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chr15:50,944,589-53,052,565

Best TWAS P=3.7e-11 · Best GWAS P=2.32e-11 conditioned to 0.0283

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	TMOD3	0.17	0.02	enet	11	0.05	7.1e-04	-5.7	-5.8	8.7e-09	-0.34	0.25	0.71	FALSE
2	GTEx	Artery Aorta	GLDN	0.19	0.03	lasso	9	0.08	3.0e-05	5.9	-5.8	7.3e-09	-0.53	0.41	0.57	FALSE
3	GTEx	Artery Tibial	GLDN	0.10	0.02	lasso	6	0.05	1.2e-04	3.8	-5.6	2.0e-08	-0.32	0.43	0.18	TRUE
4	GTEx	Artery Tibial	RP11-707P17.2	0.07	0.01	lasso	5	0.01	3.3e-02	6.4	6.5	1.1e-10	0.84	0.05	0.76	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	DMXL2	0.17	0.13	lasso	3	0.06	4.2e-03	6.7	6.2	6.9e-10	0.97	0.04	0.92	FALSE
6	GTEx	Cells Transformed fibroblasts	DMXL2	0.06	0.06	lasso	3	0.05	5.9e-05	6.3	-6.3	2.8e-10	-0.54	0.27	0.65	FALSE
7	GTEx	Cells Transformed fibroblasts	TMOD2	0.09	0.10	enet	8	0.10	3.0e-08	-6.4	-6.4	1.3e-10	-0.44	0.10	0.90	FALSE
8	GTEx	Esophagus Mucosa	DMXL2	0.09	0.01	lasso	2	0.00	1.7e-01	5.3	-5.9	3.1e-09	-0.68	0.18	0.38	FALSE
9	GTEx	Esophagus Muscularis	TMOD2	0.07	0.03	lasso	3	0.00	2.8e-01	5.1	-5.4	7.7e-08	-0.68	0.06	0.71	FALSE
10	GTEx	Muscle Skeletal	LYSMD2	0.23	0.23	lasso	4	0.21	1.6e-20	-6.5	6.6	3.7e-11	0.47	0.06	0.94	TRUE
11	GTEx	Skin Not Sun Exposed Suprapubic	TMOD3	0.05	0.07	enet	13	0.07	6.4e-05	-6.4	6.3	3.8e-10	0.44	0.14	0.83	FALSE
12	GTEx	Skin Sun Exposed Lower leg	TMOD3	0.07	0.07	enet	22	0.06	6.0e-06	-6.4	6.5	9.8e-11	0.46	0.09	0.91	FALSE
13	GTEx	Thyroid	MAPK6	0.04	0.02	lasso	4	0.01	8.8e-02	-5.6	6.4	2.0e-10	0.43	0.25	0.50	FALSE
14	GTEx	Thyroid	LEO1	0.05	0.05	lasso	3	0.04	3.7e-04	-5.5	5.6	1.9e-08	0.37	0.50	0.40	FALSE
15	METSIM	Adipose	TMOD2	0.03	0.03	lasso	10	0.02	1.9e-03	-5.6	-5.5	3.1e-08	-0.42	0.77	0.21	FALSE
16	NTR	Blood	TMOD2	0.07	0.09	enet	29	0.09	3.0e-28	-5.5	-5.7	1.5e-08	-0.42	0.94	0.06	FALSE
17	YFS	Blood	TMOD2	0.10	0.19	bslmm	435	0.19	4.4e-60	-5.5	-5.5	4.6e-08	-0.46	0.97	0.03	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMOD2	0.04	0.03	blup	76	0.04	5.5e-05	-5.7	-5.7	1.1e-08	-0.41	0.09	0.91	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	SCG3	0.06	0.02	blup	67	0.03	5.3e-04	6.2	-6.2	6.6e-10	-0.79	0.07	0.83	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	TMOD2	0.02	0.01	blup	78	0.02	2.3e-03	-5.7	-6.5	7.4e-11	-0.43	0.04	0.83	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMOD2	0.13	0.10	lasso	2	0.07	1.0e-03	5.8	-5.9	4.4e-09	-0.23	0.04	0.66	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	LYSMD2	0.06	0.01	blup	74	0.01	5.2e-02	-5.5	5.2	1.7e-07	0.19	0.02	0.26	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	LEO1	0.14	0.12	enet	7	0.13	9.2e-13	-6.4	5.8	7.9e-09	0.40	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LYSMD2	0.17	0.06	enet	4	0.05	2.1e-02	5.3	-5.8	7.7e-09	-0.44	0.03	0.34	FALSE