Best TWAS P=1e-86 · Best GWAS P=4.37e-146 conditioned to 4.98e-47
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SSR1 | 0.20 | 0.03 | bslmm | 635 | 0.14 | 2.3e-16 | -3.3 | -9.9 | 2.6e-23 | -0.01 | 0.92 | 0.00 | TRUE |
| 2 | GTEx | Artery Aorta | RIOK1 | 0.18 | 0.01 | enet | 9 | 0.01 | 5.1e-02 | -1.9 | -5.5 | 3.4e-08 | -0.03 | 0.15 | 0.04 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | SSR1 | 0.14 | 0.10 | lasso | 5 | 0.12 | 4.2e-09 | 6.7 | -7.8 | 6.0e-15 | -0.07 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RP11-69L16.4 | 0.15 | 0.06 | lasso | 4 | 0.07 | 4.6e-06 | 6.7 | -7.4 | 1.6e-13 | -0.08 | 0.94 | 0.00 | FALSE |
| 5 | GTEx | Stomach | RIOK1 | 0.23 | 0.06 | enet | 28 | 0.07 | 2.6e-04 | -3.6 | 11.4 | 3.3e-30 | 0.22 | 0.44 | 0.11 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | LY86-AS1 | 0.12 | 0.02 | enet | 15 | 0.08 | 1.5e-10 | -4.1 | -6.7 | 1.9e-11 | -0.04 | 0.99 | 0.00 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | TXNDC5 | 0.07 | 0.07 | bslmm | 589 | 0.05 | 1.9e-07 | -7.0 | 5.1 | 2.8e-07 | -0.11 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TXNDC5 | 0.05 | 0.03 | lasso | 5 | 0.03 | 1.6e-06 | -7.0 | 6.0 | 1.4e-09 | -0.09 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TXNDC5 | 0.07 | 0.05 | lasso | 3 | 0.05 | 2.1e-06 | -7.0 | 7.0 | 1.9e-12 | -0.05 | 0.99 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TXNDC5 | 0.24 | 0.13 | lasso | 7 | 0.12 | 2.0e-07 | -7.0 | 5.9 | 2.9e-09 | -0.04 | 0.98 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | TXNDC5 | 0.12 | 0.06 | enet | 8 | 0.06 | 1.8e-07 | -6.6 | 6.6 | 3.9e-11 | -0.05 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | BMP6 | 0.29 | 0.00 | blup | 162 | 0.03 | 5.6e-02 | 6.1 | 19.7 | 1.0e-86 | 0.49 | 0.02 | 0.19 | TRUE |
| 13 | The Cancer Genome Atlas | Thyroid Carcinoma | TXNDC5 | 0.08 | 0.06 | lasso | 2 | 0.05 | 1.1e-05 | -7.0 | 6.8 | 8.3e-12 | -0.05 | 0.99 | 0.00 | FALSE |