[Hub]/) : Traits : BMI :

chr2:46,021,381-47,829,230

Best TWAS P=4.67e-13 · Best GWAS P=6.36e-16 conditioned to 0.000201

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CRIPT 0.23 0.23 lasso 5 0.24 6.2e-29 -6.4 -5.9 3.0e-09 0.31 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous CRIPT 0.12 0.10 lasso 3 0.09 7.1e-08 -6.4 -7.1 9.7e-13 0.41 0.95 0.04 FALSE
3 GTEx Adrenal Gland CRIPT 0.16 0.10 enet 11 0.13 2.3e-05 -6.1 -6.4 1.9e-10 0.34 0.68 0.03 FALSE
4 GTEx Artery Aorta CRIPT 0.16 0.06 lasso 6 0.06 3.8e-04 -6.5 -6.4 1.7e-10 0.36 0.84 0.04 FALSE
5 GTEx Artery Tibial CRIPT 0.22 0.17 lasso 5 0.22 7.5e-17 -5.2 -5.9 2.9e-09 0.34 1.00 0.00 FALSE
6 GTEx Brain Cortex CRIPT 0.35 0.17 lasso 7 0.09 2.1e-03 -5.2 -5.2 2.1e-07 0.35 0.25 0.11 FALSE
7 GTEx Brain Nucleus accumbens basal ganglia CRIPT 0.27 -0.01 enet 8 0.02 1.2e-01 -6.5 -5.1 2.7e-07 0.36 0.12 0.10 FALSE
8 GTEx Breast Mammary Tissue (Female) AC016722.4 0.20 0.05 lasso 3 0.05 1.3e-02 3.9 5.8 8.8e-09 -0.38 0.06 0.34 FALSE
9 GTEx Cells EBV-transformed lymphocytes CRIPT 0.28 0.16 enet 10 0.23 5.4e-08 -5.2 -6.8 8.4e-12 0.41 0.77 0.10 FALSE
10 GTEx Colon Sigmoid ATP6V1E2 0.25 0.08 enet 17 0.13 3.3e-05 -4.8 5.3 1.3e-07 -0.34 0.54 0.21 FALSE
11 GTEx Esophagus Gastroesophageal Junction CRIPT 0.21 0.14 enet 9 0.18 6.4e-07 -4.0 -5.8 8.1e-09 0.35 0.77 0.02 FALSE
12 GTEx Esophagus Mucosa ATP6V1E2 0.26 0.17 lasso 9 0.18 5.4e-12 -3.4 5.6 2.3e-08 -0.39 1.00 0.00 FALSE
13 GTEx Esophagus Muscularis CRIPT 0.15 0.21 lasso 4 0.20 2.1e-12 -6.4 -6.4 1.5e-10 0.29 1.00 0.00 FALSE
14 GTEx Muscle Skeletal CRIPT 0.14 0.05 enet 25 0.08 1.8e-08 -5.2 -7.0 2.0e-12 0.36 0.99 0.00 FALSE
15 GTEx Muscle Skeletal ATP6V1E2 0.30 0.16 enet 27 0.21 2.5e-20 3.1 5.7 1.0e-08 -0.37 1.00 0.00 FALSE
16 GTEx Nerve Tibial CRIPT 0.17 0.16 enet 9 0.20 2.3e-14 -4.0 -5.9 4.4e-09 0.32 1.00 0.00 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic CRIPT 0.16 0.19 enet 8 0.21 9.7e-12 -6.3 -6.2 5.5e-10 0.31 1.00 0.00 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic PIGF 0.14 0.08 lasso 4 0.07 1.7e-04 -7.2 7.2 4.7e-13 -0.83 0.01 0.98 TRUE
19 GTEx Skin Sun Exposed Lower leg CRIPT 0.19 0.09 lasso 6 0.10 8.6e-09 -6.4 -5.8 9.0e-09 0.32 1.00 0.00 FALSE
20 GTEx Skin Sun Exposed Lower leg ATP6V1E2 0.36 0.17 lasso 10 0.28 2.8e-23 -3.5 5.7 9.7e-09 -0.46 1.00 0.00 FALSE
21 GTEx Stomach CRIPT 0.14 0.14 lasso 2 0.16 5.0e-08 -4.0 -5.3 1.2e-07 0.28 0.92 0.01 FALSE
22 GTEx Testis CRIPT 0.32 0.25 lasso 5 0.24 7.3e-11 -6.4 -5.7 9.7e-09 0.30 1.00 0.00 FALSE
23 GTEx Testis SOCS5 0.17 0.01 lasso 3 0.03 1.2e-02 4.8 6.6 3.4e-11 -0.36 0.09 0.55 FALSE
24 GTEx Thyroid CRIPT 0.08 0.10 lasso 2 0.11 5.1e-09 -6.4 -6.3 3.7e-10 0.31 0.98 0.01 FALSE
25 GTEx Vagina ATP6V1E2 0.31 0.00 lasso 7 -0.01 6.5e-01 -3.5 6.1 1.3e-09 -0.36 0.08 0.18 FALSE
26 GTEx Whole Blood CRIPT 0.11 0.04 enet 18 0.05 1.2e-05 -6.3 -5.8 5.7e-09 0.33 0.84 0.08 FALSE
27 METSIM Adipose CRIPT 0.07 0.08 bslmm 667 0.07 2.0e-10 -5.2 -5.5 3.2e-08 0.36 1.00 0.00 FALSE
28 NTR Blood CRIPT 0.04 0.05 lasso 6 0.05 3.0e-15 -6.3 6.7 2.4e-11 -0.34 1.00 0.00 FALSE
29 ROSMAP Brain Pre-frontal Cortex CRIPT 0.36 0.31 enet 24 0.32 1.3e-41 -6.3 -6.7 1.8e-11 0.33 1.00 0.00 FALSE
30 YFS Blood CRIPT 0.42 0.51 lasso 5 0.52 1.1e-203 -6.3 -6.3 3.5e-10 0.31 1.00 0.00 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma ATP6V1E2 0.13 0.03 blup 76 0.04 3.8e-09 -4.8 6.8 7.7e-12 -0.36 0.19 0.79 FALSE
32 The Cancer Genome Atlas Colon Adenocarcinoma CRIPT 0.10 0.06 blup 66 0.07 5.6e-05 -5.0 -6.6 5.2e-11 0.33 0.46 0.25 FALSE
33 The Cancer Genome Atlas Esophageal Carcinoma CRIPT 0.20 0.10 enet 10 0.16 1.3e-05 -5.2 -5.5 4.3e-08 0.34 0.18 0.40 FALSE
34 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CRIPT 0.13 0.12 lasso 5 0.11 5.5e-12 -6.4 -6.4 2.0e-10 0.31 0.22 0.78 FALSE
35 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CRIPT 0.11 0.11 lasso 3 0.10 1.7e-06 -6.1 -6.7 2.3e-11 0.34 0.26 0.73 FALSE
36 The Cancer Genome Atlas Brain Lower Grade Glioma CRIPT 0.18 0.14 lasso 3 0.17 2.1e-18 -6.4 -6.2 6.4e-10 0.33 0.32 0.68 FALSE
37 The Cancer Genome Atlas Lung Adenocarcinoma CRIPT 0.07 0.08 lasso 2 0.08 3.6e-09 -6.3 -6.0 1.6e-09 0.28 0.23 0.77 FALSE
38 The Cancer Genome Atlas Pancreatic Adenocarcinoma CRIPT 0.13 0.07 enet 13 0.10 7.9e-05 -6.3 -6.1 9.8e-10 0.35 0.09 0.40 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma CRIPT 0.13 0.13 lasso 3 0.15 1.2e-15 -6.5 -6.8 1.3e-11 0.37 0.16 0.84 FALSE
40 The Cancer Genome Atlas Rectum Adenocarcinoma CRIPT 0.25 0.10 enet 7 0.15 1.9e-04 -5.2 -6.0 1.9e-09 0.33 0.06 0.15 FALSE
41 The Cancer Genome Atlas Testicular Germ Cell Tumors PIGF 0.18 0.10 enet 7 0.08 9.3e-04 -4.0 -5.9 4.1e-09 0.34 0.10 0.32 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma CRIPT 0.11 0.10 lasso 4 0.11 1.6e-10 -5.2 -6.2 5.0e-10 0.32 0.57 0.42 FALSE