Best TWAS P=1.26e-09 · Best GWAS P=6.7e-10 conditioned to 0.00026
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CPE | 0.19 | 0.04 | enet | 31 | 0.06 | 5.2e-06 | -1.5 | 5.3 | 9.0e-08 | 0.52 | 0.05 | 0.94 | FALSE |
| 2 | GTEx | Adrenal Gland | CPE | 0.24 | 0.00 | lasso | 11 | 0.03 | 2.5e-02 | 5.1 | -5.9 | 4.4e-09 | -0.65 | 0.03 | 0.74 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | RP11-219C20.3 | 0.18 | 0.00 | enet | 3 | 0.00 | 5.2e-01 | -5.4 | -5.5 | 5.0e-08 | -0.93 | 0.03 | 0.46 | FALSE |
| 4 | GTEx | Esophagus Muscularis | CPE | 0.12 | 0.09 | lasso | 2 | 0.06 | 9.3e-05 | 5.8 | 5.5 | 4.0e-08 | 0.49 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | CPE | 0.16 | 0.02 | lasso | 4 | 0.01 | 1.1e-01 | -5.3 | 5.2 | 2.0e-07 | 0.74 | 0.06 | 0.64 | FALSE |
| 6 | GTEx | Nerve Tibial | CPE | 0.21 | 0.21 | lasso | 8 | 0.19 | 1.6e-13 | 5.9 | 5.9 | 3.2e-09 | 0.45 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CPE | 0.09 | 0.06 | lasso | 8 | 0.04 | 1.4e-04 | 5.9 | 5.9 | 2.8e-09 | 0.49 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Testis | CPE | 0.39 | 0.38 | lasso | 10 | 0.34 | 4.7e-16 | 5.9 | -6.1 | 1.3e-09 | -0.49 | 0.02 | 0.98 | TRUE |
| 9 | METSIM | Adipose | CPE | 0.04 | 0.01 | lasso | 9 | 0.01 | 5.9e-03 | 5.9 | 6.0 | 2.0e-09 | 0.61 | 0.02 | 0.97 | FALSE |