Best TWAS P=1.75e-08 · Best GWAS P=4.8e-09 conditioned to 0.0835
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | DOCK7 | 0.14 | 0.08 | lasso | 4 | 0.09 | 1.2e-05 | -5.6 | 5.3 | 1.4e-07 | -0.90 | 0.06 | 0.93 | FALSE |
2 | GTEx | Artery Tibial | DOCK7 | 0.07 | 0.07 | enet | 20 | 0.07 | 3.5e-06 | -5.5 | 5.2 | 2.2e-07 | -0.95 | 0.08 | 0.92 | FALSE |
3 | GTEx | Skin Not Sun Exposed Suprapubic | DOCK7 | 0.17 | 0.01 | lasso | 2 | 0.00 | 2.5e-01 | -5.5 | 5.5 | 3.8e-08 | -0.97 | 0.06 | 0.62 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | DOCK7 | 0.09 | 0.10 | lasso | 3 | 0.10 | 2.7e-08 | -5.5 | 5.5 | 4.0e-08 | -0.97 | 0.05 | 0.95 | FALSE |
5 | GTEx | Whole Blood | DOCK7 | 0.06 | 0.00 | lasso | 6 | 0.00 | 1.6e-01 | -5.3 | 5.2 | 2.6e-07 | -0.96 | 0.09 | 0.83 | FALSE |
6 | GTEx | Whole Blood | USP1 | 0.05 | 0.02 | lasso | 1 | 0.02 | 1.0e-02 | -5.5 | 5.5 | 3.9e-08 | -0.97 | 0.05 | 0.90 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | DOCK7 | 0.06 | 0.06 | lasso | 6 | 0.06 | 3.7e-08 | -5.7 | -5.6 | 1.8e-08 | 0.92 | 0.06 | 0.94 | TRUE |
8 | YFS | Blood | DOCK7 | 0.05 | 0.04 | lasso | 8 | 0.05 | 1.3e-14 | -5.5 | 5.3 | 1.1e-07 | -0.95 | 0.06 | 0.94 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DOCK7 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.1e-03 | -5.7 | 5.5 | 4.3e-08 | -0.98 | 0.04 | 0.93 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DOCK7 | 0.06 | 0.07 | blup | 86 | 0.07 | 1.0e-04 | -5.5 | 5.3 | 1.1e-07 | -0.96 | 0.05 | 0.94 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | DOCK7 | 0.04 | 0.01 | enet | 3 | 0.02 | 3.0e-03 | -5.7 | 5.5 | 3.7e-08 | -0.98 | 0.04 | 0.73 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | DOCK7 | 0.05 | 0.03 | blup | 86 | 0.02 | 1.6e-03 | -4.5 | 5.5 | 4.8e-08 | -0.92 | 0.05 | 0.91 | FALSE |