[Hub]/) : Traits : BMI : ← →

chr5:95,168,155-97,065,386

Best TWAS P=3.51e-16 · Best GWAS P=9.31e-14 conditioned to 1.05e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	ERAP1	0.38	0.14	lasso	7	0.22	1.4e-08	-6.1	-6.1	8.8e-10	-0.02	0.96	0.01	FALSE
2	GTEx	Brain Frontal Cortex BA9	ERAP1	0.26	0.16	lasso	6	0.20	5.1e-06	-5.7	-5.7	1.3e-08	0.00	0.50	0.03	FALSE
3	GTEx	Breast Mammary Tissue (Female)	ERAP1	0.18	0.05	lasso	5	0.05	1.5e-02	-5.7	-5.7	1.2e-08	-0.01	0.15	0.05	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	ERAP1	0.66	0.35	lasso	14	0.53	3.5e-20	-5.6	-5.8	6.4e-09	-0.02	1.00	0.00	FALSE
5	GTEx	Cells Transformed fibroblasts	ERAP1	0.48	0.37	enet	37	0.47	3.3e-39	-5.7	-5.8	8.8e-09	-0.01	1.00	0.00	FALSE
6	GTEx	Cells Transformed fibroblasts	CTD-2260A17.1	0.35	0.27	lasso	7	0.37	6.8e-29	-5.7	-5.6	2.2e-08	-0.03	1.00	0.00	FALSE
7	GTEx	Colon Sigmoid	ERAP1	0.31	0.25	lasso	11	0.26	9.6e-10	-5.7	-5.7	1.4e-08	-0.01	0.99	0.00	FALSE
8	GTEx	Colon Transverse	ERAP1	0.44	0.28	lasso	11	0.31	2.2e-15	-5.7	-6.6	4.2e-11	-0.02	0.99	0.01	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	ERAP1	0.29	0.18	lasso	8	0.13	2.6e-05	-5.7	-6.8	1.1e-11	-0.01	0.57	0.03	FALSE
10	GTEx	Esophagus Mucosa	ERAP1	0.23	0.19	lasso	15	0.22	1.1e-14	-4.9	-5.5	3.6e-08	-0.04	1.00	0.00	FALSE
11	GTEx	Esophagus Muscularis	ERAP1	0.19	0.06	enet	19	0.11	2.5e-07	-3.9	-6.2	4.6e-10	-0.04	0.97	0.00	FALSE
12	GTEx	Heart Left Ventricle	ERAP1	0.20	0.10	enet	14	0.09	2.2e-05	-5.7	-5.5	4.0e-08	0.01	0.98	0.00	FALSE
13	GTEx	Liver	CAST	0.32	0.03	enet	23	0.12	4.4e-04	-6.1	-8.2	3.5e-16	-0.08	0.18	0.05	TRUE
14	GTEx	Liver	ERAP1	0.24	0.15	lasso	3	0.12	3.4e-04	-5.7	-6.0	2.3e-09	0.01	0.45	0.03	FALSE
15	GTEx	Liver	CTC-506B8.1	0.34	0.07	enet	22	0.05	1.9e-02	-5.0	-6.0	1.8e-09	0.01	0.16	0.05	FALSE
16	GTEx	Lung	ERAP1	0.41	0.27	enet	37	0.37	3.2e-29	-5.7	-5.4	6.4e-08	-0.05	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	ERAP1	0.39	0.23	enet	32	0.26	1.1e-18	-5.5	-5.3	1.2e-07	0.00	1.00	0.00	FALSE
18	GTEx	Pancreas	ERAP1	0.38	0.36	lasso	12	0.43	1.0e-19	-4.9	-5.9	4.0e-09	-0.03	1.00	0.00	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	CAST	0.17	-0.01	lasso	6	0.02	2.3e-02	-2.4	-5.3	9.2e-08	-0.05	0.08	0.11	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	ERAP1	0.30	0.23	lasso	4	0.25	5.9e-14	-5.5	-5.2	2.1e-07	-0.01	1.00	0.00	FALSE
21	GTEx	Skin Sun Exposed Lower leg	ERAP1	0.26	0.23	lasso	5	0.26	3.0e-21	-5.5	-5.2	1.5e-07	-0.01	1.00	0.00	FALSE
22	GTEx	Stomach	ERAP1	0.29	0.13	lasso	10	0.18	7.5e-09	-4.9	-6.0	1.8e-09	-0.04	0.99	0.00	FALSE
23	GTEx	Thyroid	CTC-506B8.1	0.09	0.03	enet	28	0.03	3.6e-03	-2.4	-5.2	1.5e-07	-0.01	0.48	0.02	FALSE
24	GTEx	Whole Blood	ERAP1	0.24	0.18	lasso	14	0.22	4.5e-20	-4.9	-5.4	7.5e-08	-0.03	1.00	0.00	FALSE
25	GTEx	Whole Blood	CTD-2260A17.1	0.23	0.07	lasso	9	0.17	3.9e-15	-4.0	-5.6	2.1e-08	0.01	1.00	0.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	AC008865.1	0.05	0.00	bslmm	458	0.02	8.2e-04	2.9	-5.5	3.2e-08	-0.07	0.21	0.07	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERAP1	0.19	0.16	blup	130	0.23	1.0e-19	-5.5	-5.8	6.1e-09	-0.04	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERAP1	0.24	0.24	lasso	10	0.29	1.8e-59	-5.7	-5.7	1.3e-08	-0.02	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ERAP1	0.42	0.32	blup	131	0.43	1.0e-22	-5.5	-5.5	3.8e-08	-0.01	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	ERAP1	0.32	0.29	blup	130	0.36	6.4e-22	-5.7	-6.3	3.7e-10	0.01	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Esophageal Carcinoma	ERAP1	0.24	0.09	blup	130	0.14	4.6e-05	-5.5	-6.1	1.3e-09	-0.03	0.04	0.91	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	CAST	0.16	0.04	blup	168	0.03	4.4e-02	-2.6	-5.7	1.6e-08	-0.01	0.05	0.62	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	ERAP1	0.57	0.41	lasso	10	0.42	3.0e-14	-5.7	-5.4	8.2e-08	0.00	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ERAP1	0.24	0.24	lasso	8	0.30	1.2e-34	-5.7	-5.5	4.4e-08	0.00	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERAP1	0.39	0.30	lasso	9	0.37	9.0e-44	-5.7	-5.6	2.2e-08	-0.02	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ERAP1	0.29	0.24	enet	17	0.29	7.7e-17	-4.9	-5.4	7.5e-08	-0.02	0.17	0.83	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ERAP1	0.47	0.33	blup	130	0.36	7.0e-18	-5.7	-5.8	5.3e-09	0.00	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	ERAP1	0.30	0.36	lasso	7	0.40	4.0e-49	-5.7	-5.5	3.6e-08	-0.01	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ERAP1	0.19	0.20	blup	131	0.21	3.0e-23	-4.9	-5.5	3.6e-08	-0.01	0.32	0.68	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ERAP1	0.23	0.26	lasso	10	0.27	2.8e-18	-5.7	-5.2	2.1e-07	-0.01	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ERAP1	0.40	0.25	lasso	13	0.34	5.0e-15	-5.5	-5.4	6.9e-08	-0.02	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERAP1	0.15	0.08	lasso	13	0.10	1.2e-04	-4.9	-5.2	1.8e-07	-0.03	0.06	0.89	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERAP1	0.31	0.32	lasso	9	0.38	1.2e-41	-5.7	-5.4	7.7e-08	-0.01	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Rectum Adenocarcinoma	ERAP1	0.28	0.06	blup	131	0.12	8.1e-04	2.6	-5.2	1.6e-07	-0.01	0.03	0.81	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	ERAP1	0.20	0.12	enet	13	0.21	6.9e-13	-5.5	-5.6	2.1e-08	-0.02	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ERAP1	0.20	0.00	blup	131	0.09	2.3e-03	2.6	-5.3	1.1e-07	-0.02	0.04	0.58	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERAP1	0.26	0.31	lasso	9	0.35	4.1e-26	-5.7	-5.8	6.8e-09	-0.02	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ERAP1	0.40	0.17	enet	18	0.29	1.1e-10	-6.1	-5.5	4.5e-08	-0.03	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	ERAP1	0.39	0.35	enet	17	0.44	4.9e-47	-5.7	-5.6	1.9e-08	-0.01	0.01	0.99	FALSE