Best TWAS P=6.41e-09 · Best GWAS P=2.67e-10 conditioned to 6.3e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NOP14 | 0.12 | 0.06 | enet | 11 | 0.09 | 2.9e-07 | -4.8 | 5.8 | 6.4e-09 | 0.17 | 0.77 | 0.16 | TRUE |
| 2 | GTEx | Colon Transverse | GRK4 | 0.27 | 0.25 | enet | 18 | 0.25 | 2.4e-12 | -4.9 | 5.4 | 5.1e-08 | 0.15 | 0.74 | 0.26 | FALSE |
| 3 | GTEx | Pituitary | GRK4 | 0.17 | 0.00 | enet | 6 | -0.01 | 5.6e-01 | -5.3 | 5.2 | 2.0e-07 | 0.11 | 0.08 | 0.20 | FALSE |
| 4 | GTEx | Stomach | GRK4 | 0.22 | 0.19 | lasso | 7 | 0.19 | 2.6e-09 | -4.9 | 5.2 | 1.6e-07 | 0.10 | 0.75 | 0.25 | FALSE |
| 5 | METSIM | Adipose | MFSD10 | 0.16 | 0.03 | enet | 48 | 0.05 | 2.1e-08 | 3.7 | 5.3 | 1.2e-07 | 0.33 | 0.03 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GRK4 | 0.09 | 0.12 | blup | 76 | 0.12 | 1.7e-06 | -4.7 | 5.2 | 2.3e-07 | 0.14 | 0.04 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRK4 | 0.09 | 0.18 | lasso | 5 | 0.20 | 1.5e-22 | -5.3 | 5.5 | 3.5e-08 | 0.16 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRK4 | 0.10 | 0.14 | enet | 16 | 0.14 | 4.6e-15 | -4.7 | 5.1 | 2.7e-07 | 0.12 | 0.08 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | GRK4 | 0.27 | 0.10 | blup | 76 | 0.13 | 7.3e-04 | -4.7 | 5.3 | 1.3e-07 | 0.14 | 0.03 | 0.80 | FALSE |
| 10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GRK4 | 0.08 | 0.07 | blup | 77 | 0.09 | 4.4e-06 | -5.2 | 5.3 | 1.3e-07 | 0.18 | 0.03 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | GRK4 | 0.11 | 0.12 | lasso | 1 | 0.10 | 8.4e-04 | -5.2 | 5.2 | 1.9e-07 | 0.10 | 0.02 | 0.84 | FALSE |