Best TWAS P=1.69e-10 · Best GWAS P=3.3e-07 conditioned to 0.026
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Nucleus accumbens basal ganglia | REEP1 | 0.17 | 0.03 | enet | 14 | 0.07 | 5.0e-03 | -4.4 | 5.2 | 1.6e-07 | -0.81 | 0.05 | 0.68 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | MRPL35 | 0.10 | 0.05 | lasso | 8 | 0.08 | 8.9e-05 | -4.0 | 5.2 | 2.3e-07 | -0.92 | 0.04 | 0.90 | FALSE |
| 3 | GTEx | Ovary | MRPL35 | 0.17 | 0.04 | enet | 15 | 0.07 | 1.0e-02 | 2.8 | 5.5 | 4.1e-08 | -0.54 | 0.09 | 0.18 | FALSE |
| 4 | GTEx | Thyroid | MRPL35 | 0.14 | 0.01 | enet | 31 | 0.07 | 7.9e-06 | 2.2 | 6.4 | 1.7e-10 | -0.50 | 0.08 | 0.73 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPL35 | 0.04 | 0.02 | enet | 7 | 0.02 | 1.6e-04 | -4.9 | 5.5 | 4.2e-08 | -0.93 | 0.00 | 0.99 | FALSE |