Best TWAS P=7.18e-09 · Best GWAS P=2.1e-08 conditioned to 0.152
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | EXOC2 | 0.13 | 0.07 | lasso | 3 | 0.07 | 1.0e-04 | -5.5 | -5.2 | 2.3e-07 | 0.84 | 0.00 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | EXOC2 | 0.33 | 0.10 | lasso | 10 | 0.09 | 1.3e-05 | -5.6 | -5.3 | 1.2e-07 | 0.83 | 0.01 | 0.99 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | EXOC2 | 0.23 | 0.16 | lasso | 4 | 0.16 | 4.0e-12 | -5.6 | -5.8 | 8.6e-09 | 0.86 | 0.00 | 1.00 | FALSE |
4 | GTEx | Colon Sigmoid | EXOC2 | 0.37 | 0.07 | lasso | 10 | 0.03 | 2.6e-02 | -5.6 | -5.8 | 7.2e-09 | 0.83 | 0.01 | 0.98 | TRUE |
5 | GTEx | Esophagus Mucosa | EXOC2 | 0.29 | 0.12 | lasso | 6 | 0.09 | 1.4e-06 | -4.3 | -5.8 | 7.9e-09 | 0.69 | 0.08 | 0.91 | FALSE |
6 | GTEx | Muscle Skeletal | EXOC2 | 0.21 | 0.06 | lasso | 8 | 0.09 | 2.1e-09 | -5.6 | -5.1 | 2.7e-07 | 0.83 | 0.00 | 1.00 | FALSE |
7 | METSIM | Adipose | EXOC2 | 0.10 | 0.04 | lasso | 11 | 0.06 | 9.8e-10 | -5.6 | -5.2 | 1.6e-07 | 0.71 | 0.00 | 1.00 | FALSE |
8 | METSIM | Adipose | RP11-532F6.3 | 0.28 | 0.27 | lasso | 3 | 0.27 | 1.2e-40 | -5.3 | 5.3 | 1.4e-07 | -0.72 | 0.02 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EXOC2 | 0.07 | 0.06 | lasso | 5 | 0.06 | 2.6e-07 | -3.6 | -5.2 | 2.1e-07 | 0.44 | 0.78 | 0.10 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | EXOC2 | 0.10 | 0.01 | blup | 204 | 0.03 | 6.8e-05 | -3.8 | -5.7 | 1.3e-08 | 0.63 | 0.02 | 0.90 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EXOC2 | 0.14 | 0.02 | blup | 203 | 0.06 | 3.1e-07 | -5.6 | -5.4 | 7.8e-08 | 0.60 | 0.00 | 0.99 | FALSE |