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chr11:46,033,104-48,783,497

Best TWAS P=3.53e-18 · Best GWAS P=4.27e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Cells EBV-transformed lymphocytes	ACP2	0.17	0.03	lasso	6	0.03	4.2e-02	-6.2	8.7	3.5e-18	-0.83	0.04	0.88	TRUE
27	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	7.2	-8.1	8.0e-16	0.58	0.13	0.82	TRUE
2	CommonMind	Brain Pre-frontal Cortex	PTPRJ	0.06	0.04	lasso	4	0.05	7.6e-07	-7.2	-7.3	2.1e-13	0.65	0.07	0.93	TRUE
26	GTEx	Thyroid	ACP2	0.19	0.14	lasso	4	0.12	3.0e-09	-7.1	7.0	3.4e-12	-0.82	0.21	0.79	TRUE
24	GTEx	Spleen	PTPRJ	0.22	0.05	lasso	5	0.03	7.5e-02	6.6	6.7	2.8e-11	-0.10	0.07	0.10	TRUE
28	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	-7.6	6.6	4.4e-11	-0.91	0.01	0.97	TRUE
42	The Cancer Genome Atlas	Thyroid Carcinoma	DDB2	0.06	0.04	enet	17	0.03	1.3e-03	-7.8	-6.4	1.3e-10	0.86	0.00	1.00	TRUE
43	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	-7.6	6.4	1.3e-10	-0.74	0.01	0.81	TRUE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	-7.7	5.6	2.4e-08	-0.85	0.01	0.81	TRUE
17	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-7.8	8.3	8.6e-17	-0.71	0.02	0.96	FALSE
15	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	-7.6	8.0	8.9e-16	-0.93	0.02	0.98	FALSE
19	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	-6.1	7.5	7.7e-14	-0.84	0.05	0.90	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	5.7	-7.5	9.1e-14	0.24	0.27	0.06	FALSE
4	GTEx	Adipose Visceral Omentum	ACP2	0.08	0.05	lasso	5	0.05	1.4e-03	-7.1	7.3	2.5e-13	-0.83	0.10	0.77	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AGBL2	0.03	0.02	enet	7	0.03	7.9e-05	-7.4	-7.3	3.0e-13	0.72	0.36	0.61	FALSE
29	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	-6.3	7.2	4.2e-13	-0.88	0.08	0.76	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACP2	0.02	0.03	lasso	1	0.02	1.5e-03	-7.1	7.1	9.3e-13	-0.83	0.04	0.55	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	-6.3	7.0	2.2e-12	-0.78	0.18	0.77	FALSE
9	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	-6.9	-7.0	3.1e-12	0.65	0.13	0.18	FALSE
10	GTEx	Breast Mammary Tissue (Female)	ACP2	0.03	0.00	lasso	1	0.02	1.0e-01	-6.9	7.0	3.6e-12	-0.79	0.03	0.11	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	SLC39A13	0.07	0.11	lasso	2	0.10	5.2e-06	-6.7	-6.8	1.4e-11	0.82	0.16	0.58	FALSE
18	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	-7.8	6.7	2.1e-11	-0.86	0.03	0.97	FALSE
25	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	-6.3	6.6	4.5e-11	-0.70	0.17	0.73	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	6.4	-6.4	1.5e-10	0.29	0.44	0.04	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	-6.1	-6.3	2.4e-10	0.82	0.30	0.70	FALSE
6	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	-6.8	6.2	4.0e-10	-0.63	0.10	0.76	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-6.8	-6.2	5.3e-10	0.71	0.00	0.93	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDB2	0.02	0.03	lasso	1	0.02	1.0e-03	-6.1	-6.1	8.8e-10	0.61	0.12	0.23	FALSE
16	GTEx	Esophagus Mucosa	C11orf49	0.19	0.05	enet	21	0.12	3.2e-08	-5.9	-6.1	9.0e-10	0.61	0.70	0.12	FALSE
7	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	-6.1	6.1	1.1e-09	-0.74	0.08	0.15	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	6.4	-5.9	4.7e-09	0.36	0.06	0.31	FALSE
13	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	-7.1	5.8	6.0e-09	-0.56	0.03	0.94	FALSE
3	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	-6.8	5.6	1.7e-08	-0.54	0.19	0.50	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACP2	0.02	0.01	blup	44	0.02	2.7e-04	-7.1	5.6	1.7e-08	-0.67	0.03	0.45	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	6.8	-5.4	8.1e-08	-0.04	0.02	0.48	FALSE
20	GTEx	Muscle Skeletal	FNBP4	0.05	0.03	lasso	5	0.04	5.0e-05	-6.7	-5.3	9.8e-08	0.68	0.24	0.64	FALSE
23	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	-7.0	5.3	1.0e-07	-0.61	0.90	0.10	FALSE
31	YFS	Blood	DDB2	0.02	0.00	bslmm	306	0.01	1.9e-04	-7.8	5.3	1.1e-07	-0.66	0.02	0.91	FALSE
11	GTEx	Breast Mammary Tissue (Female)	PSMC3	0.02	0.01	lasso	1	0.04	2.5e-02	-5.3	5.3	1.2e-07	-0.51	0.03	0.07	FALSE
5	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-1.3	5.3	1.3e-07	-0.47	0.22	0.41	FALSE
21	GTEx	Nerve Tibial	C11orf49	0.17	0.01	enet	21	0.05	9.5e-05	-7.7	-5.3	1.4e-07	0.75	0.05	0.89	FALSE
32	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	-6.1	5.2	1.8e-07	-0.46	0.98	0.02	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf49	0.05	0.00	blup	90	0.02	3.0e-04	-6.3	-5.2	2.1e-07	0.57	0.00	0.98	FALSE