TWAS hub - USP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.053	0.025	0.0042	0.017	NA	-0.001	NA	0.017	0.009	NA	0.3700	NA	0.010
2	TCGA	Thyroid Carcinoma	0.071	0.038	0.0013	0.004	0.023	0.023	NA	0.010	0.120	0.0023	0.0022	NA	0.036

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Triglycerides	59.6	97.6	185.0	13.6	3.2
High cholesterol (Self-reported)	26.7	47.4	94.7	9.7	-0.3
LDL Cholesterol	24.3	38.5	72.8	8.5	2.0
Medication: Cholesterol lowering	16.2	25.2	50.3	7.1	0.3
Medication: Simvastatin	15.5	22.8	45.6	6.8	0.1
Cholesterol lowering medication	13.6	20.1	39.3	6.3	-0.9
Medication for cholesterol	7.3	11.1	20.4	-4.5	-1.3
Medication: Atorvastatin	7.0	8.7	17.3	4.2	0.2
Crohns Disease (2012)	5.8	9.3	16.7	-4.1	1.4
Cardiovascular Disease	5.0	16.5	30.1	5.5	1.7
Mouth/teeth dental problems: Bleeding gums	4.5	5.9	6.2	-2.5	-2.4
Crohns Disease (2017)	4.3	9.5	13.8	-3.7	2.2
Time employed in main current job	4.3	4.9	9.6	3.1	0.4
Mouth/teeth dental problems	4.1	6.3	12.4	3.5	0.5
Medication: Atenolol	3.6	4.5	7.7	-1.1	-2.8
Qualifications: nursing, teaching	3.6	5.7	11.3	3.4	-0.1
HDL Cholesterol	3.4	5.7	9.4	3.1	1.4
Loneliness, isolation	3.4	4.7	8.2	-1.1	-2.9
Financial situation satisfaction	3.3	4.1	7.8	-0.5	-2.8
Qualifications: None of the above	3.2	6.8	12.8	-3.6	-0.9
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	9.9	-3.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.8	7.7	-2.8	0.1
Mouth/teeth dental problems: Loose teeth	3.0	3.6	6.7	0.7	-2.6
Leg pain on walking	3.0	3.8	5.6	-2.4	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.8	7.8	-2.4	-2.8
Vitamin and mineral supplements	2.8	3.8	7.6	2.8	-0.0
Noisy workplace	2.6	3.2	6.4	-0.2	-2.5
Shortness of breath walking on level ground	2.6	3.1	3.5	-1.7	-1.9
Medication: Metformin	2.5	3.5	6.2	2.5	0.9
Qualifications: A levels/AS levels or equivalent	2.4	5.4	8.9	3.0	-1.4
Number of full sisters	2.4	2.9	5.8	-2.4	-0.3
Fluid intelligence score	2.3	4.8	8.3	2.9	1.2
Heart disease (siblings)	2.3	2.8	5.2	-2.3	0.5
Alzheimer’s Disease (including proxy)	2.2	3.1	5.8	-2.4	0.7
Supplements: Zinc	2.2	2.4	3.8	-1.9	1.0
Illnesses of siblings	2.2	3.1	6.1	2.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	4.4	-2.1	1.1
Number of full brothers	2.2	2.7	3.1	-1.8	-1.5
Irritable Bowel Disease (IBD)	2.1	4.9	5.6	-2.1	2.4
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	3.6	-1.2	-1.9
Wears glasses or contact lenses	2.0	2.3	4.3	-2.1	0.4
Alzheimer’s Disease (in mother)	1.9	2.3	2.6	-1.6	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	5.1	-2.3	-1.9
Multivitamins +/- minerals	1.9	2.4	4.7	-2.2	0.2
Hearing difficulty/problems with background noise	1.9	3.0	4.1	-2.0	-1.4
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.5	-2.1	-0.4
Health satisfaction	1.9	2.4	4.3	-0.7	-2.1
Qualifications: College or University degree	1.9	6.0	8.8	3.0	1.8
Migraine (self-reported)	1.9	2.3	4.5	2.1	0.3
Pulse rate, automated reading	1.9	6.1	10.8	3.3	1.2
Osteoarthritis (self-reported)	1.9	2.4	2.6	-1.5	-1.6
Medication: Bendroflumethiazide	1.9	2.9	4.5	2.1	1.2
Ovarian Cancer	1.8	2.3	3.6	-1.9	1.0
Diabetes (father)	1.8	2.2	4.1	0.5	-2.0
High blood pressure (mother)	1.8	2.6	5.0	0.4	-2.2
Number of incorrect matches in round	1.8	2.9	3.6	-1.5	1.9
Chest pain or discomfort	1.8	2.7	3.0	-1.7	-1.5
Illnesses of father: Heart disease	1.8	2.5	4.6	2.1	-0.7
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.6	1.9	-1.0
Bipolar Disorder (2011)	1.7	1.7	1.8	-1.2	1.3
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.7	-1.9	0.5
Eye problems/disorders: None of the above	1.7	2.0	4.0	-0.1	-2.0
Angina (self-reported)	1.7	2.2	4.2	-0.4	-2.1
Eye problems/disorders: Cataract	1.7	2.0	3.8	-1.9	0.4
Blood Platelet Count	1.6	18.2	36.1	-6.0	-0.5
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.6	-0.7	-1.9
Angina	1.6	2.2	3.9	-0.7	-2.0
Birth weight of first child	1.6	2.9	5.5	-0.6	-2.4
Wheeze or whistling in the chest in last year	1.6	2.9	5.1	-2.3	-0.9
Heart disease (mother)	1.6	1.9	3.2	0.7	-1.8
Suffer from ‘nerves’	1.6	2.5	2.9	-1.4	-1.7
Mood swings	1.6	2.8	5.7	-2.4	-0.1
Prostate Cancer	1.5	2.1	3.6	-1.9	-0.8
Coronary Artery Disease (CAD)	1.5	1.8	1.9	-1.3	-1.4
Blood Red Count	1.5	14.5	23.7	-2.3	-4.9
Medication for hormone replacement therapy	1.5	1.6	2.8	0.7	1.7
Pulse rate	1.5	2.5	4.6	2.1	0.7
Average weekly red wine intake	1.5	2.1	4.0	-2.0	-0.6
Type 2 Diabetes (T2D) (2012)	1.4	1.7	1.7	-1.3	1.3
Heel T-Score	1.4	10.8	14.7	-3.8	-2.6
Hearing difficulty/problems: Yes	1.4	2.1	3.7	-0.8	-1.9
Age when periods started (menarche)	1.4	3.3	5.1	-2.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.0	1.1	1.4
Mouth/teeth dental problems: Dentures	1.4	2.3	2.8	-1.4	1.7
Medication: Paracetamol	1.4	2.3	4.3	-2.1	0.5
Overall health rating	1.4	3.1	5.4	-0.9	-2.3
Medication: Aspirin	1.4	1.8	3.2	1.8	-0.7
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.2	-1.5	1.1
Schizophrenia vs Biploar Disorder	1.3	1.8	2.2	-1.1	1.5
Mean Putamen Volume	1.3	1.5	2.8	1.7	0.4
Heart attack	1.3	1.7	2.4	1.5	-1.0
Illnesses of mother	1.3	1.6	1.7	1.3	1.2
Gout (self-reported)	1.3	1.8	2.0	-1.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.8	1.4	-1.1
Age at first live birth	1.3	2.4	2.7	1.7	1.4
Emphysema/chronic bronchitis	1.3	1.4	2.4	-1.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	3.8	-2.0	0.4
Eye problems/disorders: Glaucoma	1.3	1.5	2.8	0.6	1.7
Medication: Blood pressure	1.3	2.5	4.8	2.2	0.5
Medication: Lisinopril	1.3	1.7	1.8	1.4	1.2
Intelligence (Savage-Jansen 2018)	1.2	3.6	7.1	2.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.0	-1.4	-1.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.3	1.5	0.6
Serious illness, injury or assault to yourself	1.2	1.4	2.1	-0.9	-1.4
Exposure to tobacco smoke outside home	1.2	1.6	3.1	-1.8	-0.4
Commuting to job workplace: Public transport	1.2	1.4	2.8	-0.3	1.7
Supplements: Fish oil (including cod liver oil)	1.2	1.6	1.8	-1.1	-1.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.3	1.1	-1.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.2	-1.5	0.4
Medication: Aspirin	1.1	1.4	2.7	1.6	-0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	2.8	-0.1	1.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.1	-0.8	1.4
Neuroticism (2016)	1.0	1.5	2.2	-0.9	-1.5
Blood White Count	1.0	7.5	15.0	3.9	-0.1
Average weekly spirits intake	1.0	1.2	2.4	0.2	-1.6
Waist circumference	1.0	3.7	4.2	1.8	-2.0
Friendships satisfaction	1.0	1.3	1.5	-1.0	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.7	-1.3	0.8
Back pain experienced in last month	1.0	1.4	2.2	-1.5	-0.8
Mineral and other dietary supplements	1.0	1.4	2.5	1.6	0.5
Medication: Gliclazide	1.0	1.1	1.5	-0.8	1.2
Illnesses of father: High blood pressure	1.0	1.3	2.2	-0.6	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.5	1.9	0.9
Body Mass Index (BMI) (2010)	0.9	1.2	2.2	0.5	-1.5
Lupus	0.9	1.3	2.0	-0.7	-1.4
Blood Eosinophil Count	0.9	6.9	11.9	-3.5	-1.4
BMI	0.9	5.2	9.4	3.1	-1.0
Sensitivity / hurt feelings	0.9	1.5	1.6	1.3	-1.2
Stomach or abdominal pain in last month	0.9	1.1	1.8	-1.3	-0.6
Impedance of leg (left)	0.9	4.4	6.7	-2.6	-1.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.1	-1.1	-1.0
Arm fat percentage (right)	0.9	3.5	5.0	1.4	-2.2
Father’s age at death	0.9	1.2	2.2	1.5	-0.3
Falls in the last year	0.9	1.2	1.3	-1.2	1.1
Exposure to tobacco smoke at home	0.9	1.0	1.3	-0.9	-1.1
Body fat percentage	0.9	3.6	6.8	0.6	-2.6
Arm fat percentage (left)	0.9	3.5	5.7	1.1	-2.4
Long-standing illness, disability or infirmity	0.9	1.4	2.5	-0.6	-1.6
Medication: Paracetamol	0.9	1.4	2.8	-1.7	0.1
Leg fat percentage (left)	0.9	3.1	5.9	0.6	-2.4
Myopia	0.9	1.3	1.5	1.2	1.0
Ulcerative Colitis (UC)	0.8	1.5	2.8	0.4	1.7
Trunk fat percentage	0.8	3.0	5.8	0.5	-2.4
Hip circumference	0.8	3.3	5.9	0.9	-2.4
Loud music exposure frequency	0.8	0.9	1.5	-0.6	-1.2
Medication: Amlodipine	0.8	1.1	2.2	1.5	0.3
Pulse wave peak to peak time	0.8	0.9	1.3	-0.7	-1.1
Neck or shoulder pain in last month	0.8	1.2	1.8	-0.7	1.3
Medication: Omeprazole	0.8	1.0	1.8	-0.4	1.3
Family relationship satisfaction	0.8	1.0	1.9	-0.4	-1.4
Hypertension (Self-reported)	0.8	2.2	4.5	0.0	2.1
Commuting to job workplace: Walk	0.8	0.8	1.7	-1.3	-0.2
Alcohol drinker status: Never	0.8	0.9	1.8	-1.3	0.4
Ever depressed for a whole week	0.8	0.9	1.0	-0.9	-1.0
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.7	-0.7	-1.9
Alcohol drinker status: Previous	0.8	1.0	1.9	-1.4	0.1
Bipolar Disorder (2018)	0.7	1.2	2.3	-0.2	1.5
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.0	1.0	-0.9
Systolic blood pressure, automated reading	0.7	2.0	2.2	-1.5	1.3
Impedance of leg (right)	0.7	3.1	5.6	-2.4	-0.9
Fed-up feelings	0.7	1.2	2.0	-0.7	-1.4
Neuroticism score	0.7	1.5	3.0	-0.2	-1.7
Depression (self-reported)	0.7	0.8	0.9	-0.9	-0.8
Arm fat mass (right)	0.7	2.7	4.2	1.1	-2.1
Number of children fathered	0.7	0.8	1.6	-1.3	-0.3
Medication: Ibuprofen	0.7	0.9	1.6	-1.3	0.4
Whole body fat mass	0.7	2.9	5.0	0.9	-2.2
Arm fat mass (left)	0.7	2.7	4.2	1.1	-2.1
Unable to work because of sickness or disability	0.7	0.9	1.7	-0.0	-1.3
Impedance of whole body	0.7	3.8	6.0	-2.5	-1.3
Bipolar Disorder or Schizophrenia	0.6	1.4	2.8	0.3	1.7
High blood pressure	0.6	1.8	3.5	-0.2	1.9
Supplements: Glucosamine	0.6	0.8	1.4	-1.2	0.5
Body mass index (BMI)	0.6	2.3	2.8	1.7	-1.4
Trunk fat mass	0.6	2.7	4.9	0.7	-2.2
Had other major operations	0.6	0.7	1.2	-1.1	0.5
Alcohol intake versus 10 years previously	0.6	0.9	1.6	0.5	1.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	0.5	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	-1.3	-0.3
Leg fat percentage (right)	0.6	2.2	4.2	0.4	-2.1
Worry too long after embarrassment	0.6	1.1	2.1	-0.2	-1.4
Had major operations	0.6	0.6	0.7	0.8	-0.8
Smoking status: Current	0.6	0.9	1.4	-0.7	-1.2
Basal cell carcinoma (self-reported)	0.6	0.7	0.8	-0.8	0.9
Leg fat mass (left)	0.6	2.4	3.6	1.1	-1.9
Lung FVC	0.5	2.8	4.8	2.2	0.9
Number of treatments/medications taken	0.5	0.8	1.5	0.4	1.2
Diabetes (mother)	0.5	0.7	1.4	1.2	-0.1
Nervous feelings	0.5	0.9	1.7	-1.3	-0.3
Hair/balding pattern: Pattern 2	0.5	0.6	0.9	-0.6	-1.0
Had menopause	0.5	0.6	1.2	0.1	1.1
Pain all over the body in last month	0.5	0.6	0.9	-0.9	0.5
Medication: Ramipril	0.5	0.7	1.2	1.1	0.3
Prospective memory result	0.5	0.6	1.2	-1.1	0.1
Lung cancer (father)	0.5	0.5	0.9	-0.9	0.5
Blood clot in the leg (DVT)	0.5	0.7	1.1	-1.1	0.5
High blood pressure (siblings)	0.5	0.7	1.2	-1.1	0.4
Leg fat mass (right)	0.5	2.0	2.9	1.0	-1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.1	1.0	-0.1
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	0.4	-1.2
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.5	-1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.1	0.2
Average weekly beer plus cider intake	0.5	0.7	1.4	-0.3	-1.2
Pack years of smoking	0.5	0.7	1.1	-0.5	1.1
HbA1C	0.4	0.4	0.8	-0.9	0.0
Schizophrenia (2014)	0.4	1.0	1.9	0.2	1.4
Systolic Blood Pressure	0.4	1.9	2.9	-0.9	1.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	-0.5	0.9
Townsend deprivation index at recruitment	0.4	0.6	0.8	-0.9	-0.6
Current tobacco smoking	0.4	0.7	1.1	-0.5	-1.1
Taking other prescription medications	0.4	0.6	1.1	-1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.7	0.6	-0.9
Weight	0.4	2.1	3.2	1.0	-1.8
Number of live births	0.4	0.5	1.0	0.2	-1.0
Impedance of arm (left)	0.4	2.0	3.3	-1.8	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	0.4	1.0
Comparative body size at age 10	0.4	1.0	1.0	1.0	1.0
Medication: Allopurinol	0.4	0.6	1.1	-1.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	1.0	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.5	-0.7	-0.7
Miserableness	0.4	0.8	1.5	-1.2	0.2
Hearing aid user	0.4	0.4	0.7	-0.4	-0.8
Mother’s age at death	0.4	0.5	0.9	0.9	-0.2
Ever smoked	0.4	0.6	0.8	-0.9	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.7	-0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.8	-0.9	0.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	-1.0	0.4
Schizophrenia (2018)	0.3	0.6	0.9	0.6	0.9
Reaction Time	0.3	0.7	1.3	-0.1	-1.1
Fasting Glucose	0.3	0.3	0.6	0.0	0.8
Rheumatoid Arthritis	0.3	0.4	0.4	0.6	-0.6
Maternal smoking around birth	0.3	0.5	0.6	-0.8	0.6
Diabetes (self-reported)	0.3	0.5	0.6	0.6	0.8
Impedance of arm (right)	0.3	1.5	2.4	-1.6	-0.7
Peak expiratory flow (PEF)	0.3	0.6	1.2	-1.1	0.2
Forced vital capacity (FVC), Best measure	0.3	1.1	1.1	-1.1	1.0
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	1.0	-0.4
Medication: Seretide 50 evohaler	0.3	0.4	0.8	0.9	-0.2
Supplements: Vitamin C	0.3	0.4	0.7	-0.9	0.1
Breast cancer (self-reported)	0.3	0.4	0.8	0.2	0.9
Guilty feelings	0.3	0.4	0.5	0.5	-0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.2	-0.4	-0.5
Major Depression (MDD)	0.2	0.3	0.4	0.4	-0.6
Ulcerative Colitis	0.2	0.2	0.3	0.4	0.6
Allergy or Eczema	0.2	0.4	0.4	-0.7	-0.7
Chronotype (morning person)	0.2	0.4	0.7	0.2	-0.8
Hand grip strength (left)	0.2	0.7	1.1	1.0	-0.5
Leg fat-free mass (left)	0.2	1.3	2.2	1.5	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.5	-0.6
Sitting height	0.2	1.6	2.4	-0.9	-1.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	0.3	0.6
Leg predicted mass (left)	0.2	1.3	2.3	1.5	-0.5
Past tobacco smoking	0.2	0.4	0.4	0.6	0.6
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.0	-0.7
Worrier / anxious feelings	0.2	0.4	0.4	0.7	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.8	-0.2
Happiness	0.2	0.3	0.5	-0.7	0.2
Length of working week for main job	0.2	0.3	0.5	-0.1	0.7
Breastfed as a baby	0.2	0.3	0.4	0.7	-0.3
Tense / ‘highly strung’	0.2	0.3	0.5	0.2	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	-0.9	0.3
Headache pain in last month	0.2	0.4	0.6	0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.4	-0.7	-0.4
Mean time to correctly identify matches	0.2	0.5	0.6	-0.6	-0.8
Arm predicted mass (right)	0.2	0.8	1.0	1.0	-0.8
Whole body fat-free mass	0.2	0.9	1.7	1.3	-0.3
Leg fat-free mass (right)	0.2	1.3	2.1	1.4	-0.7
Ever had bowel cancer screening	0.2	0.3	0.3	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.9	-0.1
Whole body water mass	0.2	1.0	1.8	1.3	-0.4
Leg predicted mass (right)	0.2	1.2	2.0	1.4	-0.7
Basal metabolic rate	0.2	1.1	1.4	1.2	-0.9
Arm fat-free mass (left)	0.2	1.1	1.3	1.1	-0.9
Irritability	0.2	0.4	0.6	-0.5	-0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.6	0.3
Diastolic blood pressure, automated reading	0.2	0.6	0.7	0.7	0.9
Arm predicted mass (left)	0.2	0.9	0.9	1.0	-0.9
Depression (Nagel 2018)	0.1	0.1	0.2	0.0	-0.4
Breast Cancer	0.1	0.3	0.4	0.6	0.4
Age at First Birth	0.1	0.1	0.1	0.4	0.4
Hypothyroidism (self reported)	0.1	0.2	0.3	0.1	-0.5
Respiratory disease	0.1	0.2	0.3	0.5	-0.3
Lung FEV1/FVC ratio	0.1	0.7	0.7	-0.9	0.9
Neuroticism	0.1	0.3	0.5	0.4	-0.7
Tanning	0.1	0.8	1.5	-1.2	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.3	0.4
Medication: Co-codamol	0.1	0.1	0.1	-0.3	-0.4
Severe depression (siblings)	0.1	0.1	0.2	0.0	-0.5
Pack years adult smoking proportion	0.1	0.2	0.3	-0.1	0.5
Average weekly fortified wine intake	0.1	0.1	0.2	-0.2	-0.4
Relative age voice broke	0.1	0.1	0.1	0.3	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.3	0.5
Trunk fat-free mass	0.1	0.8	1.6	1.3	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	-0.6	0.5
Trunk predicted mass	0.1	0.7	1.3	1.1	-0.1
Standing height	0.1	1.0	1.4	-1.2	-0.8
Pulse wave reflection index	0.1	0.1	0.1	0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.5	-0.2
Glaucoma (self-reported)	0.1	0.2	0.3	0.6	0.0
Birth weight	0.1	0.1	0.2	-0.3	0.4
Arm fat-free mass (right)	0.1	0.6	0.8	0.9	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	0.1
Medication: Blood pressure	0.1	0.1	0.2	-0.3	0.4
Alcohol intake frequency.	0.1	0.1	0.2	0.5	-0.1
Comparative height size at age 10	0.1	0.4	0.4	-0.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.2	-0.4	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.3	-0.4
Diabetes diagnosed by doctor	0.1	0.1	0.1	0.4	-0.3
Asthma (self-reported)	0.1	0.2	0.4	0.6	-0.0
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.3	-0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.3	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	0.3
Risk taking	0.1	0.1	0.2	0.0	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.4	-0.2
Pain experienced in last month	0.1	0.2	0.4	0.6	-0.4
Supplements: Calcium	0.1	0.1	0.2	-0.3	-0.4
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.2	0.1
Worry (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.2
Primary Biliary Cirrhosis	0.0	0.1	0.1	0.3	0.2
Height	0.0	0.5	0.7	-0.8	0.6
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.6	-0.1
Smoking Status	0.0	0.1	0.2	-0.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.1	-0.4
Hair Pigment	0.0	0.8	1.7	0.2	1.3
Relative age of first facial hair	0.0	0.1	0.1	-0.2	0.4
Hand grip strength (right)	0.0	0.0	0.0	0.2	-0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.3	0.1
Alcohol usually taken with meals	0.0	0.0	0.0	0.2	-0.2
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.2	0.1
Allergy	0.0	0.1	0.2	-0.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	-0.2	0.2
Asthma	0.0	0.1	0.2	0.4	0.1
Medication: Lansoprazole	0.0	0.0	0.1	0.2	0.3
Age at last live birth	0.0	0.1	0.1	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.2	-0.2
Knee pain experienced in last month	0.0	0.1	0.1	0.4	0.1
Smoking status: Previous	0.0	0.1	0.1	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.1	-0.3
Number of operations (self-reported)	0.0	0.0	0.0	0.0	-0.1
Age started oral contraceptive pill	0.0	0.1	0.1	0.1	0.3

Hub : Genes

USP1

Models

Trait associations