Best TWAS P=3.8e-09 · Best GWAS P=3.03e-09 conditioned to 0.189
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RNF111 | 0.07 | 0.00 | blup | 466 | 0.03 | 1.6e-04 | 4.8 | 5.7 | 1.4e-08 | 0.51 | 0.28 | 0.37 | FALSE |
2 | GTEx | Adipose Subcutaneous | ADAM10 | 0.06 | 0.02 | lasso | 3 | 0.02 | 1.3e-02 | 5.4 | 5.5 | 4.2e-08 | 0.97 | 0.06 | 0.92 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | RP11-50C13.1 | 0.12 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | 5.4 | -5.3 | 9.4e-08 | -0.91 | 0.05 | 0.94 | FALSE |
4 | GTEx | Esophagus Mucosa | ADAM10 | 0.17 | 0.06 | lasso | 11 | 0.10 | 3.2e-07 | 5.6 | 5.1 | 2.9e-07 | 0.84 | 0.04 | 0.96 | FALSE |
5 | GTEx | Esophagus Muscularis | ADAM10 | 0.11 | 0.03 | lasso | 5 | 0.03 | 8.6e-03 | 4.8 | 5.4 | 6.0e-08 | 0.83 | 0.06 | 0.90 | FALSE |
6 | GTEx | Heart Atrial Appendage | ADAM10 | 0.09 | 0.01 | lasso | 2 | 0.01 | 1.8e-01 | 5.7 | 5.8 | 7.5e-09 | 0.90 | 0.03 | 0.93 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | ADAM10 | 0.09 | 0.05 | lasso | 7 | 0.02 | 5.3e-03 | 5.4 | 5.3 | 1.3e-07 | 0.96 | 0.05 | 0.94 | FALSE |
8 | GTEx | Thyroid | ADAM10 | 0.13 | 0.00 | lasso | 3 | 0.00 | 1.6e-01 | 5.5 | 5.3 | 1.4e-07 | 0.82 | 0.04 | 0.84 | FALSE |
9 | METSIM | Adipose | ADAM10 | 0.06 | 0.06 | lasso | 3 | 0.05 | 8.2e-08 | 5.8 | 5.9 | 3.8e-09 | 0.92 | 0.02 | 0.98 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HSP90AB4P | 0.02 | 0.01 | blup | 31 | 0.01 | 2.5e-02 | 5.6 | -5.7 | 1.5e-08 | -0.94 | 0.01 | 0.80 | FALSE |