4 | -0.01 | 8.3e-01 | 9.7 | -6.6 | 5.2e-11 | -0.41 | 0.05 | 0.21 | FALSE |
3 | GTEx | Artery Tibial | UFL1 | 0.08 | 0.05 | lasso | 4 | 0.04 | 7.9e-04 | 9.5 | 9.5 | 2.4e-21 | 0.71 | 0.14 | 0.78 | FALSE |
4 | GTEx | Artery Tibial | FHL5 | 0.08 | 0.00 | enet | 48 | 0.02 | 7.2e-03 | 9.5 | -5.4 | 7.4e-08 | -0.50 | 0.11 | 0.42 | FALSE |
5 | GTEx | Nerve Tibial | UFL1 | 0.09 | 0.11 | lasso | 8 | 0.08 | 2.8e-06 | 9.6 | 9.4 | 3.7e-21 | 0.68 | 0.98 | 0.01 | FALSE |
6 | GTEx | Pancreas | UFL1 | 0.08 | 0.11 | enet | 7 | 0.09 | 1.1e-04 | 8.6 | 9.1 | 8.0e-20 | 0.70 | 0.19 | 0.59 | FALSE |
7 | GTEx | Testis | FHL5 | 0.11 | 0.11 | lasso | 5 | 0.10 | 3.5e-05 | 7.8 | -9.6 | 1.3e-21 | -0.76 | 0.14 | 0.60 | FALSE |
8 | GTEx | Thyroid | UFL1 | 0.06 | 0.00 | lasso | 2 | 0.00 | 6.6e-01 | 9.5 | 9.1 | 1.3e-19 | 0.68 | 0.10 | 0.51 | FALSE |
9 | NTR | Blood | KIAA0776 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.1e-07 | 10.6 | 10.6 | 2.5e-26 | 0.89 | 0.28 | 0.72 | TRUE |
10 | ROSMAP | Brain Pre-frontal Cortex | FHL5 | 0.04 | 0.03 | bslmm | 444 | 0.02 | 2.9e-03 | 8.6 | -7.9 | 2.1e-15 | -0.50 | 0.64 | 0.08 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | FUT9 | 0.04 | 0.00 | bslmm | 486 | 0.01 | 1.1e-02 | 1.4 | 6.8 | 1.1e-11 | 0.51 | 0.08 | 0.26 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | FHL5 | 0.03 | 0.02 | blup | 55 | 0.01 | 7.1e-03 | 9.5 | -9.7 | 4.0e-22 | -0.73 | 0.03 | 0.67 | TRUE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FHL5 | 0.03 | 0.03 | enet | 3 | 0.02 | 1.9e-03 | 9.9 | -8.0 | 1.5e-15 | -0.56 | 0.04 | 0.16 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | FHL5 | 0.07 | 0.00 | blup | 55 | 0.01 | 4.8e-02 | 9.6 | -6.4 | 1.4e-10 | -0.58 | 0.02 | 0.10 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0776 | 0.05 | 0.07 | lasso | 2 | 0.06 | 1.8e-06 | 9.5 | 9.9 | 2.5e-23 | 0.74 | 0.37 | 0.59 | FALSE |