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chr11:42,881,882-44,596,817

Best TWAS P=1.68e-10 · Best GWAS P=1.27e-09 conditioned to 0.273

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Breast Mammary Tissue	RP11-613D13.5	0.18	0.11	lasso	5	0.15	6.3e-08	5.3	-6.4	1.7e-10	0.86	0.03	0.96	TRUE
14	GTEx	Brain Cerebellar Hemisphere	HSD17B12	0.50	0.41	enet	33	0.29	3.0e-08	6.0	-6.2	6.6e-10	0.61	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	HSD17B12	0.28	0.25	enet	17	0.21	2.6e-11	5.3	-6.2	7.1e-10	0.64	0.03	0.97	FALSE
77	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HSD17B12	0.34	0.26	blup	115	0.26	1.6e-09	5.3	-6.1	1.1e-09	0.50	0.04	0.96	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	RP11-613D13.5	0.17	0.12	enet	19	0.15	2.2e-08	5.9	-6.0	2.6e-09	0.71	0.04	0.96	FALSE
39	GTEx	Nerve Tibial	RP11-613D13.5	0.14	0.19	lasso	2	0.18	1.1e-12	5.8	-5.9	3.4e-09	0.60	0.05	0.95	FALSE
56	METSIM	Adipose	HSD17B12	0.19	0.29	bslmm	660	0.29	4.7e-43	5.9	-5.9	3.7e-09	0.60	0.04	0.96	FALSE
30	GTEx	Esophagus Muscularis	RP11-613D13.5	0.21	0.20	lasso	2	0.19	9.6e-12	5.3	-5.9	4.4e-09	0.70	0.03	0.97	FALSE
73	The Cancer Genome Atlas	Rectum Adenocarcinoma	HSD17B12	0.39	0.25	lasso	4	0.26	7.2e-07	5.7	-5.9	4.6e-09	0.65	0.03	0.96	FALSE
53	GTEx	Uterus	HSD17B12	0.60	0.48	enet	20	0.52	2.1e-12	5.7	-5.8	5.1e-09	0.59	0.03	0.97	FALSE
50	GTEx	Testis	HSD17B12	0.67	0.58	lasso	10	0.60	8.5e-33	5.8	-5.8	6.8e-09	0.62	0.03	0.97	FALSE
28	GTEx	Esophagus Mucosa	RP11-613D13.5	0.17	0.19	lasso	6	0.18	2.5e-12	5.8	-5.8	7.1e-09	0.58	0.04	0.96	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSD17B12	0.35	0.52	lasso	4	0.54	4.7e-71	6.0	-5.8	7.3e-09	0.57	0.02	0.98	FALSE
16	GTEx	Brain Cortex	HSD17B12	0.52	0.37	lasso	9	0.40	5.4e-12	6.0	-5.8	7.5e-09	0.55	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HSD17B12	0.19	0.27	enet	10	0.27	6.1e-23	5.3	-5.8	8.0e-09	0.60	0.04	0.96	FALSE
15	GTEx	Brain Cerebellum	HSD17B12	0.52	0.39	lasso	16	0.36	2.4e-11	6.0	-5.8	8.2e-09	0.59	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HSD17B12	0.19	0.24	lasso	6	0.24	4.7e-14	5.3	-5.8	8.2e-09	0.60	0.03	0.97	FALSE
8	GTEx	Artery Aorta	RP11-613D13.5	0.31	0.27	lasso	3	0.27	3.0e-15	5.3	-5.8	8.4e-09	0.67	0.05	0.95	FALSE
21	GTEx	Breast Mammary Tissue (Male)	HSD17B12	0.48	0.34	lasso	14	0.34	1.1e-08	5.9	-5.8	8.4e-09	0.57	0.03	0.97	FALSE
23	GTEx	Cells Transformed fibroblasts	RP11-613D13.5	0.34	0.42	lasso	9	0.42	4.5e-34	5.8	-5.8	9.2e-09	0.57	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	HSD17B12	0.22	0.33	enet	18	0.33	1.1e-39	5.3	-5.7	1.1e-08	0.53	0.03	0.97	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD17B12	0.18	0.23	lasso	4	0.23	6.6e-16	5.8	-5.7	1.3e-08	0.58	0.03	0.97	FALSE
9	GTEx	Artery Coronary	HSD17B12	0.61	0.41	lasso	19	0.43	4.5e-16	5.3	-5.6	1.9e-08	0.56	0.03	0.97	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-613D13.5	0.18	0.01	lasso	3	0.05	8.9e-04	5.3	-5.6	2.0e-08	0.53	0.05	0.94	FALSE
18	GTEx	Brain Putamen basal ganglia	HSD17B12	0.51	0.30	enet	28	0.33	1.3e-08	6.0	-5.6	2.1e-08	0.55	0.03	0.96	FALSE
22	GTEx	Cells Transformed fibroblasts	HSD17B12	0.60	0.69	lasso	10	0.69	2.0e-71	5.3	-5.6	2.3e-08	0.57	0.03	0.97	FALSE
46	GTEx	Skin Sun Exposed Lower leg	HSD17B12	0.46	0.60	lasso	7	0.61	9.2e-63	5.3	-5.6	2.3e-08	0.57	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	HSD17B12	0.33	0.36	enet	17	0.39	7.5e-24	5.8	-5.6	2.3e-08	0.53	0.03	0.97	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	HSD17B12	0.43	0.43	lasso	6	0.45	3.4e-15	6.0	-5.6	2.4e-08	0.53	0.03	0.97	FALSE
38	GTEx	Nerve Tibial	HSD17B12	0.58	0.52	enet	56	0.56	3.5e-47	6.0	-5.6	2.5e-08	0.59	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD17B12	0.19	0.27	lasso	3	0.27	9.8e-31	5.3	-5.6	2.6e-08	0.57	0.04	0.96	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	HSD17B12	0.51	0.35	lasso	7	0.37	3.1e-14	5.3	-5.6	2.7e-08	0.58	0.03	0.97	FALSE
32	GTEx	Heart Atrial Appendage	RP11-613D13.5	0.18	0.02	enet	11	0.07	5.3e-04	5.3	-5.6	2.7e-08	0.71	0.04	0.95	FALSE
75	The Cancer Genome Atlas	Skin Cutaneous Melanoma	HSD17B12	0.15	0.08	enet	17	0.08	3.0e-03	6.0	-5.5	2.9e-08	0.60	0.03	0.75	FALSE
2	GTEx	Adipose Subcutaneous	HSD17B12	0.31	0.35	lasso	5	0.37	2.8e-31	5.8	-5.5	3.0e-08	0.57	0.04	0.96	FALSE
40	GTEx	Ovary	HSD17B12	0.45	0.36	lasso	17	0.33	5.4e-09	5.3	-5.5	3.2e-08	0.55	0.03	0.97	FALSE
11	GTEx	Artery Tibial	RP11-613D13.5	0.17	0.18	lasso	6	0.18	2.4e-14	5.3	-5.5	3.5e-08	0.62	0.06	0.94	FALSE
24	GTEx	Colon Transverse	HSD17B12	0.48	0.49	lasso	4	0.50	1.3e-26	5.3	-5.5	3.5e-08	0.57	0.03	0.97	FALSE
17	GTEx	Brain Hippocampus	HSD17B12	0.49	0.43	lasso	6	0.41	8.9e-11	5.3	-5.5	3.7e-08	0.57	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	RP11-613D13.5	0.10	0.11	lasso	2	0.10	8.1e-09	5.3	-5.5	3.9e-08	0.56	0.04	0.96	FALSE
55	GTEx	Whole Blood	RP11-613D13.5	0.06	0.01	lasso	4	0.00	1.2e-01	-5.5	-5.5	4.1e-08	0.89	0.05	0.43	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HSD17B12	0.44	0.51	lasso	11	0.53	6.0e-76	5.3	-5.5	4.3e-08	0.60	0.21	0.79	FALSE
36	GTEx	Lung	RP11-613D13.5	0.18	0.20	lasso	2	0.17	6.0e-13	5.3	-5.5	4.5e-08	0.59	0.04	0.96	FALSE
27	GTEx	Esophagus Mucosa	HSD17B12	0.54	0.58	lasso	12	0.58	1.3e-47	5.3	-5.5	4.7e-08	0.56	0.03	0.97	FALSE
54	GTEx	Whole Blood	HSD17B12	0.29	0.36	lasso	3	0.36	4.5e-34	5.3	-5.5	4.7e-08	0.56	0.04	0.96	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HSD17B12	0.20	0.26	lasso	2	0.26	1.3e-29	5.3	-5.5	4.8e-08	0.56	0.09	0.91	FALSE
12	GTEx	Brain Caudate basal ganglia	HSD17B12	0.68	0.43	lasso	18	0.49	6.0e-16	6.0	-5.5	4.9e-08	0.46	0.03	0.97	FALSE
13	GTEx	Brain Caudate basal ganglia	RP11-613D13.5	0.32	0.14	enet	24	0.13	1.6e-04	5.9	-5.5	5.1e-08	0.57	0.04	0.92	FALSE
34	GTEx	Liver	HSD17B12	0.46	0.38	enet	24	0.28	1.3e-08	5.8	-5.4	5.4e-08	0.54	0.03	0.97	FALSE
74	The Cancer Genome Atlas	Soft Tissue Sarcoma	HSD17B12	0.13	0.20	lasso	3	0.18	3.9e-11	5.3	-5.4	5.6e-08	0.58	0.06	0.94	FALSE
25	GTEx	Colon Transverse	RP11-613D13.5	0.21	0.24	lasso	3	0.23	3.4e-11	5.3	-5.4	5.9e-08	0.56	0.03	0.97	FALSE
10	GTEx	Artery Tibial	HSD17B12	0.47	0.54	lasso	5	0.59	8.9e-57	5.3	-5.4	6.0e-08	0.61	0.06	0.94	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B12	0.32	0.48	lasso	4	0.47	1.5e-60	5.3	-5.4	6.4e-08	0.57	0.26	0.74	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B12	0.60	0.66	lasso	2	0.65	4.5e-84	5.3	-5.4	6.7e-08	0.56	0.44	0.56	FALSE
52	GTEx	Thyroid	RP11-613D13.5	0.24	0.18	lasso	2	0.15	7.3e-12	5.3	-5.4	7.2e-08	0.57	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD17B12	0.10	0.20	lasso	4	0.20	7.5e-39	5.3	-5.4	7.2e-08	0.56	0.26	0.74	FALSE
7	GTEx	Artery Aorta	HSD17B12	0.61	0.55	lasso	9	0.59	3.4e-39	5.3	-5.4	7.7e-08	0.60	0.03	0.97	FALSE
37	GTEx	Muscle Skeletal	HSD17B12	0.35	0.38	enet	24	0.37	3.4e-38	5.3	-5.4	7.7e-08	0.52	0.04	0.96	FALSE
71	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HSD17B12	0.28	0.30	lasso	4	0.29	8.1e-13	5.3	-5.3	1.0e-07	0.55	0.03	0.97	FALSE
19	GTEx	Breast Mammary Tissue	HSD17B12	0.21	0.17	lasso	1	0.12	6.0e-07	5.3	-5.3	1.1e-07	0.55	0.04	0.96	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	HSD17B12	0.45	0.59	lasso	1	0.59	1.9e-39	5.3	-5.3	1.1e-07	0.55	0.38	0.62	FALSE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HSD17B12	0.18	0.22	lasso	2	0.20	2.2e-10	5.3	-5.3	1.1e-07	0.54	0.04	0.96	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD17B12	0.22	0.25	lasso	1	0.24	9.8e-12	5.3	-5.3	1.1e-07	0.55	0.04	0.96	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD17B12	0.36	0.52	lasso	6	0.52	3.8e-63	5.3	-5.3	1.1e-07	0.53	0.08	0.92	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	HSD17B12	0.17	0.27	lasso	1	0.26	6.0e-19	5.3	-5.3	1.1e-07	0.55	0.13	0.87	FALSE
79	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	HSD17B12	0.21	0.20	lasso	1	0.16	4.3e-05	5.3	-5.3	1.1e-07	0.55	0.03	0.94	FALSE
49	GTEx	Stomach	RP11-613D13.5	0.18	0.21	lasso	3	0.21	1.6e-10	5.3	-5.3	1.2e-07	0.55	0.04	0.96	FALSE
31	GTEx	Heart Atrial Appendage	HSD17B12	0.52	0.46	lasso	6	0.44	1.2e-21	5.3	-5.3	1.3e-07	0.56	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Esophageal Carcinoma	HSD17B12	0.27	0.31	enet	17	0.31	1.2e-10	5.8	-5.3	1.3e-07	0.45	0.03	0.97	FALSE
47	GTEx	Skin Sun Exposed Lower leg	RP11-613D13.5	0.17	0.22	lasso	3	0.21	2.2e-17	5.3	-5.3	1.4e-07	0.57	0.05	0.95	FALSE
48	GTEx	Stomach	HSD17B12	0.37	0.51	lasso	2	0.51	9.5e-28	5.3	-5.3	1.4e-07	0.54	0.04	0.96	FALSE
29	GTEx	Esophagus Muscularis	HSD17B12	0.57	0.56	lasso	8	0.58	1.1e-42	5.3	-5.2	1.5e-07	0.54	0.03	0.97	FALSE
41	GTEx	Pancreas	HSD17B12	0.43	0.40	lasso	2	0.40	7.6e-18	5.3	-5.2	1.5e-07	0.56	0.05	0.95	FALSE
33	GTEx	Heart Left Ventricle	HSD17B12	0.25	0.28	lasso	4	0.25	8.2e-14	5.3	-5.2	1.9e-07	0.54	0.04	0.96	FALSE
42	GTEx	Prostate	HSD17B12	0.65	0.51	enet	34	0.53	8.8e-16	6.0	-5.2	1.9e-07	0.46	0.03	0.97	FALSE
6	GTEx	Adrenal Gland	HSD17B12	0.20	0.19	lasso	7	0.18	5.2e-07	5.3	-5.2	2.1e-07	0.54	0.03	0.96	FALSE
51	GTEx	Thyroid	HSD17B12	0.52	0.59	lasso	4	0.59	1.1e-55	5.3	-5.2	2.2e-07	0.53	0.13	0.87	FALSE
43	GTEx	Prostate	RP11-613D13.5	0.29	0.07	enet	27	0.16	8.2e-05	6.0	-5.2	2.3e-07	0.31	0.03	0.91	FALSE
35	GTEx	Lung	HSD17B12	0.54	0.59	enet	32	0.61	8.3e-59	5.3	-5.2	2.6e-07	0.46	0.03	0.97	FALSE