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chr6:56,123,698-57,687,035

Best TWAS P=4.33e-15 · Best GWAS P=1.75e-12 conditioned to 0.0113

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BEND6	0.21	0.30	lasso	6	0.30	2.1e-36	-5.7	6.2	5.9e-10	-0.87	0.90	0.10	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RAB23	0.04	0.01	blup	202	0.02	1.3e-03	-4.3	-7.8	4.3e-15	0.66	0.06	0.32	TRUE
3	GTEx	Brain Putamen basal ganglia	BAG2	0.14	0.08	lasso	4	0.10	2.9e-03	-5.2	-5.5	4.6e-08	0.77	0.03	0.69	FALSE
4	GTEx	Testis	RP11-203B9.4	0.09	0.03	enet	6	0.08	1.3e-04	-5.6	-6.0	1.4e-09	0.76	0.08	0.62	FALSE
5	GTEx	Whole Blood	RAB23	0.04	0.02	enet	14	0.01	1.7e-02	-5.5	-7.1	1.4e-12	0.87	0.02	0.95	FALSE
6	METSIM	Adipose	RAB23	0.03	0.00	bslmm	197	0.01	2.3e-02	-6.1	-7.0	1.8e-12	0.67	0.05	0.66	FALSE
7	NTR	Blood	RAB23	0.01	0.02	lasso	2	0.01	5.4e-05	-5.2	-5.6	2.7e-08	0.77	0.15	0.83	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	BEND6	0.28	0.36	lasso	4	0.35	1.1e-46	-5.7	5.9	4.3e-09	-0.82	0.91	0.09	FALSE
9	YFS	Blood	RAB23	0.11	0.24	enet	19	0.24	1.9e-77	-5.5	-6.3	3.7e-10	0.85	0.99	0.01	FALSE
10	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	BEND6	0.05	0.06	blup	44	0.06	8.9e-06	-6.8	6.5	8.9e-11	-0.92	0.02	0.98	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	BEND6	0.05	0.08	blup	44	0.09	6.1e-18	-5.7	6.5	1.1e-10	-0.91	0.18	0.82	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	BEND6	0.12	0.12	blup	44	0.15	5.7e-09	-5.8	6.6	4.9e-11	-0.91	0.09	0.91	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BEND6	0.11	0.10	lasso	3	0.13	1.4e-14	-6.8	6.5	8.2e-11	-0.92	0.03	0.97	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BEND6	0.06	0.08	blup	44	0.07	1.7e-08	-5.7	5.8	8.3e-09	-0.84	0.19	0.81	FALSE
15	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BEND6	0.06	0.04	blup	44	0.05	1.1e-03	-7.1	6.0	1.6e-09	-0.93	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	BEND6	0.07	0.09	lasso	6	0.11	2.0e-12	-5.6	6.6	4.6e-11	-0.93	0.05	0.95	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BEND6	0.06	0.06	enet	11	0.09	4.5e-10	-5.7	6.2	5.2e-10	-0.89	0.04	0.96	FALSE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	BEND6	0.19	0.16	lasso	3	0.18	8.3e-08	-6.9	6.8	1.1e-11	-0.98	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	BEND6	0.15	0.26	lasso	7	0.29	8.9e-31	-6.9	6.8	1.3e-11	-0.95	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Rectum Adenocarcinoma	BEND6	0.20	0.15	blup	44	0.18	6.4e-05	-5.7	7.0	1.8e-12	-0.92	0.02	0.91	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	BEND6	0.09	0.07	lasso	5	0.08	2.9e-05	-5.7	5.7	9.4e-09	-0.83	0.02	0.95	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	BEND6	0.07	0.09	enet	5	0.09	8.1e-07	-5.6	6.1	1.3e-09	-0.86	0.08	0.92	FALSE