Best TWAS P=6.1e-14 · Best GWAS P=3.19e-12 conditioned to 0.00262
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | PIK3C3 | 0.10 | 0.05 | lasso | 6 | 0.04 | 7.1e-04 | 6.2 | -5.7 | 1.0e-08 | -0.53 | 0.12 | 0.85 | FALSE |
| 2 | GTEx | Nerve Tibial | PIK3C3 | 0.16 | 0.12 | enet | 13 | 0.15 | 1.2e-10 | 6.2 | -7.0 | 1.8e-12 | -0.69 | 0.08 | 0.92 | FALSE |
| 3 | GTEx | Testis | PIK3C3 | 0.10 | 0.01 | enet | 24 | 0.02 | 4.8e-02 | 6.6 | -7.5 | 6.1e-14 | -0.50 | 0.06 | 0.61 | TRUE |
| 4 | METSIM | Adipose | PIK3C3 | 0.10 | 0.08 | enet | 28 | 0.08 | 1.8e-12 | 6.7 | -6.5 | 9.6e-11 | -0.76 | 0.02 | 0.98 | FALSE |
| 5 | YFS | Blood | PIK3C3 | 0.07 | 0.05 | blup | 418 | 0.05 | 4.4e-17 | 6.5 | -5.7 | 1.5e-08 | -0.47 | 0.10 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | PIK3C3 | 0.09 | 0.04 | lasso | 8 | 0.03 | 6.0e-03 | 6.5 | -5.8 | 5.8e-09 | -0.37 | 0.07 | 0.57 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | PIK3C3 | 0.06 | 0.04 | enet | 9 | 0.05 | 2.7e-05 | 6.4 | -6.4 | 1.1e-10 | -0.72 | 0.06 | 0.94 | FALSE |