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chr7:37,260,712-38,687,833

Best TWAS P=1.1e-27 · Best GWAS P=2.91e-37 conditioned to 5.5e-18

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EPDR1	0.24	0.11	lasso	10	0.12	2.4e-14	7.2	9.9	3.6e-23	-0.11	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	EPDR1	0.18	0.01	lasso	4	0.01	8.9e-02	6.7	6.2	4.9e-10	-0.13	0.17	0.11	FALSE
3	GTEx	Artery Aorta	EPDR1	0.51	0.38	lasso	7	0.47	1.3e-28	-1.3	5.8	6.7e-09	-0.25	1.00	0.00	FALSE
4	GTEx	Artery Tibial	EPDR1	0.27	0.15	lasso	12	0.16	3.4e-12	6.7	8.3	1.4e-16	-0.26	1.00	0.00	FALSE
5	GTEx	Cells Transformed fibroblasts	EPDR1	0.21	0.18	lasso	4	0.17	1.3e-12	-7.6	7.5	7.3e-14	-0.06	1.00	0.00	FALSE
6	GTEx	Esophagus Muscularis	EPDR1	0.35	0.08	lasso	5	0.21	1.0e-12	7.1	8.4	4.1e-17	-0.12	1.00	0.00	FALSE
7	GTEx	Lung	EPDR1	0.15	0.06	enet	24	0.08	9.8e-07	5.1	5.5	4.5e-08	-0.05	0.71	0.01	FALSE
8	GTEx	Nerve Tibial	EPDR1	0.29	0.14	lasso	4	0.23	2.7e-16	6.5	6.7	3.0e-11	-0.13	1.00	0.00	FALSE
9	GTEx	Thyroid	EPDR1	0.19	0.06	enet	25	0.10	4.0e-08	6.7	7.9	2.9e-15	-0.23	0.83	0.01	FALSE
10	GTEx	Whole Blood	EPDR1	0.10	0.03	lasso	2	0.02	4.4e-03	3.2	5.8	7.3e-09	-0.01	0.28	0.03	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	EPDR1	0.17	0.06	lasso	6	0.10	2.5e-13	3.6	9.3	1.1e-20	-0.07	1.00	0.00	TRUE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	EPDR1	0.06	0.01	enet	22	0.06	6.7e-12	6.4	10.9	1.1e-27	-0.25	0.11	0.88	TRUE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EPDR1	0.08	0.04	enet	3	0.05	5.4e-06	6.7	7.9	2.7e-15	-0.25	0.86	0.00	TRUE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EPDR1	0.04	0.00	blup	113	0.01	8.5e-03	7.2	7.8	5.9e-15	-0.26	0.04	0.08	FALSE
15	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EPDR1	0.12	0.10	lasso	2	0.08	5.1e-04	7.2	7.2	8.2e-13	-0.14	0.05	0.53	FALSE
16	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EPDR1	0.09	0.10	lasso	2	0.06	2.8e-03	-10.2	10.5	8.9e-26	-0.15	0.00	0.95	TRUE