Best TWAS P=2.41e-16 · Best GWAS P=3.99e-16 conditioned to 0.00257
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AGT | 0.67 | 0.50 | enet | 12 | 0.40 | 3.4e-11 | 7.4 | -7.6 | 3.0e-14 | -0.93 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Brain Cerebellum | AGT | 0.60 | 0.40 | lasso | 6 | 0.36 | 1.4e-11 | 7.8 | 8.2 | 3.6e-16 | 0.90 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | AGT | 0.07 | 0.05 | lasso | 3 | 0.04 | 3.6e-03 | 4.5 | 5.7 | 1.3e-08 | 0.84 | 0.01 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AGT | 0.07 | 0.02 | enet | 12 | 0.04 | 1.8e-05 | 5.7 | 8.2 | 2.4e-16 | 0.75 | 0.05 | 0.94 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AGT | 0.11 | 0.05 | blup | 125 | 0.04 | 1.4e-03 | 6.9 | 6.5 | 8.1e-11 | 0.71 | 0.02 | 0.87 | FALSE |