TWAS hub - ZDHHC8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1850	0.0590	2.5e-03	0.148	NA	0.161	NA	0.152	1.5e-08	NA	3.2e-09	NA	9.8e-09
2	GTEx	Brain Cerebellar Hemisphere	0.2690	0.1000	3.9e-03	0.145	NA	0.031	NA	0.068	1.5e-04	NA	5.5e-02	NA	8.1e-03
3	GTEx	Brain Cerebellum	0.3760	0.0990	1.0e-04	0.054	NA	0.026	NA	0.036	1.1e-02	NA	5.8e-02	NA	3.2e-02
4	GTEx	Brain Cortex	0.2990	0.0970	2.9e-03	0.041	NA	0.023	NA	0.027	2.8e-02	NA	7.5e-02	NA	6.1e-02
5	GTEx	Cells Transformed fibroblasts	0.1760	0.0430	3.0e-08	0.075	NA	0.142	NA	0.122	2.9e-06	NA	8.9e-11	NA	2.2e-09
6	GTEx	Nerve Tibial	0.2124	0.0605	2.7e-05	-0.003	NA	0.042	NA	0.006	5.8e-01	NA	5.6e-04	NA	1.2e-01
7	GTEx	Testis	0.1910	0.0700	2.0e-03	0.013	NA	0.024	NA	0.017	8.5e-02	NA	3.1e-02	NA	5.6e-02
8	METSIM	Adipose	0.0398	0.0184	9.3e-03	0.002	0.004	0.004	0.005	0.004	1.5e-01	6.6e-02	6.6e-02	5.9e-02	7.8e-02
9	YFS	Blood	0.0437	0.0109	1.0e-10	0.031	0.038	0.036	0.038	0.042	1.4e-10	1.4e-12	8.6e-12	2.0e-12	1.3e-13
10	TCGA	Colon Adenocarcinoma	0.0510	0.0280	4.5e-03	0.015	0.039	0.034	NA	0.020	4.2e-02	2.6e-03	4.4e-03	NA	2.3e-02
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0354	0.0183	1.1e-03	0.034	0.024	0.009	NA	0.023	8.4e-05	8.2e-04	2.8e-02	NA	1.1e-03
12	TCGA	Lung Squamous Cell Carcinoma	0.0214	0.0126	6.9e-03	0.004	0.018	0.011	NA	0.008	1.0e-01	3.3e-03	1.9e-02	NA	3.7e-02
13	TCGA	Thyroid Carcinoma	0.0450	0.0240	5.5e-04	0.007	0.016	0.001	NA	0.002	6.7e-02	1.0e-02	2.4e-01	NA	1.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Average weekly spirits intake	5.3	6.6	13.6	0.7	-1.2	-2.3	-1.1	2.5	-2.9	3.1	-1.9	-1.2	3.3	3.7	3.2	3.6
Seen doctor (GP) for nerves, anxiety, tension or depression	5.3	8.1	17.1	0.2	-0.6	3.3	-0.1	-3.9	2.1	-3.1	1.4	1.6	-3.9	-3.6	-3.9	-4.1
Guilty feelings	4.8	7.3	16.4	-1.1	-1.3	2.7	-0.8	-3.5	0.1	-3.0	1.7	2.3	-3.5	-3.3	-4.1	-3.8
Irritability	4.1	6.9	15.8	-0.6	0.4	1.6	0.8	-3.6	0.9	-3.7	1.2	0.8	-4.0	-3.7	-3.8	-3.6
Pain type(s) experienced in last month: Hip pain	3.8	4.8	10.9	0.5	-0.3	2.7	-0.5	-3.2	1.6	-2.3	0.7	1.1	-3.2	-2.7	-2.4	-3.3
Bipolar Disorder (2018)	3.6	5.6	13.8	-0.1	-1.5	-2.3	-1.0	3.1	-1.9	2.3	-1.6	-1.9	3.7	2.4	3.4	2.9
Taking other prescription medications	3.5	5.4	11.6	-2.5	-1.9	3.1	0.7	-2.8	-0.2	-0.3	3.4	2.7	-2.2	-2.7	-2.6	-2.3
Hearing difficulty/problems with background noise	3.5	5.5	11.2	0.7	1.4	1.7	2.1	-3.3	1.3	-2.9	0.3	1.0	-3.2	-3.0	-3.1	-3.4
Ever had bowel cancer screening	3.5	4.1	8.7	-0.8	1.2	2.1	1.1	-2.5	1.3	-1.4	1.9	2.1	-2.5	-2.6	-2.9	-2.7
Number of operations (self-reported)	3.5	5.1	12.3	0.7	-1.2	1.7	0.1	-3.3	1.2	-3.1	-0.7	0.8	-3.5	-2.9	-2.9	-3.1
Impedance of leg (right)	3.4	16.5	41.4	-0.1	-0.3	-5.1	-0.6	6.4	-2.0	2.3	-2.8	-4.6	5.5	4.9	4.9	5.4
Illnesses of siblings	3.4	4.8	11.4	-0.3	1.5	-2.0	0.4	2.9	-1.3	2.3	-1.9	-1.8	2.7	3.0	2.4	3.4
Heart disease (siblings)	3.4	4.1	9.4	-0.5	0.6	1.8	1.3	-2.8	1.7	-2.0	1.4	1.6	-2.6	-2.5	-2.5	-3.1
Number of treatments/medications taken	3.1	5.6	11.0	-2.1	-1.6	3.2	1.0	-2.9	0.0	-0.8	3.3	2.0	-2.5	-3.0	-2.8	-2.7
Bipolar Disorder or Schizophrenia	2.9	7.0	15.6	2.9	0.5	-2.9	-0.2	3.2	-0.5	3.0	-2.7	-1.9	4.0	2.1	3.9	2.7
Mean Putamen Volume	2.9	3.4	6.5	-0.1	0.8	-2.3	-0.2	2.5	-2.0	0.9	-1.3	-2.5	2.0	2.2	1.9	2.5
Number of live births	2.9	4.1	12.6	3.5	-0.9	-2.6	-3.0	0.9	-0.5	-0.7	-3.3	-2.8	0.3	1.0	1.4	1.0
Medication: Gliclazide	2.9	3.3	6.9	0.3	0.1	2.1	-0.7	-2.6	1.4	-2.2	0.8	0.9	-2.5	-2.0	-2.4	-2.6
Impedance of whole body	2.9	14.7	38.7	0.3	-1.0	-5.1	-0.8	6.2	-1.5	1.9	-2.5	-4.5	5.2	4.5	4.7	4.9
Impedance of leg (left)	2.8	13.5	33.5	-0.1	-0.9	-4.8	-1.1	5.8	-2.0	2.0	-2.3	-4.5	4.7	4.4	4.2	4.9
Impedance of arm (right)	2.8	13.1	35.3	0.8	-0.7	-4.9	-0.4	5.9	-1.9	1.1	-2.8	-4.4	4.8	3.9	4.5	4.3
High blood pressure (siblings)	2.8	4.0	8.6	-0.4	-0.6	1.8	-0.1	-2.6	1.7	-2.2	1.8	1.9	-2.5	-2.6	-2.4	-2.9
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	11.4	3.2	-0.1	-2.4	-2.1	2.0	-0.5	0.3	-3.4	-2.1	1.7	2.0	2.2	1.8
Worry too long after embarrassment	2.6	4.3	9.7	-1.9	-0.7	2.0	0.7	-2.0	1.7	-2.1	2.3	1.2	-2.6	-2.5	-2.5	-3.1
Neck or shoulder pain in last month	2.6	3.7	8.6	0.4	-1.1	2.1	-0.4	-2.4	0.4	-2.8	0.3	-0.4	-2.9	-2.7	-2.2	-2.9
Prostate Cancer	2.5	3.5	9.7	2.8	-1.2	-2.8	-1.2	1.2	-1.0	-1.3	-3.1	-2.5	0.8	0.9	1.7	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	9.9	0.1	-1.2	0.1	-1.0	-2.4	0.6	-3.1	0.3	0.8	-2.6	-2.3	-2.5	-2.5
Supplements: Glucosamine	2.5	3.2	7.5	0.4	-0.8	1.9	-0.7	-2.1	-0.2	-1.5	2.1	1.1	-2.7	-2.2	-2.4	-2.5
Medication: Blood pressure	2.5	4.5	9.8	-2.6	0.4	3.1	1.9	-2.5	1.4	-0.5	2.2	2.3	-2.1	-2.1	-2.2	-2.4
Medication: Metformin	2.3	3.3	7.3	0.2	-2.0	1.1	-2.2	-1.9	-0.7	-2.2	-0.3	-0.3	-2.7	-1.8	-2.7	-2.4
Comparative body size at age 10	2.3	6.3	10.8	-1.3	-0.2	3.3	0.9	-3.3	1.2	-1.6	2.5	3.1	-3.3	-3.2	-3.1	-2.8
Lung FEV1/FVC ratio	2.2	11.3	68.1	-1.6	7.5	1.6	8.2	-2.3	1.0	-0.7	0.0	0.6	-1.3	-2.0	-1.8	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	8.6	-2.4	1.7	2.5	2.1	-1.7	2.7	-0.4	2.9	2.7	-1.5	-2.1	-2.2	-1.6
Depression (Nagel 2018)	2.1	3.1	7.9	-0.1	-0.9	0.3	-0.4	-2.1	0.8	-2.8	0.2	0.5	-2.5	-2.8	-2.3	-2.6
Type 2 Diabetes (T2D) (2018)	2.1	3.9	11.0	0.1	-1.1	1.8	-1.8	-3.0	-0.3	-1.4	0.7	0.5	-3.3	-2.0	-2.9	-2.9
Lung cancer (father)	2.1	2.5	7.0	-1.6	2.5	1.3	2.4	-0.5	2.6	-0.4	0.0	1.1	-0.9	-1.7	-1.5	-1.3
Fractured/broken bones in last 5 years	2.1	2.7	5.9	0.6	0.1	2.2	-0.1	-2.3	2.2	-0.6	1.0	2.4	-1.8	-1.8	-1.6	-1.9
BMI	2.0	11.7	28.0	-1.5	-0.0	4.7	1.8	-5.3	0.2	-1.8	2.7	4.6	-4.3	-3.6	-4.2	-4.0
Diabetes (mother)	2.0	2.6	6.8	1.9	-1.0	1.1	-2.6	-2.2	-1.0	-1.3	-0.2	-0.5	-2.3	-1.4	-1.5	-1.7
Nervous feelings	2.0	3.7	8.9	1.1	-0.8	-3.0	-0.4	2.6	-0.3	0.8	-2.9	-1.8	2.5	1.7	2.2	1.9
Medication: Ramipril	2.0	2.6	5.9	-1.8	1.0	1.8	2.4	-1.3	2.0	-0.7	2.0	2.2	-0.7	-1.6	-0.9	-1.1
Pulse wave Arterial Stiffness index	2.0	2.3	6.0	1.8	-1.2	1.0	-1.6	-2.4	-0.9	-2.0	0.6	0.7	-2.3	-1.5	-1.3	-1.0
Impedance of arm (left)	2.0	9.3	26.8	0.5	-0.5	-3.9	-0.2	5.2	-1.1	1.2	-2.1	-3.4	4.4	3.4	3.9	3.8
Number of self-reported non-cancer illnesses	2.0	3.4	9.0	-1.5	-0.7	2.7	0.8	-2.4	0.1	0.5	3.0	2.3	-1.8	-1.8	-1.6	-2.2
Medication: Paracetamol	1.9	3.1	7.3	-1.3	-0.6	2.3	1.3	-2.0	0.5	-1.1	2.1	1.2	-1.9	-2.3	-2.0	-2.7
Headache pain in last month	1.9	3.3	7.4	1.6	-0.2	-2.3	-0.7	1.9	-0.9	0.6	-2.7	-2.6	1.7	1.9	2.2	1.7
Pulse wave peak to peak time	1.9	2.2	5.5	-1.9	1.5	-0.8	1.8	2.3	1.0	1.8	-0.7	-0.8	2.2	1.4	1.2	0.7
Neuroticism (Nagel 2018)	1.8	4.3	13.4	-0.5	-0.3	0.5	0.5	-2.0	1.7	-3.7	-0.1	0.3	-2.6	-3.4	-2.8	-3.0
Schizophrenia (2018)	1.8	3.7	14.5	3.8	1.8	-1.9	0.5	1.5	0.9	2.1	-2.4	-1.0	2.2	0.8	2.3	1.1
Medication for hormone replacement therapy	1.8	2.0	4.6	0.5	0.4	0.8	-1.0	-1.7	1.6	-1.9	0.4	0.4	-2.1	-1.7	-1.8	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	8.3	-1.0	-0.9	0.9	0.0	-2.0	1.6	-1.7	-0.2	1.0	-2.1	-2.9	-2.0	-2.5
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.8	0.8	-0.1	0.8	-0.3	-1.8	0.2	-2.1	-1.0	1.0	-1.7	-2.4	-1.6	-2.3
Average weekly champagne plus white wine intake	1.8	2.5	7.7	-2.8	0.6	2.6	1.6	-0.7	0.6	-0.2	2.2	1.8	-0.8	-1.2	-1.8	-0.8
Townsend deprivation index at recruitment	1.7	2.4	8.2	0.2	-0.6	2.7	-0.9	-2.9	0.7	-1.2	0.3	1.1	-2.0	-1.5	-1.3	-1.8
Medication: Levothyroxine sodium	1.7	2.8	10.7	0.2	-3.3	-1.0	-2.0	1.9	-2.4	1.1	-0.2	-1.7	1.5	1.3	1.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.9	-1.2	-0.2	1.6	0.5	-1.4	0.6	-1.1	1.4	0.6	-2.1	-1.5	-2.2	-2.1
Commuting to job workplace: Car/motor vehicle	1.7	2.0	5.4	-1.3	1.3	0.3	1.9	-0.7	2.3	-1.4	1.0	0.3	-1.1	-1.8	-1.6	-1.6
Back pain experienced in last month	1.7	2.5	5.1	0.7	-1.3	-0.3	-1.7	-1.5	-0.0	-2.3	-2.2	-2.2	-2.1	-1.4	-1.3	-1.8
Blood Eosinophil Count	1.6	12.1	24.8	-0.4	2.4	5.0	-0.3	-4.7	2.3	-1.2	4.8	3.7	-4.6	-3.6	-3.6	-3.7
Cardiovascular Disease	1.6	5.3	9.8	-2.7	-0.2	2.4	0.8	-3.1	0.7	-0.9	3.0	2.2	-3.0	-2.2	-3.0	-2.8
Neuroticism	1.6	4.0	11.3	-0.6	-0.1	0.5	1.0	-2.2	1.3	-3.2	-0.6	0.4	-2.4	-3.4	-2.8	-2.8
Body mass index (BMI)	1.6	6.8	15.8	-0.4	-1.2	3.3	0.2	-4.0	0.4	-1.6	1.7	3.1	-3.4	-3.1	-3.4	-3.4
Waist circumference	1.6	6.0	16.1	0.3	-1.0	3.0	-0.2	-4.0	0.3	-1.5	1.9	2.9	-3.2	-2.8	-2.9	-3.3
Pain all over the body in last month	1.6	1.8	5.4	0.2	-0.7	1.6	-0.1	-2.3	-0.1	-0.2	1.4	1.0	-1.8	-1.7	-1.5	-1.8
Diabetes (self-reported)	1.6	2.4	5.2	-0.2	-2.0	1.2	-1.8	-2.1	-1.3	-0.9	-0.1	0.0	-2.3	-1.4	-2.1	-2.2
Breast Cancer	1.5	3.6	6.9	-0.2	1.2	2.5	-0.7	-2.3	1.6	-1.7	1.2	1.7	-2.3	-2.5	-2.2	-2.6
Neuroticism (2016)	1.5	2.2	6.4	-0.6	-0.7	0.4	-0.4	-1.1	1.0	-2.5	-0.6	-0.1	-1.7	-2.1	-2.5	-2.2
Number of incorrect matches in round	1.5	2.5	10.0	-0.9	0.0	-0.4	1.2	1.8	0.5	3.2	0.3	0.5	2.5	1.8	1.6	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.2	0.6	-1.7	0.7	-1.3	-2.4	-0.6	-1.7	-0.1	0.6	-2.3	-1.8	-1.3	-2.5
Medication: Cholesterol lowering	1.5	2.3	9.3	-3.1	-1.1	0.9	1.2	-1.1	-1.7	0.1	2.9	1.4	-0.9	-0.9	-1.2	-0.4
Exposure to tobacco smoke at home	1.5	1.7	5.5	-0.1	0.2	1.5	-0.8	-1.2	0.1	-2.4	-0.3	-0.1	-1.9	-1.8	-1.8	-1.6
Health satisfaction	1.5	1.9	4.3	-0.4	-2.1	-1.3	-0.5	1.1	-2.0	1.9	-0.2	-0.8	1.5	1.4	1.6	1.5
Chest pain or discomfort	1.5	2.1	6.6	-0.9	-0.3	1.2	-0.0	-2.6	0.7	-0.8	2.1	2.0	-2.0	-1.3	-1.3	-1.3
Knee pain experienced in last month	1.5	2.3	5.5	0.3	-0.0	1.5	-0.5	-2.2	0.8	-1.9	-1.0	0.5	-2.1	-2.1	-1.5	-2.3
Leg fat-free mass (right)	1.5	7.8	22.2	0.8	1.1	3.3	0.9	-4.7	2.2	-1.2	1.8	3.0	-3.8	-2.8	-2.8	-4.0
Commuting to job workplace: Walk	1.5	1.7	3.9	1.3	-1.7	-0.8	-2.0	0.9	-1.8	1.0	-1.0	-1.0	0.9	1.5	1.2	1.0
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	5.2	-1.1	1.0	1.3	0.6	-2.1	1.6	-1.8	1.4	0.9	-2.3	-1.4	-2.1	-1.7
Miserableness	1.5	2.5	9.7	-0.7	0.7	-0.2	1.6	-1.1	1.5	-3.1	-0.7	-0.9	-1.7	-2.1	-2.1	-1.7
Unable to work because of sickness or disability	1.5	2.0	5.5	2.2	-2.3	-0.4	-2.2	0.4	-1.9	1.0	-1.5	-1.2	0.5	1.0	0.9	0.4
Vascular/heart problems diagnosed by doctor	1.5	4.1	8.9	3.0	1.2	-2.9	-0.8	2.2	-0.7	-0.0	-2.6	-2.6	1.9	1.6	2.1	2.1
Ulcerative Colitis (UC)	1.4	2.6	6.5	-0.5	1.5	-1.0	0.5	2.0	-1.1	1.8	-1.3	-1.4	2.6	1.6	2.2	2.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.7	1.8	0.3	0.6	-0.6	-1.1	1.1	-1.9	-1.0	-0.6	-1.8	-1.8	-1.5	-1.8
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.8	0.4	0.0	0.5	-0.5	-2.1	1.2	-1.6	0.5	0.8	-2.4	-1.6	-1.6	-2.0
Depression (self-reported)	1.4	1.7	3.6	-0.2	1.1	1.5	0.7	-1.5	1.1	-1.9	0.3	0.3	-1.6	-1.6	-1.7	-1.6
Gout (self-reported)	1.4	1.9	8.4	-2.2	1.1	-0.5	2.9	0.9	-0.4	1.8	0.5	0.7	1.4	0.6	1.1	1.4
Illnesses of siblings: Diabetes	1.4	1.7	6.3	0.7	-2.1	0.7	-2.5	-1.5	-0.1	-0.4	1.4	0.8	-1.2	-1.2	-1.2	-1.3
Diabetes diagnosed by doctor	1.4	2.3	5.9	0.2	-1.5	1.0	-1.9	-2.1	-1.2	-0.9	0.5	0.2	-2.4	-1.4	-2.0	-2.0
Medication: Aspirin	1.4	1.8	10.2	-0.0	-3.2	-0.9	-1.8	0.3	-2.3	0.3	-1.1	-1.6	-0.0	0.5	0.0	0.5
Leg predicted mass (right)	1.4	7.7	21.8	0.7	1.1	3.3	1.0	-4.7	2.2	-1.2	1.7	3.0	-3.8	-2.8	-2.8	-4.0
Mother’s age at death	1.4	1.7	6.3	0.6	2.5	0.9	1.2	-1.5	-0.5	-1.2	1.1	-0.3	-2.0	-0.8	-1.6	-1.1
Primary Biliary Cirrhosis	1.3	1.9	5.2	0.2	0.8	-0.8	0.8	1.9	-0.9	2.3	0.2	-0.7	2.0	1.6	1.4	1.8
Schizophrenia (2014)	1.3	2.9	9.5	3.1	1.8	-1.3	0.5	1.5	0.6	1.9	-1.6	-0.8	2.1	0.7	2.6	1.2
Ulcerative Colitis	1.3	1.8	4.8	-0.3	1.2	-1.1	0.5	1.5	-0.6	1.0	-1.9	-1.3	1.8	1.1	2.2	1.6
Leg fat-free mass (left)	1.3	6.7	17.9	0.4	1.5	3.2	1.4	-4.2	2.2	-0.9	1.7	3.1	-3.2	-2.5	-2.4	-3.6
Falls in the last year	1.3	1.8	6.7	2.6	-0.2	-0.2	-1.6	-1.8	-1.1	-0.4	-1.4	-1.8	-1.6	0.3	-0.7	-0.6
Happiness	1.3	1.6	4.6	-0.1	-0.5	-1.7	-0.3	1.5	-0.4	0.6	-2.1	-1.7	1.5	1.0	1.6	1.1
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.8	1.6	-1.7	-1.2	-1.0	-0.4	-0.6	-1.6	-1.3	-1.7	-1.2	-1.3	-0.5	-1.2
Medication: Amlodipine	1.3	1.8	3.6	-1.9	0.1	1.5	1.7	-0.9	0.1	-1.1	1.6	0.9	-1.2	-1.1	-1.9	-1.5
Number of full brothers	1.3	1.7	3.4	1.8	0.7	-1.1	1.3	0.8	1.4	1.4	-1.8	-1.0	1.3	1.2	1.5	1.0
Smoking status: Previous	1.3	1.9	8.9	0.8	3.0	1.2	0.4	-1.5	1.6	-1.7	0.4	0.0	-1.4	-0.8	-0.7	-1.7
Pain experienced in last month	1.3	2.1	4.9	-0.3	0.6	-0.4	0.9	1.8	0.1	2.2	1.4	1.4	2.1	1.9	1.2	2.2
Systolic Blood Pressure	1.2	6.0	12.5	-3.2	-0.1	2.5	2.9	-3.0	1.4	1.4	3.3	3.5	-1.9	-2.0	-2.2	-2.1
High blood pressure	1.2	3.3	7.6	-2.4	-1.2	2.8	0.5	-1.9	0.7	0.3	2.2	2.3	-1.7	-1.5	-1.9	-2.0
Leg predicted mass (left)	1.2	6.5	17.3	0.4	1.5	3.1	1.4	-4.2	2.2	-0.9	1.6	3.0	-3.2	-2.4	-2.4	-3.6
Hair/balding pattern: Pattern 3	1.2	1.8	6.3	1.6	-2.0	-1.0	-2.5	-0.1	-0.8	-0.0	-2.5	-1.6	-0.1	0.1	0.3	0.0
Loud music exposure frequency	1.2	1.3	2.5	-1.4	0.2	-1.0	1.1	1.3	-1.4	1.1	0.4	-1.2	1.1	1.6	1.4	1.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	8.3	-0.2	-2.9	-0.7	-1.4	1.9	-2.3	1.4	0.6	-0.7	1.6	1.2	1.4	1.3
Arm predicted mass (right)	1.2	6.1	19.7	0.3	1.5	3.3	0.5	-4.4	1.7	-0.6	1.4	2.6	-3.5	-2.1	-2.5	-3.3
Loneliness, isolation	1.2	1.7	3.6	1.0	-1.5	-0.6	-1.9	-1.6	0.1	-1.9	-1.1	-0.5	-1.6	-0.9	-1.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	-0.2	-0.3	0.7	-0.3	-1.0	1.4	-1.2	1.7	0.2	-1.6	-1.5	-1.3	-1.5
Medication: Lisinopril	1.2	1.5	8.8	-3.0	-1.6	-0.2	1.0	0.3	0.6	2.0	0.7	0.8	0.6	0.7	-0.1	0.7
Ever depressed for a whole week	1.2	1.4	6.9	-0.9	-2.6	0.6	-1.8	-1.0	-0.8	-1.4	0.3	0.3	-1.0	-0.6	-1.1	-1.0
Schizophrenia vs Biploar Disorder	1.1	1.5	6.0	1.7	2.4	0.9	1.8	-0.6	2.0	0.2	-0.7	0.7	-0.0	-0.2	0.6	-0.4
Ovarian Cancer	1.1	1.4	8.4	2.9	0.7	-1.1	-0.4	-0.3	-0.9	-1.3	-1.1	-1.8	-0.8	-0.1	-0.5	-0.2
Crohns Disease (2012)	1.1	1.8	5.1	1.0	-0.6	-1.1	-0.9	1.0	-2.3	-0.1	-2.2	-1.5	1.1	1.2	1.5	1.1
Systolic blood pressure, automated reading	1.1	3.2	11.8	-1.8	-0.7	2.1	1.8	-1.8	1.2	1.8	2.4	3.4	-0.7	-1.2	-1.2	-1.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	-1.2	1.5	0.1	1.5	0.5	-0.6	1.9	1.1	0.5	1.3	1.2	0.8	0.9
Hair/balding pattern: Pattern 2	1.1	1.4	3.2	0.4	1.2	0.5	0.4	-1.1	1.2	-1.8	-0.2	-0.6	-1.6	-1.6	-1.5	-1.7
Illnesses of mother	1.1	1.4	4.2	0.2	-0.2	-1.1	0.3	1.2	-0.4	1.9	-0.6	-0.0	1.7	1.2	1.7	2.0
Pulse wave reflection index	1.1	1.4	4.9	1.6	-1.2	-0.4	-1.0	-0.3	-0.5	-2.2	-1.4	-1.4	-1.4	-1.0	-0.9	-0.1
Glaucoma (self-reported)	1.1	1.2	3.9	0.1	-0.8	0.7	0.3	-2.0	-0.2	-0.9	0.6	0.8	-1.9	-1.5	-1.1	-1.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.9	0.6	-0.6	1.3	-0.6	-1.2	-0.5	-1.1	0.5	0.1	-1.6	-0.8	-1.6	-2.2
Arm fat-free mass (right)	1.1	5.7	17.9	0.3	1.3	3.0	0.6	-4.2	2.0	-0.6	1.3	2.5	-3.4	-2.1	-2.4	-3.2
Medication for pain relief, constipation, heartburn	1.1	1.9	5.4	0.9	2.3	-1.1	-0.2	1.2	1.1	1.2	-0.5	0.4	1.6	2.0	1.6	1.9
Suffer from ‘nerves’	1.1	1.8	4.4	1.8	-1.0	-1.4	-0.7	0.8	-1.3	1.5	-2.1	-1.0	1.4	1.1	1.3	1.2
Medication: Aspirin	1.1	1.4	7.8	-0.1	-2.8	-0.6	-1.6	-0.0	-2.2	-0.4	-0.9	-1.3	-0.5	-0.0	-0.4	0.1
Medication: Paracetamol	1.1	1.7	4.3	-0.6	-1.3	1.5	0.2	-1.6	-0.1	-0.9	1.2	0.6	-1.5	-1.7	-1.6	-2.1
Age started oral contraceptive pill	1.1	1.4	4.5	-1.1	-0.0	1.8	-0.2	-0.3	0.1	-0.1	2.1	1.2	-1.1	-1.0	-2.0	-1.1
Depressed Affect (Nagel 2018)	1.0	2.2	8.0	-0.5	-0.1	-0.7	1.3	-1.4	0.5	-2.8	-0.4	-0.3	-1.7	-2.4	-2.0	-1.8
Sensitivity / hurt feelings	1.0	1.7	5.5	-1.1	-0.6	0.5	0.7	-1.3	0.6	-2.3	0.6	0.8	-1.5	-1.6	-1.6	-1.7
Alcohol usually taken with meals	1.0	1.6	6.0	0.7	-1.3	-0.7	-2.2	0.4	-2.4	1.7	0.2	-0.8	0.4	1.3	0.4	1.3
Had menopause	1.0	1.2	2.7	0.8	-1.4	0.5	-1.2	-0.4	1.3	-1.6	0.6	0.5	-1.3	-1.2	-1.5	-1.3
Neuroticism score	1.0	2.1	5.8	-1.0	-0.4	0.2	1.3	-1.6	0.5	-2.4	-0.3	0.7	-1.5	-2.3	-1.9	-1.9
Hip circumference	1.0	4.2	11.4	-0.3	-0.5	2.8	-0.2	-3.4	0.7	-1.2	1.4	1.9	-2.9	-1.9	-2.6	-2.9
Birth weight	1.0	2.2	5.1	-1.1	1.7	1.8	1.6	-1.0	1.6	0.1	2.0	2.3	-1.1	-1.2	-1.2	-1.4
Angina (self-reported)	1.0	1.3	9.9	-0.4	-1.4	-0.7	-0.8	-0.6	-3.1	-0.3	0.1	-1.8	-0.8	0.2	-0.0	0.0
Pulse rate, automated reading	1.0	3.3	10.4	-0.1	-1.5	-1.4	0.4	1.5	-0.7	3.2	0.4	0.1	2.6	2.2	2.7	2.4
Alcohol intake frequency.	1.0	2.4	7.1	0.8	-0.9	-2.2	-0.9	0.9	-2.0	-0.2	-2.2	-2.7	0.6	1.9	1.4	1.1
Hypertension (Self-reported)	1.0	2.8	6.0	-2.4	-1.5	2.5	0.5	-1.8	0.5	0.2	1.8	2.0	-1.6	-1.2	-1.8	-1.9
Medication for cholesterol	1.0	1.5	3.5	-0.3	0.7	-0.5	1.2	1.5	0.4	1.7	0.3	-0.5	1.9	1.6	1.7	1.7
Eye problems/disorders: Glaucoma	1.0	1.2	2.6	-0.4	-1.5	0.8	0.4	-1.5	-1.3	-0.6	0.8	1.0	-1.6	-1.0	-1.3	-0.9
Leg fat mass (left)	1.0	3.9	8.4	-0.6	-0.7	2.5	0.5	-2.9	0.6	-1.1	1.4	2.3	-2.5	-2.4	-2.7	-2.6
Blood Platelet Count	0.9	10.4	35.3	1.0	-0.9	2.8	-0.9	-5.6	-5.9	1.7	2.1	0.7	-4.7	-2.7	-3.0	-3.4
Heel T-Score	0.9	7.1	16.4	1.1	-1.3	-3.0	-2.2	4.0	0.9	1.9	-0.3	-3.6	3.2	2.9	3.4	3.3
Angina	0.9	1.2	9.0	-0.5	-1.3	-0.6	-0.6	-0.7	-3.0	-0.4	0.4	-1.5	-1.0	0.0	-0.2	-0.2
Multivitamins +/- minerals	0.9	1.1	3.1	1.1	0.6	0.6	0.5	-0.8	1.8	0.2	1.6	1.5	-1.0	-0.9	-0.6	-1.1
Weight	0.9	4.3	12.4	0.2	-0.1	2.7	0.4	-3.5	0.9	-1.0	1.1	2.4	-2.9	-2.1	-2.4	-3.0
Shortness of breath walking on level ground	0.9	1.1	2.6	-0.3	-1.3	1.5	-0.5	-1.4	0.7	0.3	1.6	0.7	-1.0	-0.9	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.9	-0.3	0.8	1.1	0.6	-1.7	-0.8	0.9	1.7	1.4	-1.0	-0.6	-0.9	-0.7
Whole body water mass	0.9	5.0	15.9	0.6	1.7	2.8	1.1	-4.0	1.5	-0.6	0.9	2.1	-3.1	-1.9	-2.1	-3.2
Arm fat mass (left)	0.9	3.9	9.4	0.3	-0.8	2.5	0.5	-3.1	0.7	-1.4	0.7	2.0	-2.7	-2.3	-2.6	-2.8
Ever taken oral contraceptive pill	0.9	1.0	2.3	0.9	1.0	1.2	-0.0	-1.4	-0.2	-0.6	0.5	1.0	-1.2	-1.5	-1.2	-0.9
Commuting to job workplace: Public transport	0.9	1.0	2.3	0.3	-0.9	0.2	-1.5	1.0	-0.1	1.5	-0.9	0.4	1.5	0.9	1.3	1.2
Fasting Glucose	0.8	1.0	3.1	1.4	1.8	0.6	0.2	-1.2	0.9	-0.7	-0.3	-0.2	-1.1	-1.3	-0.7	-1.0
Hypothyroidism (self reported)	0.8	1.8	5.3	0.2	-2.1	-0.9	-1.4	1.7	-2.3	0.9	-0.4	-1.4	1.3	1.1	1.2	1.2
Supplements: Zinc	0.8	0.8	4.1	1.2	0.2	0.0	-0.3	-0.8	0.4	-1.3	2.0	0.4	-1.2	-0.6	-0.8	-0.3
Medication: Co-codamol	0.8	0.9	2.8	1.7	-1.4	0.4	0.1	-1.4	-0.5	-0.1	-0.7	-0.4	-1.0	-0.9	-0.8	-1.4
Qualifications: CSEs or equivalent	0.8	1.1	3.2	0.6	-1.0	-1.0	-1.1	-0.9	0.8	-1.2	-1.8	-0.7	-1.2	-0.7	-0.9	-1.3
Financial difficulties in last 2 years	0.8	1.1	4.9	1.3	-0.4	-0.1	-0.1	-1.5	-0.3	-2.2	-0.7	-0.7	-1.3	-0.7	-0.3	-1.2
Heart attack	0.8	1.0	5.1	-2.3	-0.7	-0.2	2.0	0.3	0.4	1.1	0.7	0.5	0.7	0.1	0.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	6.0	-0.2	2.1	1.5	1.3	-1.9	2.1	-0.2	2.5	1.8	-1.4	-1.0	-0.8	-1.3
Arm fat mass (right)	0.8	3.3	8.1	0.2	-0.8	2.3	0.4	-2.8	0.4	-1.2	0.6	1.9	-2.4	-2.1	-2.3	-2.6
Blood clot in the leg (DVT)	0.8	1.0	4.1	2.0	-0.4	-1.1	-0.6	-0.3	-0.4	-0.2	-1.9	-1.9	-0.5	-0.4	-0.2	-0.3
Medication: Ibuprofen	0.8	1.0	2.3	-1.1	-1.4	0.5	-0.1	-0.6	-0.1	-1.5	0.0	-0.4	-1.0	-1.5	-1.3	-1.4
Leg fat mass (right)	0.8	3.0	5.9	-0.9	-0.6	2.3	0.8	-2.4	0.5	-0.9	1.2	2.2	-2.0	-2.0	-2.3	-2.3
Overall health rating	0.8	1.7	6.2	0.5	-2.5	-1.8	0.0	0.7	-0.7	0.6	-2.4	-1.6	0.9	0.6	1.3	0.6
Leg pain on walking	0.8	1.0	3.1	1.2	-0.4	0.5	-0.2	-1.8	-0.0	-0.1	1.0	0.1	-1.6	-1.1	-1.3	-1.4
Whole body fat-free mass	0.8	4.8	15.6	0.6	1.6	2.8	1.0	-3.9	1.5	-0.5	1.0	2.2	-3.0	-1.8	-2.0	-3.1
Qualifications: nursing, teaching	0.8	1.2	2.4	0.2	-1.0	1.5	-1.3	-1.2	0.8	-0.8	1.4	1.0	-1.2	-0.8	-1.2	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.5	0.1	0.1	-0.7	-0.4	1.3	0.2	1.3	-1.4	-0.6	1.6	1.0	1.2	1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.7	0.5	0.7	-1.9	0.7	1.3	0.6	0.4	-0.8	-1.4	0.6	0.8	0.3	0.9
Basal metabolic rate	0.8	4.6	15.1	0.5	1.3	2.8	0.8	-3.9	1.4	-0.6	0.9	2.2	-3.0	-1.9	-2.0	-3.1
Arm fat-free mass (left)	0.8	3.9	13.6	0.4	1.0	2.4	0.5	-3.7	1.6	-0.6	0.6	1.7	-3.0	-1.6	-2.0	-2.8
Myopia	0.8	1.1	3.0	-1.0	-0.1	-0.7	0.5	1.5	-0.1	0.7	-0.1	0.3	1.6	1.6	1.7	1.4
Basal cell carcinoma (self-reported)	0.8	0.9	3.3	0.9	1.8	-0.6	0.7	0.5	1.0	1.4	-1.0	-0.2	1.0	0.1	1.3	0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.1	5.4	-2.3	-1.0	-0.4	1.7	0.5	-0.2	1.4	0.6	0.3	0.9	0.4	0.2	0.9
Arm predicted mass (left)	0.8	4.0	14.1	0.6	0.8	2.4	0.2	-3.8	1.5	-0.6	0.5	1.8	-3.0	-1.7	-2.0	-2.9
Age at First Birth	0.7	1.0	9.2	-3.0	-0.1	0.6	0.8	0.4	0.6	0.0	0.5	1.4	0.7	0.4	0.4	0.2
Lupus	0.7	1.0	5.1	-1.9	1.3	-0.2	2.3	1.2	-0.1	-0.3	-0.1	0.2	0.8	-0.6	0.3	0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	-0.0	-0.6	0.3	-0.3	-1.4	0.9	-1.6	-0.3	0.6	-1.2	-1.4	-0.9	-1.6
Ever had hysterectomy (womb removed)	0.7	0.8	2.4	0.4	-0.6	-0.3	-1.2	0.3	-1.0	-1.4	-1.5	-1.5	-0.5	0.2	-0.2	-0.2
Current tobacco smoking	0.7	1.1	5.5	0.4	-1.3	-0.2	-0.4	0.5	-2.0	0.4	-2.3	-1.0	0.7	0.2	0.5	0.7
Average weekly fortified wine intake	0.7	0.8	5.9	-0.1	-0.4	-0.7	-1.3	-0.4	-2.4	-0.5	0.5	0.1	-0.2	1.2	0.1	0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.8	-0.8	-2.0	-0.4	-1.6	0.6	0.2	0.8	-0.5	0.5	0.9	0.1	0.6	0.4
High blood pressure (mother)	0.7	1.0	2.7	-0.2	0.1	1.3	0.2	-1.3	-0.1	-0.6	0.4	0.8	-1.4	-1.3	-1.4	-1.6
Medication: Simvastatin	0.7	1.0	3.6	-1.2	-0.3	0.8	0.9	-1.5	-0.5	0.2	1.9	1.1	-1.2	-0.9	-1.0	-0.4
Pulse rate	0.7	1.1	4.3	-1.1	-1.2	0.8	-0.5	-0.9	1.4	0.9	1.7	2.1	0.2	-0.2	-0.2	-0.4
Noisy workplace	0.7	0.8	2.9	-0.7	1.2	-0.2	1.4	-0.1	-0.7	-0.4	-1.7	-1.6	0.1	1.0	-0.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.5	-1.0	-1.5	0.2	-0.3	-0.5	-0.1	-1.6	0.4	-0.1	-0.9	-1.4	-0.9	-1.0
Medication: Lansoprazole	0.7	0.8	2.8	-0.3	-0.0	-1.3	0.6	0.7	-1.7	0.1	-0.6	-1.6	0.6	0.6	0.7	0.7
Tense / ‘highly strung’	0.7	1.2	7.1	0.4	0.9	-0.8	0.7	0.2	2.2	-0.7	-2.7	-0.3	0.3	-0.6	0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.1	0.1	0.8	1.8	0.2	-1.2	1.1	0.0	0.9	1.2	-0.8	-0.9	-0.7	-0.7
Exposure to tobacco smoke outside home	0.7	0.9	3.8	-0.5	0.5	0.2	0.6	-1.5	-0.1	-1.5	0.2	-0.3	-1.9	-0.7	-1.0	-1.0
Age at first live birth	0.7	1.3	3.6	-0.8	1.9	-0.4	1.5	1.2	0.6	1.6	-0.1	0.2	1.7	1.1	0.8	1.0
Migraine (self-reported)	0.7	0.8	3.4	-1.4	0.9	-0.6	1.8	1.1	-0.2	-0.0	-0.5	-1.3	0.7	0.1	0.5	0.5
Heart disease (mother)	0.7	0.8	1.9	-1.4	0.5	0.1	1.2	-0.3	1.1	-1.0	1.1	0.4	-0.6	-0.8	-1.3	-0.8
Number of full sisters	0.7	0.8	5.4	2.3	-0.4	-0.0	-1.0	-0.5	-0.4	0.2	-1.4	-0.2	0.2	1.1	0.3	0.3
Arm fat percentage (left)	0.7	2.8	5.0	-0.1	-1.3	2.2	0.6	-2.2	0.1	-1.4	0.8	2.0	-1.9	-2.2	-2.2	-2.1
Smoking status: Current	0.7	1.1	5.5	-0.2	-1.6	-0.2	-0.5	0.5	-1.9	0.4	-2.3	-0.8	0.7	-0.0	0.4	0.6
Illnesses of father: High blood pressure	0.7	0.9	2.8	-0.9	0.6	0.6	0.8	-1.4	0.6	-0.4	1.5	1.7	-0.9	-0.4	-1.0	-0.6
Ever smoked	0.7	1.2	3.7	1.8	1.6	-0.3	0.2	-0.5	-0.0	-1.3	-1.9	-1.9	-0.7	-0.3	0.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.7	1.9	-0.4	-1.0	-0.5	0.1	-0.1	0.0	-1.7	-1.8	-0.1	-0.2	0.2	-0.0
Irritable Bowel Disease (IBD)	0.6	1.5	4.7	-0.6	0.7	-0.6	-0.2	1.3	-2.2	0.8	-1.4	-1.0	1.9	0.8	1.6	1.3
Body Mass Index (BMI) (2010)	0.6	0.8	3.5	-0.8	0.0	1.0	1.3	-0.4	-0.6	0.9	1.9	1.3	0.1	-0.1	-0.7	-0.2
Smoking Status	0.6	1.6	4.1	-0.0	1.8	2.0	0.4	-1.7	0.6	-0.9	-0.7	0.7	-1.3	-1.5	-1.2	-1.5
Lung FVC	0.6	2.9	6.9	-1.4	-1.3	1.8	-1.9	-1.5	0.3	-0.4	2.0	2.6	-1.4	-2.0	-1.8	-2.0
Diabetes (father)	0.6	0.7	2.4	1.6	0.5	1.0	0.0	-1.2	1.0	-0.4	0.5	0.9	-0.5	-0.8	-0.6	-0.9
Fed-up feelings	0.6	1.2	4.3	0.2	0.5	-0.5	0.7	-1.4	0.3	-2.1	-0.3	0.1	-1.4	-1.7	-1.3	-1.1
Past tobacco smoking	0.6	1.2	3.0	-0.8	-1.7	-0.7	0.1	1.1	-1.3	1.7	0.9	0.8	1.1	0.9	0.3	1.3
Trunk fat-free mass	0.6	3.2	11.4	0.6	2.0	2.4	0.9	-3.4	0.8	-0.2	0.4	1.5	-2.5	-1.2	-1.4	-2.5
Time employed in main current job	0.6	0.7	5.5	-2.3	-0.6	0.2	0.9	-0.4	-0.2	0.5	0.8	0.9	0.1	0.3	-0.3	0.3
Father’s age at death	0.6	0.9	2.0	0.0	1.2	-0.7	0.6	1.1	-1.1	1.4	-0.1	-0.5	1.1	0.8	0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.6	-0.3	2.4	1.2	1.6	-1.6	2.0	-0.2	1.6	1.5	-1.1	-1.0	-0.9	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	3.0	-1.2	1.5	0.2	1.7	-0.0	-0.5	0.1	-0.6	1.0	0.4	0.1	-0.0	0.1
Asthma	0.6	1.2	9.4	3.1	-0.6	0.5	-1.1	-0.9	1.1	0.7	-0.5	-0.5	-0.5	-0.2	0.6	-0.5
Eye problems/disorders: None of the above	0.6	0.7	3.7	-0.6	1.9	-0.2	0.6	0.7	0.3	1.2	0.8	0.1	0.7	1.1	0.7	0.8
Emphysema/chronic bronchitis	0.6	0.6	3.2	1.1	0.6	-0.9	-0.1	0.4	-1.8	0.5	0.2	-1.1	-0.0	0.3	0.9	0.2
Had major operations	0.6	0.7	3.7	0.5	-1.9	-0.5	-0.7	-0.7	-1.3	0.7	-1.2	0.3	0.2	0.5	0.4	0.0
Long-standing illness, disability or infirmity	0.6	1.0	3.9	0.5	-1.1	0.8	0.1	-1.9	-2.0	-0.2	0.4	0.3	-1.1	-0.4	-0.6	-1.0
Wears glasses or contact lenses	0.6	0.7	2.8	-1.7	-0.1	0.1	-0.3	1.1	-1.2	0.5	0.8	0.7	1.1	0.4	0.2	0.6
High cholesterol (Self-reported)	0.6	1.1	3.4	-1.5	-0.8	0.4	0.0	-1.0	-1.5	-0.4	1.8	0.7	-1.1	-0.9	-1.2	-0.8
Medication: Bendroflumethiazide	0.6	1.0	3.4	-1.8	-0.7	0.9	0.1	-0.5	1.3	-1.1	0.7	1.1	-0.8	-0.7	-1.1	-1.1
Leg fat percentage (left)	0.6	2.0	5.2	-0.7	-1.8	1.5	-0.2	-1.7	-0.6	-1.1	0.8	1.3	-1.7	-1.7	-2.3	-1.5
Risk taking	0.6	0.9	2.7	0.6	-1.2	0.8	-0.4	-1.6	0.1	-1.4	0.4	0.8	-1.4	-0.5	-0.9	-0.6
Crohns Disease (2017)	0.5	1.0	8.2	-0.1	-0.0	-0.5	-0.4	0.5	-2.9	-0.6	-1.3	-1.0	0.7	0.4	0.6	0.4
HDL Cholesterol	0.5	0.8	4.2	-2.1	0.5	1.5	1.0	-0.3	-0.1	0.6	0.9	1.2	-0.0	-0.2	-0.3	-0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	0.4	1.3	-0.0	0.6	-0.5	-0.5	-1.3	0.0	-0.2	-0.9	-0.8	-1.4	-0.4
Hearing difficulty/problems: Yes	0.5	0.7	3.6	0.6	1.2	-0.7	1.9	-0.4	-0.6	-0.8	-1.1	0.2	-0.3	-0.4	-0.1	-0.5
Severe depression (siblings)	0.5	0.6	3.6	0.8	-1.9	0.2	-0.9	0.1	0.4	1.0	0.3	0.7	0.4	-0.7	0.0	-0.4
Age when periods started (menarche)	0.5	1.3	3.6	1.2	0.6	1.4	-0.7	-1.2	1.9	0.4	0.5	1.1	-1.0	-1.5	-1.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	-0.6	-0.4	1.1	0.4	-0.9	-1.1	-0.4	0.8	0.7	-1.0	-0.1	-1.4	-0.5
Trunk fat mass	0.5	2.1	4.5	-0.1	-1.0	1.8	0.7	-2.1	0.7	-0.7	0.9	1.8	-1.7	-1.7	-1.8	-2.1
Had other major operations	0.5	0.6	2.0	0.6	-0.6	0.3	0.2	-1.2	0.8	-0.6	-0.4	0.1	-1.4	-0.8	-1.0	-0.7
Mouth/teeth dental problems	0.5	0.8	2.9	-1.7	0.2	-0.2	1.2	0.6	-0.1	1.2	0.9	0.9	1.0	0.7	0.5	0.8
Allergy	0.5	1.1	7.1	-2.7	1.1	0.4	1.3	1.0	-0.8	-0.4	-0.5	0.3	1.1	0.8	-0.2	0.7
Arm fat percentage (right)	0.5	1.9	3.6	0.1	-1.4	1.6	0.5	-1.7	-0.2	-1.3	0.2	1.3	-1.6	-1.8	-1.9	-1.9
Trunk predicted mass	0.5	3.1	11.3	0.6	2.0	2.4	0.9	-3.4	0.8	-0.2	0.3	1.4	-2.5	-1.2	-1.4	-2.4
Length of working week for main job	0.5	0.5	1.8	-1.2	-1.3	-0.4	-0.9	-0.5	-0.1	-0.1	0.9	0.5	-0.6	-0.3	-0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.9	-1.0	-0.6	1.0	0.0	-1.0	0.9	-0.1	0.8	1.4	-0.9	-1.1	-0.7	-1.1
Number of children fathered	0.5	0.5	2.6	-0.4	-0.9	0.8	0.1	0.7	-1.6	1.0	-0.2	-0.7	0.7	0.0	-0.2	0.4
Medication: Allopurinol	0.5	0.7	2.6	-1.6	-0.3	0.9	1.4	-0.5	-0.7	0.6	1.1	1.1	-0.1	-0.5	-0.5	-0.2
Medication: Seretide 50 evohaler	0.5	0.6	3.9	-0.0	-0.7	0.6	0.7	0.4	2.0	0.6	0.7	0.6	0.5	-0.3	0.2	-0.1
Whole body fat mass	0.5	2.3	5.1	-0.1	-1.0	2.0	0.6	-2.2	0.4	-0.6	0.9	1.8	-1.8	-1.7	-1.9	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	0.3	-0.8	-0.4	-0.1	-0.8	0.1	-1.4	-0.9	-0.3	-1.0	-0.6	-0.9	-1.2
Illnesses of father: Heart disease	0.5	0.7	1.9	-1.4	0.4	0.2	0.8	-0.8	-1.2	-0.7	1.1	0.2	-0.8	-0.8	-0.7	-0.6
Average weekly red wine intake	0.5	0.7	2.3	0.5	0.1	-0.7	-1.5	0.5	0.1	1.4	0.4	-0.4	0.7	0.8	0.9	1.5
Mineral and other dietary supplements	0.5	0.7	2.0	0.7	0.3	-0.8	-0.8	-0.1	-1.4	-1.1	-1.3	-1.3	-0.3	0.6	0.0	0.3
Asthma (self-reported)	0.5	1.0	8.1	2.8	-0.7	0.4	-1.0	-0.9	1.1	0.6	-0.3	-0.5	-0.5	-0.3	0.6	-0.4
Osteoporosis (self-reported)	0.5	0.6	3.4	0.0	1.4	-0.0	1.9	-0.1	1.0	-0.7	0.2	0.1	-0.1	-0.7	-0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.4	0.9	-0.5	-0.7	-0.1	0.9	0.7	1.5	-1.0	-0.7	0.9	0.3	1.0	0.7
Medication: Atorvastatin	0.5	0.6	2.5	-1.2	-0.8	-0.1	-0.1	-0.4	-1.6	-0.8	0.5	0.2	-0.7	-0.3	-0.8	-0.6
Alcohol drinker status: Never	0.5	0.6	4.5	-2.1	-0.2	-0.3	1.2	-0.3	-0.5	0.1	1.1	0.4	-0.2	0.2	-0.4	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.6	0.2	-1.0	0.2	0.3	0.9	-0.9	0.9	-1.3	0.1	1.0	0.4	0.7	0.6
Worry (Nagel 2018)	0.4	0.8	3.1	0.0	-0.0	-0.9	1.0	0.6	1.6	-1.1	-1.8	-0.3	0.5	-1.1	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	2.9	-0.8	-1.7	0.2	-1.3	0.4	-0.2	-0.8	0.1	-0.1	-0.2	-0.1	-0.3	-0.3
LDL Cholesterol	0.4	0.7	1.4	0.3	0.8	1.1	0.7	-0.9	1.2	-0.1	0.9	0.0	-0.9	-1.1	-0.7	-1.0
Blood Red Count	0.4	3.8	11.4	2.6	0.6	-3.1	-1.2	1.2	-2.2	-1.1	-2.6	-3.4	0.3	1.6	1.2	1.1
Blood White Count	0.4	2.6	10.0	1.4	-1.6	0.2	-2.7	-1.7	-3.2	2.5	0.1	-0.5	-0.9	0.7	0.9	0.5
Allergy or Eczema	0.4	1.1	2.7	1.1	-1.0	-0.1	-1.2	-1.6	0.2	-0.6	1.0	0.1	-1.7	-0.9	-1.2	-1.4
Chronotype (morning person)	0.4	0.9	6.5	-0.2	-0.0	-0.1	-0.8	0.6	0.1	0.4	-2.5	0.4	1.5	0.6	1.2	0.5
Hand grip strength (left)	0.4	1.1	6.3	-1.0	2.5	0.3	1.6	-0.7	0.7	-0.3	0.9	-0.4	-1.0	-0.2	-1.1	-0.1
Relative age of first facial hair	0.4	0.7	2.7	1.6	-1.1	-0.4	-1.6	0.5	0.2	-0.9	-0.4	-1.2	-0.2	0.6	-0.0	-0.0
Maternal smoking around birth	0.4	0.6	2.0	-1.1	0.7	0.2	1.0	-0.6	-0.2	-1.4	-1.3	-0.3	-0.5	-0.8	-0.4	-0.6
Serious illness, injury or assault to yourself	0.4	0.4	2.4	-0.4	0.1	0.2	1.5	-0.8	0.3	0.4	0.3	1.4	0.1	-0.2	0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.0	1.4	-0.5	-0.2	-0.7	-1.3	1.0	0.0	1.0	0.1	-1.4	-0.9	-0.8	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.6	0.5	1.1	0.2	1.1	1.0	-1.1	-0.1	-0.6	-1.3	0.7	0.4	0.6	0.6
Breastfed as a baby	0.4	0.6	3.1	0.8	1.8	-0.0	0.3	-0.1	-0.0	-0.2	1.0	-0.3	-1.2	-0.3	-0.8	-0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	1.4	0.1	-0.1	-1.1	-0.7	1.0	-0.4	-0.8	-0.5	-0.8	-0.5	-0.4	-0.4
Comparative height size at age 10	0.4	2.3	5.5	1.3	1.4	-1.5	0.4	1.7	-0.2	0.8	-1.4	-2.3	1.6	1.9	2.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.5	-1.6	-0.0	0.2	0.5	1.2	0.1	0.7	1.0	-0.1	0.6	-0.1	-0.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.8	-0.9	0.5	0.3	0.7	-0.5	-0.9	-0.9	1.3	0.4	-0.7	-0.3	-0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.9	-0.2	-0.8	1.4	-0.7	-0.4	-0.4	-0.5	0.5	0.4	-0.4	-0.8	-0.9	-0.9
Hearing aid user	0.4	0.4	1.8	0.5	0.4	-0.6	0.8	0.4	0.2	0.6	-0.6	-1.4	0.2	0.9	0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.9	0.1	-0.8	-0.0	1.1	-0.0	-1.7	-0.0	-0.3	-0.7	-0.2	-0.1	-0.6	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	1.4	0.2	-1.0	0.3	-0.6	0.7	-0.6	1.2	0.1	-0.4	0.4	0.1	0.4	0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	2.4	-0.8	-1.6	0.5	-1.3	0.8	-0.4	-0.1	0.8	0.1	0.1	-0.2	-0.0	-0.2
Reaction Time	0.3	0.5	2.1	1.4	0.9	-0.5	0.4	0.2	-1.2	0.9	0.3	-0.0	0.5	0.4	0.7	0.7
Triglycerides	0.3	0.6	3.4	1.8	0.3	-0.5	-0.8	-0.7	-0.1	-1.0	-0.7	-0.4	-0.7	-0.3	-0.2	-0.5
Respiratory disease	0.3	0.6	2.3	1.5	-0.5	-0.3	-0.9	0.3	0.3	1.0	0.2	-0.8	0.5	0.4	1.5	0.4
Tanning	0.3	3.3	6.7	-2.2	1.0	-0.6	2.6	1.9	-0.4	2.6	1.1	0.5	2.4	2.0	1.7	2.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.9	-0.6	0.3	0.2	0.0	-1.0	-0.4	0.3	-0.4	-0.6	-0.7	-0.4	-0.6
Hand grip strength (right)	0.3	0.7	3.3	-0.9	1.8	0.2	1.5	-0.5	0.9	0.1	1.0	-0.4	-0.6	0.4	-0.7	0.5
Relative age voice broke	0.3	0.5	2.2	0.4	0.8	0.7	0.0	-0.6	1.5	-0.7	0.5	0.9	-0.8	0.2	-0.6	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.3	0.1	-0.8	0.4	1.0	0.8	-1.2	-0.4	-0.5	0.2	-0.2	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.5	-0.0	-0.7	-0.8	-1.3	1.0	0.2	-0.4	-0.9	-1.6	0.6	-0.1	0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	3.1	-1.0	-1.8	-0.1	-0.6	-0.3	-0.4	-0.3	-0.2	0.1	-0.3	-0.1	-0.6	-0.2
Qualifications: None of the above	0.3	0.7	1.5	-0.2	-0.2	1.2	-0.3	-1.2	-0.5	-0.3	0.7	0.9	-1.2	-1.0	-1.2	-1.0
Worrier / anxious feelings	0.3	0.6	2.2	-1.3	-0.8	-0.2	-0.0	0.4	1.2	-1.5	-0.2	0.3	-0.2	-0.9	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.1	0.9	1.4	0.6	-0.9	-1.0	0.5	-0.4	1.4	0.3	-0.9	0.0	-0.8	-0.6
Prospective memory result	0.3	0.3	0.8	0.8	-0.3	-0.6	0.7	-0.5	0.6	-0.3	0.4	-0.2	-0.6	-0.9	-0.2	-0.7
Hair/balding pattern: Pattern 4	0.3	0.6	2.2	-0.2	-1.3	1.4	-0.8	-0.9	-0.4	-0.0	0.1	1.5	-0.5	-0.4	-0.4	-0.5
Birth weight of first child	0.3	0.5	1.0	-0.7	-0.4	0.4	-0.7	0.4	0.2	0.8	0.7	0.6	0.7	1.0	0.8	1.0
Body fat percentage	0.3	1.1	3.6	-0.2	-1.9	1.2	0.1	-1.1	0.0	-0.7	0.5	1.3	-0.9	-1.2	-1.4	-1.3
Leg fat percentage (right)	0.3	1.2	3.0	-1.0	-1.2	1.3	0.3	-1.2	-0.6	-0.8	0.6	1.2	-1.1	-1.3	-1.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.9	-0.1	0.8	0.4	1.2	-0.5	1.4	0.1	0.3	-0.3	-0.1	0.1	0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	2.0	0.4	-0.9	-0.4	-0.1	0.3	0.4	-0.5	0.3	1.4	-0.0	-0.8	-0.3	-0.3
Medication: Omeprazole	0.3	0.4	1.9	0.4	-0.7	-0.1	0.5	-0.3	-1.4	-0.5	-0.1	-0.7	-0.6	-0.2	-0.8	-0.5
Mood swings	0.3	0.5	1.4	-1.1	-0.4	0.2	0.7	-0.8	0.4	-1.2	0.5	0.9	-0.4	-0.8	-0.6	-0.6
Eye problems/disorders: Cataract	0.3	0.4	1.6	-0.7	-0.6	-0.1	0.5	0.2	0.8	-1.3	-0.5	0.2	0.2	-0.7	-0.5	-0.3
Breast cancer (self-reported)	0.3	0.3	1.2	-0.1	-1.1	-0.6	-0.7	0.3	0.4	0.8	-0.4	0.4	0.5	0.1	0.7	0.3
Financial situation satisfaction	0.3	0.3	1.5	-0.9	-0.4	-0.7	0.2	0.4	-0.1	-0.1	-1.2	-0.6	0.4	0.2	0.5	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	-1.2	0.2	0.7	-0.4	-0.2	-0.7	-1.0	1.4	0.4	-0.8	-0.2	-0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-0.7	1.0	-0.5	0.6	0.9	-0.6	-0.5	0.8	-0.9	0.1	0.5	0.1	0.4
Rheumatoid Arthritis	0.2	0.2	1.6	-0.9	-1.3	0.3	-0.0	0.2	-0.4	0.3	-0.2	-0.3	0.1	0.1	0.0	0.3
Waist Hip Ratio (WHR)	0.2	1.0	2.4	1.5	-0.0	0.5	-0.3	-1.3	-0.5	-1.0	1.3	1.6	-1.0	-0.9	-0.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	0.2	-0.1	0.7	0.7	-0.7	-0.7	0.1	0.1	0.8	-0.1	-0.5	0.4	0.0
Vitamin and mineral supplements	0.2	0.3	2.9	-1.7	0.6	0.5	0.4	-0.2	0.1	-0.1	0.2	-0.2	0.0	0.1	-0.5	0.2
Pack years adult smoking proportion	0.2	0.4	1.8	0.2	0.1	0.2	1.4	-0.4	-0.8	0.4	-1.2	0.6	0.2	0.1	-0.0	0.1
Trunk fat percentage	0.2	1.0	3.0	-0.2	-1.7	1.0	0.4	-1.0	0.4	-0.7	0.6	1.2	-0.8	-1.1	-1.2	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	-0.4	0.1	-0.4	-0.7	1.3	0.9	-0.3	0.0	-0.8	0.9	0.2	0.8	0.5
Medication: Atenolol	0.2	0.3	1.6	-1.3	0.2	0.1	0.5	-0.4	-1.2	-0.0	-0.4	0.2	-0.3	0.1	-0.3	0.0
Sitting height	0.2	1.2	7.9	0.7	1.5	0.6	1.1	-1.0	2.8	-0.4	0.0	0.1	-0.8	-0.5	-0.0	-1.3
Forced vital capacity (FVC)	0.2	0.7	2.0	-0.6	0.9	1.0	-0.2	-0.7	1.4	0.2	1.3	1.4	-0.5	-0.3	-0.5	-1.0
Standing height	0.2	2.2	6.0	1.7	2.5	-1.1	0.5	0.8	1.2	1.2	-1.3	-1.6	1.0	1.9	2.2	0.5
Peak expiratory flow (PEF)	0.2	0.4	2.8	0.1	1.7	-0.3	1.1	-0.3	0.3	-0.4	-0.5	-0.6	-0.2	-0.1	0.5	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	2.8	-0.0	0.7	0.9	-0.4	-1.0	1.7	-0.0	1.6	1.3	-0.8	-0.5	-0.2	-0.9
Qualifications: College or University degree	0.2	0.7	4.4	-0.3	0.5	0.9	-0.1	-0.6	-0.1	-0.4	2.1	1.2	-0.5	0.1	-0.9	-0.1
Age at last live birth	0.2	0.2	1.2	0.5	1.1	0.1	0.2	-0.3	0.6	0.4	-0.8	0.3	0.3	0.2	0.0	0.1
Family relationship satisfaction	0.2	0.3	1.0	0.3	-0.4	0.0	-0.5	0.3	0.1	1.0	-0.6	-0.4	0.6	0.7	0.6	0.6
Supplements: Vitamin C	0.2	0.2	1.0	1.0	-0.3	0.0	0.0	-0.4	-0.6	0.1	0.4	0.8	-0.2	-0.7	0.2	-0.5
Osteoarthritis (self-reported)	0.2	0.3	1.0	0.4	-0.2	-0.1	1.0	-0.8	0.3	-0.1	-0.2	0.1	-0.7	-0.1	-0.9	-0.4
Medication: Blood pressure	0.2	0.4	2.4	-1.0	-1.2	-0.2	0.2	-0.4	-1.5	0.0	-0.3	0.1	-0.3	-0.1	-0.4	-0.3
Average weekly beer plus cider intake	0.2	0.3	2.2	0.4	0.1	-0.1	0.9	0.4	1.5	-0.5	-0.4	-0.7	0.1	-0.2	0.1	-0.0
Commuting to job workplace: Cycle	0.2	0.2	1.0	0.6	0.1	0.4	-0.5	-1.0	-0.4	-0.5	0.2	0.3	-0.7	-0.3	0.1	-0.3
Cholesterol lowering medication	0.2	0.3	1.3	-0.0	-0.8	-0.5	-0.8	-0.3	-1.2	-0.5	-0.2	-0.0	-0.7	-0.4	-0.4	-0.2
Supplements: Calcium	0.2	0.2	1.3	0.1	0.0	-0.1	1.2	0.1	0.2	-0.8	0.5	-0.3	-0.2	-0.2	-0.5	-0.1
Alcohol drinker status: Previous	0.2	0.3	0.9	-0.7	-0.2	0.3	-0.1	-0.8	1.0	-0.4	0.7	0.6	-0.6	0.1	-0.2	-0.3
Pack years of smoking	0.2	0.4	2.0	-0.4	0.1	0.5	1.4	-0.3	-0.7	0.5	-0.9	0.7	0.2	0.0	-0.1	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.7	0.5	0.6	0.4
HbA1C	0.1	0.1	1.2	-0.5	0.1	0.0	1.1	-0.3	-0.1	-0.1	0.5	0.2	0.1	-0.0	-0.0	0.3
Height	0.1	2.3	5.6	-1.1	1.9	-1.4	2.2	1.5	2.4	0.7	-0.7	-1.9	1.1	1.4	1.8	0.1
Hair Pigment	0.1	1.8	5.7	-0.0	1.4	-1.1	1.2	2.4	2.2	0.2	-1.1	-1.5	1.5	0.5	0.9	0.8
Stomach or abdominal pain in last month	0.1	0.2	0.6	-0.1	-0.0	0.6	0.1	-0.8	0.2	0.2	0.3	-0.0	-0.5	-0.6	-0.6	-0.3
Fluid intelligence score	0.1	0.3	1.4	-1.2	0.1	0.2	0.5	0.4	0.7	0.3	0.8	0.4	0.1	0.2	-0.2	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.9	-0.0	-0.9	-0.3	-0.4	-0.2	0.2	-0.4	-0.9	0.1	-0.1	-0.6	0.2	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.9	1.0	-0.7	0.1	-0.5	-0.9	-0.2	0.1	0.2	-0.0	-0.6	-0.3	0.1	-0.2
Mean time to correctly identify matches	0.1	0.2	1.0	0.4	0.5	0.2	0.4	-0.2	-1.0	0.7	0.2	0.4	0.1	-0.4	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.0	-0.3	0.5	-0.0	-0.1	0.6	0.4	-0.2	0.2	0.6	0.7	0.8	0.1
Friendships satisfaction	0.1	0.2	0.7	0.2	-0.0	0.2	-0.1	-0.7	0.8	0.3	0.4	0.2	-0.3	-0.0	-0.5	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	3.3	-0.5	-1.8	-0.2	0.1	-0.2	0.1	0.6	0.3	0.6	0.4	-0.1	-0.2	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

ZDHHC8

Models

Trait associations