[Hub]/) : Traits : BMI :

chr5:95,168,155-97,065,386

Best TWAS P=3.51e-16 · Best GWAS P=9.31e-14 conditioned to 1.05e-11

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adrenal Gland ERAP1 0.38 0.14 lasso 7 0.22 1.4e-08 -6.1 -6.1 8.8e-10 -0.02 0.96 0.01 FALSE
2 GTEx Brain Frontal Cortex BA9 ERAP1 0.26 0.16 lasso 6 0.20 5.1e-06 -5.7 -5.7 1.3e-08 0.00 0.50 0.03 FALSE
3 GTEx Breast Mammary Tissue (Female) ERAP1 0.18 0.05 lasso 5 0.05 1.5e-02 -5.7 -5.7 1.2e-08 -0.01 0.15 0.05 FALSE
4 GTEx Cells EBV-transformed lymphocytes ERAP1 0.66 0.35 lasso 14 0.53 3.5e-20 -5.6 -5.8 6.4e-09 -0.02 1.00 0.00 FALSE
5 GTEx Cells Transformed fibroblasts ERAP1 0.48 0.37 enet 37 0.47 3.3e-39 -5.7 -5.8 8.8e-09 -0.01 1.00 0.00 FALSE
6 GTEx Cells Transformed fibroblasts CTD-2260A17.1 0.35 0.27 lasso 7 0.37 6.8e-29 -5.7 -5.6 2.2e-08 -0.03 1.00 0.00 FALSE
7 GTEx Colon Sigmoid ERAP1 0.31 0.25 lasso 11 0.26 9.6e-10 -5.7 -5.7 1.4e-08 -0.01 0.99 0.00 FALSE
8 GTEx Colon Transverse ERAP1 0.44 0.28 lasso 11 0.31 2.2e-15 -5.7 -6.6 4.2e-11 -0.02 0.99 0.01 FALSE
9 GTEx Esophagus Gastroesophageal Junction ERAP1 0.29 0.18 lasso 8 0.13 2.6e-05 -5.7 -6.8 1.1e-11 -0.01 0.57 0.03 FALSE
10 GTEx Esophagus Mucosa ERAP1 0.23 0.19 lasso 15 0.22 1.1e-14 -4.9 -5.5 3.6e-08 -0.04 1.00 0.00 FALSE
11 GTEx Esophagus Muscularis ERAP1 0.19 0.06 enet 19 0.11 2.5e-07 -3.9 -6.2 4.6e-10 -0.04 0.97 0.00 FALSE
12 GTEx Heart Left Ventricle ERAP1 0.20 0.10 enet 14 0.09 2.2e-05 -5.7 -5.5 4.0e-08 0.01 0.98 0.00 FALSE
13 GTEx Liver CAST 0.32 0.03 enet 23 0.12 4.4e-04 -6.1 -8.2 3.5e-16 -0.08 0.18 0.05 TRUE
14 GTEx Liver ERAP1 0.24 0.15 lasso 3 0.12 3.4e-04 -5.7 -6.0 2.3e-09 0.01 0.45 0.03 FALSE
15 GTEx Liver CTC-506B8.1 0.34 0.07 enet 22 0.05 1.9e-02 -5.0 -6.0 1.8e-09 0.01 0.16 0.05 FALSE
16 GTEx Lung ERAP1 0.41 0.27 enet 37 0.37 3.2e-29 -5.7 -5.4 6.4e-08 -0.05 1.00 0.00 FALSE
17 GTEx Nerve Tibial ERAP1 0.39 0.23 enet 32 0.26 1.1e-18 -5.5 -5.3 1.2e-07 0.00 1.00 0.00 FALSE
18 GTEx Pancreas ERAP1 0.38 0.36 lasso 12 0.43 1.0e-19 -4.9 -5.9 4.0e-09 -0.03 1.00 0.00 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic CAST 0.17 -0.01 lasso 6 0.02 2.3e-02 -2.4 -5.3 9.2e-08 -0.05 0.08 0.11 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic ERAP1 0.30 0.23 lasso 4 0.25 5.9e-14 -5.5 -5.2 2.1e-07 -0.01 1.00 0.00 FALSE
21 GTEx Skin Sun Exposed Lower leg ERAP1 0.26 0.23 lasso 5 0.26 3.0e-21 -5.5 -5.2 1.5e-07 -0.01 1.00 0.00 FALSE
22 GTEx Stomach ERAP1 0.29 0.13 lasso 10 0.18 7.5e-09 -4.9 -6.0 1.8e-09 -0.04 0.99 0.00 FALSE
23 GTEx Thyroid CTC-506B8.1 0.09 0.03 enet 28 0.03 3.6e-03 -2.4 -5.2 1.5e-07 -0.01 0.48 0.02 FALSE
24 GTEx Whole Blood ERAP1 0.24 0.18 lasso 14 0.22 4.5e-20 -4.9 -5.4 7.5e-08 -0.03 1.00 0.00 FALSE
25 GTEx Whole Blood CTD-2260A17.1 0.23 0.07 lasso 9 0.17 3.9e-15 -4.0 -5.6 2.1e-08 0.01 1.00 0.00 FALSE
26 ROSMAP Brain Pre-frontal Cortex AC008865.1 0.05 0.00 bslmm 458 0.02 8.2e-04 2.9 -5.5 3.2e-08 -0.07 0.21 0.07 FALSE
27 The Cancer Genome Atlas Bladder Urothelial Carcinoma ERAP1 0.19 0.16 blup 130 0.23 1.0e-19 -5.5 -5.8 6.1e-09 -0.04 0.01 0.99 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma ERAP1 0.24 0.24 lasso 10 0.29 1.8e-59 -5.7 -5.7 1.3e-08 -0.02 0.01 0.99 FALSE
29 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ERAP1 0.42 0.32 blup 131 0.43 1.0e-22 -5.5 -5.5 3.8e-08 -0.01 0.01 0.99 FALSE
30 The Cancer Genome Atlas Colon Adenocarcinoma ERAP1 0.32 0.29 blup 130 0.36 6.4e-22 -5.7 -6.3 3.7e-10 0.01 0.02 0.98 FALSE
31 The Cancer Genome Atlas Esophageal Carcinoma ERAP1 0.24 0.09 blup 130 0.14 4.6e-05 -5.5 -6.1 1.3e-09 -0.03 0.04 0.91 FALSE
32 The Cancer Genome Atlas Glioblastoma Multiforme CAST 0.16 0.04 blup 168 0.03 4.4e-02 -2.6 -5.7 1.6e-08 -0.01 0.05 0.62 FALSE
33 The Cancer Genome Atlas Glioblastoma Multiforme ERAP1 0.57 0.41 lasso 10 0.42 3.0e-14 -5.7 -5.4 8.2e-08 0.00 0.02 0.98 FALSE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ERAP1 0.24 0.24 lasso 8 0.30 1.2e-34 -5.7 -5.5 4.4e-08 0.00 0.01 0.99 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ERAP1 0.39 0.30 lasso 9 0.37 9.0e-44 -5.7 -5.6 2.2e-08 -0.02 0.01 0.99 FALSE
36 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ERAP1 0.29 0.24 enet 17 0.29 7.7e-17 -4.9 -5.4 7.5e-08 -0.02 0.17 0.83 FALSE
37 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ERAP1 0.47 0.33 blup 130 0.36 7.0e-18 -5.7 -5.8 5.3e-09 0.00 0.02 0.98 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma ERAP1 0.30 0.36 lasso 7 0.40 4.0e-49 -5.7 -5.5 3.6e-08 -0.01 0.01 0.99 FALSE
39 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ERAP1 0.19 0.20 blup 131 0.21 3.0e-23 -4.9 -5.5 3.6e-08 -0.01 0.32 0.68 FALSE
40 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ERAP1 0.23 0.26 lasso 10 0.27 2.8e-18 -5.7 -5.2 2.1e-07 -0.01 0.02 0.98 FALSE
41 The Cancer Genome Atlas Pancreatic Adenocarcinoma ERAP1 0.40 0.25 lasso 13 0.34 5.0e-15 -5.5 -5.4 6.9e-08 -0.02 0.02 0.98 FALSE
42 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERAP1 0.15 0.08 lasso 13 0.10 1.2e-04 -4.9 -5.2 1.8e-07 -0.03 0.06 0.89 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma ERAP1 0.31 0.32 lasso 9 0.38 1.2e-41 -5.7 -5.4 7.7e-08 -0.01 0.01 0.99 FALSE
44 The Cancer Genome Atlas Rectum Adenocarcinoma ERAP1 0.28 0.06 blup 131 0.12 8.1e-04 2.6 -5.2 1.6e-07 -0.01 0.03 0.81 FALSE
45 The Cancer Genome Atlas Soft Tissue Sarcoma ERAP1 0.20 0.12 enet 13 0.21 6.9e-13 -5.5 -5.6 2.1e-08 -0.02 0.01 0.99 FALSE
46 The Cancer Genome Atlas Skin Cutaneous Melanoma ERAP1 0.20 0.00 blup 131 0.09 2.3e-03 2.6 -5.3 1.1e-07 -0.02 0.04 0.58 FALSE
47 The Cancer Genome Atlas Stomach Adenocarcinoma ERAP1 0.26 0.31 lasso 9 0.35 4.1e-26 -5.7 -5.8 6.8e-09 -0.02 0.02 0.98 FALSE
48 The Cancer Genome Atlas Testicular Germ Cell Tumors ERAP1 0.40 0.17 enet 18 0.29 1.1e-10 -6.1 -5.5 4.5e-08 -0.03 0.00 1.00 FALSE
49 The Cancer Genome Atlas Thyroid Carcinoma ERAP1 0.39 0.35 enet 17 0.44 4.9e-47 -5.7 -5.6 1.9e-08 -0.01 0.01 0.99 FALSE