TWAS
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Models
Genes
Traits
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Traits
:
BMI
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chr22:19,420,959-20,330,744
Best TWAS P=1.68e-10 · Best GWAS P=1.14e-08 conditioned to 0.00858
19.4M
19.6M
19.8M
20M
20.2M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Tibial
AC006547.14
0.09
0.00
lasso
4
0.00
6.9e-01
4.8
-6.4
1.7e-10
0.55
0.04
0.33
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
ARVCF
0.04
0.00
blup
116
0.00
1.8e-01
4.8
-5.6
2.0e-08
0.53
0.03
0.14
FALSE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
ARVCF
0.03
0.01
blup
116
0.01
1.1e-02
-2.8
-5.4
6.2e-08
0.58
0.02
0.45
FALSE
2
GTEx
Cells Transformed fibroblasts
ZDHHC8
0.18
0.07
enet
26
0.14
8.9e-11
-5.0
-5.3
1.2e-07
0.32
0.09
0.91
FALSE