Best TWAS P=1.43e-09 · Best GWAS P=1.77e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CDC14A | 0.22 | 0.20 | lasso | 4 | 0.18 | 8.3e-14 | -6.0 | 5.9 | 3.0e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Nerve Tibial | LRRC39 | 0.10 | 0.02 | enet | 23 | 0.05 | 1.7e-04 | 4.4 | 5.6 | 1.9e-08 | 0.00 | 0.48 | 0.12 | TRUE |
| 3 | GTEx | Stomach | LRRC39 | 0.12 | 0.08 | enet | 17 | 0.03 | 9.2e-03 | 4.5 | 5.2 | 2.5e-07 | 0.05 | 0.63 | 0.18 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | CDC14A | 0.14 | 0.12 | lasso | 4 | 0.16 | 2.0e-09 | -4.7 | 5.5 | 4.6e-08 | -0.85 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14A | 0.04 | 0.05 | lasso | 2 | 0.04 | 1.2e-05 | -6.0 | 6.0 | 1.4e-09 | -1.00 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CDC14A | 0.19 | 0.14 | lasso | 3 | 0.14 | 6.0e-07 | -6.0 | 6.0 | 2.6e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LRRC39 | 0.08 | 0.00 | blup | 40 | 0.04 | 1.6e-03 | 4.5 | 5.2 | 1.5e-07 | -0.11 | 0.00 | 0.16 | FALSE |