Best TWAS P=9.76e-09 · Best GWAS P=4.28e-09 conditioned to 0.029
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | RAD50 | 0.12 | 0.09 | lasso | 11 | 0.08 | 1.3e-06 | 5.9 | 5.5 | 4.1e-08 | 0.98 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Lung | AC004041.2 | 0.13 | 0.08 | lasso | 9 | 0.08 | 8.8e-07 | 5.9 | 5.7 | 1.5e-08 | 0.99 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Testis | HSPA4 | 0.13 | 0.13 | lasso | 2 | 0.12 | 9.1e-06 | -5.4 | -5.4 | 6.8e-08 | 0.03 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Whole Blood | AC116366.6 | 0.05 | 0.04 | lasso | 17 | 0.03 | 5.7e-04 | 5.9 | -5.4 | 5.9e-08 | -0.93 | 0.02 | 0.97 | FALSE |
| 5 | METSIM | Adipose | SLC22A4 | 0.05 | 0.02 | lasso | 3 | 0.03 | 8.4e-06 | -3.2 | 5.2 | 1.6e-07 | 0.82 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HSPA4 | 0.03 | 0.02 | blup | 50 | 0.02 | 5.8e-05 | -5.4 | 5.7 | 9.8e-09 | -0.01 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZCCHC10 | 0.03 | 0.02 | blup | 30 | 0.02 | 1.3e-05 | -5.4 | 5.3 | 9.4e-08 | -0.04 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C5orf56 | 0.03 | 0.01 | blup | 98 | 0.02 | 4.2e-03 | 5.8 | -5.7 | 9.8e-09 | -0.81 | 0.01 | 0.92 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | C5orf56 | 0.06 | 0.04 | blup | 98 | 0.03 | 1.3e-03 | 5.7 | -5.4 | 5.9e-08 | -0.86 | 0.01 | 0.99 | FALSE |