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chr5:12,225-1,462,720

Best TWAS P=1.18e-27 · Best GWAS P=9.4e-27 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AHRR	0.25	0.18	lasso	12	0.21	1.2e-25	9.03	9.4	7.5e-21	0.49	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SDHA	0.12	0.06	bslmm	290	0.11	8.6e-14	8.94	-9.5	2.4e-21	-0.58	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SDHA	0.10	0.09	lasso	5	0.07	1.9e-06	9.03	9.5	2.5e-21	0.53	0.98	0.00	FALSE
4	GTEx	Adipose Subcutaneous	CCDC127	0.07	0.00	lasso	4	0.00	2.1e-01	5.05	7.7	1.1e-14	0.42	0.07	0.70	TRUE
5	GTEx	Adipose Visceral Omentum	SDHA	0.10	0.05	lasso	3	0.07	1.5e-04	9.17	9.1	1.2e-19	0.48	0.30	0.12	FALSE
6	GTEx	Adipose Visceral Omentum	CCDC127	0.13	0.03	lasso	4	0.05	9.0e-04	9.95	10.9	1.2e-27	0.74	0.03	0.95	TRUE
7	GTEx	Artery Aorta	PDCD6	0.26	0.17	lasso	4	0.14	2.8e-08	9.03	-8.4	3.0e-17	-0.52	0.99	0.00	FALSE
8	GTEx	Artery Coronary	CCDC127	0.27	0.02	lasso	7	0.00	2.7e-01	6.52	7.6	3.1e-14	0.45	0.02	0.61	FALSE
9	GTEx	Artery Tibial	PDCD6	0.22	0.07	lasso	4	0.06	2.1e-05	9.03	-7.4	1.7e-13	-0.50	0.66	0.29	FALSE
10	GTEx	Brain Cerebellum	CTD-2083E4.5	0.14	0.01	lasso	10	0.03	5.9e-02	6.09	-7.5	7.0e-14	-0.30	0.10	0.12	FALSE
11	GTEx	Brain Frontal Cortex BA9	AHRR	0.32	0.21	lasso	4	0.18	1.6e-05	9.03	8.3	1.3e-16	0.51	0.12	0.06	TRUE
12	GTEx	Cells Transformed fibroblasts	SDHA	0.23	0.18	lasso	2	0.17	1.6e-12	9.03	9.1	1.4e-19	0.53	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	CCDC127	0.25	0.13	lasso	5	0.14	9.0e-11	7.06	9.2	2.8e-20	0.49	0.81	0.19	FALSE
14	GTEx	Cells Transformed fibroblasts	CTD-2083E4.5	0.09	0.07	lasso	3	0.05	1.2e-04	9.17	-8.7	3.9e-18	-0.52	0.42	0.11	FALSE
15	GTEx	Colon Sigmoid	SLC9A3	0.18	0.05	enet	16	0.09	5.1e-04	-0.54	-5.5	3.7e-08	-0.22	0.06	0.20	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	CCDC127	0.13	0.09	lasso	3	0.03	2.8e-02	7.18	7.0	1.9e-12	0.53	0.08	0.16	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	PDCD6	0.22	0.17	lasso	3	0.19	1.8e-07	7.06	-6.0	1.6e-09	-0.36	0.19	0.45	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	CTD-2083E4.5	0.25	0.11	enet	10	0.12	3.3e-05	-0.16	-5.1	3.1e-07	-0.25	0.28	0.13	FALSE
19	GTEx	Heart Atrial Appendage	SDHA	0.15	0.04	lasso	3	0.02	4.3e-02	9.95	-10.3	6.3e-25	-0.82	0.02	0.94	FALSE
20	GTEx	Muscle Skeletal	ZDHHC11B	0.11	0.01	enet	16	0.03	4.0e-04	5.77	6.6	4.9e-11	0.25	0.37	0.03	FALSE
21	GTEx	Muscle Skeletal	PDCD6	0.08	0.04	lasso	6	0.01	1.8e-02	8.93	-6.7	2.8e-11	-0.49	0.07	0.80	FALSE
22	GTEx	Nerve Tibial	CCDC127	0.05	0.01	lasso	4	0.02	2.2e-02	9.95	10.4	3.1e-25	0.80	0.04	0.80	FALSE
23	GTEx	Pancreas	EXOC3	0.15	0.09	lasso	4	0.14	2.0e-06	-3.36	5.6	2.0e-08	0.21	0.60	0.02	TRUE
24	GTEx	Testis	SDHA	0.33	0.24	lasso	7	0.20	2.9e-09	5.77	8.6	7.4e-18	0.33	0.99	0.00	FALSE
25	GTEx	Thyroid	EXOC3	0.16	0.04	lasso	5	0.06	3.6e-05	7.42	7.2	4.4e-13	0.28	0.82	0.01	FALSE
26	GTEx	Thyroid	PDCD6	0.33	0.05	enet	39	0.22	1.6e-16	8.93	-5.8	8.2e-09	-0.55	0.82	0.18	FALSE
27	GTEx	Thyroid	CTD-2083E4.5	0.07	0.06	lasso	2	0.04	3.6e-04	9.10	-9.6	9.1e-22	-0.53	0.31	0.12	TRUE
28	GTEx	Whole Blood	SDHA	0.05	0.01	lasso	5	0.01	3.4e-02	8.05	-8.5	1.5e-17	-0.62	0.23	0.30	FALSE
29	METSIM	Adipose	CTD-2228K2.5	0.05	0.01	blup	315	0.02	1.4e-04	5.50	6.3	3.6e-10	0.23	0.16	0.02	TRUE
30	METSIM	Adipose	PDCD6	0.09	0.04	lasso	9	0.05	1.5e-07	-7.34	6.8	8.4e-12	0.19	1.00	0.00	TRUE
31	METSIM	Adipose	SDHA	0.09	0.04	lasso	12	0.03	8.5e-06	8.94	8.6	8.3e-18	0.55	1.00	0.00	FALSE
32	NTR	Blood	CCDC127	0.02	0.01	blup	284	0.02	1.5e-06	7.18	-9.7	4.1e-22	-0.45	0.87	0.08	FALSE
33	NTR	Blood	LOC100288152	0.01	0.01	blup	318	0.01	2.6e-04	4.43	-5.9	4.7e-09	-0.24	0.52	0.07	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	AHRR	0.35	0.19	enet	29	0.28	1.4e-36	2.63	7.3	3.1e-13	0.36	1.00	0.00	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	SDHA	0.07	0.04	lasso	4	0.04	2.3e-06	7.18	-7.8	4.3e-15	-0.25	0.94	0.01	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	CCDC127	0.19	0.18	lasso	6	0.19	3.3e-24	7.85	-6.4	1.9e-10	-0.19	1.00	0.00	TRUE
37	ROSMAP	Brain Pre-frontal Cortex	EXOC3	0.40	0.32	enet	19	0.36	5.3e-49	-2.77	5.2	1.7e-07	0.35	1.00	0.00	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	ZDHHC11B	0.05	0.00	bslmm	350	0.02	4.9e-04	9.70	5.4	5.8e-08	0.39	0.04	0.23	FALSE
39	YFS	Blood	PDCD6	0.03	0.03	bslmm	276	0.03	1.6e-09	9.03	10.7	1.5e-26	0.60	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHRR	0.04	0.03	lasso	3	0.03	1.1e-06	7.85	10.7	8.9e-27	0.68	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AHRR	0.10	0.01	blup	100	0.05	2.4e-06	8.05	6.4	1.9e-10	0.37	0.09	0.27	TRUE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRC14B	0.04	0.02	blup	63	0.01	2.0e-02	3.54	6.0	1.5e-09	0.21	0.09	0.26	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDCD6	0.03	0.02	blup	49	0.02	2.9e-03	8.94	9.2	2.8e-20	0.66	0.36	0.10	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDHA	0.04	0.03	blup	62	0.05	3.3e-06	9.03	9.6	1.0e-21	0.49	0.80	0.11	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AHRR	0.09	0.01	blup	100	0.06	2.7e-04	-7.34	7.8	4.2e-15	0.32	0.05	0.20	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCDC127	0.10	0.05	enet	7	0.06	4.0e-04	7.06	6.0	2.2e-09	0.38	0.02	0.59	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRRC14B	0.08	0.04	lasso	5	0.03	6.7e-03	8.94	8.9	3.9e-19	0.58	0.01	0.96	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDHA	0.05	0.02	lasso	4	0.01	1.3e-01	7.12	8.8	1.1e-18	0.47	0.08	0.25	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	AHRR	0.30	0.17	lasso	3	0.25	7.9e-28	7.85	10.2	1.9e-24	0.65	0.99	0.01	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AHRR	0.11	0.05	lasso	3	0.07	2.5e-04	9.03	9.2	2.5e-20	0.42	0.13	0.06	TRUE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	AHRR	0.05	0.01	blup	99	0.01	1.4e-02	3.74	8.1	8.2e-16	0.35	0.10	0.30	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	AHRR	0.12	0.04	blup	99	0.05	9.0e-06	3.74	6.1	1.2e-09	0.15	0.98	0.00	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	AHRR	0.04	0.03	blup	100	0.04	9.1e-04	3.22	8.3	1.3e-16	0.37	0.05	0.40	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	AHRR	0.13	0.04	blup	100	0.08	1.3e-08	7.85	6.8	7.8e-12	0.33	0.90	0.04	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC127	0.05	0.02	enet	7	0.04	5.3e-05	9.10	7.0	2.1e-12	0.48	0.01	0.97	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	PDCD6	0.07	0.06	enet	5	0.07	2.0e-07	9.10	-7.5	7.6e-14	-0.53	0.89	0.08	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	SDHA	0.06	0.09	lasso	13	0.08	1.8e-08	9.03	9.0	3.4e-19	0.54	0.86	0.14	FALSE