Hub : Genes

ZNF35

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.157 0.0354 0.0000 0.063 0.090 0.116 0.117 0.113 8.5e-20 5.5e-28 6.5e-36 2.8e-36 6.7e-35
2 TCGA Thyroid Carcinoma 0.027 0.0190 0.0017 0.014 0.025 0.009 NA 0.017 1.6e-02 1.5e-03 4.0e-02 NA 8.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.6 5.6 10.4 -0.9 3.2
Bipolar Disorder or Schizophrenia 0.8 2.0 3.8 0.4 2.0
Depressed Affect (Nagel 2018) 2.5 5.3 5.4 -2.3 2.3
Depression (Nagel 2018) 4.1 6.1 11.5 -0.9 3.4
Intelligence (Savage-Jansen 2018) 3.2 9.7 12.2 2.7 -3.5
Neuroticism (Nagel 2018) 4.4 10.5 13.0 -2.8 3.6
Schizophrenia (2018) 0.4 0.8 1.6 1.3 -0.1
Schizophrenia vs Biploar Disorder 1.8 2.4 3.5 1.1 -1.9
Worry (Nagel 2018) 4.3 9.0 14.5 -1.9 3.8
Alzheimer’s Disease (in mother) 2.7 3.1 3.4 1.7 -1.8
Alzheimer’s Disease (in father) 0.3 0.3 0.7 0.8 -0.0
Alzheimer’s Disease (including proxy) 0.8 1.2 1.7 1.3 -0.9
Crohns Disease (2017) 0.1 0.3 0.4 -0.7 0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.1 0.7
Ulcerative Colitis (UC) 0.2 0.4 0.7 0.8 0.0
Major Depression (MDD) 2.7 3.3 6.7 -0.1 2.6
Reaction Time 2.0 3.8 7.3 -2.7 0.6
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.1 1.8 -0.5
Breast Cancer 1.2 2.9 3.8 -1.4 2.0
Ovarian Cancer 0.1 0.1 0.2 -0.1 0.4
Prostate Cancer 0.8 1.1 1.9 -1.4 0.5
Age at First Birth 1.6 2.3 3.8 0.9 -2.0
Bipolar Disorder (2011) 0.9 0.9 1.1 -0.8 1.0
Body Mass Index (BMI) (2010) 4.2 5.7 10.9 -3.3 0.7
Coronary Artery Disease (CAD) 0.8 0.9 1.8 0.0 1.4
Crohns Disease (2012) 0.0 0.0 0.0 -0.1 0.2
Mean Putamen Volume 0.3 0.3 0.3 -0.6 0.5
Fasting Glucose 1.4 1.6 2.9 -0.6 1.7
HbA1C 2.2 2.4 4.5 -0.6 -2.1
HDL Cholesterol 1.5 2.5 5.0 2.2 -0.3
LDL Cholesterol 0.6 1.0 1.9 -0.1 -1.4
Lupus 0.3 0.4 0.4 -0.6 -0.6
Neuroticism (2016) 3.8 5.5 8.2 -1.6 2.9
Primary Biliary Cirrhosis 1.0 1.5 1.7 -1.3 -1.1
Rheumatoid Arthritis 1.4 2.0 3.5 -1.9 -0.7
Schizophrenia (2014) 0.5 1.1 2.1 1.4 -0.3
Triglycerides 1.4 2.3 3.2 -1.8 -1.2
Type 2 Diabetes (T2D) (2012) 2.7 3.2 4.2 -2.1 -1.4
Ulcerative Colitis 2.9 4.2 6.7 1.3 2.6
Blood Eosinophil Count 0.0 0.1 0.2 -0.1 -0.5
Blood Platelet Count 0.3 3.6 6.6 -0.8 2.6
Blood Red Count 0.7 6.5 12.4 -3.5 -0.7
Blood White Count 0.3 1.9 3.8 -1.9 0.3
Heel T-Score 0.5 4.1 8.1 -0.3 2.8
BMI 4.0 23.2 46.0 -6.8 -0.6
Height 0.1 1.3 1.9 1.4 0.8
Waist Hip Ratio (WHR) 0.1 0.6 1.0 0.5 1.0
Systolic Blood Pressure 0.2 1.2 2.5 -1.6 -0.1
Smoking Status 0.3 0.8 1.1 1.0 0.8
Allergy or Eczema 0.2 0.5 0.9 -0.4 0.9
Cardiovascular Disease 0.8 2.6 5.1 -2.3 -0.0
Hypothyroidism (self reported) 1.9 4.3 8.1 -2.9 -0.7
Respiratory disease 0.4 0.8 1.6 -1.3 0.2
Type 2 Diabetes (T2D) (2018) 1.3 2.4 4.4 -2.1 -0.6
Lung FEV1/FVC ratio 1.3 6.8 11.0 -1.6 -3.3
Lung FVC 1.6 8.1 15.2 3.9 1.0
Neuroticism 3.4 8.1 9.6 -2.6 3.1
Chronotype (morning person) 3.6 8.4 15.3 -3.9 1.2
Hair Pigment 0.1 1.5 1.7 -1.1 1.3
Tanning 0.1 1.5 2.9 -0.3 -1.7
Hand grip strength (left) 0.2 0.6 1.2 0.1 1.1
Number of treatments/medications taken 4.1 7.4 7.6 -2.7 2.7
Average weekly spirits intake 0.7 0.9 1.6 -1.2 0.4
Sensitivity / hurt feelings 2.8 4.8 5.3 -2.3 2.1
Frequency of depressed mood in last 2 weeks 5.0 7.0 13.1 -1.0 3.6
Hearing difficulty/problems: Yes 2.1 3.1 4.8 2.2 -1.2
Relative age of first facial hair 0.2 0.3 0.5 0.7 -0.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.7 0.4 1.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 -0.7 0.2
Ever had hysterectomy (womb removed) 0.6 0.6 1.1 -1.0 0.5
Systolic blood pressure, automated reading 0.9 2.5 5.1 -2.3 -0.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.9 -0.9 0.1
Angina 2.3 3.0 4.7 -2.2 1.1
Medication for hormone replacement therapy 1.4 1.6 1.7 -1.2 1.3
Vitamin and mineral supplements 2.4 3.3 3.7 -1.7 -1.9
Supplements: Zinc 3.4 3.7 4.9 2.2 1.6
Medication: Co-codamol 1.3 1.5 2.0 -1.0 1.4
Medication: Metformin 3.4 4.8 8.6 -2.9 -1.0
Diabetes (father) 1.1 1.3 2.2 0.6 -1.5
Diabetes (mother) 0.0 0.0 0.1 0.3 -0.1
Severe depression (siblings) 0.4 0.5 1.0 -1.0 0.1
Pack years adult smoking proportion 1.6 2.4 4.4 -0.7 2.1
Impedance of leg (right) 1.2 5.7 7.1 2.1 2.7
Leg fat-free mass (left) 1.4 7.6 15.2 -3.9 -0.4
Trunk fat percentage 4.0 16.0 23.3 -4.8 -2.9
Hand grip strength (right) 0.6 1.6 3.2 -0.2 1.8
Townsend deprivation index at recruitment 0.9 1.2 2.2 0.5 1.5
Current tobacco smoking 0.1 0.2 0.3 -0.5 0.2
Average weekly fortified wine intake 0.2 0.2 0.3 0.5 0.4
Maternal smoking around birth 2.5 3.6 6.6 -0.8 -2.6
Fed-up feelings 1.5 2.7 5.2 -2.3 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.7 7.3 -0.3 2.7
Relative age voice broke 0.3 0.5 0.9 -0.9 -0.1
Taking other prescription medications 4.4 6.8 7.9 -2.8 2.4
Age when periods started (menarche) 2.1 5.1 8.5 1.3 -2.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.0 0.2 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 1.5 -1.0 1.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 0.7 -0.4
Qualifications: CSEs or equivalent 1.2 1.5 2.6 -0.6 1.6
Serious illness, injury or assault to yourself 0.9 1.1 1.6 -1.3 -0.8
High blood pressure 1.7 4.7 8.9 -3.0 0.7
Hayfever, allergic rhinitis or eczema 0.6 1.2 1.4 -1.0 1.2
Multivitamins +/- minerals 4.6 5.8 6.7 2.6 2.2
Stomach or abdominal pain in last month 0.8 1.0 1.4 -0.7 1.2
Supplements: Glucosamine 1.6 2.1 3.8 0.5 2.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 0.6 -0.2
Medication: Atenolol 0.1 0.1 0.2 -0.3 -0.5
Medication: Levothyroxine sodium 1.4 2.4 4.3 -2.1 -0.7
Sitting height 1.1 7.7 12.2 -1.8 3.5
Chronic bronchitis/emphysema (father) 0.6 0.7 1.4 -1.2 -0.4
High blood pressure (mother) 0.6 0.8 1.5 -0.3 1.2
Body mass index (BMI) 4.3 18.4 35.4 -6.0 -1.1
Impedance of leg (left) 1.1 5.4 6.2 2.1 2.5
Leg predicted mass (left) 1.4 7.5 14.7 -3.8 -0.4
Trunk fat mass 3.7 15.8 27.7 -5.3 -2.0
Waist circumference 3.1 11.4 20.2 -4.5 -1.6
Number of incorrect matches in round 0.5 0.9 1.6 -1.2 0.4
Past tobacco smoking 0.6 1.2 1.7 -1.3 0.8
Alcohol usually taken with meals 0.4 0.7 1.4 -0.2 -1.2
Nervous feelings 3.1 5.8 11.4 0.3 3.4
Frequency of tenseness / restlessness in last 2 weeks 7.6 11.7 22.7 -0.9 4.8
Hearing difficulty/problems with background noise 3.5 5.6 9.6 3.1 1.2
Hair/balding pattern: Pattern 2 1.4 1.7 2.9 -1.7 -0.7
Had menopause 0.3 0.3 0.5 -0.4 0.7
Had other major operations 0.1 0.1 0.2 0.2 -0.4
Forced vital capacity (FVC) 0.2 0.9 1.0 1.0 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 1.1 -1.1 1.0
Ever unenthusiastic/disinterested for a whole week 2.7 3.3 4.9 1.3 2.2
Qualifications: None of the above 2.6 5.6 11.2 -3.4 -0.2
Financial difficulties in last 2 years 3.6 4.9 9.7 0.3 3.1
Mouth/teeth dental problems 0.4 0.6 1.0 0.4 1.0
Heart attack 2.0 2.5 5.0 -2.2 0.0
Allergy 0.9 2.0 3.0 1.7 -1.0
Pain all over the body in last month 0.8 0.9 1.6 -1.3 -0.3
Diabetes (self-reported) 1.1 1.7 2.7 -1.7 -0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.3 -0.3 1.2
Medication: Ramipril 0.0 0.0 0.0 -0.2 -0.1
Medication: Simvastatin 0.0 0.0 0.1 -0.0 -0.2
Fluid intelligence score 0.6 1.2 2.4 1.5 0.1
Illnesses of siblings 0.3 0.5 0.9 1.0 0.0
Neuroticism score 3.0 6.3 7.2 -2.3 2.7
Weight 2.8 13.9 27.8 -5.3 -0.2
Impedance of arm (right) 2.2 10.1 13.5 3.7 -2.6
Arm fat percentage (right) 4.1 16.3 25.2 -5.0 -2.7
Trunk fat-free mass 1.5 8.8 11.6 -3.4 2.5
Hip circumference 2.8 12.0 20.9 -4.6 -1.7
Time employed in main current job 0.5 0.6 1.1 0.4 -1.0
Alcohol intake versus 10 years previously 2.1 3.1 6.1 0.4 -2.5
Father’s age at death 0.8 1.1 1.8 1.3 -0.6
Worrier / anxious feelings 2.5 4.8 9.5 0.0 3.1
Frequency of tiredness / lethargy in last 2 weeks 5.3 8.7 16.2 -1.1 4.0
Falls in the last year 2.4 3.3 4.2 -1.5 2.0
Hair/balding pattern: Pattern 3 1.4 2.0 4.0 2.0 0.2
Number of live births 4.2 6.0 11.2 -3.3 0.9
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.0 -0.2 0.2
Pulse rate 0.3 0.6 1.1 1.1 0.0
Happiness 0.0 0.0 0.0 0.1 0.1
Noisy workplace 1.0 1.2 2.1 -0.5 -1.5
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.1 1.8 -0.1
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 4.6 -0.4 -2.1
Mouth/teeth dental problems: Dentures 1.9 3.2 6.4 -2.5 0.2
Asthma 0.7 1.4 2.7 -1.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.1 -0.7 -1.0
Medication: Cholesterol lowering 0.8 1.3 1.5 -1.1 1.2
Depression (self-reported) 4.8 5.7 7.2 -2.0 2.7
Medication: Lansoprazole 0.2 0.3 0.5 -0.1 -0.7
Prospective memory result 0.2 0.2 0.4 0.1 0.6
Lung cancer (father) 0.3 0.4 0.8 0.1 -0.9
Illnesses of mother 0.0 0.0 0.0 -0.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.5 0.1
Pulse wave Arterial Stiffness index 0.9 1.0 1.3 -0.9 -1.1
Impedance of arm (left) 2.9 13.4 13.8 3.6 -3.7
Arm fat mass (right) 4.5 18.5 34.3 -5.9 -1.6
Trunk predicted mass 1.6 9.0 11.7 -3.4 2.5
Standing height 0.2 2.0 3.8 0.4 1.9
Length of working week for main job 0.7 0.7 1.4 -1.2 0.0
Exposure to tobacco smoke at home 0.4 0.4 0.5 0.6 -0.7
Breastfed as a baby 1.0 1.2 2.5 1.6 0.1
Tense / ‘highly strung’ 3.7 6.1 9.7 -1.6 3.1
Seen doctor (GP) for nerves, anxiety, tension or depression 8.5 13.0 22.4 -1.9 4.7
Hair/balding pattern: Pattern 4 0.2 0.6 1.1 1.1 0.0
Birth weight of first child 0.4 0.7 1.3 0.4 1.1
Peak expiratory flow (PEF) 0.1 0.2 0.4 -0.2 -0.6
Pulse wave reflection index 0.0 0.0 0.0 -0.2 0.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 -0.3 0.3
Loud music exposure frequency 1.1 1.2 2.4 -0.2 1.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.1 -0.4 0.2
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.1 0.7 -1.8
Blood clot in the leg (DVT) 0.9 1.1 1.2 -1.0 1.1
Medication: Paracetamol 1.7 2.9 3.7 -1.4 1.9
Headache pain in last month 4.8 8.3 16.0 -0.8 4.0
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 5.1 2.2 -1.1
Glaucoma (self-reported) 0.3 0.4 0.4 0.6 -0.7
Gout (self-reported) 0.8 1.1 1.7 -0.7 1.3
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 4.2 -2.0 -1.3
Medication: Amlodipine 0.8 1.1 1.5 -1.2 0.9
Medication: Ventolin 100micrograms inhaler 1.0 1.2 2.4 -1.6 -0.3
Birth weight 1.1 2.3 3.0 1.7 -1.3
Chronic bronchitis/emphysema (mother) 1.4 1.7 3.2 -1.8 0.4
High blood pressure (siblings) 0.2 0.3 0.7 -0.8 -0.2
Forced vital capacity (FVC), Best measure 0.4 1.5 2.2 1.5 0.9
Body fat percentage 3.8 15.0 24.9 -5.0 -2.3
Leg fat percentage (right) 3.7 13.5 26.9 -5.2 -0.0
Arm fat-free mass (right) 2.5 12.7 19.2 -4.4 2.5
Exposure to tobacco smoke outside home 0.1 0.1 0.3 0.1 -0.5
Comparative body size at age 10 0.1 0.3 0.5 -0.2 0.7
Number of full brothers 1.3 1.7 2.9 -0.7 -1.7
Worry too long after embarrassment 3.2 5.4 9.2 -1.3 3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 3.9 5.0 10.0 -0.1 3.2
Wheeze or whistling in the chest in last year 0.4 0.8 1.5 -1.2 0.1
Number of children fathered 0.1 0.1 0.1 0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.6 1.2 0.3 1.1
Age at first live birth 2.7 4.8 8.6 2.9 -1.0
Pulse wave peak to peak time 1.1 1.3 2.0 0.7 1.4
Health satisfaction 0.6 0.8 1.3 -0.4 1.2
Shortness of breath walking on level ground 0.2 0.2 0.3 -0.5 0.4
Qualifications: College or University degree 0.8 2.6 4.3 2.1 -0.9
Eye problems/disorders: None of the above 0.3 0.4 0.6 0.5 0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.1 1.8 1.3 -0.6
Emphysema/chronic bronchitis 1.1 1.3 2.2 -1.5 0.6
Medication for pain relief, constipation, heartburn 2.5 4.2 6.5 2.5 -1.4
Neck or shoulder pain in last month 0.2 0.3 0.4 -0.7 0.4
Medication: Blood pressure 2.4 4.3 5.1 -2.3 1.9
Angina (self-reported) 2.6 3.4 5.7 -2.4 1.0
Migraine (self-reported) 0.1 0.1 0.2 0.4 0.1
Medication: Ibuprofen 1.0 1.2 2.1 -1.4 -0.5
Medication: Allopurinol 1.8 2.5 3.7 -1.1 1.9
Medication: Omeprazole 2.2 2.7 4.6 -2.1 0.9
Medication: Seretide 50 evohaler 0.5 0.5 0.6 -0.7 0.8
Mean time to correctly identify matches 1.6 3.0 5.9 -2.4 -0.3
Heart disease (mother) 0.3 0.3 0.7 -0.2 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 2.8 -0.7 -1.7
Whole body fat mass 3.9 16.4 31.0 -5.6 -1.3
Leg fat mass (right) 4.2 16.2 32.4 -5.7 -0.0
Arm predicted mass (right) 2.6 13.3 21.6 -4.7 2.2
Pulse rate, automated reading 0.3 1.0 1.7 -1.3 0.6
Alcohol intake frequency. 0.8 1.9 2.8 -1.7 -1.0
Comparative height size at age 10 0.2 1.2 2.0 0.5 1.4
Number of full sisters 0.4 0.5 1.1 -0.0 1.0
Suffer from ‘nerves’ 2.0 3.2 5.0 -1.2 2.2
Overall health rating 0.8 1.7 2.4 -1.6 1.0
Chest pain or discomfort 0.1 0.2 0.3 -0.6 -0.3
Had major operations 1.8 2.1 3.9 2.0 0.6
Age at last live birth 1.7 2.4 2.7 1.5 -1.6
Family relationship satisfaction 0.1 0.1 0.2 0.4 -0.0
Leg pain on walking 1.7 2.1 4.2 -2.0 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.6 0.3
Commuting to job workplace: Car/motor vehicle 4.2 4.8 9.0 -3.0 0.7
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.4 -0.1
Medication: Aspirin 0.5 0.6 0.7 -0.7 0.8
Supplements: Vitamin C 0.9 1.1 1.7 0.6 1.3
Knee pain experienced in last month 4.0 6.3 11.3 -3.4 1.1
Hypertension (Self-reported) 1.9 5.2 10.2 -3.2 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.3 -0.5 -0.6
Illnesses of father: Heart disease 0.5 0.7 1.1 -0.5 -1.1
Illnesses of siblings: Diabetes 1.3 1.6 2.8 -1.7 -0.6
Smoking status: Previous 0.7 1.0 1.9 1.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.9 -0.3 1.0
Whole body fat-free mass 1.5 8.5 15.1 -3.9 1.4
Leg fat-free mass (right) 1.2 6.4 12.3 -3.5 -0.7
Arm fat percentage (left) 4.5 17.8 25.2 -5.0 -3.2
Average weekly red wine intake 2.0 3.0 6.0 2.4 0.1
Handedness (chirality/laterality): Left-handed 0.5 0.7 1.1 1.1 0.4
Mood swings 5.0 9.1 10.3 -3.2 2.8
Loneliness, isolation 0.3 0.4 0.8 -0.9 0.0
Long-standing illness, disability or infirmity 1.9 3.0 3.0 -1.7 1.7
Ever had bowel cancer screening 1.0 1.2 2.1 1.4 0.5
Diabetes diagnosed by doctor 1.7 2.9 5.4 -2.3 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 0.2 0.1
Friendships satisfaction 0.5 0.6 1.3 0.1 -1.1
Qualifications: nursing, teaching 1.8 2.8 5.3 -0.5 2.3
Commuting to job workplace: Walk 2.3 2.5 4.5 2.1 0.6
Eye problems/disorders: Cataract 1.2 1.4 2.6 -0.4 -1.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.3 0.5 0.5
Medication for cholesterol 0.2 0.4 0.5 0.7 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 5.7 6.7 12.5 -0.9 3.5
Back pain experienced in last month 3.6 5.3 10.4 -0.5 3.2
Mineral and other dietary supplements 3.2 4.3 8.1 -0.7 -2.8
Breast cancer (self-reported) 0.2 0.3 0.4 0.4 0.7
Asthma (self-reported) 0.9 1.7 3.5 -1.9 -0.2
Osteoporosis (self-reported) 0.5 0.6 1.1 -0.3 -1.0
Osteoarthritis (self-reported) 5.5 7.2 13.2 -3.6 1.1
Medication: Aspirin 0.8 1.1 1.4 -1.2 0.9
Medication: Gliclazide 1.3 1.4 2.5 -0.6 -1.6
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.4 -0.2
Smoking status: Current 0.1 0.2 0.3 -0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 0.3 -1.1
Whole body water mass 1.6 9.2 15.9 -4.0 1.6
Leg predicted mass (right) 1.2 6.5 12.5 -3.5 -0.7
Arm fat mass (left) 4.4 17.9 32.5 -5.7 -1.8
Number of self-reported non-cancer illnesses 1.5 2.7 3.7 -1.9 1.3
Average weekly champagne plus white wine intake 1.2 1.6 2.9 1.7 -0.6
Miserableness 2.6 4.6 7.4 -1.3 2.7
Guilty feelings 2.5 3.7 5.9 -1.2 2.4
Wears glasses or contact lenses 1.7 1.9 3.8 -0.2 -2.0
Ever taken oral contraceptive pill 0.3 0.3 0.5 -0.7 0.4
Hearing aid user 0.1 0.1 0.1 0.3 -0.2
Mother’s age at death 1.3 1.7 3.2 1.8 0.3
Financial situation satisfaction 1.9 2.4 3.5 1.1 1.9
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.8 -1.7 0.2
Commuting to job workplace: Public transport 1.1 1.3 2.6 1.6 -0.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.5 0.4 0.7
Medication: Blood pressure 0.6 1.1 2.2 -1.5 0.2
Pain type(s) experienced in last month: Hip pain 2.7 3.4 4.5 -2.1 1.5
Supplements: Fish oil (including cod liver oil) 4.2 5.5 10.4 0.8 3.2
High cholesterol (Self-reported) 0.2 0.3 0.5 0.7 -0.0
Medication: Bendroflumethiazide 0.3 0.4 0.5 -0.6 0.7
Medication: Paracetamol 2.3 3.5 3.8 -1.9 1.8
Medication: Lisinopril 0.8 1.0 1.3 -1.1 -0.8
Medication: Atorvastatin 0.3 0.4 0.8 0.0 0.9
Illnesses of father: High blood pressure 0.7 0.8 1.6 -1.2 0.3
Alcohol drinker status: Never 3.5 4.2 8.1 -2.8 0.5
Ever smoked 0.4 0.8 1.6 1.2 0.1
Basal metabolic rate 1.8 9.9 18.8 -4.3 1.0
Leg fat percentage (left) 3.6 12.9 25.6 -5.1 -0.3
Arm fat-free mass (left) 2.8 14.1 21.3 -4.6 2.6
Number of operations (self-reported) 0.4 0.7 0.9 0.6 0.9
Average weekly beer plus cider intake 0.1 0.2 0.3 -0.1 -0.6
Irritability 0.1 0.2 0.3 -0.6 0.1
Risk taking 0.4 0.6 1.1 -0.2 -1.1
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.9 1.0 -0.3
Fractured/broken bones in last 5 years 0.4 0.6 1.0 0.3 -1.0
Age started oral contraceptive pill 0.2 0.3 0.5 0.7 -0.1
Diastolic blood pressure, automated reading 0.3 1.0 2.0 -1.4 0.2
Ever depressed for a whole week 1.4 1.7 2.4 1.0 1.6
Unable to work because of sickness or disability 1.2 1.6 2.1 -1.4 1.0
Commuting to job workplace: Cycle 4.7 5.7 10.3 1.1 -3.2
Myopia 5.8 8.4 10.2 3.2 -2.6
Vascular/heart problems diagnosed by doctor 2.2 6.0 10.8 3.3 -1.1
Cholesterol lowering medication 0.2 0.3 0.7 0.8 -0.1
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 4.0 -2.0 0.8
Pain experienced in last month 2.1 3.5 4.4 2.1 -1.6
Supplements: Calcium 0.2 0.2 0.2 0.4 -0.4
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 1.2 0.0
Heart attack/myocardial infarction (self-reported) 2.0 2.6 5.2 -2.3 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 1.3 -1.1 0.9
Heart disease (siblings) 0.0 0.0 0.0 -0.2 0.1
Alcohol drinker status: Previous 1.3 1.4 2.1 -0.9 -1.4
Pack years of smoking 0.9 1.4 2.6 -0.3 1.6
Impedance of whole body 1.1 5.7 10.6 3.2 -0.9
Leg fat mass (left) 4.0 15.6 31.2 -5.6 -0.1
Arm predicted mass (left) 2.5 12.8 19.7 -4.4 2.4