[Hub]/) : Traits : Cardiovascular Disease : ← →

chr6:78,880,271-80,486,611

Best TWAS P=2.62e-11 · Best GWAS P=1.3e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Brain Nucleus accumbens basal ganglia	IRAK1BP1	0.11	0.08	lasso	10	0.07	6.0e-03	6.3	-6.7	2.6e-11	-0.97	0.04	0.86	TRUE
26	GTEx	Thyroid	IRAK1BP1	0.09	0.12	lasso	9	0.11	5.2e-09	6.3	6.6	5.3e-11	0.98	0.04	0.96	FALSE
19	GTEx	Muscle Skeletal	IRAK1BP1	0.10	0.11	lasso	2	0.10	1.3e-09	6.4	6.5	7.1e-11	1.00	0.02	0.98	FALSE
4	GTEx	Artery Aorta	IRAK1BP1	0.17	0.15	lasso	1	0.11	1.6e-06	6.4	6.4	1.6e-10	1.00	0.03	0.97	FALSE
15	GTEx	Esophagus Muscularis	PHIP	0.08	0.04	enet	15	0.02	3.6e-02	6.4	6.4	1.8e-10	0.88	0.04	0.92	FALSE
12	GTEx	Colon Sigmoid	IRAK1BP1	0.19	0.20	lasso	2	0.17	1.0e-06	6.4	6.4	1.9e-10	1.00	0.03	0.96	FALSE
25	GTEx	Testis	IRAK1BP1	0.39	0.56	lasso	11	0.58	7.7e-31	6.2	6.3	2.4e-10	1.00	0.04	0.96	FALSE
18	GTEx	Lung	IRAK1BP1	0.14	0.18	lasso	5	0.17	3.9e-13	6.3	6.3	3.4e-10	0.99	0.04	0.96	FALSE
17	GTEx	Heart Left Ventricle	IRAK1BP1	0.17	0.20	lasso	5	0.20	8.7e-11	6.2	6.2	4.2e-10	1.00	0.04	0.96	FALSE
21	GTEx	Ovary	IRAK1BP1	0.13	0.15	lasso	2	0.06	1.2e-02	6.2	6.2	4.8e-10	1.00	0.04	0.89	FALSE
3	GTEx	Adrenal Gland	IRAK1BP1	0.33	0.40	enet	31	0.40	1.5e-15	6.4	6.2	7.5e-10	0.97	0.03	0.97	FALSE
7	GTEx	Artery Tibial	IRAK1BP1	0.11	0.15	lasso	4	0.16	1.4e-12	6.4	6.1	1.2e-09	0.98	0.03	0.97	FALSE
23	GTEx	Prostate	IRAK1BP1	0.15	0.08	enet	7	0.09	2.4e-03	6.3	6.0	1.8e-09	0.92	0.05	0.86	FALSE
22	GTEx	Pancreas	IRAK1BP1	0.24	0.23	lasso	8	0.25	6.1e-11	6.3	6.0	1.9e-09	0.96	0.04	0.96	FALSE
14	GTEx	Esophagus Muscularis	IRAK1BP1	0.17	0.22	lasso	4	0.22	1.6e-13	6.4	5.9	3.4e-09	0.98	0.03	0.97	FALSE
16	GTEx	Heart Atrial Appendage	IRAK1BP1	0.15	0.14	lasso	2	0.12	4.6e-06	6.2	5.8	6.5e-09	0.98	0.04	0.95	FALSE
2	GTEx	Adipose Visceral Omentum	IRAK1BP1	0.17	0.16	enet	20	0.19	2.5e-10	6.4	5.8	6.8e-09	0.97	0.03	0.97	FALSE
9	GTEx	Brain Cerebellar Hemisphere	IRAK1BP1	0.21	0.13	enet	26	0.12	4.4e-04	-4.0	5.8	7.4e-09	0.85	0.04	0.94	FALSE
1	GTEx	Adipose Subcutaneous	IRAK1BP1	0.12	0.10	lasso	4	0.15	2.7e-12	6.3	5.8	7.7e-09	0.90	0.04	0.96	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	IRAK1BP1	0.18	0.18	enet	34	0.18	4.7e-07	6.2	5.7	1.1e-08	0.96	0.04	0.96	FALSE
11	GTEx	Cells Transformed fibroblasts	IRAK1BP1	0.25	0.35	enet	30	0.36	3.5e-28	6.4	5.7	1.2e-08	0.95	0.03	0.97	FALSE
24	GTEx	Stomach	IRAK1BP1	0.18	0.14	enet	32	0.14	2.6e-07	6.2	5.6	2.5e-08	0.95	0.04	0.96	FALSE
6	GTEx	Artery Coronary	PHIP	0.17	0.02	lasso	5	0.02	8.5e-02	4.5	5.4	7.0e-08	0.71	0.11	0.63	FALSE
8	GTEx	Brain Caudate basal ganglia	IRAK1BP1	0.11	0.12	enet	7	0.09	1.3e-03	-5.6	5.4	7.3e-08	0.90	0.04	0.79	FALSE
20	GTEx	Nerve Tibial	IRAK1BP1	0.12	0.16	lasso	6	0.14	8.8e-10	-4.0	5.2	1.7e-07	0.93	0.04	0.96	FALSE
5	GTEx	Artery Coronary	IRAK1BP1	0.11	-0.01	lasso	3	0.01	1.8e-01	6.3	5.2	2.3e-07	0.85	0.04	0.82	FALSE