Hub : Genes

GRPEL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.166	0.0390	5.4e-08	0.132	0.085	0.127	0.126	0.123	8.2e-16	1.5e-10	3.5e-15	4.3e-15	9.4e-15
2	GTEx	Stomach	0.159	0.0570	4.0e-03	0.025	NA	-0.006	NA	-0.002	2.2e-02	NA	9.7e-01	NA	4.2e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.147	0.0313	1.1e-08	0.097	0.082	0.087	0.084	0.088	1.9e-12	9.7e-11	2.7e-11	5.5e-11	1.9e-11
4	YFS	Blood	0.018	0.0072	1.6e-03	0.004	0.007	0.002	0.006	0.003	1.1e-02	1.6e-03	4.7e-02	2.9e-03	3.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.0	2.1	-1.5	0.7	-1.2	0.2
Bipolar Disorder or Schizophrenia	1.8	4.5	6.7	-2.5	2.2	-2.6	0.1
Depressed Affect (Nagel 2018)	1.3	2.8	5.0	1.0	-1.6	1.6	-2.2
Depression (Nagel 2018)	1.6	2.4	5.6	-0.6	-1.8	-0.4	-2.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.4	-0.6	-0.6	0.0	1.6
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.3	-0.5	0.1	-1.0
Schizophrenia (2018)	1.8	3.7	5.5	-2.0	2.3	-2.4	0.0
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	-0.2	-0.1	-0.6	-0.8
Worry (Nagel 2018)	0.1	0.3	0.7	-0.3	0.8	-0.1	-0.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-0.3	1.1	0.0	0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.5	0.7	-0.6	0.3
Alzheimer’s Disease (including proxy)	1.0	1.5	3.2	-0.6	1.5	-0.5	1.8
Crohns Disease (2017)	1.4	3.1	8.8	-1.4	-3.0	-1.1	-0.7
Irritable Bowel Disease (IBD)	0.8	1.9	7.5	0.1	-2.7	0.1	0.1
Ulcerative Colitis (UC)	0.4	0.7	1.5	0.8	-1.2	0.8	0.6
Major Depression (MDD)	0.1	0.1	0.3	-0.4	-0.0	-0.2	-0.6
Reaction Time	0.2	0.4	1.0	-0.3	1.0	-0.7	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	1.0	-0.3	1.3	0.8
Breast Cancer	0.4	1.1	1.7	-0.9	0.7	-1.2	-1.3
Ovarian Cancer	0.2	0.3	1.1	-0.1	1.0	0.2	-0.2
Prostate Cancer	0.5	0.6	1.1	-0.9	-0.8	-1.0	0.3
Age at First Birth	0.9	1.3	2.5	1.6	-0.7	1.4	0.1
Bipolar Disorder (2011)	0.4	0.4	0.8	0.0	0.9	0.2	-0.9
Body Mass Index (BMI) (2010)	1.6	2.2	5.7	-1.0	0.2	-1.4	2.4
Coronary Artery Disease (CAD)	2.3	2.8	9.4	0.7	-3.1	0.8	-0.7
Crohns Disease (2012)	1.9	3.1	8.0	-1.3	-2.8	-1.2	-1.2
Mean Putamen Volume	2.8	3.2	4.5	-1.5	1.8	-1.7	2.1
Fasting Glucose	1.0	1.2	2.3	-1.5	-0.5	-1.2	0.8
HbA1C	0.8	0.8	1.5	-0.7	-1.1	-1.2	0.2
HDL Cholesterol	0.1	0.1	0.2	0.1	-0.5	-0.3	-0.2
LDL Cholesterol	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.3
Lupus	0.8	1.2	2.8	0.6	-1.2	0.2	-1.7
Neuroticism (2016)	1.2	1.7	4.7	0.6	-1.1	0.6	-2.2
Primary Biliary Cirrhosis	1.1	1.6	2.4	1.6	0.2	1.3	1.5
Rheumatoid Arthritis	0.3	0.4	1.1	-0.1	1.1	-0.4	0.4
Schizophrenia (2014)	2.4	5.3	8.6	-2.8	2.0	-2.9	0.7
Triglycerides	0.0	0.0	0.1	-0.3	0.1	0.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	-0.4	-0.1	-0.4	1.6
Ulcerative Colitis	0.6	0.8	2.5	0.7	0.4	0.3	1.6
Blood Eosinophil Count	0.3	2.0	4.4	-0.8	-2.1	-1.6	0.4
Blood Platelet Count	0.4	4.9	13.0	-1.9	-1.4	-1.1	3.6
Blood Red Count	0.0	0.3	1.0	0.1	-0.2	-0.2	-1.0
Blood White Count	0.1	0.4	0.7	-0.8	-0.1	-0.8	0.7
Heel T-Score	1.8	14.1	28.2	-4.8	1.8	-5.3	-1.5
BMI	1.0	5.8	9.8	-2.1	0.2	-3.0	3.1
Height	1.0	18.8	39.1	6.0	-0.4	6.3	-0.2
Waist Hip Ratio (WHR)	1.5	6.6	16.3	1.6	-1.3	2.4	-4.0
Systolic Blood Pressure	1.0	4.8	6.7	1.8	2.6	1.8	-2.5
Smoking Status	0.4	0.9	1.4	-0.8	-1.2	-0.5	1.1
Allergy or Eczema	0.4	1.1	2.4	-1.0	-1.5	-1.0	-0.3
Cardiovascular Disease	1.0	3.3	9.3	1.5	-0.2	1.2	-3.0
Hypothyroidism (self reported)	1.4	3.3	5.2	1.9	2.0	2.3	-0.4
Respiratory disease	0.8	1.9	3.0	1.4	-0.2	1.6	-1.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	0.9	-1.2	0.3	-0.5
Lung FEV1/FVC ratio	1.2	6.1	10.7	-1.6	2.4	-2.3	3.3
Lung FVC	1.2	6.3	24.6	-0.5	0.6	-0.3	5.0
Neuroticism	0.4	0.9	2.4	0.5	-0.7	0.6	-1.6
Chronotype (morning person)	0.5	1.1	3.4	-0.2	-0.9	0.4	-1.8
Hair Pigment	0.0	1.4	2.0	1.4	-1.3	1.2	0.7
Tanning	0.3	3.1	7.3	-1.9	-2.7	-0.8	-1.0
Hand grip strength (left)	0.8	2.0	2.8	1.6	1.3	1.7	0.9
Number of treatments/medications taken	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.1
Average weekly spirits intake	0.6	0.7	1.8	-0.5	0.2	-0.9	1.3
Sensitivity / hurt feelings	0.3	0.4	0.6	-0.7	0.7	-0.5	0.7
Frequency of depressed mood in last 2 weeks	1.7	2.4	7.8	-0.1	-1.4	-0.1	-2.8
Hearing difficulty/problems: Yes	3.4	5.1	14.7	0.6	-2.3	0.4	-3.8
Relative age of first facial hair	0.2	0.5	1.2	0.6	-0.5	1.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-1.1	-0.3	-0.9	-0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.5	-1.2	-0.4	-0.6	-0.8
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.3	0.9	0.9	-0.3
Systolic blood pressure, automated reading	0.2	0.5	1.9	-0.2	1.4	0.3	-0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	0.6	0.9	0.4	-0.4
Angina	0.3	0.4	0.8	0.7	-0.4	0.9	-0.1
Medication for hormone replacement therapy	0.7	0.8	2.2	0.2	1.5	0.6	0.8
Vitamin and mineral supplements	0.4	0.6	1.1	0.8	0.6	1.1	-0.4
Supplements: Zinc	1.2	1.3	2.1	1.4	0.1	1.1	-1.4
Medication: Co-codamol	0.2	0.2	0.7	0.8	-0.1	0.0	-0.2
Medication: Metformin	1.9	2.7	4.7	2.2	-1.6	1.8	0.0
Diabetes (father)	0.3	0.4	0.6	-0.6	-0.6	-0.7	-0.5
Diabetes (mother)	0.4	0.6	0.9	-0.6	-0.9	-0.9	0.4
Severe depression (siblings)	2.1	2.3	5.0	-0.4	-1.8	-1.0	-2.2
Pack years adult smoking proportion	3.0	4.5	8.9	-2.1	3.0	-1.7	1.3
Impedance of leg (right)	0.5	2.5	3.3	1.8	0.9	1.7	-1.8
Leg fat-free mass (left)	0.3	1.6	3.5	1.2	-0.5	1.1	1.9
Trunk fat percentage	1.2	4.6	12.9	-1.4	0.3	-1.9	3.6
Hand grip strength (right)	0.5	1.3	2.3	1.4	-0.3	1.5	0.9
Townsend deprivation index at recruitment	0.4	0.5	1.1	0.1	1.1	0.6	-0.9
Current tobacco smoking	1.3	2.1	2.9	-1.6	-0.7	-1.5	1.7
Average weekly fortified wine intake	0.6	0.7	1.3	-1.0	1.1	-0.6	-0.6
Maternal smoking around birth	1.4	2.1	3.5	1.3	-1.9	1.0	-1.4
Fed-up feelings	1.9	3.4	7.2	1.0	-1.7	1.6	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.6	-0.5	-0.4	-0.4	-1.6
Relative age voice broke	0.1	0.1	0.5	0.0	-0.0	0.7	-0.0
Taking other prescription medications	0.1	0.1	0.3	-0.0	0.5	0.4	-0.0
Age when periods started (menarche)	0.1	0.1	0.3	-0.5	-0.1	-0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.1	-0.1	-1.1	-0.0	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	4.0	-1.7	0.9	-2.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.1	0.0	-0.4	-0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.3	-0.3	0.2	-0.7
Serious illness, injury or assault to yourself	1.8	2.2	6.6	0.1	-2.6	0.5	-1.3
High blood pressure	1.1	3.0	7.4	1.6	0.2	1.5	-2.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.3	-1.1	-0.7	-0.4
Multivitamins +/- minerals	0.3	0.4	0.9	-0.1	-0.9	-0.7	0.2
Stomach or abdominal pain in last month	0.8	1.0	1.7	0.9	-0.3	1.2	-1.3
Supplements: Glucosamine	0.3	0.4	0.6	-0.8	-0.7	-0.8	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	0.1	0.5	0.4	0.5
Medication: Atenolol	0.8	1.1	2.6	-1.2	0.2	-1.6	-0.5
Medication: Levothyroxine sodium	1.8	3.1	4.7	1.8	2.2	1.9	-1.0
Sitting height	0.4	2.6	4.8	2.2	1.4	1.8	0.7
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	1.0	-0.3	1.5	0.4
High blood pressure (mother)	1.2	1.6	3.0	1.7	0.6	1.7	-0.6
Body mass index (BMI)	1.1	4.5	6.7	-2.2	-0.6	-2.5	2.6
Impedance of leg (left)	0.3	1.6	2.0	1.4	0.9	1.3	-1.3
Leg predicted mass (left)	0.3	1.6	3.5	1.2	-0.5	1.1	1.9
Trunk fat mass	0.8	3.3	11.2	-0.8	0.2	-1.2	3.4
Waist circumference	0.4	1.3	3.4	-0.7	-0.7	-0.9	1.8
Number of incorrect matches in round	1.5	2.4	3.6	1.3	1.5	1.4	1.9
Past tobacco smoking	0.3	0.6	0.9	0.8	0.9	-0.0	-0.9
Alcohol usually taken with meals	0.1	0.2	0.6	0.3	-0.4	-0.1	0.8
Nervous feelings	0.4	0.8	2.5	0.4	-0.6	0.4	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-0.5	-0.9	-0.2	-1.2
Hearing difficulty/problems with background noise	1.1	1.8	4.8	0.5	-1.5	-0.2	-2.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.7	-0.4	-0.1	-0.2
Had menopause	1.4	1.7	5.0	-2.2	-0.0	-1.4	-0.1
Had other major operations	0.2	0.3	0.5	0.2	-0.7	-0.6	0.3
Forced vital capacity (FVC)	0.8	3.1	6.4	1.9	0.7	1.5	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.7	-1.5	1.0	-1.9	0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.2	-0.6	-1.1	0.1	-1.1
Qualifications: None of the above	1.4	3.1	7.0	-1.3	-2.6	-1.4	-1.3
Financial difficulties in last 2 years	0.5	0.7	2.0	0.5	-0.1	0.8	-1.4
Mouth/teeth dental problems	0.6	1.0	2.7	1.6	-0.1	0.9	0.7
Heart attack	0.9	1.2	2.9	-1.7	0.7	-1.0	0.6
Allergy	0.1	0.3	0.7	-0.2	0.9	0.3	0.6
Pain all over the body in last month	0.4	0.4	1.3	-0.2	-0.6	0.0	-1.2
Diabetes (self-reported)	0.5	0.7	1.1	1.0	-1.0	0.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.6	1.1	-1.3	0.4	-0.1
Medication: Ramipril	0.5	0.6	1.2	0.6	-0.2	1.1	-1.0
Medication: Simvastatin	0.3	0.5	1.6	0.7	-1.2	0.0	-0.1
Fluid intelligence score	0.4	0.9	2.7	0.5	-1.6	0.8	-0.2
Illnesses of siblings	1.0	1.4	1.9	1.2	-0.8	1.4	-1.3
Neuroticism score	0.9	2.0	4.5	1.0	-1.1	1.1	-2.1
Weight	0.4	1.8	7.0	-0.1	-0.3	-0.5	2.6
Impedance of arm (right)	0.2	1.0	2.7	0.8	1.7	0.5	0.5
Arm fat percentage (right)	1.7	6.7	13.7	-2.3	0.2	-2.8	3.7
Trunk fat-free mass	0.3	2.0	3.7	1.9	-0.5	1.9	0.7
Hip circumference	1.0	4.3	15.7	-0.3	0.3	-1.2	4.0
Time employed in main current job	1.0	1.1	2.1	-1.4	0.5	-1.1	1.0
Alcohol intake versus 10 years previously	0.8	1.2	3.6	-0.6	1.9	-0.3	-0.9
Father’s age at death	0.4	0.5	1.3	-0.1	1.1	-0.3	0.9
Worrier / anxious feelings	0.1	0.2	0.4	0.2	0.7	0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.1	-0.2	0.3	-0.7
Falls in the last year	1.1	1.4	2.7	-1.6	-0.7	-1.6	-0.2
Hair/balding pattern: Pattern 3	1.4	2.1	3.7	-1.9	-0.3	-1.9	1.0
Number of live births	0.3	0.5	0.6	0.7	0.7	0.5	0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.6	1.5	1.3	0.7	2.4
Pulse rate	3.8	6.4	9.9	3.1	-2.4	3.1	-0.6
Happiness	0.2	0.3	0.8	-0.5	0.1	-0.2	0.9
Noisy workplace	1.4	1.7	2.9	-1.7	-0.7	-1.5	-1.2
Qualifications: A levels/AS levels or equivalent	1.8	3.9	4.4	2.1	1.8	2.1	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.4	0.4	-0.4	0.6
Mouth/teeth dental problems: Dentures	1.6	2.7	6.0	-2.5	-0.1	-1.5	1.5
Asthma	0.5	0.9	3.4	0.5	0.1	0.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.7	-0.4	-0.6	0.4
Medication: Cholesterol lowering	0.4	0.5	0.9	-1.0	-0.6	-0.8	0.5
Depression (self-reported)	1.8	2.2	5.2	-1.3	0.4	-2.3	-1.3
Medication: Lansoprazole	0.6	0.7	1.3	-1.0	-1.1	-0.5	0.3
Prospective memory result	0.5	0.7	1.3	1.1	0.1	1.1	-0.3
Lung cancer (father)	1.2	1.5	2.2	-1.5	1.2	-1.4	0.5
Illnesses of mother	0.3	0.4	0.9	-0.3	-0.5	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.8	1.6	0.8	0.6	2.6
Pulse wave Arterial Stiffness index	1.7	2.0	3.4	1.8	-0.9	1.2	-1.6
Impedance of arm (left)	0.3	1.3	3.2	1.0	1.8	0.8	0.7
Arm fat mass (right)	1.0	4.1	10.0	-1.5	-0.0	-2.0	3.2
Trunk predicted mass	0.3	1.9	3.5	1.9	-0.5	1.9	0.6
Standing height	0.9	9.1	18.9	4.3	0.6	4.1	0.5
Length of working week for main job	0.5	0.5	1.1	-0.2	0.7	-0.6	1.1
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.1	-0.5	-0.3	0.7
Breastfed as a baby	0.8	1.0	1.7	-1.1	0.2	-1.0	1.3
Tense / ‘highly strung’	0.5	0.8	2.4	-0.7	1.5	-0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	8.8	-0.5	-3.0	-0.8	-2.7
Hair/balding pattern: Pattern 4	1.1	2.7	4.8	1.9	-1.4	2.2	-0.7
Birth weight of first child	0.4	0.7	1.1	-0.6	1.0	-0.6	-1.1
Peak expiratory flow (PEF)	0.2	0.5	1.7	0.2	0.2	-0.2	1.3
Pulse wave reflection index	1.9	2.4	8.9	0.7	0.1	0.1	-3.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	6.3	-0.2	-0.9	0.6	-2.5
Loud music exposure frequency	0.6	0.7	2.1	0.6	-0.4	1.5	-0.3
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	7.6	2.3	-1.2	2.8	-0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.1	-1.1	0.8	-0.5	-0.5
Blood clot in the leg (DVT)	1.0	1.3	2.8	1.4	-1.7	0.6	0.4
Medication: Paracetamol	0.6	0.9	2.0	-1.1	-0.6	-1.4	0.2
Headache pain in last month	0.2	0.4	0.7	0.4	-0.4	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	0.4	0.6	-0.5
Glaucoma (self-reported)	0.4	0.5	1.0	0.6	1.0	0.7	0.5
Gout (self-reported)	1.2	1.6	4.2	1.3	-0.3	0.6	2.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.1	1.1	2.3	1.5	-0.2
Medication: Amlodipine	0.3	0.4	1.5	-0.4	-1.2	-0.4	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	-0.3	-0.0	0.3
Birth weight	0.4	0.8	1.9	-0.5	0.9	-0.6	-1.4
Chronic bronchitis/emphysema (mother)	1.9	2.3	3.8	1.3	-1.9	1.5	-1.2
High blood pressure (siblings)	0.4	0.6	1.5	-0.6	0.8	-0.3	1.2
Forced vital capacity (FVC), Best measure	0.6	2.3	6.2	1.4	0.7	0.8	2.5
Body fat percentage	1.3	5.1	12.7	-1.7	0.4	-2.2	3.6
Leg fat percentage (right)	0.9	3.3	5.7	-2.0	-0.0	-1.9	2.4
Arm fat-free mass (right)	0.4	1.8	2.5	1.6	-0.4	1.6	1.4
Exposure to tobacco smoke outside home	0.8	1.1	2.5	1.3	0.2	1.6	-0.6
Comparative body size at age 10	0.3	0.9	1.7	-0.9	-0.7	-1.3	0.7
Number of full brothers	1.7	2.1	3.4	-1.6	1.9	-1.5	-0.6
Worry too long after embarrassment	1.2	2.1	4.4	-1.9	-0.3	-2.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	-0.7	-0.7	-0.8	-1.0
Wheeze or whistling in the chest in last year	1.4	2.5	4.0	-1.9	-1.4	-2.0	-0.6
Number of children fathered	0.6	0.7	2.4	-0.5	0.1	-0.5	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.3	0.4	1.5	0.3	0.3
Age at first live birth	0.6	1.0	1.4	1.2	0.4	1.1	1.2
Pulse wave peak to peak time	1.0	1.2	2.2	-1.3	0.8	-0.7	1.5
Health satisfaction	0.9	1.2	2.3	-1.3	-0.3	-1.5	-0.7
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.7	-0.8	-1.2	-0.0
Qualifications: College or University degree	0.6	1.8	6.6	-0.2	0.7	-0.4	2.6
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.6	-0.4	-0.2	0.8
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.6	-1.6	0.3	-1.3	0.4
Emphysema/chronic bronchitis	1.1	1.3	1.9	0.9	-0.7	1.3	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.3	2.7	1.5	0.4	1.7	-0.2
Neck or shoulder pain in last month	0.3	0.5	1.7	-0.4	-0.1	-0.3	-1.3
Medication: Blood pressure	0.2	0.4	0.6	-0.6	0.5	-0.7	0.5
Angina (self-reported)	0.4	0.6	1.0	0.9	-0.6	1.0	-0.4
Migraine (self-reported)	0.1	0.1	0.3	-0.6	-0.4	-0.0	-0.1
Medication: Ibuprofen	0.3	0.4	0.6	-0.7	-0.7	-0.8	0.2
Medication: Allopurinol	0.6	0.8	2.6	0.1	-0.4	-0.7	1.6
Medication: Omeprazole	1.0	1.3	2.8	-0.7	-1.3	-0.3	-1.7
Medication: Seretide 50 evohaler	1.7	2.0	4.3	1.4	0.9	2.1	1.0
Mean time to correctly identify matches	0.8	1.6	1.9	-1.3	1.3	-1.4	0.9
Heart disease (mother)	1.1	1.4	3.1	-1.8	0.1	-1.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.1	0.1	-1.8	0.1	-1.7
Whole body fat mass	0.8	3.3	10.3	-1.0	0.2	-1.4	3.2
Leg fat mass (right)	0.6	2.4	7.3	-1.1	-0.2	-1.1	2.7
Arm predicted mass (right)	0.4	1.9	2.9	1.6	-0.6	1.7	1.3
Pulse rate, automated reading	3.0	9.7	14.8	3.5	-3.8	3.4	-0.4
Alcohol intake frequency.	0.6	1.5	5.4	0.1	-0.8	-0.0	-2.3
Comparative height size at age 10	0.8	4.5	8.7	3.0	-0.5	2.9	0.6
Number of full sisters	0.7	0.9	2.7	-0.2	0.1	-0.8	1.6
Suffer from ‘nerves’	0.2	0.3	1.0	0.0	-0.4	-0.1	-1.0
Overall health rating	0.4	0.8	1.8	-0.8	0.2	-0.8	-1.4
Chest pain or discomfort	0.2	0.3	0.4	-0.2	0.5	-0.6	-0.6
Had major operations	0.3	0.4	1.4	-0.2	-0.2	0.0	1.2
Age at last live birth	0.5	0.7	2.0	-0.4	0.8	-0.3	1.4
Family relationship satisfaction	0.0	0.1	0.1	0.3	-0.2	0.3	-0.0
Leg pain on walking	1.4	1.7	6.2	-0.2	-2.5	0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.5	-0.1	0.2	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.3	0.6	0.7	1.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.2	0.4	-0.7	-0.2
Medication: Aspirin	0.1	0.2	0.5	0.2	0.7	-0.3	0.2
Supplements: Vitamin C	0.9	1.1	2.1	-1.1	-1.5	-1.0	0.0
Knee pain experienced in last month	0.4	0.6	1.0	-1.0	0.8	-0.8	0.6
Hypertension (Self-reported)	1.0	2.7	6.7	1.5	-0.1	1.4	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	-0.8	-1.2	-0.6	-0.2
Illnesses of father: Heart disease	1.1	1.5	4.7	0.9	-0.5	0.3	-2.2
Illnesses of siblings: Diabetes	1.1	1.4	2.8	-1.4	0.8	-1.7	0.4
Smoking status: Previous	0.6	0.9	1.5	0.6	-1.2	1.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	1.6	0.4	1.1	0.4
Whole body fat-free mass	0.3	1.7	2.7	1.6	-0.6	1.6	1.1
Leg fat-free mass (right)	0.3	1.5	4.0	1.0	-0.4	0.8	2.0
Arm fat percentage (left)	1.7	6.9	16.1	-2.2	0.6	-2.5	4.0
Average weekly red wine intake	0.4	0.6	2.0	1.4	-0.3	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.2	0.4	0.1	-0.4
Mood swings	0.6	1.1	2.0	-0.4	-1.4	0.4	-1.4
Loneliness, isolation	0.8	1.1	3.3	0.3	-1.0	0.3	-1.8
Long-standing illness, disability or infirmity	2.2	3.4	6.5	-1.6	-1.4	-1.6	-2.6
Ever had bowel cancer screening	1.8	2.1	4.1	-2.0	-0.4	-1.9	-0.9
Diabetes diagnosed by doctor	0.4	0.7	1.7	0.8	-1.3	0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.0	0.4	-1.0	0.4	0.8
Friendships satisfaction	1.7	2.1	5.0	-1.1	0.6	-1.4	2.2
Qualifications: nursing, teaching	0.6	0.9	3.0	0.0	0.4	-0.5	1.7
Commuting to job workplace: Walk	0.4	0.4	0.7	-0.6	-0.3	-0.8	-0.8
Eye problems/disorders: Cataract	0.2	0.3	0.4	-0.4	0.4	-0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.4	1.0	-1.0	0.7	-2.1
Medication for cholesterol	0.1	0.2	0.6	-0.3	-0.2	-0.8	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	-1.3	0.6	-0.3	1.1
Back pain experienced in last month	0.2	0.4	1.2	-0.3	-0.4	-0.1	-1.1
Mineral and other dietary supplements	1.7	2.3	3.4	1.8	1.6	1.8	-0.4
Breast cancer (self-reported)	0.0	0.1	0.1	0.1	0.4	0.1	-0.3
Asthma (self-reported)	0.5	0.9	2.9	0.7	0.3	0.5	-1.7
Osteoporosis (self-reported)	2.0	2.5	5.1	2.0	-0.8	2.2	-0.5
Osteoarthritis (self-reported)	1.5	2.0	3.2	-1.8	0.7	-1.6	-1.3
Medication: Aspirin	0.1	0.1	0.4	0.0	0.6	-0.3	0.2
Medication: Gliclazide	0.5	0.6	1.3	-0.0	-1.0	-0.3	1.1
Illnesses of father: None of the above (group 1)	2.6	3.2	4.0	-2.0	-1.5	-2.0	1.6
Smoking status: Current	1.6	2.5	4.0	-1.9	-0.1	-2.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	6.6	-1.5	0.3	-1.4	2.6
Whole body water mass	0.3	1.9	2.9	1.7	-0.6	1.7	1.2
Leg predicted mass (right)	0.3	1.5	4.1	1.0	-0.4	0.8	2.0
Arm fat mass (left)	1.0	3.9	10.5	-1.4	0.0	-1.8	3.2
Number of self-reported non-cancer illnesses	1.1	1.8	4.4	1.2	-0.6	1.0	-2.1
Average weekly champagne plus white wine intake	0.8	1.0	3.2	0.2	-1.8	-0.2	-0.9
Miserableness	1.7	3.0	5.2	2.0	-0.7	2.3	-1.5
Guilty feelings	0.9	1.4	2.4	1.6	-0.2	1.1	-1.3
Wears glasses or contact lenses	1.2	1.4	2.5	-1.6	-1.2	-1.3	-0.1
Ever taken oral contraceptive pill	2.1	2.3	3.9	1.7	-1.3	2.0	0.9
Hearing aid user	0.5	0.6	2.4	0.1	-1.5	-0.1	-0.2
Mother’s age at death	0.9	1.1	2.9	0.9	0.7	0.4	1.7
Financial situation satisfaction	0.2	0.2	0.3	0.5	-0.5	0.5	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	0.3	-0.2	0.3	-1.4
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.6	-1.1	-0.4	-1.1
Eye problems/disorders: Glaucoma	0.4	0.4	0.6	0.5	0.8	0.6	0.8
Medication: Blood pressure	0.6	1.1	1.6	0.9	-0.9	1.1	-1.3
Pain type(s) experienced in last month: Hip pain	2.0	2.5	5.2	-2.3	0.1	-2.2	-0.3
Supplements: Fish oil (including cod liver oil)	3.1	4.0	6.7	-2.3	-1.9	-2.6	0.8
High cholesterol (Self-reported)	0.6	1.1	1.9	-1.1	-1.2	-1.4	-0.0
Medication: Bendroflumethiazide	0.7	1.1	2.7	0.5	-1.1	0.4	-1.7
Medication: Paracetamol	0.8	1.2	2.5	-1.4	-0.7	-1.6	-0.0
Medication: Lisinopril	0.2	0.3	0.7	-0.2	-0.3	-0.8	-0.7
Medication: Atorvastatin	1.2	1.4	3.4	-1.9	0.6	-1.4	-0.1
Illnesses of father: High blood pressure	3.0	3.7	6.0	1.4	2.5	1.6	-2.1
Alcohol drinker status: Never	0.8	1.0	2.2	0.2	-1.3	0.1	-1.5
Ever smoked	0.5	0.8	1.6	-1.1	-0.7	-0.3	1.2
Basal metabolic rate	0.3	1.5	2.5	1.4	-0.5	1.2	1.6
Leg fat percentage (left)	1.1	4.1	7.1	-2.2	0.1	-2.1	2.7
Arm fat-free mass (left)	0.2	1.1	1.5	1.2	-0.6	1.1	1.2
Number of operations (self-reported)	1.1	1.6	5.8	-0.1	-2.4	-0.6	-0.4
Average weekly beer plus cider intake	0.5	0.7	0.9	0.9	-0.9	0.9	-0.8
Irritability	0.1	0.2	0.4	-0.5	-0.1	-0.2	-0.6
Risk taking	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	-1.0	0.3	-0.2	-0.8
Fractured/broken bones in last 5 years	1.0	1.4	3.2	1.4	-0.2	1.8	0.3
Age started oral contraceptive pill	0.5	0.6	1.7	-0.2	-0.3	0.6	1.3
Diastolic blood pressure, automated reading	0.9	2.7	5.1	2.1	0.2	2.3	-1.2
Ever depressed for a whole week	0.2	0.3	0.9	-0.3	0.1	0.1	-0.9
Unable to work because of sickness or disability	0.5	0.6	1.2	-1.1	-0.8	-0.8	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.7	0.6	-1.3	-0.4	-0.1
Myopia	0.6	0.8	1.6	0.8	1.3	1.0	-0.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	7.3	-0.8	0.2	-0.9	2.7
Cholesterol lowering medication	0.2	0.3	0.4	0.5	-0.5	0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.2	-0.9	-0.7	-0.5	-1.5
Pain experienced in last month	0.3	0.4	1.4	0.0	-1.2	-0.3	-0.4
Supplements: Calcium	1.4	1.5	3.6	1.9	-0.0	1.6	-0.3
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.8	0.6	0.3	-0.6
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.0	-1.7	0.8	-1.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	1.1	-1.4	0.4	0.5
Heart disease (siblings)	2.3	2.8	5.4	-1.1	2.3	-1.6	1.5
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.4
Pack years of smoking	3.0	4.5	8.1	-2.2	2.9	-1.6	1.5
Impedance of whole body	0.2	1.0	2.4	1.0	1.6	0.8	-0.2
Leg fat mass (left)	0.7	2.6	7.5	-1.1	-0.2	-1.2	2.7
Arm predicted mass (left)	0.3	1.4	1.8	1.3	-0.9	1.1	1.4