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Cardiovascular Disease
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chr2:85,731,858-87,126,250
Best TWAS P=1.69e-10 · Best GWAS P=3.3e-07 conditioned to 0.026
85.8M
86M
86.2M
86.4M
86.6M
86.8M
87M
87.2M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
GTEx
Thyroid
MRPL35
0.14
0.01
enet
31
0.07
7.9e-06
2.2
6.4
1.7e-10
-0.50
0.08
0.73
TRUE
3
GTEx
Ovary
MRPL35
0.17
0.04
enet
15
0.07
1.0e-02
2.8
5.5
4.1e-08
-0.54
0.09
0.18
FALSE
5
The Cancer Genome Atlas
Breast Invasive Carcinoma
MRPL35
0.04
0.02
enet
7
0.02
1.6e-04
-4.9
5.5
4.2e-08
-0.93
0.00
0.99
FALSE
1
GTEx
Brain Nucleus accumbens basal ganglia
REEP1
0.17
0.03
enet
14
0.07
5.0e-03
-4.4
5.2
1.6e-07
-0.81
0.05
0.68
FALSE
2
GTEx
Breast Mammary Tissue
MRPL35
0.10
0.05
lasso
8
0.08
8.9e-05
-4.0
5.2
2.3e-07
-0.92
0.04
0.90
FALSE