Hub : Genes

ZDHHC8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1850	0.0590	2.5e-03	0.148	NA	0.161	NA	0.152	1.5e-08	NA	3.2e-09	NA	9.8e-09
2	GTEx	Brain Cerebellar Hemisphere	0.2690	0.1000	3.9e-03	0.145	NA	0.031	NA	0.068	1.5e-04	NA	5.5e-02	NA	8.1e-03
3	GTEx	Brain Cerebellum	0.3760	0.0990	1.0e-04	0.054	NA	0.026	NA	0.036	1.1e-02	NA	5.8e-02	NA	3.2e-02
4	GTEx	Brain Cortex	0.2990	0.0970	2.9e-03	0.041	NA	0.023	NA	0.027	2.8e-02	NA	7.5e-02	NA	6.1e-02
5	GTEx	Cells Transformed fibroblasts	0.1760	0.0430	3.0e-08	0.075	NA	0.142	NA	0.122	2.9e-06	NA	8.9e-11	NA	2.2e-09
6	GTEx	Nerve Tibial	0.2124	0.0605	2.7e-05	-0.003	NA	0.042	NA	0.006	5.8e-01	NA	5.6e-04	NA	1.2e-01
7	GTEx	Testis	0.1910	0.0700	2.0e-03	0.013	NA	0.024	NA	0.017	8.5e-02	NA	3.1e-02	NA	5.6e-02
8	METSIM	Adipose	0.0398	0.0184	9.3e-03	0.002	0.004	0.004	0.005	0.004	1.5e-01	6.6e-02	6.6e-02	5.9e-02	7.8e-02
9	YFS	Blood	0.0437	0.0109	1.0e-10	0.031	0.038	0.036	0.038	0.042	1.4e-10	1.4e-12	8.6e-12	2.0e-12	1.3e-13
10	TCGA	Colon Adenocarcinoma	0.0510	0.0280	4.5e-03	0.015	0.039	0.034	NA	0.020	4.2e-02	2.6e-03	4.4e-03	NA	2.3e-02
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0354	0.0183	1.1e-03	0.034	0.024	0.009	NA	0.023	8.4e-05	8.2e-04	2.8e-02	NA	1.1e-03
12	TCGA	Lung Squamous Cell Carcinoma	0.0214	0.0126	6.9e-03	0.004	0.018	0.011	NA	0.008	1.0e-01	3.3e-03	1.9e-02	NA	3.7e-02
13	TCGA	Thyroid Carcinoma	0.0450	0.0240	5.5e-04	0.007	0.016	0.001	NA	0.002	6.7e-02	1.0e-02	2.4e-01	NA	1.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	3.6	5.6	13.8	-0.1	-1.5	-2.3	-1.0	3.1	-1.9	2.3	-1.6	-1.9	3.7	2.4	3.4	2.9
Bipolar Disorder or Schizophrenia	2.9	7.0	15.6	2.9	0.5	-2.9	-0.2	3.2	-0.5	3.0	-2.7	-1.9	4.0	2.1	3.9	2.7
Depressed Affect (Nagel 2018)	1.0	2.2	8.0	-0.5	-0.1	-0.7	1.3	-1.4	0.5	-2.8	-0.4	-0.3	-1.7	-2.4	-2.0	-1.8
Depression (Nagel 2018)	2.1	3.1	7.9	-0.1	-0.9	0.3	-0.4	-2.1	0.8	-2.8	0.2	0.5	-2.5	-2.8	-2.3	-2.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	-1.2	0.2	0.7	-0.4	-0.2	-0.7	-1.0	1.4	0.4	-0.8	-0.2	-0.7	-0.6
Neuroticism (Nagel 2018)	1.8	4.3	13.4	-0.5	-0.3	0.5	0.5	-2.0	1.7	-3.7	-0.1	0.3	-2.6	-3.4	-2.8	-3.0
Schizophrenia (2018)	1.8	3.7	14.5	3.8	1.8	-1.9	0.5	1.5	0.9	2.1	-2.4	-1.0	2.2	0.8	2.3	1.1
Schizophrenia vs Biploar Disorder	1.1	1.5	6.0	1.7	2.4	0.9	1.8	-0.6	2.0	0.2	-0.7	0.7	-0.0	-0.2	0.6	-0.4
Worry (Nagel 2018)	0.4	0.8	3.1	0.0	-0.0	-0.9	1.0	0.6	1.6	-1.1	-1.8	-0.3	0.5	-1.1	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	2.9	-0.8	-1.7	0.2	-1.3	0.4	-0.2	-0.8	0.1	-0.1	-0.2	-0.1	-0.3	-0.3
Alzheimer’s Disease (in father)	0.3	0.3	1.4	0.2	-1.0	0.3	-0.6	0.7	-0.6	1.2	0.1	-0.4	0.4	0.1	0.4	0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	2.4	-0.8	-1.6	0.5	-1.3	0.8	-0.4	-0.1	0.8	0.1	0.1	-0.2	-0.0	-0.2
Crohns Disease (2017)	0.5	1.0	8.2	-0.1	-0.0	-0.5	-0.4	0.5	-2.9	-0.6	-1.3	-1.0	0.7	0.4	0.6	0.4
Irritable Bowel Disease (IBD)	0.6	1.5	4.7	-0.6	0.7	-0.6	-0.2	1.3	-2.2	0.8	-1.4	-1.0	1.9	0.8	1.6	1.3
Ulcerative Colitis (UC)	1.4	2.6	6.5	-0.5	1.5	-1.0	0.5	2.0	-1.1	1.8	-1.3	-1.4	2.6	1.6	2.2	2.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.3	0.5	2.1	1.4	0.9	-0.5	0.4	0.2	-1.2	0.9	0.3	-0.0	0.5	0.4	0.7	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-0.7	1.0	-0.5	0.6	0.9	-0.6	-0.5	0.8	-0.9	0.1	0.5	0.1	0.4
Breast Cancer	1.5	3.6	6.9	-0.2	1.2	2.5	-0.7	-2.3	1.6	-1.7	1.2	1.7	-2.3	-2.5	-2.2	-2.6
Ovarian Cancer	1.1	1.4	8.4	2.9	0.7	-1.1	-0.4	-0.3	-0.9	-1.3	-1.1	-1.8	-0.8	-0.1	-0.5	-0.2
Prostate Cancer	2.5	3.5	9.7	2.8	-1.2	-2.8	-1.2	1.2	-1.0	-1.3	-3.1	-2.5	0.8	0.9	1.7	1.5
Age at First Birth	0.7	1.0	9.2	-3.0	-0.1	0.6	0.8	0.4	0.6	0.0	0.5	1.4	0.7	0.4	0.4	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	3.5	-0.8	0.0	1.0	1.3	-0.4	-0.6	0.9	1.9	1.3	0.1	-0.1	-0.7	-0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.7	0.5	0.6	0.4
Crohns Disease (2012)	1.1	1.8	5.1	1.0	-0.6	-1.1	-0.9	1.0	-2.3	-0.1	-2.2	-1.5	1.1	1.2	1.5	1.1
Mean Putamen Volume	2.9	3.4	6.5	-0.1	0.8	-2.3	-0.2	2.5	-2.0	0.9	-1.3	-2.5	2.0	2.2	1.9	2.5
Fasting Glucose	0.8	1.0	3.1	1.4	1.8	0.6	0.2	-1.2	0.9	-0.7	-0.3	-0.2	-1.1	-1.3	-0.7	-1.0
HbA1C	0.1	0.1	1.2	-0.5	0.1	0.0	1.1	-0.3	-0.1	-0.1	0.5	0.2	0.1	-0.0	-0.0	0.3
HDL Cholesterol	0.5	0.8	4.2	-2.1	0.5	1.5	1.0	-0.3	-0.1	0.6	0.9	1.2	-0.0	-0.2	-0.3	-0.0
LDL Cholesterol	0.4	0.7	1.4	0.3	0.8	1.1	0.7	-0.9	1.2	-0.1	0.9	0.0	-0.9	-1.1	-0.7	-1.0
Lupus	0.7	1.0	5.1	-1.9	1.3	-0.2	2.3	1.2	-0.1	-0.3	-0.1	0.2	0.8	-0.6	0.3	0.4
Neuroticism (2016)	1.5	2.2	6.4	-0.6	-0.7	0.4	-0.4	-1.1	1.0	-2.5	-0.6	-0.1	-1.7	-2.1	-2.5	-2.2
Primary Biliary Cirrhosis	1.3	1.9	5.2	0.2	0.8	-0.8	0.8	1.9	-0.9	2.3	0.2	-0.7	2.0	1.6	1.4	1.8
Rheumatoid Arthritis	0.2	0.2	1.6	-0.9	-1.3	0.3	-0.0	0.2	-0.4	0.3	-0.2	-0.3	0.1	0.1	0.0	0.3
Schizophrenia (2014)	1.3	2.9	9.5	3.1	1.8	-1.3	0.5	1.5	0.6	1.9	-1.6	-0.8	2.1	0.7	2.6	1.2
Triglycerides	0.3	0.6	3.4	1.8	0.3	-0.5	-0.8	-0.7	-0.1	-1.0	-0.7	-0.4	-0.7	-0.3	-0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	0.4	1.3	-0.0	0.6	-0.5	-0.5	-1.3	0.0	-0.2	-0.9	-0.8	-1.4	-0.4
Ulcerative Colitis	1.3	1.8	4.8	-0.3	1.2	-1.1	0.5	1.5	-0.6	1.0	-1.9	-1.3	1.8	1.1	2.2	1.6
Blood Eosinophil Count	1.6	12.1	24.8	-0.4	2.4	5.0	-0.3	-4.7	2.3	-1.2	4.8	3.7	-4.6	-3.6	-3.6	-3.7
Blood Platelet Count	0.9	10.4	35.3	1.0	-0.9	2.8	-0.9	-5.6	-5.9	1.7	2.1	0.7	-4.7	-2.7	-3.0	-3.4
Blood Red Count	0.4	3.8	11.4	2.6	0.6	-3.1	-1.2	1.2	-2.2	-1.1	-2.6	-3.4	0.3	1.6	1.2	1.1
Blood White Count	0.4	2.6	10.0	1.4	-1.6	0.2	-2.7	-1.7	-3.2	2.5	0.1	-0.5	-0.9	0.7	0.9	0.5
Heel T-Score	0.9	7.1	16.4	1.1	-1.3	-3.0	-2.2	4.0	0.9	1.9	-0.3	-3.6	3.2	2.9	3.4	3.3
BMI	2.0	11.7	28.0	-1.5	-0.0	4.7	1.8	-5.3	0.2	-1.8	2.7	4.6	-4.3	-3.6	-4.2	-4.0
Height	0.1	2.3	5.6	-1.1	1.9	-1.4	2.2	1.5	2.4	0.7	-0.7	-1.9	1.1	1.4	1.8	0.1
Waist Hip Ratio (WHR)	0.2	1.0	2.4	1.5	-0.0	0.5	-0.3	-1.3	-0.5	-1.0	1.3	1.6	-1.0	-0.9	-0.5	-1.0
Systolic Blood Pressure	1.2	6.0	12.5	-3.2	-0.1	2.5	2.9	-3.0	1.4	1.4	3.3	3.5	-1.9	-2.0	-2.2	-2.1
Smoking Status	0.6	1.6	4.1	-0.0	1.8	2.0	0.4	-1.7	0.6	-0.9	-0.7	0.7	-1.3	-1.5	-1.2	-1.5
Allergy or Eczema	0.4	1.1	2.7	1.1	-1.0	-0.1	-1.2	-1.6	0.2	-0.6	1.0	0.1	-1.7	-0.9	-1.2	-1.4
Cardiovascular Disease	1.6	5.3	9.8	-2.7	-0.2	2.4	0.8	-3.1	0.7	-0.9	3.0	2.2	-3.0	-2.2	-3.0	-2.8
Hypothyroidism (self reported)	0.8	1.8	5.3	0.2	-2.1	-0.9	-1.4	1.7	-2.3	0.9	-0.4	-1.4	1.3	1.1	1.2	1.2
Respiratory disease	0.3	0.6	2.3	1.5	-0.5	-0.3	-0.9	0.3	0.3	1.0	0.2	-0.8	0.5	0.4	1.5	0.4
Type 2 Diabetes (T2D) (2018)	2.1	3.9	11.0	0.1	-1.1	1.8	-1.8	-3.0	-0.3	-1.4	0.7	0.5	-3.3	-2.0	-2.9	-2.9
Lung FEV1/FVC ratio	2.2	11.3	68.1	-1.6	7.5	1.6	8.2	-2.3	1.0	-0.7	0.0	0.6	-1.3	-2.0	-1.8	-1.2
Lung FVC	0.6	2.9	6.9	-1.4	-1.3	1.8	-1.9	-1.5	0.3	-0.4	2.0	2.6	-1.4	-2.0	-1.8	-2.0
Neuroticism	1.6	4.0	11.3	-0.6	-0.1	0.5	1.0	-2.2	1.3	-3.2	-0.6	0.4	-2.4	-3.4	-2.8	-2.8
Chronotype (morning person)	0.4	0.9	6.5	-0.2	-0.0	-0.1	-0.8	0.6	0.1	0.4	-2.5	0.4	1.5	0.6	1.2	0.5
Hair Pigment	0.1	1.8	5.7	-0.0	1.4	-1.1	1.2	2.4	2.2	0.2	-1.1	-1.5	1.5	0.5	0.9	0.8
Tanning	0.3	3.3	6.7	-2.2	1.0	-0.6	2.6	1.9	-0.4	2.6	1.1	0.5	2.4	2.0	1.7	2.3
Hand grip strength (left)	0.4	1.1	6.3	-1.0	2.5	0.3	1.6	-0.7	0.7	-0.3	0.9	-0.4	-1.0	-0.2	-1.1	-0.1
Number of treatments/medications taken	3.1	5.6	11.0	-2.1	-1.6	3.2	1.0	-2.9	0.0	-0.8	3.3	2.0	-2.5	-3.0	-2.8	-2.7
Average weekly spirits intake	5.3	6.6	13.6	0.7	-1.2	-2.3	-1.1	2.5	-2.9	3.1	-1.9	-1.2	3.3	3.7	3.2	3.6
Sensitivity / hurt feelings	1.0	1.7	5.5	-1.1	-0.6	0.5	0.7	-1.3	0.6	-2.3	0.6	0.8	-1.5	-1.6	-1.6	-1.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	-0.0	-0.6	0.3	-0.3	-1.4	0.9	-1.6	-0.3	0.6	-1.2	-1.4	-0.9	-1.6
Hearing difficulty/problems: Yes	0.5	0.7	3.6	0.6	1.2	-0.7	1.9	-0.4	-0.6	-0.8	-1.1	0.2	-0.3	-0.4	-0.1	-0.5
Relative age of first facial hair	0.4	0.7	2.7	1.6	-1.1	-0.4	-1.6	0.5	0.2	-0.9	-0.4	-1.2	-0.2	0.6	-0.0	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	0.2	-0.1	0.7	0.7	-0.7	-0.7	0.1	0.1	0.8	-0.1	-0.5	0.4	0.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.7	1.8	0.3	0.6	-0.6	-1.1	1.1	-1.9	-1.0	-0.6	-1.8	-1.8	-1.5	-1.8
Ever had hysterectomy (womb removed)	0.7	0.8	2.4	0.4	-0.6	-0.3	-1.2	0.3	-1.0	-1.4	-1.5	-1.5	-0.5	0.2	-0.2	-0.2
Systolic blood pressure, automated reading	1.1	3.2	11.8	-1.8	-0.7	2.1	1.8	-1.8	1.2	1.8	2.4	3.4	-0.7	-1.2	-1.2	-1.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.9	-0.6	0.3	0.2	0.0	-1.0	-0.4	0.3	-0.4	-0.6	-0.7	-0.4	-0.6
Angina	0.9	1.2	9.0	-0.5	-1.3	-0.6	-0.6	-0.7	-3.0	-0.4	0.4	-1.5	-1.0	0.0	-0.2	-0.2
Medication for hormone replacement therapy	1.8	2.0	4.6	0.5	0.4	0.8	-1.0	-1.7	1.6	-1.9	0.4	0.4	-2.1	-1.7	-1.8	-2.1
Vitamin and mineral supplements	0.2	0.3	2.9	-1.7	0.6	0.5	0.4	-0.2	0.1	-0.1	0.2	-0.2	0.0	0.1	-0.5	0.2
Supplements: Zinc	0.8	0.8	4.1	1.2	0.2	0.0	-0.3	-0.8	0.4	-1.3	2.0	0.4	-1.2	-0.6	-0.8	-0.3
Medication: Co-codamol	0.8	0.9	2.8	1.7	-1.4	0.4	0.1	-1.4	-0.5	-0.1	-0.7	-0.4	-1.0	-0.9	-0.8	-1.4
Medication: Metformin	2.3	3.3	7.3	0.2	-2.0	1.1	-2.2	-1.9	-0.7	-2.2	-0.3	-0.3	-2.7	-1.8	-2.7	-2.4
Diabetes (father)	0.6	0.7	2.4	1.6	0.5	1.0	0.0	-1.2	1.0	-0.4	0.5	0.9	-0.5	-0.8	-0.6	-0.9
Diabetes (mother)	2.0	2.6	6.8	1.9	-1.0	1.1	-2.6	-2.2	-1.0	-1.3	-0.2	-0.5	-2.3	-1.4	-1.5	-1.7
Severe depression (siblings)	0.5	0.6	3.6	0.8	-1.9	0.2	-0.9	0.1	0.4	1.0	0.3	0.7	0.4	-0.7	0.0	-0.4
Pack years adult smoking proportion	0.2	0.4	1.8	0.2	0.1	0.2	1.4	-0.4	-0.8	0.4	-1.2	0.6	0.2	0.1	-0.0	0.1
Impedance of leg (right)	3.4	16.5	41.4	-0.1	-0.3	-5.1	-0.6	6.4	-2.0	2.3	-2.8	-4.6	5.5	4.9	4.9	5.4
Leg fat-free mass (left)	1.3	6.7	17.9	0.4	1.5	3.2	1.4	-4.2	2.2	-0.9	1.7	3.1	-3.2	-2.5	-2.4	-3.6
Trunk fat percentage	0.2	1.0	3.0	-0.2	-1.7	1.0	0.4	-1.0	0.4	-0.7	0.6	1.2	-0.8	-1.1	-1.2	-1.3
Hand grip strength (right)	0.3	0.7	3.3	-0.9	1.8	0.2	1.5	-0.5	0.9	0.1	1.0	-0.4	-0.6	0.4	-0.7	0.5
Townsend deprivation index at recruitment	1.7	2.4	8.2	0.2	-0.6	2.7	-0.9	-2.9	0.7	-1.2	0.3	1.1	-2.0	-1.5	-1.3	-1.8
Current tobacco smoking	0.7	1.1	5.5	0.4	-1.3	-0.2	-0.4	0.5	-2.0	0.4	-2.3	-1.0	0.7	0.2	0.5	0.7
Average weekly fortified wine intake	0.7	0.8	5.9	-0.1	-0.4	-0.7	-1.3	-0.4	-2.4	-0.5	0.5	0.1	-0.2	1.2	0.1	0.9
Maternal smoking around birth	0.4	0.6	2.0	-1.1	0.7	0.2	1.0	-0.6	-0.2	-1.4	-1.3	-0.3	-0.5	-0.8	-0.4	-0.6
Fed-up feelings	0.6	1.2	4.3	0.2	0.5	-0.5	0.7	-1.4	0.3	-2.1	-0.3	0.1	-1.4	-1.7	-1.3	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	9.9	0.1	-1.2	0.1	-1.0	-2.4	0.6	-3.1	0.3	0.8	-2.6	-2.3	-2.5	-2.5
Relative age voice broke	0.3	0.5	2.2	0.4	0.8	0.7	0.0	-0.6	1.5	-0.7	0.5	0.9	-0.8	0.2	-0.6	-0.6
Taking other prescription medications	3.5	5.4	11.6	-2.5	-1.9	3.1	0.7	-2.8	-0.2	-0.3	3.4	2.7	-2.2	-2.7	-2.6	-2.3
Age when periods started (menarche)	0.5	1.3	3.6	1.2	0.6	1.4	-0.7	-1.2	1.9	0.4	0.5	1.1	-1.0	-1.5	-1.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.8	-0.8	-2.0	-0.4	-1.6	0.6	0.2	0.8	-0.5	0.5	0.9	0.1	0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	-0.4	0.1	-0.4	-0.7	1.3	0.9	-0.3	0.0	-0.8	0.9	0.2	0.8	0.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	-1.2	1.5	0.1	1.5	0.5	-0.6	1.9	1.1	0.5	1.3	1.2	0.8	0.9
Qualifications: CSEs or equivalent	0.8	1.1	3.2	0.6	-1.0	-1.0	-1.1	-0.9	0.8	-1.2	-1.8	-0.7	-1.2	-0.7	-0.9	-1.3
Serious illness, injury or assault to yourself	0.4	0.4	2.4	-0.4	0.1	0.2	1.5	-0.8	0.3	0.4	0.3	1.4	0.1	-0.2	0.1	-0.4
High blood pressure	1.2	3.3	7.6	-2.4	-1.2	2.8	0.5	-1.9	0.7	0.3	2.2	2.3	-1.7	-1.5	-1.9	-2.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.0	1.4	-0.5	-0.2	-0.7	-1.3	1.0	0.0	1.0	0.1	-1.4	-0.9	-0.8	-1.0
Multivitamins +/- minerals	0.9	1.1	3.1	1.1	0.6	0.6	0.5	-0.8	1.8	0.2	1.6	1.5	-1.0	-0.9	-0.6	-1.1
Stomach or abdominal pain in last month	0.1	0.2	0.6	-0.1	-0.0	0.6	0.1	-0.8	0.2	0.2	0.3	-0.0	-0.5	-0.6	-0.6	-0.3
Supplements: Glucosamine	2.5	3.2	7.5	0.4	-0.8	1.9	-0.7	-2.1	-0.2	-1.5	2.1	1.1	-2.7	-2.2	-2.4	-2.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	-0.6	-0.4	1.1	0.4	-0.9	-1.1	-0.4	0.8	0.7	-1.0	-0.1	-1.4	-0.5
Medication: Atenolol	0.2	0.3	1.6	-1.3	0.2	0.1	0.5	-0.4	-1.2	-0.0	-0.4	0.2	-0.3	0.1	-0.3	0.0
Medication: Levothyroxine sodium	1.7	2.8	10.7	0.2	-3.3	-1.0	-2.0	1.9	-2.4	1.1	-0.2	-1.7	1.5	1.3	1.2	1.3
Sitting height	0.2	1.2	7.9	0.7	1.5	0.6	1.1	-1.0	2.8	-0.4	0.0	0.1	-0.8	-0.5	-0.0	-1.3
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.3	0.1	-0.8	0.4	1.0	0.8	-1.2	-0.4	-0.5	0.2	-0.2	0.3	-0.4
High blood pressure (mother)	0.7	1.0	2.7	-0.2	0.1	1.3	0.2	-1.3	-0.1	-0.6	0.4	0.8	-1.4	-1.3	-1.4	-1.6
Body mass index (BMI)	1.6	6.8	15.8	-0.4	-1.2	3.3	0.2	-4.0	0.4	-1.6	1.7	3.1	-3.4	-3.1	-3.4	-3.4
Impedance of leg (left)	2.8	13.5	33.5	-0.1	-0.9	-4.8	-1.1	5.8	-2.0	2.0	-2.3	-4.5	4.7	4.4	4.2	4.9
Leg predicted mass (left)	1.2	6.5	17.3	0.4	1.5	3.1	1.4	-4.2	2.2	-0.9	1.6	3.0	-3.2	-2.4	-2.4	-3.6
Trunk fat mass	0.5	2.1	4.5	-0.1	-1.0	1.8	0.7	-2.1	0.7	-0.7	0.9	1.8	-1.7	-1.7	-1.8	-2.1
Waist circumference	1.6	6.0	16.1	0.3	-1.0	3.0	-0.2	-4.0	0.3	-1.5	1.9	2.9	-3.2	-2.8	-2.9	-3.3
Number of incorrect matches in round	1.5	2.5	10.0	-0.9	0.0	-0.4	1.2	1.8	0.5	3.2	0.3	0.5	2.5	1.8	1.6	2.0
Past tobacco smoking	0.6	1.2	3.0	-0.8	-1.7	-0.7	0.1	1.1	-1.3	1.7	0.9	0.8	1.1	0.9	0.3	1.3
Alcohol usually taken with meals	1.0	1.6	6.0	0.7	-1.3	-0.7	-2.2	0.4	-2.4	1.7	0.2	-0.8	0.4	1.3	0.4	1.3
Nervous feelings	2.0	3.7	8.9	1.1	-0.8	-3.0	-0.4	2.6	-0.3	0.8	-2.9	-1.8	2.5	1.7	2.2	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	8.3	-1.0	-0.9	0.9	0.0	-2.0	1.6	-1.7	-0.2	1.0	-2.1	-2.9	-2.0	-2.5
Hearing difficulty/problems with background noise	3.5	5.5	11.2	0.7	1.4	1.7	2.1	-3.3	1.3	-2.9	0.3	1.0	-3.2	-3.0	-3.1	-3.4
Hair/balding pattern: Pattern 2	1.1	1.4	3.2	0.4	1.2	0.5	0.4	-1.1	1.2	-1.8	-0.2	-0.6	-1.6	-1.6	-1.5	-1.7
Had menopause	1.0	1.2	2.7	0.8	-1.4	0.5	-1.2	-0.4	1.3	-1.6	0.6	0.5	-1.3	-1.2	-1.5	-1.3
Had other major operations	0.5	0.6	2.0	0.6	-0.6	0.3	0.2	-1.2	0.8	-0.6	-0.4	0.1	-1.4	-0.8	-1.0	-0.7
Forced vital capacity (FVC)	0.2	0.7	2.0	-0.6	0.9	1.0	-0.2	-0.7	1.4	0.2	1.3	1.4	-0.5	-0.3	-0.5	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.5	-0.0	-0.7	-0.8	-1.3	1.0	0.2	-0.4	-0.9	-1.6	0.6	-0.1	0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	3.1	-1.0	-1.8	-0.1	-0.6	-0.3	-0.4	-0.3	-0.2	0.1	-0.3	-0.1	-0.6	-0.2
Qualifications: None of the above	0.3	0.7	1.5	-0.2	-0.2	1.2	-0.3	-1.2	-0.5	-0.3	0.7	0.9	-1.2	-1.0	-1.2	-1.0
Financial difficulties in last 2 years	0.8	1.1	4.9	1.3	-0.4	-0.1	-0.1	-1.5	-0.3	-2.2	-0.7	-0.7	-1.3	-0.7	-0.3	-1.2
Mouth/teeth dental problems	0.5	0.8	2.9	-1.7	0.2	-0.2	1.2	0.6	-0.1	1.2	0.9	0.9	1.0	0.7	0.5	0.8
Heart attack	0.8	1.0	5.1	-2.3	-0.7	-0.2	2.0	0.3	0.4	1.1	0.7	0.5	0.7	0.1	0.1	0.7
Allergy	0.5	1.1	7.1	-2.7	1.1	0.4	1.3	1.0	-0.8	-0.4	-0.5	0.3	1.1	0.8	-0.2	0.7
Pain all over the body in last month	1.6	1.8	5.4	0.2	-0.7	1.6	-0.1	-2.3	-0.1	-0.2	1.4	1.0	-1.8	-1.7	-1.5	-1.8
Diabetes (self-reported)	1.6	2.4	5.2	-0.2	-2.0	1.2	-1.8	-2.1	-1.3	-0.9	-0.1	0.0	-2.3	-1.4	-2.1	-2.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.8	0.4	0.0	0.5	-0.5	-2.1	1.2	-1.6	0.5	0.8	-2.4	-1.6	-1.6	-2.0
Medication: Ramipril	2.0	2.6	5.9	-1.8	1.0	1.8	2.4	-1.3	2.0	-0.7	2.0	2.2	-0.7	-1.6	-0.9	-1.1
Medication: Simvastatin	0.7	1.0	3.6	-1.2	-0.3	0.8	0.9	-1.5	-0.5	0.2	1.9	1.1	-1.2	-0.9	-1.0	-0.4
Fluid intelligence score	0.1	0.3	1.4	-1.2	0.1	0.2	0.5	0.4	0.7	0.3	0.8	0.4	0.1	0.2	-0.2	0.2
Illnesses of siblings	3.4	4.8	11.4	-0.3	1.5	-2.0	0.4	2.9	-1.3	2.3	-1.9	-1.8	2.7	3.0	2.4	3.4
Neuroticism score	1.0	2.1	5.8	-1.0	-0.4	0.2	1.3	-1.6	0.5	-2.4	-0.3	0.7	-1.5	-2.3	-1.9	-1.9
Weight	0.9	4.3	12.4	0.2	-0.1	2.7	0.4	-3.5	0.9	-1.0	1.1	2.4	-2.9	-2.1	-2.4	-3.0
Impedance of arm (right)	2.8	13.1	35.3	0.8	-0.7	-4.9	-0.4	5.9	-1.9	1.1	-2.8	-4.4	4.8	3.9	4.5	4.3
Arm fat percentage (right)	0.5	1.9	3.6	0.1	-1.4	1.6	0.5	-1.7	-0.2	-1.3	0.2	1.3	-1.6	-1.8	-1.9	-1.9
Trunk fat-free mass	0.6	3.2	11.4	0.6	2.0	2.4	0.9	-3.4	0.8	-0.2	0.4	1.5	-2.5	-1.2	-1.4	-2.5
Hip circumference	1.0	4.2	11.4	-0.3	-0.5	2.8	-0.2	-3.4	0.7	-1.2	1.4	1.9	-2.9	-1.9	-2.6	-2.9
Time employed in main current job	0.6	0.7	5.5	-2.3	-0.6	0.2	0.9	-0.4	-0.2	0.5	0.8	0.9	0.1	0.3	-0.3	0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.9	-0.0	-0.9	-0.3	-0.4	-0.2	0.2	-0.4	-0.9	0.1	-0.1	-0.6	0.2	-0.3
Father’s age at death	0.6	0.9	2.0	0.0	1.2	-0.7	0.6	1.1	-1.1	1.4	-0.1	-0.5	1.1	0.8	0.8	1.2
Worrier / anxious feelings	0.3	0.6	2.2	-1.3	-0.8	-0.2	-0.0	0.4	1.2	-1.5	-0.2	0.3	-0.2	-0.9	-0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.2	0.6	-1.7	0.7	-1.3	-2.4	-0.6	-1.7	-0.1	0.6	-2.3	-1.8	-1.3	-2.5
Falls in the last year	1.3	1.8	6.7	2.6	-0.2	-0.2	-1.6	-1.8	-1.1	-0.4	-1.4	-1.8	-1.6	0.3	-0.7	-0.6
Hair/balding pattern: Pattern 3	1.2	1.8	6.3	1.6	-2.0	-1.0	-2.5	-0.1	-0.8	-0.0	-2.5	-1.6	-0.1	0.1	0.3	0.0
Number of live births	2.9	4.1	12.6	3.5	-0.9	-2.6	-3.0	0.9	-0.5	-0.7	-3.3	-2.8	0.3	1.0	1.4	1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.6	-0.3	2.4	1.2	1.6	-1.6	2.0	-0.2	1.6	1.5	-1.1	-1.0	-0.9	-1.5
Pulse rate	0.7	1.1	4.3	-1.1	-1.2	0.8	-0.5	-0.9	1.4	0.9	1.7	2.1	0.2	-0.2	-0.2	-0.4
Happiness	1.3	1.6	4.6	-0.1	-0.5	-1.7	-0.3	1.5	-0.4	0.6	-2.1	-1.7	1.5	1.0	1.6	1.1
Noisy workplace	0.7	0.8	2.9	-0.7	1.2	-0.2	1.4	-0.1	-0.7	-0.4	-1.7	-1.6	0.1	1.0	-0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.1	0.9	1.4	0.6	-0.9	-1.0	0.5	-0.4	1.4	0.3	-0.9	0.0	-0.8	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	3.0	-1.2	1.5	0.2	1.7	-0.0	-0.5	0.1	-0.6	1.0	0.4	0.1	-0.0	0.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.6	0.5	1.1	0.2	1.1	1.0	-1.1	-0.1	-0.6	-1.3	0.7	0.4	0.6	0.6
Asthma	0.6	1.2	9.4	3.1	-0.6	0.5	-1.1	-0.9	1.1	0.7	-0.5	-0.5	-0.5	-0.2	0.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.5	-1.0	-1.5	0.2	-0.3	-0.5	-0.1	-1.6	0.4	-0.1	-0.9	-1.4	-0.9	-1.0
Medication: Cholesterol lowering	1.5	2.3	9.3	-3.1	-1.1	0.9	1.2	-1.1	-1.7	0.1	2.9	1.4	-0.9	-0.9	-1.2	-0.4
Depression (self-reported)	1.4	1.7	3.6	-0.2	1.1	1.5	0.7	-1.5	1.1	-1.9	0.3	0.3	-1.6	-1.6	-1.7	-1.6
Medication: Lansoprazole	0.7	0.8	2.8	-0.3	-0.0	-1.3	0.6	0.7	-1.7	0.1	-0.6	-1.6	0.6	0.6	0.7	0.7
Prospective memory result	0.3	0.3	0.8	0.8	-0.3	-0.6	0.7	-0.5	0.6	-0.3	0.4	-0.2	-0.6	-0.9	-0.2	-0.7
Lung cancer (father)	2.1	2.5	7.0	-1.6	2.5	1.3	2.4	-0.5	2.6	-0.4	0.0	1.1	-0.9	-1.7	-1.5	-1.3
Illnesses of mother	1.1	1.4	4.2	0.2	-0.2	-1.1	0.3	1.2	-0.4	1.9	-0.6	-0.0	1.7	1.2	1.7	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	6.0	-0.2	2.1	1.5	1.3	-1.9	2.1	-0.2	2.5	1.8	-1.4	-1.0	-0.8	-1.3
Pulse wave Arterial Stiffness index	2.0	2.3	6.0	1.8	-1.2	1.0	-1.6	-2.4	-0.9	-2.0	0.6	0.7	-2.3	-1.5	-1.3	-1.0
Impedance of arm (left)	2.0	9.3	26.8	0.5	-0.5	-3.9	-0.2	5.2	-1.1	1.2	-2.1	-3.4	4.4	3.4	3.9	3.8
Arm fat mass (right)	0.8	3.3	8.1	0.2	-0.8	2.3	0.4	-2.8	0.4	-1.2	0.6	1.9	-2.4	-2.1	-2.3	-2.6
Trunk predicted mass	0.5	3.1	11.3	0.6	2.0	2.4	0.9	-3.4	0.8	-0.2	0.3	1.4	-2.5	-1.2	-1.4	-2.4
Standing height	0.2	2.2	6.0	1.7	2.5	-1.1	0.5	0.8	1.2	1.2	-1.3	-1.6	1.0	1.9	2.2	0.5
Length of working week for main job	0.5	0.5	1.8	-1.2	-1.3	-0.4	-0.9	-0.5	-0.1	-0.1	0.9	0.5	-0.6	-0.3	-0.6	-0.5
Exposure to tobacco smoke at home	1.5	1.7	5.5	-0.1	0.2	1.5	-0.8	-1.2	0.1	-2.4	-0.3	-0.1	-1.9	-1.8	-1.8	-1.6
Breastfed as a baby	0.4	0.6	3.1	0.8	1.8	-0.0	0.3	-0.1	-0.0	-0.2	1.0	-0.3	-1.2	-0.3	-0.8	-0.4
Tense / ‘highly strung’	0.7	1.2	7.1	0.4	0.9	-0.8	0.7	0.2	2.2	-0.7	-2.7	-0.3	0.3	-0.6	0.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	5.3	8.1	17.1	0.2	-0.6	3.3	-0.1	-3.9	2.1	-3.1	1.4	1.6	-3.9	-3.6	-3.9	-4.1
Hair/balding pattern: Pattern 4	0.3	0.6	2.2	-0.2	-1.3	1.4	-0.8	-0.9	-0.4	-0.0	0.1	1.5	-0.5	-0.4	-0.4	-0.5
Birth weight of first child	0.3	0.5	1.0	-0.7	-0.4	0.4	-0.7	0.4	0.2	0.8	0.7	0.6	0.7	1.0	0.8	1.0
Peak expiratory flow (PEF)	0.2	0.4	2.8	0.1	1.7	-0.3	1.1	-0.3	0.3	-0.4	-0.5	-0.6	-0.2	-0.1	0.5	-0.3
Pulse wave reflection index	1.1	1.4	4.9	1.6	-1.2	-0.4	-1.0	-0.3	-0.5	-2.2	-1.4	-1.4	-1.4	-1.0	-0.9	-0.1
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.8	1.6	-1.7	-1.2	-1.0	-0.4	-0.6	-1.6	-1.3	-1.7	-1.2	-1.3	-0.5	-1.2
Loud music exposure frequency	1.2	1.3	2.5	-1.4	0.2	-1.0	1.1	1.3	-1.4	1.1	0.4	-1.2	1.1	1.6	1.4	1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.9	-1.0	-0.6	1.0	0.0	-1.0	0.9	-0.1	0.8	1.4	-0.9	-1.1	-0.7	-1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	1.4	0.1	-0.1	-1.1	-0.7	1.0	-0.4	-0.8	-0.5	-0.8	-0.5	-0.4	-0.4
Blood clot in the leg (DVT)	0.8	1.0	4.1	2.0	-0.4	-1.1	-0.6	-0.3	-0.4	-0.2	-1.9	-1.9	-0.5	-0.4	-0.2	-0.3
Medication: Paracetamol	1.9	3.1	7.3	-1.3	-0.6	2.3	1.3	-2.0	0.5	-1.1	2.1	1.2	-1.9	-2.3	-2.0	-2.7
Headache pain in last month	1.9	3.3	7.4	1.6	-0.2	-2.3	-0.7	1.9	-0.9	0.6	-2.7	-2.6	1.7	1.9	2.2	1.7
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	11.4	3.2	-0.1	-2.4	-2.1	2.0	-0.5	0.3	-3.4	-2.1	1.7	2.0	2.2	1.8
Glaucoma (self-reported)	1.1	1.2	3.9	0.1	-0.8	0.7	0.3	-2.0	-0.2	-0.9	0.6	0.8	-1.9	-1.5	-1.1	-1.4
Gout (self-reported)	1.4	1.9	8.4	-2.2	1.1	-0.5	2.9	0.9	-0.4	1.8	0.5	0.7	1.4	0.6	1.1	1.4
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	8.3	-0.2	-2.9	-0.7	-1.4	1.9	-2.3	1.4	0.6	-0.7	1.6	1.2	1.4	1.3
Medication: Amlodipine	1.3	1.8	3.6	-1.9	0.1	1.5	1.7	-0.9	0.1	-1.1	1.6	0.9	-1.2	-1.1	-1.9	-1.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.1	0.1	0.8	1.8	0.2	-1.2	1.1	0.0	0.9	1.2	-0.8	-0.9	-0.7	-0.7
Birth weight	1.0	2.2	5.1	-1.1	1.7	1.8	1.6	-1.0	1.6	0.1	2.0	2.3	-1.1	-1.2	-1.2	-1.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.9	0.6	-0.6	1.3	-0.6	-1.2	-0.5	-1.1	0.5	0.1	-1.6	-0.8	-1.6	-2.2
High blood pressure (siblings)	2.8	4.0	8.6	-0.4	-0.6	1.8	-0.1	-2.6	1.7	-2.2	1.8	1.9	-2.5	-2.6	-2.4	-2.9
Forced vital capacity (FVC), Best measure	0.2	0.8	2.8	-0.0	0.7	0.9	-0.4	-1.0	1.7	-0.0	1.6	1.3	-0.8	-0.5	-0.2	-0.9
Body fat percentage	0.3	1.1	3.6	-0.2	-1.9	1.2	0.1	-1.1	0.0	-0.7	0.5	1.3	-0.9	-1.2	-1.4	-1.3
Leg fat percentage (right)	0.3	1.2	3.0	-1.0	-1.2	1.3	0.3	-1.2	-0.6	-0.8	0.6	1.2	-1.1	-1.3	-1.7	-1.2
Arm fat-free mass (right)	1.1	5.7	17.9	0.3	1.3	3.0	0.6	-4.2	2.0	-0.6	1.3	2.5	-3.4	-2.1	-2.4	-3.2
Exposure to tobacco smoke outside home	0.7	0.9	3.8	-0.5	0.5	0.2	0.6	-1.5	-0.1	-1.5	0.2	-0.3	-1.9	-0.7	-1.0	-1.0
Comparative body size at age 10	2.3	6.3	10.8	-1.3	-0.2	3.3	0.9	-3.3	1.2	-1.6	2.5	3.1	-3.3	-3.2	-3.1	-2.8
Number of full brothers	1.3	1.7	3.4	1.8	0.7	-1.1	1.3	0.8	1.4	1.4	-1.8	-1.0	1.3	1.2	1.5	1.0
Worry too long after embarrassment	2.6	4.3	9.7	-1.9	-0.7	2.0	0.7	-2.0	1.7	-2.1	2.3	1.2	-2.6	-2.5	-2.5	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.9	-0.1	0.8	0.4	1.2	-0.5	1.4	0.1	0.3	-0.3	-0.1	0.1	0.1	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.9	1.0	-0.7	0.1	-0.5	-0.9	-0.2	0.1	0.2	-0.0	-0.6	-0.3	0.1	-0.2
Number of children fathered	0.5	0.5	2.6	-0.4	-0.9	0.8	0.1	0.7	-1.6	1.0	-0.2	-0.7	0.7	0.0	-0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	2.0	0.4	-0.9	-0.4	-0.1	0.3	0.4	-0.5	0.3	1.4	-0.0	-0.8	-0.3	-0.3
Age at first live birth	0.7	1.3	3.6	-0.8	1.9	-0.4	1.5	1.2	0.6	1.6	-0.1	0.2	1.7	1.1	0.8	1.0
Pulse wave peak to peak time	1.9	2.2	5.5	-1.9	1.5	-0.8	1.8	2.3	1.0	1.8	-0.7	-0.8	2.2	1.4	1.2	0.7
Health satisfaction	1.5	1.9	4.3	-0.4	-2.1	-1.3	-0.5	1.1	-2.0	1.9	-0.2	-0.8	1.5	1.4	1.6	1.5
Shortness of breath walking on level ground	0.9	1.1	2.6	-0.3	-1.3	1.5	-0.5	-1.4	0.7	0.3	1.6	0.7	-1.0	-0.9	-1.0	-1.0
Qualifications: College or University degree	0.2	0.7	4.4	-0.3	0.5	0.9	-0.1	-0.6	-0.1	-0.4	2.1	1.2	-0.5	0.1	-0.9	-0.1
Eye problems/disorders: None of the above	0.6	0.7	3.7	-0.6	1.9	-0.2	0.6	0.7	0.3	1.2	0.8	0.1	0.7	1.1	0.7	0.8
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.8	0.8	-0.1	0.8	-0.3	-1.8	0.2	-2.1	-1.0	1.0	-1.7	-2.4	-1.6	-2.3
Emphysema/chronic bronchitis	0.6	0.6	3.2	1.1	0.6	-0.9	-0.1	0.4	-1.8	0.5	0.2	-1.1	-0.0	0.3	0.9	0.2
Medication for pain relief, constipation, heartburn	1.1	1.9	5.4	0.9	2.3	-1.1	-0.2	1.2	1.1	1.2	-0.5	0.4	1.6	2.0	1.6	1.9
Neck or shoulder pain in last month	2.6	3.7	8.6	0.4	-1.1	2.1	-0.4	-2.4	0.4	-2.8	0.3	-0.4	-2.9	-2.7	-2.2	-2.9
Medication: Blood pressure	2.5	4.5	9.8	-2.6	0.4	3.1	1.9	-2.5	1.4	-0.5	2.2	2.3	-2.1	-2.1	-2.2	-2.4
Angina (self-reported)	1.0	1.3	9.9	-0.4	-1.4	-0.7	-0.8	-0.6	-3.1	-0.3	0.1	-1.8	-0.8	0.2	-0.0	0.0
Migraine (self-reported)	0.7	0.8	3.4	-1.4	0.9	-0.6	1.8	1.1	-0.2	-0.0	-0.5	-1.3	0.7	0.1	0.5	0.5
Medication: Ibuprofen	0.8	1.0	2.3	-1.1	-1.4	0.5	-0.1	-0.6	-0.1	-1.5	0.0	-0.4	-1.0	-1.5	-1.3	-1.4
Medication: Allopurinol	0.5	0.7	2.6	-1.6	-0.3	0.9	1.4	-0.5	-0.7	0.6	1.1	1.1	-0.1	-0.5	-0.5	-0.2
Medication: Omeprazole	0.3	0.4	1.9	0.4	-0.7	-0.1	0.5	-0.3	-1.4	-0.5	-0.1	-0.7	-0.6	-0.2	-0.8	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	3.9	-0.0	-0.7	0.6	0.7	0.4	2.0	0.6	0.7	0.6	0.5	-0.3	0.2	-0.1
Mean time to correctly identify matches	0.1	0.2	1.0	0.4	0.5	0.2	0.4	-0.2	-1.0	0.7	0.2	0.4	0.1	-0.4	-0.0	0.2
Heart disease (mother)	0.7	0.8	1.9	-1.4	0.5	0.1	1.2	-0.3	1.1	-1.0	1.1	0.4	-0.6	-0.8	-1.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.9	-1.2	-0.2	1.6	0.5	-1.4	0.6	-1.1	1.4	0.6	-2.1	-1.5	-2.2	-2.1
Whole body fat mass	0.5	2.3	5.1	-0.1	-1.0	2.0	0.6	-2.2	0.4	-0.6	0.9	1.8	-1.8	-1.7	-1.9	-2.1
Leg fat mass (right)	0.8	3.0	5.9	-0.9	-0.6	2.3	0.8	-2.4	0.5	-0.9	1.2	2.2	-2.0	-2.0	-2.3	-2.3
Arm predicted mass (right)	1.2	6.1	19.7	0.3	1.5	3.3	0.5	-4.4	1.7	-0.6	1.4	2.6	-3.5	-2.1	-2.5	-3.3
Pulse rate, automated reading	1.0	3.3	10.4	-0.1	-1.5	-1.4	0.4	1.5	-0.7	3.2	0.4	0.1	2.6	2.2	2.7	2.4
Alcohol intake frequency.	1.0	2.4	7.1	0.8	-0.9	-2.2	-0.9	0.9	-2.0	-0.2	-2.2	-2.7	0.6	1.9	1.4	1.1
Comparative height size at age 10	0.4	2.3	5.5	1.3	1.4	-1.5	0.4	1.7	-0.2	0.8	-1.4	-2.3	1.6	1.9	2.3	1.2
Number of full sisters	0.7	0.8	5.4	2.3	-0.4	-0.0	-1.0	-0.5	-0.4	0.2	-1.4	-0.2	0.2	1.1	0.3	0.3
Suffer from ‘nerves’	1.1	1.8	4.4	1.8	-1.0	-1.4	-0.7	0.8	-1.3	1.5	-2.1	-1.0	1.4	1.1	1.3	1.2
Overall health rating	0.8	1.7	6.2	0.5	-2.5	-1.8	0.0	0.7	-0.7	0.6	-2.4	-1.6	0.9	0.6	1.3	0.6
Chest pain or discomfort	1.5	2.1	6.6	-0.9	-0.3	1.2	-0.0	-2.6	0.7	-0.8	2.1	2.0	-2.0	-1.3	-1.3	-1.3
Had major operations	0.6	0.7	3.7	0.5	-1.9	-0.5	-0.7	-0.7	-1.3	0.7	-1.2	0.3	0.2	0.5	0.4	0.0
Age at last live birth	0.2	0.2	1.2	0.5	1.1	0.1	0.2	-0.3	0.6	0.4	-0.8	0.3	0.3	0.2	0.0	0.1
Family relationship satisfaction	0.2	0.3	1.0	0.3	-0.4	0.0	-0.5	0.3	0.1	1.0	-0.6	-0.4	0.6	0.7	0.6	0.6
Leg pain on walking	0.8	1.0	3.1	1.2	-0.4	0.5	-0.2	-1.8	-0.0	-0.1	1.0	0.1	-1.6	-1.1	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	0.3	-0.8	-0.4	-0.1	-0.8	0.1	-1.4	-0.9	-0.3	-1.0	-0.6	-0.9	-1.2
Commuting to job workplace: Car/motor vehicle	1.7	2.0	5.4	-1.3	1.3	0.3	1.9	-0.7	2.3	-1.4	1.0	0.3	-1.1	-1.8	-1.6	-1.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.5	-1.6	-0.0	0.2	0.5	1.2	0.1	0.7	1.0	-0.1	0.6	-0.1	-0.2	0.9
Medication: Aspirin	1.1	1.4	7.8	-0.1	-2.8	-0.6	-1.6	-0.0	-2.2	-0.4	-0.9	-1.3	-0.5	-0.0	-0.4	0.1
Supplements: Vitamin C	0.2	0.2	1.0	1.0	-0.3	0.0	0.0	-0.4	-0.6	0.1	0.4	0.8	-0.2	-0.7	0.2	-0.5
Knee pain experienced in last month	1.5	2.3	5.5	0.3	-0.0	1.5	-0.5	-2.2	0.8	-1.9	-1.0	0.5	-2.1	-2.1	-1.5	-2.3
Hypertension (Self-reported)	1.0	2.8	6.0	-2.4	-1.5	2.5	0.5	-1.8	0.5	0.2	1.8	2.0	-1.6	-1.2	-1.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.8	-0.9	0.5	0.3	0.7	-0.5	-0.9	-0.9	1.3	0.4	-0.7	-0.3	-0.3	-0.4
Illnesses of father: Heart disease	0.5	0.7	1.9	-1.4	0.4	0.2	0.8	-0.8	-1.2	-0.7	1.1	0.2	-0.8	-0.8	-0.7	-0.6
Illnesses of siblings: Diabetes	1.4	1.7	6.3	0.7	-2.1	0.7	-2.5	-1.5	-0.1	-0.4	1.4	0.8	-1.2	-1.2	-1.2	-1.3
Smoking status: Previous	1.3	1.9	8.9	0.8	3.0	1.2	0.4	-1.5	1.6	-1.7	0.4	0.0	-1.4	-0.8	-0.7	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.0	-0.3	0.5	-0.0	-0.1	0.6	0.4	-0.2	0.2	0.6	0.7	0.8	0.1
Whole body fat-free mass	0.8	4.8	15.6	0.6	1.6	2.8	1.0	-3.9	1.5	-0.5	1.0	2.2	-3.0	-1.8	-2.0	-3.1
Leg fat-free mass (right)	1.5	7.8	22.2	0.8	1.1	3.3	0.9	-4.7	2.2	-1.2	1.8	3.0	-3.8	-2.8	-2.8	-4.0
Arm fat percentage (left)	0.7	2.8	5.0	-0.1	-1.3	2.2	0.6	-2.2	0.1	-1.4	0.8	2.0	-1.9	-2.2	-2.2	-2.1
Average weekly red wine intake	0.5	0.7	2.3	0.5	0.1	-0.7	-1.5	0.5	0.1	1.4	0.4	-0.4	0.7	0.8	0.9	1.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.9	-0.2	-0.8	1.4	-0.7	-0.4	-0.4	-0.5	0.5	0.4	-0.4	-0.8	-0.9	-0.9
Mood swings	0.3	0.5	1.4	-1.1	-0.4	0.2	0.7	-0.8	0.4	-1.2	0.5	0.9	-0.4	-0.8	-0.6	-0.6
Loneliness, isolation	1.2	1.7	3.6	1.0	-1.5	-0.6	-1.9	-1.6	0.1	-1.9	-1.1	-0.5	-1.6	-0.9	-1.2	-1.4
Long-standing illness, disability or infirmity	0.6	1.0	3.9	0.5	-1.1	0.8	0.1	-1.9	-2.0	-0.2	0.4	0.3	-1.1	-0.4	-0.6	-1.0
Ever had bowel cancer screening	3.5	4.1	8.7	-0.8	1.2	2.1	1.1	-2.5	1.3	-1.4	1.9	2.1	-2.5	-2.6	-2.9	-2.7
Diabetes diagnosed by doctor	1.4	2.3	5.9	0.2	-1.5	1.0	-1.9	-2.1	-1.2	-0.9	0.5	0.2	-2.4	-1.4	-2.0	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	-0.2	-0.3	0.7	-0.3	-1.0	1.4	-1.2	1.7	0.2	-1.6	-1.5	-1.3	-1.5
Friendships satisfaction	0.1	0.2	0.7	0.2	-0.0	0.2	-0.1	-0.7	0.8	0.3	0.4	0.2	-0.3	-0.0	-0.5	-0.5
Qualifications: nursing, teaching	0.8	1.2	2.4	0.2	-1.0	1.5	-1.3	-1.2	0.8	-0.8	1.4	1.0	-1.2	-0.8	-1.2	-1.2
Commuting to job workplace: Walk	1.5	1.7	3.9	1.3	-1.7	-0.8	-2.0	0.9	-1.8	1.0	-1.0	-1.0	0.9	1.5	1.2	1.0
Eye problems/disorders: Cataract	0.3	0.4	1.6	-0.7	-0.6	-0.1	0.5	0.2	0.8	-1.3	-0.5	0.2	0.2	-0.7	-0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	5.2	-1.1	1.0	1.3	0.6	-2.1	1.6	-1.8	1.4	0.9	-2.3	-1.4	-2.1	-1.7
Medication for cholesterol	1.0	1.5	3.5	-0.3	0.7	-0.5	1.2	1.5	0.4	1.7	0.3	-0.5	1.9	1.6	1.7	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.9	-0.3	0.8	1.1	0.6	-1.7	-0.8	0.9	1.7	1.4	-1.0	-0.6	-0.9	-0.7
Back pain experienced in last month	1.7	2.5	5.1	0.7	-1.3	-0.3	-1.7	-1.5	-0.0	-2.3	-2.2	-2.2	-2.1	-1.4	-1.3	-1.8
Mineral and other dietary supplements	0.5	0.7	2.0	0.7	0.3	-0.8	-0.8	-0.1	-1.4	-1.1	-1.3	-1.3	-0.3	0.6	0.0	0.3
Breast cancer (self-reported)	0.3	0.3	1.2	-0.1	-1.1	-0.6	-0.7	0.3	0.4	0.8	-0.4	0.4	0.5	0.1	0.7	0.3
Asthma (self-reported)	0.5	1.0	8.1	2.8	-0.7	0.4	-1.0	-0.9	1.1	0.6	-0.3	-0.5	-0.5	-0.3	0.6	-0.4
Osteoporosis (self-reported)	0.5	0.6	3.4	0.0	1.4	-0.0	1.9	-0.1	1.0	-0.7	0.2	0.1	-0.1	-0.7	-0.0	0.1
Osteoarthritis (self-reported)	0.2	0.3	1.0	0.4	-0.2	-0.1	1.0	-0.8	0.3	-0.1	-0.2	0.1	-0.7	-0.1	-0.9	-0.4
Medication: Aspirin	1.4	1.8	10.2	-0.0	-3.2	-0.9	-1.8	0.3	-2.3	0.3	-1.1	-1.6	-0.0	0.5	0.0	0.5
Medication: Gliclazide	2.9	3.3	6.9	0.3	0.1	2.1	-0.7	-2.6	1.4	-2.2	0.8	0.9	-2.5	-2.0	-2.4	-2.6
Illnesses of father: None of the above (group 1)	0.8	1.0	2.5	0.1	0.1	-0.7	-0.4	1.3	0.2	1.3	-1.4	-0.6	1.6	1.0	1.2	1.1
Smoking status: Current	0.7	1.1	5.5	-0.2	-1.6	-0.2	-0.5	0.5	-1.9	0.4	-2.3	-0.8	0.7	-0.0	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	8.6	-2.4	1.7	2.5	2.1	-1.7	2.7	-0.4	2.9	2.7	-1.5	-2.1	-2.2	-1.6
Whole body water mass	0.9	5.0	15.9	0.6	1.7	2.8	1.1	-4.0	1.5	-0.6	0.9	2.1	-3.1	-1.9	-2.1	-3.2
Leg predicted mass (right)	1.4	7.7	21.8	0.7	1.1	3.3	1.0	-4.7	2.2	-1.2	1.7	3.0	-3.8	-2.8	-2.8	-4.0
Arm fat mass (left)	0.9	3.9	9.4	0.3	-0.8	2.5	0.5	-3.1	0.7	-1.4	0.7	2.0	-2.7	-2.3	-2.6	-2.8
Number of self-reported non-cancer illnesses	2.0	3.4	9.0	-1.5	-0.7	2.7	0.8	-2.4	0.1	0.5	3.0	2.3	-1.8	-1.8	-1.6	-2.2
Average weekly champagne plus white wine intake	1.8	2.5	7.7	-2.8	0.6	2.6	1.6	-0.7	0.6	-0.2	2.2	1.8	-0.8	-1.2	-1.8	-0.8
Miserableness	1.5	2.5	9.7	-0.7	0.7	-0.2	1.6	-1.1	1.5	-3.1	-0.7	-0.9	-1.7	-2.1	-2.1	-1.7
Guilty feelings	4.8	7.3	16.4	-1.1	-1.3	2.7	-0.8	-3.5	0.1	-3.0	1.7	2.3	-3.5	-3.3	-4.1	-3.8
Wears glasses or contact lenses	0.6	0.7	2.8	-1.7	-0.1	0.1	-0.3	1.1	-1.2	0.5	0.8	0.7	1.1	0.4	0.2	0.6
Ever taken oral contraceptive pill	0.9	1.0	2.3	0.9	1.0	1.2	-0.0	-1.4	-0.2	-0.6	0.5	1.0	-1.2	-1.5	-1.2	-0.9
Hearing aid user	0.4	0.4	1.8	0.5	0.4	-0.6	0.8	0.4	0.2	0.6	-0.6	-1.4	0.2	0.9	0.5	0.4
Mother’s age at death	1.4	1.7	6.3	0.6	2.5	0.9	1.2	-1.5	-0.5	-1.2	1.1	-0.3	-2.0	-0.8	-1.6	-1.1
Financial situation satisfaction	0.3	0.3	1.5	-0.9	-0.4	-0.7	0.2	0.4	-0.1	-0.1	-1.2	-0.6	0.4	0.2	0.5	-0.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.7	0.5	0.7	-1.9	0.7	1.3	0.6	0.4	-0.8	-1.4	0.6	0.8	0.3	0.9
Commuting to job workplace: Public transport	0.9	1.0	2.3	0.3	-0.9	0.2	-1.5	1.0	-0.1	1.5	-0.9	0.4	1.5	0.9	1.3	1.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.6	-0.4	-1.5	0.8	0.4	-1.5	-1.3	-0.6	0.8	1.0	-1.6	-1.0	-1.3	-0.9
Medication: Blood pressure	0.2	0.4	2.4	-1.0	-1.2	-0.2	0.2	-0.4	-1.5	0.0	-0.3	0.1	-0.3	-0.1	-0.4	-0.3
Pain type(s) experienced in last month: Hip pain	3.8	4.8	10.9	0.5	-0.3	2.7	-0.5	-3.2	1.6	-2.3	0.7	1.1	-3.2	-2.7	-2.4	-3.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.4	0.9	-0.5	-0.7	-0.1	0.9	0.7	1.5	-1.0	-0.7	0.9	0.3	1.0	0.7
High cholesterol (Self-reported)	0.6	1.1	3.4	-1.5	-0.8	0.4	0.0	-1.0	-1.5	-0.4	1.8	0.7	-1.1	-0.9	-1.2	-0.8
Medication: Bendroflumethiazide	0.6	1.0	3.4	-1.8	-0.7	0.9	0.1	-0.5	1.3	-1.1	0.7	1.1	-0.8	-0.7	-1.1	-1.1
Medication: Paracetamol	1.1	1.7	4.3	-0.6	-1.3	1.5	0.2	-1.6	-0.1	-0.9	1.2	0.6	-1.5	-1.7	-1.6	-2.1
Medication: Lisinopril	1.2	1.5	8.8	-3.0	-1.6	-0.2	1.0	0.3	0.6	2.0	0.7	0.8	0.6	0.7	-0.1	0.7
Medication: Atorvastatin	0.5	0.6	2.5	-1.2	-0.8	-0.1	-0.1	-0.4	-1.6	-0.8	0.5	0.2	-0.7	-0.3	-0.8	-0.6
Illnesses of father: High blood pressure	0.7	0.9	2.8	-0.9	0.6	0.6	0.8	-1.4	0.6	-0.4	1.5	1.7	-0.9	-0.4	-1.0	-0.6
Alcohol drinker status: Never	0.5	0.6	4.5	-2.1	-0.2	-0.3	1.2	-0.3	-0.5	0.1	1.1	0.4	-0.2	0.2	-0.4	0.4
Ever smoked	0.7	1.2	3.7	1.8	1.6	-0.3	0.2	-0.5	-0.0	-1.3	-1.9	-1.9	-0.7	-0.3	0.1	-0.7
Basal metabolic rate	0.8	4.6	15.1	0.5	1.3	2.8	0.8	-3.9	1.4	-0.6	0.9	2.2	-3.0	-1.9	-2.0	-3.1
Leg fat percentage (left)	0.6	2.0	5.2	-0.7	-1.8	1.5	-0.2	-1.7	-0.6	-1.1	0.8	1.3	-1.7	-1.7	-2.3	-1.5
Arm fat-free mass (left)	0.8	3.9	13.6	0.4	1.0	2.4	0.5	-3.7	1.6	-0.6	0.6	1.7	-3.0	-1.6	-2.0	-2.8
Number of operations (self-reported)	3.5	5.1	12.3	0.7	-1.2	1.7	0.1	-3.3	1.2	-3.1	-0.7	0.8	-3.5	-2.9	-2.9	-3.1
Average weekly beer plus cider intake	0.2	0.3	2.2	0.4	0.1	-0.1	0.9	0.4	1.5	-0.5	-0.4	-0.7	0.1	-0.2	0.1	-0.0
Irritability	4.1	6.9	15.8	-0.6	0.4	1.6	0.8	-3.6	0.9	-3.7	1.2	0.8	-4.0	-3.7	-3.8	-3.6
Risk taking	0.6	0.9	2.7	0.6	-1.2	0.8	-0.4	-1.6	0.1	-1.4	0.4	0.8	-1.4	-0.5	-0.9	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.6	0.2	-1.0	0.2	0.3	0.9	-0.9	0.9	-1.3	0.1	1.0	0.4	0.7	0.6
Fractured/broken bones in last 5 years	2.1	2.7	5.9	0.6	0.1	2.2	-0.1	-2.3	2.2	-0.6	1.0	2.4	-1.8	-1.8	-1.6	-1.9
Age started oral contraceptive pill	1.1	1.4	4.5	-1.1	-0.0	1.8	-0.2	-0.3	0.1	-0.1	2.1	1.2	-1.1	-1.0	-2.0	-1.1
Diastolic blood pressure, automated reading	0.1	0.4	3.3	-0.5	-1.8	-0.2	0.1	-0.2	0.1	0.6	0.3	0.6	0.4	-0.1	-0.2	0.3
Ever depressed for a whole week	1.2	1.4	6.9	-0.9	-2.6	0.6	-1.8	-1.0	-0.8	-1.4	0.3	0.3	-1.0	-0.6	-1.1	-1.0
Unable to work because of sickness or disability	1.5	2.0	5.5	2.2	-2.3	-0.4	-2.2	0.4	-1.9	1.0	-1.5	-1.2	0.5	1.0	0.9	0.4
Commuting to job workplace: Cycle	0.2	0.2	1.0	0.6	0.1	0.4	-0.5	-1.0	-0.4	-0.5	0.2	0.3	-0.7	-0.3	0.1	-0.3
Myopia	0.8	1.1	3.0	-1.0	-0.1	-0.7	0.5	1.5	-0.1	0.7	-0.1	0.3	1.6	1.6	1.7	1.4
Vascular/heart problems diagnosed by doctor	1.5	4.1	8.9	3.0	1.2	-2.9	-0.8	2.2	-0.7	-0.0	-2.6	-2.6	1.9	1.6	2.1	2.1
Cholesterol lowering medication	0.2	0.3	1.3	-0.0	-0.8	-0.5	-0.8	-0.3	-1.2	-0.5	-0.2	-0.0	-0.7	-0.4	-0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.9	0.1	-0.8	-0.0	1.1	-0.0	-1.7	-0.0	-0.3	-0.7	-0.2	-0.1	-0.6	-0.2
Pain experienced in last month	1.3	2.1	4.9	-0.3	0.6	-0.4	0.9	1.8	0.1	2.2	1.4	1.4	2.1	1.9	1.2	2.2
Supplements: Calcium	0.2	0.2	1.3	0.1	0.0	-0.1	1.2	0.1	0.2	-0.8	0.5	-0.3	-0.2	-0.2	-0.5	-0.1
Basal cell carcinoma (self-reported)	0.8	0.9	3.3	0.9	1.8	-0.6	0.7	0.5	1.0	1.4	-1.0	-0.2	1.0	0.1	1.3	0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.1	5.4	-2.3	-1.0	-0.4	1.7	0.5	-0.2	1.4	0.6	0.3	0.9	0.4	0.2	0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.7	1.9	-0.4	-1.0	-0.5	0.1	-0.1	0.0	-1.7	-1.8	-0.1	-0.2	0.2	-0.0
Heart disease (siblings)	3.4	4.1	9.4	-0.5	0.6	1.8	1.3	-2.8	1.7	-2.0	1.4	1.6	-2.6	-2.5	-2.5	-3.1
Alcohol drinker status: Previous	0.2	0.3	0.9	-0.7	-0.2	0.3	-0.1	-0.8	1.0	-0.4	0.7	0.6	-0.6	0.1	-0.2	-0.3
Pack years of smoking	0.2	0.4	2.0	-0.4	0.1	0.5	1.4	-0.3	-0.7	0.5	-0.9	0.7	0.2	0.0	-0.1	0.1
Impedance of whole body	2.9	14.7	38.7	0.3	-1.0	-5.1	-0.8	6.2	-1.5	1.9	-2.5	-4.5	5.2	4.5	4.7	4.9
Leg fat mass (left)	1.0	3.9	8.4	-0.6	-0.7	2.5	0.5	-2.9	0.6	-1.1	1.4	2.3	-2.5	-2.4	-2.7	-2.6
Arm predicted mass (left)	0.8	4.0	14.1	0.6	0.8	2.4	0.2	-3.8	1.5	-0.6	0.5	1.8	-3.0	-1.7	-2.0	-2.9