Best TWAS P=1.24e-11 · Best GWAS P=5.79e-12 conditioned to 2.45e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZNF501 | 0.19 | 0.14 | lasso | 4 | 0.12 | 3.4e-07 | -5.0 | -5.7 | 9.2e-09 | -0.08 | 0.36 | 0.59 | FALSE |
| 2 | GTEx | Artery Aorta | ZNF502 | 0.25 | 0.24 | lasso | 3 | 0.24 | 1.8e-13 | -5.0 | -5.3 | 9.3e-08 | -0.08 | 0.49 | 0.51 | FALSE |
| 3 | GTEx | Artery Tibial | ZNF501 | 0.11 | 0.08 | lasso | 2 | 0.06 | 3.8e-05 | -5.0 | -5.2 | 1.7e-07 | -0.07 | 0.34 | 0.51 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | LARS2 | 0.25 | 0.00 | enet | 16 | 0.01 | 1.2e-01 | -1.5 | 5.4 | 5.6e-08 | 0.57 | 0.04 | 0.60 | TRUE |
| 5 | GTEx | Esophagus Mucosa | CDCP1 | 0.15 | 0.03 | lasso | 9 | 0.06 | 1.4e-04 | -1.1 | 5.4 | 7.7e-08 | 0.49 | 0.07 | 0.81 | FALSE |
| 6 | GTEx | Pancreas | ZNF502 | 0.27 | 0.12 | lasso | 3 | 0.09 | 1.7e-04 | -5.0 | -5.2 | 1.9e-07 | -0.08 | 0.05 | 0.57 | FALSE |
| 7 | GTEx | Thyroid | ZNF501 | 0.10 | 0.04 | enet | 15 | 0.07 | 3.6e-06 | -5.0 | -5.1 | 2.8e-07 | -0.10 | 0.44 | 0.48 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | TMEM42 | 0.06 | 0.01 | bslmm | 382 | 0.03 | 1.0e-04 | -5.0 | -5.2 | 1.9e-07 | -0.09 | 0.07 | 0.07 | FALSE |
| 9 | YFS | Blood | ZNF35 | 0.16 | 0.06 | bslmm | 327 | 0.12 | 2.8e-36 | 5.5 | -6.8 | 1.2e-11 | -0.05 | 0.05 | 0.95 | TRUE |