TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
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Cardiovascular Disease
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chr1:230,142,626-231,548,480
Best TWAS P=2.41e-16 · Best GWAS P=3.99e-16 conditioned to 0.00257
230.2M
230.4M
230.6M
230.8M
231M
231.2M
231.4M
231.6M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
AGT
0.07
0.02
enet
12
0.04
1.8e-05
5.7
8.2
2.4e-16
0.75
0.05
0.94
TRUE
2
GTEx
Brain Cerebellum
AGT
0.60
0.40
lasso
6
0.36
1.4e-11
7.8
8.2
3.6e-16
0.90
0.01
0.99
FALSE
1
GTEx
Brain Cerebellar Hemisphere
AGT
0.67
0.50
enet
12
0.40
3.4e-11
7.4
-7.6
3.0e-14
-0.93
0.02
0.98
FALSE
5
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
AGT
0.11
0.05
blup
125
0.04
1.4e-03
6.9
6.5
8.1e-11
0.71
0.02
0.87
FALSE
3
The Cancer Genome Atlas
Colon Adenocarcinoma
AGT
0.07
0.05
lasso
3
0.04
3.6e-03
4.5
5.7
1.3e-08
0.84
0.01
0.96
FALSE