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chr5:95,416,676-96,832,363

Best TWAS P=6.99e-11 · Best GWAS P=3.41e-08 conditioned to 0.459

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ERAP1	0.31	0.17	lasso	9	0.22	6.5e-18	-5.2	-5.4	6.7e-08	0.73	0.03	0.97	FALSE
2	GTEx	Adipose Visceral Omentum	ERAP1	0.23	0.14	lasso	4	0.15	2.2e-08	-5.3	-5.5	3.0e-08	0.71	0.01	0.98	FALSE
3	GTEx	Brain Frontal Cortex BA9	ERAP1	0.26	0.16	lasso	6	0.20	5.1e-06	-5.1	-5.4	8.4e-08	0.79	0.02	0.96	FALSE
4	GTEx	Breast Mammary Tissue	ERAP1	0.21	0.11	lasso	5	0.12	1.7e-06	-5.2	-5.5	3.3e-08	0.73	0.02	0.97	FALSE
5	GTEx	Cells Transformed fibroblasts	ERAP1	0.48	0.37	enet	37	0.47	3.3e-39	-5.1	-5.4	6.6e-08	0.66	0.03	0.97	FALSE
6	GTEx	Cells Transformed fibroblasts	CTD-2260A17.1	0.35	0.27	lasso	7	0.37	6.8e-29	-5.1	-5.3	1.2e-07	0.65	0.03	0.97	FALSE
7	GTEx	Colon Sigmoid	ERAP1	0.31	0.25	lasso	11	0.26	9.6e-10	-5.1	-5.5	4.5e-08	0.76	0.03	0.97	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	ERAP1	0.29	0.18	lasso	8	0.13	2.6e-05	-5.1	-5.9	3.9e-09	0.76	0.03	0.95	FALSE
9	GTEx	Esophagus Muscularis	ERAP1	0.19	0.06	enet	19	0.11	2.5e-07	-5.2	-5.9	3.4e-09	0.51	0.02	0.97	FALSE
10	GTEx	Heart Left Ventricle	ERAP1	0.20	0.10	enet	14	0.09	2.2e-05	-5.1	-5.4	7.6e-08	0.81	0.02	0.97	FALSE
11	GTEx	Heart Left Ventricle	CTD-2260A17.1	0.15	0.00	lasso	5	0.04	2.8e-03	-4.8	-5.2	2.5e-07	0.53	0.03	0.91	FALSE
12	GTEx	Liver	ERAP1	0.24	0.15	lasso	3	0.12	3.4e-04	-5.1	-5.5	3.7e-08	0.80	0.02	0.95	FALSE
13	GTEx	Lung	ERAP1	0.41	0.27	enet	37	0.37	3.2e-29	-5.1	-5.7	1.5e-08	0.74	0.05	0.94	FALSE
14	GTEx	Lung	CTD-2260A17.1	0.21	0.07	enet	16	0.17	2.8e-13	1.6	-5.4	7.2e-08	0.46	0.12	0.87	FALSE
15	GTEx	Muscle Skeletal	ERAP1	0.24	0.09	lasso	14	0.24	8.0e-23	-5.2	-5.5	3.2e-08	0.63	0.03	0.96	FALSE
16	GTEx	Muscle Skeletal	CTD-2260A17.1	0.17	0.09	enet	27	0.13	1.1e-12	-5.2	-5.9	2.9e-09	0.58	0.03	0.97	FALSE
17	GTEx	Nerve Tibial	ERAP1	0.39	0.23	enet	32	0.26	1.1e-18	-5.2	-5.4	6.8e-08	0.72	0.02	0.98	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	ERAP1	0.30	0.23	lasso	4	0.25	5.9e-14	-5.2	-5.6	2.4e-08	0.77	0.02	0.98	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ERAP1	0.26	0.23	lasso	5	0.26	3.0e-21	-5.2	-5.6	2.7e-08	0.72	0.02	0.98	FALSE
20	GTEx	Whole Blood	ERAP1	0.24	0.18	lasso	14	0.22	4.5e-20	-3.9	-5.3	1.4e-07	0.63	0.33	0.66	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	ERAP1	0.38	0.32	lasso	13	0.46	5.3e-67	-4.2	-5.5	3.3e-08	0.64	0.70	0.27	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERAP1	0.19	0.16	blup	130	0.23	1.0e-19	-5.2	-6.0	1.9e-09	0.78	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERAP1	0.24	0.24	lasso	10	0.29	1.8e-59	-5.1	-5.6	2.2e-08	0.71	0.04	0.96	FALSE
24	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ERAP1	0.42	0.32	blup	131	0.43	1.0e-22	-5.2	-6.5	7.0e-11	0.77	0.03	0.97	TRUE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	ERAP1	0.32	0.29	blup	130	0.36	6.4e-22	-5.1	-5.9	2.9e-09	0.73	0.03	0.97	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	ERAP1	0.24	0.09	blup	130	0.14	4.6e-05	-5.2	-6.0	2.5e-09	0.81	0.02	0.96	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	CAST	0.16	0.04	blup	168	0.03	4.4e-02	-4.6	-5.4	5.6e-08	0.62	0.09	0.36	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	ERAP1	0.57	0.41	lasso	10	0.42	3.0e-14	-5.1	-5.3	9.1e-08	0.72	0.03	0.97	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ERAP1	0.24	0.24	lasso	8	0.30	1.2e-34	-5.1	-5.8	5.1e-09	0.67	0.04	0.96	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERAP1	0.39	0.30	lasso	9	0.37	9.0e-44	-5.1	-5.6	1.9e-08	0.73	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ERAP1	0.29	0.24	enet	17	0.29	7.7e-17	-3.8	-5.2	2.1e-07	0.63	0.35	0.63	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERAP1	0.31	0.21	lasso	17	0.38	2.1e-45	-5.1	-5.4	5.2e-08	0.65	0.06	0.94	FALSE
33	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ERAP1	0.47	0.33	blup	130	0.36	7.0e-18	-5.1	-5.7	1.4e-08	0.79	0.03	0.96	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	ERAP1	0.30	0.36	lasso	7	0.40	4.0e-49	-5.1	-5.7	1.4e-08	0.76	0.04	0.96	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ERAP1	0.23	0.26	lasso	10	0.27	2.8e-18	-5.1	-5.4	7.2e-08	0.79	0.03	0.97	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ERAP1	0.40	0.25	lasso	13	0.34	5.0e-15	-5.2	-5.5	4.8e-08	0.75	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERAP1	0.31	0.32	lasso	9	0.38	1.2e-41	-5.1	-5.6	2.2e-08	0.75	0.04	0.96	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	ERAP1	0.28	0.06	blup	131	0.12	8.1e-04	2.3	-5.2	1.6e-07	0.66	0.04	0.71	FALSE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	ERAP1	0.20	0.12	enet	13	0.21	6.9e-13	-5.2	-5.7	1.0e-08	0.75	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ERAP1	0.20	0.00	blup	131	0.09	2.3e-03	2.3	-5.3	9.1e-08	0.50	0.05	0.39	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERAP1	0.26	0.31	lasso	9	0.35	4.1e-26	-5.1	-5.3	1.1e-07	0.79	0.03	0.97	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	ERAP1	0.39	0.35	enet	17	0.44	4.9e-47	-5.1	-5.5	3.0e-08	0.69	0.04	0.96	FALSE