Best TWAS P=1.14e-48 · Best GWAS P=5.29e-63 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FILIP1 | 0.03 | 0.01 | bslmm | 344 | 0.02 | 3.2e-03 | -2.6 | -7.7 | 1.2e-14 | -0.10 | 0.14 | 0.03 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IMPG1 | 0.07 | 0.01 | lasso | 5 | 0.02 | 1.5e-03 | -2.0 | -7.0 | 3.3e-12 | -0.46 | 0.35 | 0.08 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | MYO6 | 0.21 | 0.07 | bslmm | 366 | 0.12 | 8.8e-15 | 11.6 | -9.4 | 5.7e-21 | -0.37 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | TMEM30A | 0.14 | 0.05 | enet | 15 | 0.05 | 1.1e-04 | -3.6 | 6.2 | 5.7e-10 | 0.11 | 0.87 | 0.00 | TRUE |
| 5 | GTEx | Artery Aorta | MYO6 | 0.15 | 0.05 | lasso | 6 | 0.09 | 1.6e-05 | -5.3 | 8.9 | 3.6e-19 | 0.46 | 0.41 | 0.02 | TRUE |
| 6 | GTEx | Artery Tibial | SENP6 | 0.08 | 0.00 | enet | 5 | 0.00 | 8.2e-01 | 15.8 | 14.5 | 2.0e-47 | 0.76 | 0.04 | 0.46 | TRUE |
| 7 | GTEx | Artery Tibial | MYO6 | 0.07 | 0.01 | enet | 16 | 0.01 | 2.3e-02 | 11.6 | 10.2 | 2.3e-24 | 0.28 | 0.17 | 0.12 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | FILIP1 | 0.28 | 0.22 | lasso | 7 | 0.28 | 8.8e-08 | -1.9 | -5.2 | 2.0e-07 | -0.21 | 0.93 | 0.02 | TRUE |
| 9 | GTEx | Brain Cerebellum | MYO6 | 0.34 | 0.21 | enet | 22 | 0.32 | 2.9e-10 | 7.8 | 6.8 | 1.2e-11 | -0.03 | 0.98 | 0.00 | TRUE |
| 10 | GTEx | Heart Left Ventricle | MYO6 | 0.09 | 0.00 | lasso | 7 | 0.00 | 5.6e-01 | -10.3 | 9.5 | 2.6e-21 | 0.13 | 0.16 | 0.04 | TRUE |
| 11 | GTEx | Lung | MYO6 | 0.09 | 0.08 | enet | 21 | 0.08 | 1.6e-06 | 11.0 | 10.0 | 1.2e-23 | 0.24 | 0.94 | 0.00 | TRUE |
| 12 | GTEx | Muscle Skeletal | FILIP1 | 0.04 | 0.00 | enet | 13 | 0.01 | 1.6e-02 | 15.8 | -10.6 | 4.1e-26 | -0.59 | 0.15 | 0.10 | FALSE |
| 13 | GTEx | Nerve Tibial | MYO6 | 0.12 | 0.02 | enet | 12 | 0.06 | 3.4e-05 | 11.2 | 8.2 | 3.7e-16 | 0.23 | 0.88 | 0.00 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | MYO6 | 0.11 | 0.03 | lasso | 3 | 0.04 | 2.1e-03 | 15.8 | -10.4 | 2.3e-25 | -0.70 | 0.15 | 0.46 | FALSE |
| 15 | GTEx | Spleen | SENP6 | 0.21 | 0.11 | lasso | 5 | 0.06 | 1.3e-02 | -9.6 | -9.6 | 8.7e-22 | -0.26 | 0.12 | 0.09 | FALSE |
| 16 | GTEx | Thyroid | MYO6 | 0.12 | 0.11 | enet | 15 | 0.12 | 1.5e-09 | 11.6 | 11.8 | 5.0e-32 | 0.37 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Whole Blood | TMEM30A | 0.05 | 0.00 | enet | 17 | 0.01 | 2.8e-02 | -3.6 | 5.8 | 6.5e-09 | 0.20 | 0.08 | 0.03 | FALSE |
| 18 | GTEx | Whole Blood | SENP6 | 0.06 | 0.06 | lasso | 5 | 0.06 | 4.3e-06 | 7.8 | -5.5 | 3.2e-08 | 0.21 | 0.95 | 0.01 | FALSE |
| 19 | METSIM | Adipose | COL12A1 | 0.04 | 0.01 | blup | 309 | 0.02 | 5.1e-04 | -1.5 | -9.4 | 3.5e-21 | -0.48 | 0.12 | 0.53 | FALSE |
| 20 | NTR | Blood | SENP6 | 0.02 | 0.01 | lasso | 2 | 0.01 | 6.5e-05 | 7.8 | -7.8 | 8.0e-15 | 0.11 | 0.94 | 0.00 | TRUE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | SENP6 | 0.17 | 0.14 | blup | 355 | 0.17 | 2.5e-21 | -9.5 | -14.7 | 1.1e-48 | -0.41 | 1.00 | 0.00 | TRUE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | MYO6 | 0.09 | 0.07 | enet | 27 | 0.08 | 4.1e-10 | 11.0 | -10.8 | 5.3e-27 | -0.40 | 1.00 | 0.00 | FALSE |
| 23 | YFS | Blood | TMEM30A | 0.03 | 0.02 | bslmm | 250 | 0.02 | 2.9e-08 | -3.6 | 5.6 | 2.1e-08 | 0.24 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | IMPG1 | 0.05 | 0.03 | lasso | 2 | 0.02 | 2.4e-03 | 9.0 | 9.2 | 2.4e-20 | 0.59 | 0.16 | 0.04 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MYO6 | 0.04 | 0.03 | blup | 105 | 0.05 | 7.0e-06 | -10.3 | -11.7 | 9.5e-32 | -0.23 | 0.67 | 0.02 | FALSE |
| 26 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | FILIP1 | 0.34 | 0.03 | blup | 88 | 0.16 | 6.3e-05 | -4.4 | 5.2 | 1.9e-07 | 0.18 | 0.02 | 0.05 | FALSE |