Best TWAS P=2.92e-16 · Best GWAS P=6.72e-19 conditioned to 0.00529
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | PIP5K1C | 0.25 | 0.14 | lasso | 4 | 0.18 | 1.8e-06 | -2.5 | -5.2 | 1.9e-07 | 0.32 | 0.27 | 0.06 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | UBXN6 | 0.09 | 0.10 | lasso | 1 | 0.08 | 1.5e-06 | -5.2 | -5.2 | 1.9e-07 | -0.08 | 0.91 | 0.01 | FALSE |
| 3 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | -6.6 | -7.5 | 8.4e-14 | 0.71 | 0.02 | 0.85 | FALSE |
| 4 | GTEx | Heart Left Ventricle | AC007292.4 | 0.18 | 0.00 | enet | 32 | 0.03 | 7.0e-03 | -4.8 | 6.2 | 5.3e-10 | -0.39 | 0.05 | 0.37 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | -7.8 | -7.9 | 3.5e-15 | 0.66 | 0.86 | 0.14 | TRUE |
| 6 | YFS | Blood | MAP2K2 | 0.02 | 0.00 | blup | 373 | 0.01 | 5.9e-03 | 4.6 | 8.2 | 2.9e-16 | -0.51 | 0.09 | 0.43 | TRUE |
| 7 | YFS | Blood | PIAS4 | 0.06 | 0.02 | bslmm | 369 | 0.04 | 4.8e-14 | -7.8 | -7.3 | 3.6e-13 | 0.67 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBXN6 | 0.03 | 0.03 | lasso | 3 | 0.03 | 2.3e-06 | -5.2 | -5.5 | 4.5e-08 | -0.06 | 0.00 | 0.99 | TRUE |