Hub : Genes

USP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Whole Blood 0.053 0.025 0.0042 0.017 NA -0.001 NA 0.017 0.009 NA 0.3700 NA 0.010
2 TCGA Thyroid Carcinoma 0.071 0.038 0.0013 0.004 0.023 0.023 NA 0.010 0.120 0.0023 0.0022 NA 0.036

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.2 2.3 -0.2 1.5
Bipolar Disorder or Schizophrenia 0.6 1.4 2.8 0.3 1.7
Depressed Affect (Nagel 2018) 0.3 0.6 1.0 -1.0 0.4
Depression (Nagel 2018) 0.1 0.1 0.2 0.0 -0.4
Intelligence (Savage-Jansen 2018) 1.2 3.6 7.1 2.7 0.4
Neuroticism (Nagel 2018) 0.0 0.0 0.0 -0.2 0.1
Schizophrenia (2018) 0.3 0.6 0.9 0.6 0.9
Schizophrenia vs Biploar Disorder 1.3 1.8 2.2 -1.1 1.5
Worry (Nagel 2018) 0.0 0.0 0.0 -0.1 -0.2
Alzheimer’s Disease (in mother) 1.9 2.3 2.6 -1.6 1.4
Alzheimer’s Disease (in father) 0.2 0.2 0.2 -0.4 -0.5
Alzheimer’s Disease (including proxy) 2.2 3.1 5.8 -2.4 0.7
Crohns Disease (2017) 4.3 9.5 13.8 -3.7 2.2
Irritable Bowel Disease (IBD) 2.1 4.9 5.6 -2.1 2.4
Ulcerative Colitis (UC) 0.8 1.5 2.8 0.4 1.7
Major Depression (MDD) 0.2 0.3 0.4 0.4 -0.6
Reaction Time 0.3 0.7 1.3 -0.1 -1.1
Verbal and Numeric Reasoning (VNR) 0.9 2.2 3.5 1.9 0.9
Breast Cancer 0.1 0.3 0.4 0.6 0.4
Ovarian Cancer 1.8 2.3 3.6 -1.9 1.0
Prostate Cancer 1.5 2.1 3.6 -1.9 -0.8
Age at First Birth 0.1 0.1 0.1 0.4 0.4
Bipolar Disorder (2011) 1.7 1.7 1.8 -1.2 1.3
Body Mass Index (BMI) (2010) 0.9 1.2 2.2 0.5 -1.5
Coronary Artery Disease (CAD) 1.5 1.8 1.9 -1.3 -1.4
Crohns Disease (2012) 5.8 9.3 16.7 -4.1 1.4
Mean Putamen Volume 1.3 1.5 2.8 1.7 0.4
Fasting Glucose 0.3 0.3 0.6 0.0 0.8
HbA1C 0.4 0.4 0.8 -0.9 0.0
HDL Cholesterol 3.4 5.7 9.4 3.1 1.4
LDL Cholesterol 24.3 38.5 72.8 8.5 2.0
Lupus 0.9 1.3 2.0 -0.7 -1.4
Neuroticism (2016) 1.0 1.5 2.2 -0.9 -1.5
Primary Biliary Cirrhosis 0.0 0.1 0.1 0.3 0.2
Rheumatoid Arthritis 0.3 0.4 0.4 0.6 -0.6
Schizophrenia (2014) 0.4 1.0 1.9 0.2 1.4
Triglycerides 59.6 97.6 185.0 13.6 3.2
Type 2 Diabetes (T2D) (2012) 1.4 1.7 1.7 -1.3 1.3
Ulcerative Colitis 0.2 0.2 0.3 0.4 0.6
Blood Eosinophil Count 0.9 6.9 11.9 -3.5 -1.4
Blood Platelet Count 1.6 18.2 36.1 -6.0 -0.5
Blood Red Count 1.5 14.5 23.7 -2.3 -4.9
Blood White Count 1.0 7.5 15.0 3.9 -0.1
Heel T-Score 1.4 10.8 14.7 -3.8 -2.6
BMI 0.9 5.2 9.4 3.1 -1.0
Height 0.0 0.5 0.7 -0.8 0.6
Waist Hip Ratio (WHR) 0.0 0.2 0.4 0.6 -0.1
Systolic Blood Pressure 0.4 1.9 2.9 -0.9 1.7
Smoking Status 0.0 0.1 0.2 -0.4 -0.2
Allergy or Eczema 0.2 0.4 0.4 -0.7 -0.7
Cardiovascular Disease 5.0 16.5 30.1 5.5 1.7
Hypothyroidism (self reported) 0.1 0.2 0.3 0.1 -0.5
Respiratory disease 0.1 0.2 0.3 0.5 -0.3
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.1 -0.4
Lung FEV1/FVC ratio 0.1 0.7 0.7 -0.9 0.9
Lung FVC 0.5 2.8 4.8 2.2 0.9
Neuroticism 0.1 0.3 0.5 0.4 -0.7
Chronotype (morning person) 0.2 0.4 0.7 0.2 -0.8
Hair Pigment 0.0 0.8 1.7 0.2 1.3
Tanning 0.1 0.8 1.5 -1.2 0.3
Hand grip strength (left) 0.2 0.7 1.1 1.0 -0.5
Number of treatments/medications taken 0.5 0.8 1.5 0.4 1.2
Average weekly spirits intake 1.0 1.2 2.4 0.2 -1.6
Sensitivity / hurt feelings 0.9 1.5 1.6 1.3 -1.2
Frequency of depressed mood in last 2 weeks 0.7 0.9 1.0 1.0 -0.9
Hearing difficulty/problems: Yes 1.4 2.1 3.7 -0.8 -1.9
Relative age of first facial hair 0.0 0.1 0.1 -0.2 0.4
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.6 -0.7 -1.9
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.8 -0.5 0.9
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 -0.3 0.4
Systolic blood pressure, automated reading 0.7 2.0 2.2 -1.5 1.3
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 1.3 1.1 -1.1
Angina 1.6 2.2 3.9 -0.7 -2.0
Medication for hormone replacement therapy 1.5 1.6 2.8 0.7 1.7
Vitamin and mineral supplements 2.8 3.8 7.6 2.8 -0.0
Supplements: Zinc 2.2 2.4 3.8 -1.9 1.0
Medication: Co-codamol 0.1 0.1 0.1 -0.3 -0.4
Medication: Metformin 2.5 3.5 6.2 2.5 0.9
Diabetes (father) 1.8 2.2 4.1 0.5 -2.0
Diabetes (mother) 0.5 0.7 1.4 1.2 -0.1
Severe depression (siblings) 0.1 0.1 0.2 0.0 -0.5
Pack years adult smoking proportion 0.1 0.2 0.3 -0.1 0.5
Impedance of leg (right) 0.7 3.1 5.6 -2.4 -0.9
Leg fat-free mass (left) 0.2 1.3 2.2 1.5 -0.5
Trunk fat percentage 0.8 3.0 5.8 0.5 -2.4
Hand grip strength (right) 0.0 0.0 0.0 0.2 -0.1
Townsend deprivation index at recruitment 0.4 0.6 0.8 -0.9 -0.6
Current tobacco smoking 0.4 0.7 1.1 -0.5 -1.1
Average weekly fortified wine intake 0.1 0.1 0.2 -0.2 -0.4
Maternal smoking around birth 0.3 0.5 0.6 -0.8 0.6
Fed-up feelings 0.7 1.2 2.0 -0.7 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 2.0 -1.4 -1.1
Relative age voice broke 0.1 0.1 0.1 0.3 0.4
Taking other prescription medications 0.4 0.6 1.1 -1.1 -0.2
Age when periods started (menarche) 1.4 3.3 5.1 -2.3 -1.2
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.3 1.5 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.3 5.1 -2.3 -1.9
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.2 -1.5 0.4
Qualifications: CSEs or equivalent 0.2 0.3 0.4 0.5 -0.6
Serious illness, injury or assault to yourself 1.2 1.4 2.1 -0.9 -1.4
High blood pressure 0.6 1.8 3.5 -0.2 1.9
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 0.2 -0.8
Multivitamins +/- minerals 1.9 2.4 4.7 -2.2 0.2
Stomach or abdominal pain in last month 0.9 1.1 1.8 -1.3 -0.6
Supplements: Glucosamine 0.6 0.8 1.4 -1.2 0.5
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 3.6 -1.2 -1.9
Medication: Atenolol 3.6 4.5 7.7 -1.1 -2.8
Medication: Levothyroxine sodium 0.0 0.1 0.1 0.3 0.1
Sitting height 0.2 1.6 2.4 -0.9 -1.6
Chronic bronchitis/emphysema (father) 0.2 0.3 0.4 0.3 0.6
High blood pressure (mother) 1.8 2.6 5.0 0.4 -2.2
Body mass index (BMI) 0.6 2.3 2.8 1.7 -1.4
Impedance of leg (left) 0.9 4.4 6.7 -2.6 -1.4
Leg predicted mass (left) 0.2 1.3 2.3 1.5 -0.5
Trunk fat mass 0.6 2.7 4.9 0.7 -2.2
Waist circumference 1.0 3.7 4.2 1.8 -2.0
Number of incorrect matches in round 1.8 2.9 3.6 -1.5 1.9
Past tobacco smoking 0.2 0.4 0.4 0.6 0.6
Alcohol usually taken with meals 0.0 0.0 0.0 0.2 -0.2
Nervous feelings 0.5 0.9 1.7 -1.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 -0.3 0.5
Hearing difficulty/problems with background noise 1.9 3.0 4.1 -2.0 -1.4
Hair/balding pattern: Pattern 2 0.5 0.6 0.9 -0.6 -1.0
Had menopause 0.5 0.6 1.2 0.1 1.1
Had other major operations 0.6 0.7 1.2 -1.1 0.5
Forced vital capacity (FVC) 0.0 0.0 0.0 -0.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 2.9 6.8 7.8 -2.4 -2.8
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.1 -1.1 -1.0
Qualifications: None of the above 3.2 6.8 12.8 -3.6 -0.9
Financial difficulties in last 2 years 0.2 0.3 0.6 -0.0 -0.7
Mouth/teeth dental problems 4.1 6.3 12.4 3.5 0.5
Heart attack 1.3 1.7 2.4 1.5 -1.0
Allergy 0.0 0.1 0.2 -0.5 0.1
Pain all over the body in last month 0.5 0.6 0.9 -0.9 0.5
Diabetes (self-reported) 0.3 0.5 0.6 0.6 0.8
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 0.7 0.6 -0.9
Medication: Ramipril 0.5 0.7 1.2 1.1 0.3
Medication: Simvastatin 15.5 22.8 45.6 6.8 0.1
Fluid intelligence score 2.3 4.8 8.3 2.9 1.2
Illnesses of siblings 2.2 3.1 6.1 2.5 0.1
Neuroticism score 0.7 1.5 3.0 -0.2 -1.7
Weight 0.4 2.1 3.2 1.0 -1.8
Impedance of arm (right) 0.3 1.5 2.4 -1.6 -0.7
Arm fat percentage (right) 0.9 3.5 5.0 1.4 -2.2
Trunk fat-free mass 0.1 0.8 1.6 1.3 -0.2
Hip circumference 0.8 3.3 5.9 0.9 -2.4
Time employed in main current job 4.3 4.9 9.6 3.1 0.4
Alcohol intake versus 10 years previously 0.6 0.9 1.6 0.5 1.3
Father’s age at death 0.9 1.2 2.2 1.5 -0.3
Worrier / anxious feelings 0.2 0.4 0.4 0.7 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.7 -0.8 -0.2
Falls in the last year 0.9 1.2 1.3 -1.2 1.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 -0.4 0.4
Number of live births 0.4 0.5 1.0 0.2 -1.0
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.0 -0.2 0.2
Pulse rate 1.5 2.5 4.6 2.1 0.7
Happiness 0.2 0.3 0.5 -0.7 0.2
Noisy workplace 2.6 3.2 6.4 -0.2 -2.5
Qualifications: A levels/AS levels or equivalent 2.4 5.4 8.9 3.0 -1.4
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 2.0 1.1 1.4
Mouth/teeth dental problems: Dentures 1.4 2.3 2.8 -1.4 1.7
Asthma 0.0 0.1 0.2 0.4 0.1
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 4.4 -2.1 1.1
Medication: Cholesterol lowering 16.2 25.2 50.3 7.1 0.3
Depression (self-reported) 0.7 0.8 0.9 -0.9 -0.8
Medication: Lansoprazole 0.0 0.0 0.1 0.2 0.3
Prospective memory result 0.5 0.6 1.2 -1.1 0.1
Lung cancer (father) 0.5 0.5 0.9 -0.9 0.5
Illnesses of mother 1.3 1.6 1.7 1.3 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.4 -0.6 0.5
Pulse wave Arterial Stiffness index 0.6 0.7 1.2 0.5 1.1
Impedance of arm (left) 0.4 2.0 3.3 -1.8 -0.9
Arm fat mass (right) 0.7 2.7 4.2 1.1 -2.1
Trunk predicted mass 0.1 0.7 1.3 1.1 -0.1
Standing height 0.1 1.0 1.4 -1.2 -0.8
Length of working week for main job 0.2 0.3 0.5 -0.1 0.7
Exposure to tobacco smoke at home 0.9 1.0 1.3 -0.9 -1.1
Breastfed as a baby 0.2 0.3 0.4 0.7 -0.3
Tense / ‘highly strung’ 0.2 0.3 0.5 0.2 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.6 -1.3 -0.3
Hair/balding pattern: Pattern 4 0.2 0.5 0.9 -0.9 0.3
Birth weight of first child 1.6 2.9 5.5 -0.6 -2.4
Peak expiratory flow (PEF) 0.3 0.6 1.2 -1.1 0.2
Pulse wave reflection index 0.1 0.1 0.1 0.3 0.1
Ever highly irritable/argumentative for 2 days 1.9 2.3 4.5 -2.1 -0.4
Loud music exposure frequency 0.8 0.9 1.5 -0.6 -1.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 0.5 -0.2
Mouth/teeth dental problems: Bleeding gums 4.5 5.9 6.2 -2.5 -2.4
Blood clot in the leg (DVT) 0.5 0.7 1.1 -1.1 0.5
Medication: Paracetamol 1.4 2.3 4.3 -2.1 0.5
Headache pain in last month 0.2 0.4 0.6 0.4 -0.8
Medication for cholesterol, blood pressure or diabetes 3.2 5.4 9.9 -3.1 -0.9
Glaucoma (self-reported) 0.1 0.2 0.3 0.6 0.0
Gout (self-reported) 1.3 1.8 2.0 -1.4 -1.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.4 -0.7 -0.4
Medication: Amlodipine 0.8 1.1 2.2 1.5 0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 0.4 1.0
Birth weight 0.1 0.1 0.2 -0.3 0.4
Chronic bronchitis/emphysema (mother) 1.7 2.0 3.7 -1.9 0.5
High blood pressure (siblings) 0.5 0.7 1.2 -1.1 0.4
Forced vital capacity (FVC), Best measure 0.3 1.1 1.1 -1.1 1.0
Body fat percentage 0.9 3.6 6.8 0.6 -2.6
Leg fat percentage (right) 0.6 2.2 4.2 0.4 -2.1
Arm fat-free mass (right) 0.1 0.6 0.8 0.9 -0.6
Exposure to tobacco smoke outside home 1.2 1.6 3.1 -1.8 -0.4
Comparative body size at age 10 0.4 1.0 1.0 1.0 1.0
Number of full brothers 2.2 2.7 3.1 -1.8 -1.5
Worry too long after embarrassment 0.6 1.1 2.1 -0.2 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.6 0.1
Wheeze or whistling in the chest in last year 1.6 2.9 5.1 -2.3 -0.9
Number of children fathered 0.7 0.8 1.6 -1.3 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 1.8 1.4 -1.1
Age at first live birth 1.3 2.4 2.7 1.7 1.4
Pulse wave peak to peak time 0.8 0.9 1.3 -0.7 -1.1
Health satisfaction 1.9 2.4 4.3 -0.7 -2.1
Shortness of breath walking on level ground 2.6 3.1 3.5 -1.7 -1.9
Qualifications: College or University degree 1.9 6.0 8.8 3.0 1.8
Eye problems/disorders: None of the above 1.7 2.0 4.0 -0.1 -2.0
Mouth/teeth dental problems: Loose teeth 3.0 3.6 6.7 0.7 -2.6
Emphysema/chronic bronchitis 1.3 1.4 2.4 -1.5 -0.7
Medication for pain relief, constipation, heartburn 0.3 0.6 1.0 1.0 -0.4
Neck or shoulder pain in last month 0.8 1.2 1.8 -0.7 1.3
Medication: Blood pressure 0.1 0.1 0.2 -0.3 0.4
Angina (self-reported) 1.7 2.2 4.2 -0.4 -2.1
Migraine (self-reported) 1.9 2.3 4.5 2.1 0.3
Medication: Ibuprofen 0.7 0.9 1.6 -1.3 0.4
Medication: Allopurinol 0.4 0.6 1.1 -1.1 0.0
Medication: Omeprazole 0.8 1.0 1.8 -0.4 1.3
Medication: Seretide 50 evohaler 0.3 0.4 0.8 0.9 -0.2
Mean time to correctly identify matches 0.2 0.5 0.6 -0.6 -0.8
Heart disease (mother) 1.6 1.9 3.2 0.7 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 1.0 0.0
Whole body fat mass 0.7 2.9 5.0 0.9 -2.2
Leg fat mass (right) 0.5 2.0 2.9 1.0 -1.7
Arm predicted mass (right) 0.2 0.8 1.0 1.0 -0.8
Pulse rate, automated reading 1.9 6.1 10.8 3.3 1.2
Alcohol intake frequency. 0.1 0.1 0.2 0.5 -0.1
Comparative height size at age 10 0.1 0.4 0.4 -0.7 -0.5
Number of full sisters 2.4 2.9 5.8 -2.4 -0.3
Suffer from ‘nerves’ 1.6 2.5 2.9 -1.4 -1.7
Overall health rating 1.4 3.1 5.4 -0.9 -2.3
Chest pain or discomfort 1.8 2.7 3.0 -1.7 -1.5
Had major operations 0.6 0.6 0.7 0.8 -0.8
Age at last live birth 0.0 0.1 0.1 -0.2 0.2
Family relationship satisfaction 0.8 1.0 1.9 -0.4 -1.4
Leg pain on walking 3.0 3.8 5.6 -2.4 -1.4
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.8 7.7 -2.8 0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.1 1.0 -0.1
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 0.2 -0.2
Medication: Aspirin 1.4 1.8 3.2 1.8 -0.7
Supplements: Vitamin C 0.3 0.4 0.7 -0.9 0.1
Knee pain experienced in last month 0.0 0.1 0.1 0.4 0.1
Hypertension (Self-reported) 0.8 2.2 4.5 0.0 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.2 -0.4 -0.4
Illnesses of father: Heart disease 1.8 2.5 4.6 2.1 -0.7
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.3 -0.4
Smoking status: Previous 0.0 0.1 0.1 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 -0.1 -0.3
Whole body fat-free mass 0.2 0.9 1.7 1.3 -0.3
Leg fat-free mass (right) 0.2 1.3 2.1 1.4 -0.7
Arm fat percentage (left) 0.9 3.5 5.7 1.1 -2.4
Average weekly red wine intake 1.5 2.1 4.0 -2.0 -0.6
Handedness (chirality/laterality): Left-handed 1.4 1.7 2.2 -1.5 1.1
Mood swings 1.6 2.8 5.7 -2.4 -0.1
Loneliness, isolation 3.4 4.7 8.2 -1.1 -2.9
Long-standing illness, disability or infirmity 0.9 1.4 2.5 -0.6 -1.6
Ever had bowel cancer screening 0.2 0.3 0.3 -0.6 0.4
Diabetes diagnosed by doctor 0.1 0.1 0.1 0.4 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.5 -0.7 -0.7
Friendships satisfaction 1.0 1.3 1.5 -1.0 -1.2
Qualifications: nursing, teaching 3.6 5.7 11.3 3.4 -0.1
Commuting to job workplace: Walk 0.8 0.8 1.7 -1.3 -0.2
Eye problems/disorders: Cataract 1.7 2.0 3.8 -1.9 0.4
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 3.8 -2.0 0.4
Medication for cholesterol 7.3 11.1 20.4 -4.5 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 1.7 -1.3 0.8
Back pain experienced in last month 1.0 1.4 2.2 -1.5 -0.8
Mineral and other dietary supplements 1.0 1.4 2.5 1.6 0.5
Breast cancer (self-reported) 0.3 0.4 0.8 0.2 0.9
Asthma (self-reported) 0.1 0.2 0.4 0.6 -0.0
Osteoporosis (self-reported) 0.1 0.1 0.1 -0.3 -0.2
Osteoarthritis (self-reported) 1.9 2.4 2.6 -1.5 -1.6
Medication: Aspirin 1.1 1.4 2.7 1.6 -0.3
Medication: Gliclazide 1.0 1.1 1.5 -0.8 1.2
Illnesses of father: None of the above (group 1) 1.1 1.4 2.8 -0.1 1.7
Smoking status: Current 0.6 0.9 1.4 -0.7 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.8 0.9 -0.1
Whole body water mass 0.2 1.0 1.8 1.3 -0.4
Leg predicted mass (right) 0.2 1.2 2.0 1.4 -0.7
Arm fat mass (left) 0.7 2.7 4.2 1.1 -2.1
Number of self-reported non-cancer illnesses 0.5 0.8 1.5 0.4 -1.2
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -0.5 -1.1
Miserableness 0.4 0.8 1.5 -1.2 0.2
Guilty feelings 0.3 0.4 0.5 0.5 -0.7
Wears glasses or contact lenses 2.0 2.3 4.3 -2.1 0.4
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.3 -0.4
Hearing aid user 0.4 0.4 0.7 -0.4 -0.8
Mother’s age at death 0.4 0.5 0.9 0.9 -0.2
Financial situation satisfaction 3.3 4.1 7.8 -0.5 -2.8
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 1.1 0.2
Commuting to job workplace: Public transport 1.2 1.4 2.8 -0.3 1.7
Eye problems/disorders: Glaucoma 1.3 1.5 2.8 0.6 1.7
Medication: Blood pressure 1.3 2.5 4.8 2.2 0.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.4 0.3
Supplements: Fish oil (including cod liver oil) 1.2 1.6 1.8 -1.1 -1.4
High cholesterol (Self-reported) 26.7 47.4 94.7 9.7 -0.3
Medication: Bendroflumethiazide 1.9 2.9 4.5 2.1 1.2
Medication: Paracetamol 0.9 1.4 2.8 -1.7 0.1
Medication: Lisinopril 1.3 1.7 1.8 1.4 1.2
Medication: Atorvastatin 7.0 8.7 17.3 4.2 0.2
Illnesses of father: High blood pressure 1.0 1.3 2.2 -0.6 -1.5
Alcohol drinker status: Never 0.8 0.9 1.8 -1.3 0.4
Ever smoked 0.4 0.6 0.8 -0.9 -0.7
Basal metabolic rate 0.2 1.1 1.4 1.2 -0.9
Leg fat percentage (left) 0.9 3.1 5.9 0.6 -2.4
Arm fat-free mass (left) 0.2 1.1 1.3 1.1 -0.9
Number of operations (self-reported) 0.0 0.0 0.0 0.0 -0.1
Average weekly beer plus cider intake 0.5 0.7 1.4 -0.3 -1.2
Irritability 0.2 0.4 0.6 -0.5 -0.8
Risk taking 0.1 0.1 0.2 0.0 -0.5
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.7 -0.8 0.5
Fractured/broken bones in last 5 years 0.2 0.2 0.3 0.6 0.3
Age started oral contraceptive pill 0.0 0.1 0.1 0.1 0.3
Diastolic blood pressure, automated reading 0.2 0.6 0.7 0.7 0.9
Ever depressed for a whole week 0.8 0.9 1.0 -0.9 -1.0
Unable to work because of sickness or disability 0.7 0.9 1.7 -0.0 -1.3
Commuting to job workplace: Cycle 0.1 0.1 0.2 0.4 -0.2
Myopia 0.9 1.3 1.5 1.2 1.0
Vascular/heart problems diagnosed by doctor 0.8 2.1 3.7 -0.7 -1.9
Cholesterol lowering medication 13.6 20.1 39.3 6.3 -0.9
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.1 -0.8 1.4
Pain experienced in last month 0.1 0.2 0.4 0.6 -0.4
Supplements: Calcium 0.1 0.1 0.2 -0.3 -0.4
Basal cell carcinoma (self-reported) 0.6 0.7 0.8 -0.8 0.9
Heart attack/myocardial infarction (self-reported) 1.8 2.3 3.6 1.9 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 0.8 -0.9 0.5
Heart disease (siblings) 2.3 2.8 5.2 -2.3 0.5
Alcohol drinker status: Previous 0.8 1.0 1.9 -1.4 0.1
Pack years of smoking 0.5 0.7 1.1 -0.5 1.1
Impedance of whole body 0.7 3.8 6.0 -2.5 -1.3
Leg fat mass (left) 0.6 2.4 3.6 1.1 -1.9
Arm predicted mass (left) 0.2 0.9 0.9 1.0 -0.9