Best TWAS P=9.81e-10 · Best GWAS P=2.07e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | YWHAZ | 0.20 | 0.16 | lasso | 4 | 0.16 | 9.2e-09 | -5.7 | -5.7 | 1.1e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adrenal Gland | YWHAZ | 0.20 | 0.04 | lasso | 6 | 0.04 | 2.0e-02 | -5.9 | -6.0 | 2.6e-09 | 0.95 | 0.01 | 0.95 | FALSE |
| 3 | GTEx | Artery Tibial | YWHAZ | 0.29 | 0.30 | lasso | 5 | 0.33 | 6.2e-27 | -5.9 | -5.8 | 5.1e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Brain Cerebellum | YWHAZ | 0.37 | 0.21 | enet | 30 | 0.21 | 9.4e-07 | -5.9 | -5.4 | 6.5e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Brain Cortex | YWHAZ | 0.37 | 0.18 | lasso | 11 | 0.21 | 1.8e-06 | -5.9 | -5.2 | 2.5e-07 | 0.93 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | YWHAZ | 0.40 | 0.18 | lasso | 6 | 0.16 | 5.2e-05 | -5.1 | -5.4 | 7.4e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | YWHAZ | 0.16 | 0.17 | lasso | 1 | 0.15 | 4.4e-08 | -5.9 | -5.9 | 3.8e-09 | 1.00 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | YWHAZ | 0.27 | 0.00 | enet | 6 | 0.02 | 7.3e-02 | -5.9 | -5.9 | 2.8e-09 | 1.00 | 0.01 | 0.84 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | YWHAZ | 0.48 | 0.40 | enet | 25 | 0.46 | 1.4e-37 | -5.9 | -5.7 | 1.0e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Colon Transverse | YWHAZ | 0.33 | 0.23 | enet | 11 | 0.25 | 2.0e-12 | -5.9 | -5.5 | 3.6e-08 | 0.97 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Esophagus Gastroesophageal Junction | YWHAZ | 0.35 | 0.21 | lasso | 4 | 0.18 | 6.0e-07 | -6.0 | -5.9 | 2.9e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Esophagus Mucosa | YWHAZ | 0.34 | 0.40 | lasso | 6 | 0.41 | 5.4e-29 | -6.0 | -5.9 | 2.8e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Esophagus Muscularis | YWHAZ | 0.43 | 0.42 | lasso | 3 | 0.42 | 4.6e-27 | -5.9 | -5.9 | 3.7e-09 | 1.00 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Heart Atrial Appendage | YWHAZ | 0.25 | 0.22 | lasso | 3 | 0.20 | 1.4e-09 | -6.0 | -5.9 | 3.8e-09 | 1.00 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Lung | YWHAZ | 0.20 | 0.22 | lasso | 4 | 0.22 | 1.3e-16 | -5.9 | -5.8 | 6.6e-09 | 0.99 | 0.01 | 0.99 | FALSE |
| 16 | GTEx | Nerve Tibial | YWHAZ | 0.34 | 0.43 | lasso | 3 | 0.44 | 6.9e-34 | -5.9 | -5.9 | 4.3e-09 | 1.00 | 0.01 | 0.99 | FALSE |
| 17 | GTEx | Pituitary | YWHAZ | 0.44 | 0.18 | lasso | 9 | 0.22 | 4.2e-06 | -5.9 | -5.9 | 4.4e-09 | 0.94 | 0.01 | 0.98 | FALSE |
| 18 | GTEx | Skin Not Sun Exposed Suprapubic | YWHAZ | 0.13 | 0.07 | lasso | 3 | 0.05 | 8.0e-04 | -5.9 | -5.5 | 4.6e-08 | 0.98 | 0.01 | 0.98 | FALSE |
| 19 | GTEx | Thyroid | YWHAZ | 0.26 | 0.21 | lasso | 5 | 0.22 | 1.9e-16 | -5.9 | -5.9 | 2.7e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Whole Blood | YWHAZ | 0.11 | 0.06 | enet | 12 | 0.06 | 1.7e-06 | -5.1 | -5.9 | 3.7e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | YWHAZ | 0.23 | 0.20 | bslmm | 465 | 0.20 | 2.6e-25 | -5.9 | -6.1 | 9.8e-10 | 0.98 | 0.00 | 1.00 | TRUE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | YWHAZ | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.2e-04 | -6.0 | -6.0 | 2.1e-09 | 1.00 | 0.00 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | YWHAZ | 0.07 | 0.07 | blup | 50 | 0.08 | 7.7e-09 | -5.9 | -5.8 | 6.5e-09 | 0.93 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | YWHAZ | 0.06 | 0.04 | blup | 52 | 0.04 | 5.2e-05 | -5.1 | -5.7 | 1.3e-08 | 0.87 | 0.01 | 0.98 | FALSE |