Best TWAS P=4.07e-10 · Best GWAS P=2.37e-14 conditioned to 1.25e-14
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GRPEL2 | 0.17 | 0.13 | enet | 16 | 0.13 | 3.5e-15 | 6.5 | 6.0 | 2.0e-09 | -0.02 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PCYOX1L | 0.08 | 0.07 | enet | 18 | 0.07 | 1.7e-08 | 6.5 | -6.1 | 8.2e-10 | 0.03 | 0.01 | 0.99 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | PCYOX1L | 0.29 | 0.06 | lasso | 7 | 0.05 | 9.1e-03 | 5.2 | 5.5 | 4.2e-08 | 0.02 | 0.10 | 0.24 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | PCYOX1L | 0.22 | 0.15 | lasso | 4 | 0.16 | 6.6e-12 | 5.2 | 5.4 | 6.3e-08 | 0.01 | 0.74 | 0.26 | FALSE |
5 | GTEx | Lung | PCYOX1L | 0.26 | 0.17 | lasso | 1 | 0.15 | 2.3e-11 | 5.2 | 5.2 | 2.5e-07 | 0.03 | 0.95 | 0.05 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | PCYOX1L | 0.25 | 0.10 | lasso | 6 | 0.10 | 2.7e-06 | 4.7 | 5.4 | 6.2e-08 | 0.02 | 0.12 | 0.83 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | PCYOX1L | 0.21 | 0.12 | enet | 11 | 0.18 | 9.2e-15 | 6.2 | 5.9 | 2.8e-09 | 0.01 | 0.10 | 0.90 | FALSE |
8 | GTEx | Spleen | PCYOX1L | 0.56 | 0.28 | enet | 16 | 0.34 | 1.4e-09 | 4.3 | 5.9 | 3.8e-09 | 0.01 | 0.04 | 0.96 | FALSE |
9 | GTEx | Whole Blood | PCYOX1L | 0.15 | 0.11 | lasso | 3 | 0.14 | 1.5e-12 | 4.2 | 5.3 | 9.8e-08 | -0.01 | 0.19 | 0.81 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | GRPEL2 | 0.15 | 0.10 | lasso | 4 | 0.09 | 1.9e-11 | -6.0 | 6.3 | 4.1e-10 | -0.01 | 0.02 | 0.98 | TRUE |
11 | YFS | Blood | PCYOX1L | 0.25 | 0.28 | bslmm | 564 | 0.30 | 8.3e-99 | 6.4 | 6.0 | 1.5e-09 | -0.02 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | PCYOX1L | 0.22 | 0.19 | blup | 57 | 0.23 | 1.3e-13 | 4.7 | 5.7 | 9.5e-09 | 0.00 | 0.92 | 0.08 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCYOX1L | 0.07 | 0.08 | enet | 12 | 0.08 | 5.5e-10 | 5.2 | 6.2 | 7.7e-10 | 0.01 | 0.06 | 0.94 | FALSE |