Best TWAS P=1.02e-08 · Best GWAS P=1.7e-09 conditioned to 5.36e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SETD5-AS1 | 0.18 | 0.17 | lasso | 9 | 0.15 | 3.3e-12 | 5.4 | -5.3 | 1.2e-07 | -0.49 | 0.08 | 0.92 | FALSE |
2 | GTEx | Adipose Subcutaneous | RP11-380O24.1 | 0.07 | 0.09 | lasso | 5 | 0.08 | 8.3e-07 | 5.2 | -5.3 | 1.1e-07 | -0.43 | 0.08 | 0.92 | FALSE |
3 | GTEx | Breast Mammary Tissue | SETD5-AS1 | 0.13 | 0.11 | lasso | 2 | 0.06 | 4.2e-04 | 5.2 | -5.5 | 5.0e-08 | -0.43 | 0.08 | 0.86 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | SETD5-AS1 | 0.19 | 0.04 | lasso | 4 | 0.03 | 3.6e-02 | 5.2 | -5.2 | 2.3e-07 | -0.55 | 0.08 | 0.46 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | SETD5-AS1 | 0.24 | 0.25 | lasso | 4 | 0.25 | 1.2e-18 | 5.4 | -5.4 | 5.6e-08 | -0.43 | 0.08 | 0.92 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | RP11-380O24.1 | 0.38 | 0.32 | lasso | 6 | 0.31 | 5.8e-24 | 5.4 | -5.6 | 2.2e-08 | -0.43 | 0.08 | 0.92 | FALSE |
7 | GTEx | Esophagus Mucosa | RP11-380O24.1 | 0.24 | 0.18 | lasso | 7 | 0.16 | 3.5e-11 | 5.4 | -5.4 | 5.3e-08 | -0.41 | 0.08 | 0.92 | FALSE |
8 | GTEx | Esophagus Muscularis | SRGAP3 | 0.52 | 0.10 | enet | 20 | 0.23 | 4.1e-14 | 5.6 | 5.3 | 1.4e-07 | 0.55 | 0.07 | 0.93 | FALSE |
9 | GTEx | Muscle Skeletal | RP11-380O24.1 | 0.17 | 0.11 | lasso | 6 | 0.12 | 1.9e-11 | 5.4 | -5.5 | 3.2e-08 | -0.40 | 0.08 | 0.92 | FALSE |
10 | GTEx | Pancreas | SETD5-AS1 | 0.21 | 0.09 | enet | 14 | 0.14 | 1.2e-06 | 5.4 | -5.1 | 3.0e-07 | -0.57 | 0.09 | 0.91 | FALSE |
11 | GTEx | Thyroid | THUMPD3 | 0.24 | 0.10 | lasso | 7 | 0.10 | 4.6e-08 | 5.6 | -5.5 | 3.7e-08 | -0.38 | 0.06 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LOC440944 | 0.07 | 0.02 | blup | 62 | 0.03 | 1.1e-02 | 5.4 | -5.7 | 1.0e-08 | -0.50 | 0.01 | 0.65 | TRUE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC440944 | 0.04 | 0.05 | enet | 10 | 0.05 | 6.0e-06 | 5.4 | -5.2 | 2.2e-07 | -0.44 | 0.01 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CIDECP | 0.08 | 0.03 | lasso | 1 | 0.02 | 7.8e-04 | 5.5 | 5.5 | 3.3e-08 | -0.06 | 0.00 | 0.92 | TRUE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | VHL | 0.04 | 0.00 | blup | 61 | 0.02 | 1.7e-03 | 1.6 | -5.2 | 1.7e-07 | 0.05 | 0.01 | 0.27 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VHL | 0.03 | 0.00 | blup | 61 | 0.01 | 8.2e-02 | 4.3 | -5.2 | 2.7e-07 | 0.09 | 0.01 | 0.29 | FALSE |