Best TWAS P=1.82e-14 · Best GWAS P=7.04e-15 conditioned to 3.23e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DPY19L1 | 0.08 | 0.05 | enet | 11 | 0.06 | 4.4e-08 | -6.1 | -6.9 | 3.8e-12 | 0.67 | 0.92 | 0.08 | FALSE |
| 2 | GTEx | Artery Aorta | KBTBD2 | 0.11 | 0.04 | enet | 22 | 0.02 | 1.6e-02 | 6.4 | 7.7 | 1.8e-14 | 0.06 | 0.08 | 0.50 | TRUE |
| 3 | GTEx | Brain Putamen basal ganglia | BBS9 | 0.22 | 0.00 | enet | 25 | 0.04 | 3.5e-02 | 3.3 | -6.7 | 1.7e-11 | -0.02 | 0.12 | 0.06 | TRUE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | RP11-265E18.1 | 0.24 | 0.07 | lasso | 8 | 0.09 | 8.4e-04 | 5.5 | 5.2 | 1.9e-07 | 0.00 | 0.45 | 0.28 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | DPY19L1 | 0.12 | 0.01 | lasso | 8 | 0.05 | 9.5e-04 | -6.7 | 6.7 | 1.9e-11 | -0.56 | 0.38 | 0.39 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | KBTBD2 | 0.17 | 0.08 | lasso | 2 | 0.06 | 1.2e-05 | 6.6 | 6.7 | 2.8e-11 | 0.04 | 0.04 | 0.95 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | DPY19L1 | 0.15 | 0.07 | lasso | 7 | 0.05 | 5.7e-05 | -7.0 | 6.8 | 8.4e-12 | -0.49 | 0.68 | 0.26 | FALSE |
| 8 | GTEx | Spleen | KBTBD2 | 0.47 | 0.20 | lasso | 6 | 0.16 | 7.0e-05 | 6.4 | 6.5 | 1.0e-10 | 0.03 | 0.05 | 0.74 | FALSE |
| 9 | GTEx | Thyroid | KBTBD2 | 0.11 | 0.06 | enet | 18 | 0.03 | 2.1e-03 | 6.4 | 7.0 | 2.4e-12 | 0.02 | 0.06 | 0.92 | FALSE |
| 10 | GTEx | Whole Blood | DPY19L1 | 0.11 | 0.02 | lasso | 8 | 0.04 | 1.6e-04 | 2.3 | 6.3 | 2.9e-10 | -0.42 | 0.67 | 0.16 | FALSE |
| 11 | NTR | Blood | AVL9 | 0.02 | 0.02 | blup | 528 | 0.01 | 1.2e-04 | 5.5 | -6.8 | 1.2e-11 | -0.01 | 0.72 | 0.18 | FALSE |
| 12 | NTR | Blood | BBS9 | 0.03 | 0.01 | blup | 574 | 0.01 | 3.9e-05 | -4.3 | -5.2 | 1.5e-07 | 0.08 | 0.85 | 0.01 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | BMPER | 0.08 | 0.02 | blup | 590 | 0.03 | 1.7e-04 | -1.8 | -5.3 | 1.2e-07 | 0.06 | 0.82 | 0.01 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | DPY19L1 | 0.06 | 0.07 | lasso | 2 | 0.06 | 8.1e-08 | -6.1 | -6.1 | 1.1e-09 | 0.60 | 0.99 | 0.01 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KBTBD2 | 0.02 | 0.01 | enet | 4 | 0.01 | 5.4e-03 | -4.3 | 5.2 | 1.7e-07 | 0.06 | 0.17 | 0.10 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPY19L2P1 | 0.04 | 0.01 | blup | 22 | 0.02 | 3.8e-03 | -5.6 | 5.3 | 1.4e-07 | -0.66 | 0.04 | 0.59 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DPY19L1 | 0.02 | 0.02 | blup | 62 | 0.02 | 8.3e-04 | -6.1 | 7.4 | 1.7e-13 | -0.53 | 0.01 | 0.75 | TRUE |
| 18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DPY19L1 | 0.07 | 0.02 | blup | 62 | 0.03 | 3.8e-03 | -6.8 | 5.7 | 1.5e-08 | -0.36 | 0.01 | 0.91 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | BBS9 | 0.29 | 0.21 | lasso | 4 | 0.27 | 1.7e-26 | -5.6 | 5.1 | 2.8e-07 | 0.05 | 0.17 | 0.83 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC441208 | 0.04 | 0.01 | enet | 3 | 0.02 | 4.8e-03 | -5.5 | 5.5 | 4.4e-08 | 0.06 | 0.00 | 0.95 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | RP9 | 0.06 | 0.06 | lasso | 3 | 0.04 | 4.8e-05 | -5.6 | 5.7 | 1.1e-08 | 0.05 | 0.01 | 0.98 | TRUE |